Clinical Trials on Craniofacial Dysostosis

Total 490 results

University of Geneva, Switzerland

Terminated

Neuroprotective Effects of Risperdal on Brain and Cognition in 22q11 Deletion Syndrome

22q11.2 Deletion Syndrome

Switzerland
Enzyvant Therapeutics GmBH
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Terminated

Serum-Free Thymus Transplantation in DiGeorge Anomaly (SerumFree)

DiGeorge Anomaly
Novo Nordisk A/S

Completed

Investigating the Long-term Efficacy and Safety of Two Doses of NN-220 (Somatropin) in Short Stature Due to Noonan Syndrome

Noonan Syndrome | Genetic Disorder

Japan
Assistance Publique - Hôpitaux de Paris

Unknown

Aromatase Inhibitor in Bone Maturation, Children With Silver Russell or Prader-Willi Syndrome (ANASILPRA)

Prader-Willi Syndrome | Silver Russell Syndrome

France
Eunice Kennedy Shriver National Institute of Child...

Recruiting

MEHMO Natural History and Biomarkers

Epilepsy | Obesity | Intellectual Disability | Microcephaly | Nervous System Malformations | Hypogonadisms

United States
Innovation Research & Training

Recruiting

Mindfulness Program for Adolescents With 22q11DS

22Q11 Deletion Syndrome

United States
Sumitomo Pharma Switzerland GmbH

Recruiting

Congenital Athymia Patient Registry

Complete DiGeorge Anomaly | Complete DiGeorge Syndrome | Congenital Athymia

United States
Novo Nordisk A/S

Completed

Post Marketing Surveillance on Long-term Use With Norditropin® (Short Stature Due to Noonan Syndrome)

Noonan Syndrome | Genetic Disorder

Japan
Enzyvant Therapeutics GmBH
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Completed

Parathyroid and Thymus Transplantation in DiGeorge #931

DiGeorge Syndrome | Hypoparathyroidism | Complete DiGeorge Syndrome

United States
Institut National de la Santé Et de la Recherche...

Completed

Hormonal Sensitivity in Patients With Noonan and LEOPARD Syndromes (NOLEO)

Noonan Syndrome | LEOPARD Syndrome

France
The University of Hong Kong
Chinese University of Hong Kong

Completed

Three-Dimensional Printing of Patient-Specific Titanium Plates in Jaw Surgery: A Pilot Study (3DJP16)

Maxillofacial Injuries | Dentofacial Deformities | Mandibular Neoplasms | Maxillary Neoplasms

Hong Kong
University Ghent
Research Foundation Flanders

Not yet recruiting

Effect and Cost-utility of of High Intensity vs. Low Intensity Speech Intervention in Children With Cleft Palate

Cleft Lip and Palate | Cleft Palate Children | Speech Therapy | Speech Disorders in Children
University Ghent
Research Foundation Flanders

Recruiting

Effect of Performance-specific Cleft Speech Intervention and Long-term Learning in Children With a Cleft Palate

Cleft Lip and Palate | Cleft Palate Children | Speech Therapy | Speech Disorders in Children

Belgium
Enzyvant Therapeutics GmBH
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Approved for marketing

Thymus Transplantation Safety-Efficacy

DiGeorge Syndrome | DiGeorge Anomaly | Complete DiGeorge Anomaly | Complete DiGeorge Syndrome

United States
Chang Gung Memorial Hospital

Unknown

Sensory Retraining Facilitates Sensory Recovery After Mandibular Nerve Injury

Surgery | Mandibular Prognathism | Injury of Trigeminal Nerve

Taiwan
Pontificia Universidade Catolica de Sao Paulo

Completed

Middle and Inner Ear Malformation in Children With Velocardiofacial Syndrome

Ear Malformations in the Velocardiofacial Syndrome
NYU Langone Health

Enrolling by invitation

Self-Face Recognition After Face Transplantation

Disfigurement of Face

United States
State University of New York - Upstate Medical...
Albert Einstein College of Medicine

Completed

Genetic Modifiers for 22q11.2 Syndrome (VCFS)

22q11.2 Deletion Syndrome

United States
Mahidol University

Completed

Resolution of Primary Immune Defect in 22q11.2 Deletion Syndrome

22q11.2 Deletion Syndrome | Immune Defect

Thailand
Bambino Gesù Hospital and Research Institute
National Alliance for Research on Schizophrenia and Depression; Orygen

Unknown

Indicated Prevention With Long-chain Polyunsaturated Omega-3 Fatty Acids in Patients With 22q11 Microdeletion Syndrome.

22q11 Deletion Syndrome

Holy See (Vatican City State)
Children's Healthcare of Atlanta

Terminated

Infection in DiGeorge Following CHD Surgery

DiGeorge Syndrome | Congenital Heart Defects

United States
Stephan Eliez

Recruiting

Using Transcranial Alternating Current Stimulation to Improve Executive Function in 22q11.2 Deletion Syndrome

tACS | 22Q11 Deletion Syndrome

Switzerland
Manchester University NHS Foundation Trust
University College, London; University Hospital Southampton NHS Foundation... and other collaborators

Recruiting

Comparing the Side-lying Sleep Positioning to Back-lying in Infants With Cleft Palate (SLUMBRS2)

Obstructive Sleep Apnea | Cleft Palate

United Kingdom
University of North Carolina, Chapel Hill
North Carolina State University

Recruiting

Orthognathic Speech Pathology: Phonetic Contrasts of Patients With Dental Discrepancies Pre- and Post-Treatment Analyses (OSP)

Malocclusion | Speech Disorders | Speech Sound Disorder | Dentofacial Deformities | Skeletal Malocclusion | Dentofacial Anomalies, Including Malocclusion | Dentofacial Abnormalities | Malocclusion in Children | Dentofacial Disharmony | Skeletal Malformation

United States
Zynerba Pharmaceuticals, Inc.

Completed

Open-Label Study of ZYN002 Administered as a Transdermal Gel to Children and Adolescents With 22q11.2 Deletion Syndrome (INSPIRE)

22Q Deletion Syndrome

United States, Australia
Universidad Industrial de Santander
University of North Carolina, Chapel Hill

Completed

Neurodevelopment Outcome of Newborns Exposed to Zika Virus (ZIKV) in Utero (ZENI)

Microcephaly | Mental Retardation

Colombia
Aevi Genomic Medicine, LLC, a Cerecor company

Completed

Safety and Efficacy Study of NFC-1 in Subjects Aged 12-17 Years With 22q11.2DS & Associated Neuropsychiatric Conditions

22q11.2 Deletion Syndrome

United States
Enzyvant Therapeutics GmBH
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Completed

Thymus Transplantation in DiGeorge Syndrome #668

DiGeorge Syndrome | Complete Typical DiGeorge Anomaly

United States
National Institute of Mental Health (NIMH)

Completed

Velocardiofacial (VCFS; 22q11.2; DiGeorge) Syndrome Study

DiGeorge Syndrome | Velocardiofacial Syndrome | 22q11.2 Syndrome

United States
Hôpital le Vinatier

Recruiting

Understanding of Psychotic Disorders in Children With 22q11.2DS (PremiCeS22)

22q11.2 Deletion Syndrome

France
Virginia Polytechnic Institute and State University

Recruiting

The FBRI VTC Neuromotor Research Clinic

Cerebral Palsy | Microcephaly | Acquired Brain Injury | Autism | Trauma, Brain | Neuromotor Impairments | Pediatric Stroke

United States
Centre Hospitalier Universitaire de Nīmes

Completed

Prenatal Examination of Deletion 22q11 Syndrome : Thymic Dysgenesis THYMI Study

22q11 Deletion Syndrome Di George Syndrome

France
UMC Utrecht
Children's Hospital of Philadelphia; Netherlands Brain Foundation

Unknown

Genetics and Psychopathology in the 22q11 Deletion Syndrome

Chromosome 22q11.2 Deletion Syndrome

United States, Netherlands
UMC Utrecht
Eindhoven University of Technology

Recruiting

Early Scoliotic Changes in Children at Increased Risk for Scoliosis Development (EARLYBIRD)

22q11.2 Deletion Syndrome | Adolescent Idiopathic Scoliosis

Netherlands
Enzyvant Therapeutics GmBH
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Completed

Thymus Transplantation With Immunosuppression (884)

DiGeorge Syndrome | DiGeorge Anomaly | Complete DiGeorge Anomaly | Complete DiGeorge Syndrome

United States
Hôpital le Vinatier

Completed

Molecular Variants Associated With Schizophrenia: Differential Analysis of Monozygotic Twins With Variable Phenotypic 22q11 (CSRK05)

Di George Syndrome

France
State University of New York - Upstate Medical...
National Institute of Mental Health (NIMH)

Completed

Computerized Cognitive Skills Training for Adolescents With Velocardiofacial Syndrome

Velocardiofacial Syndrome

United States
Duke University
National Institute of Mental Health (NIMH); University of Pittsburgh; Harvard...

Completed

Cognitive Remediation in 22q11DS

22q11.2 Deletion Syndrome | Velo-Cardio-Facial Syndrome

United States
The Hospital for Sick Children

Terminated

A Physiological Study to Determine the Enteral Threonine Requirements in Infants Aged 1 to 6 Months (INFORALTHR)

Tracheoesophageal Fistula | Diaphragmatic Hernia | Surgical Infants on NG/NJ/J/G-tube Feeds | Pierre-Robin Syndrome

Canada
Hospices Civils de Lyon

Unknown

New Variants Involved in Taybi-Linder Syndrome (NewViTALS)

Genetic Syndrome | Taybi Linder Syndrome

France
Enzyvant Therapeutics GmBH
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Completed

Thymus Transplantation Dose in DiGeorge #932

DiGeorge Syndrome | DiGeorge Anomaly | Complete DiGeorge Anomaly | Complete DiGeorge Syndrome

United States
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Scleral Buckling for Retinal Detachment Prevention in Genetically Confirmed Stickler Syndrome (STL-DR-PREV)

Stickler Syndrome

France
Assistance Publique - Hôpitaux de Paris

Completed

Microcephaly Genetic Deficiency in Neural Progenitors (MICROFANC)

Microcephaly

France
National Center for Research Resources (NCRR)
Children's Hospital of Philadelphia

Unknown

Immunologic Evaluation in Patients With DiGeorge Syndrome or Velocardiofacial Syndrome

Abnormalities, Multiple | DiGeorge Syndrome | Chromosome Abnormalities | Conotruncal Cardiac Defects | Shprintzen Syndrome

United States
National Institute of Allergy and Infectious Diseases...

Recruiting

Natural History and Genetics of Food Allergy and Related Conditions

Eosinophilic Esophagitis | Atopic Dermatitis | Food Allergy | Loeys-Dietz Syndrome

United States
Centre Hospitalier Universitaire Dijon
Novartis Pharmaceuticals

Recruiting

Assessment of the Efficacy and Safety of Alpelisib (BYL719) in Pediatric and Adult Patients With Megalencephaly-CApillary Malformation Polymicrogyria Syndrome (MCAP) (SESAM)

Megalencephaly-capillary Malformation Polymicrogyria Syndrome (MCAP)

France
Enzyvant Therapeutics GmBH
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Completed

Phase I/II Thymus Transplantation With Immunosuppression #950 (#950)

DiGeorge Anomaly | Complete DiGeorge Anomaly | Complete DiGeorge Syndrome | Complete Atypical DiGeorge Anomaly | Complete Atypical DiGeorge Syndrome

United States
Bausch Health Americas, Inc.

Terminated

Metyrosine (Demser®) for the Treatment of Psychotic Disorders in Patients With Velocardiofacial Syndrome

Psychosis | Velo-cardio-facial Syndrome

United States
Hospices Civils de Lyon

Not yet recruiting

Study of the Pathophysiology of RNU4ATAC and RTTN Associated Syndromes (ATAC)

Lowry Wood Syndrome | Roifman Syndrome | Taybi Linder Syndrome | Microcephalic Osteodysplastic Primordial Dwarfism Types I and III

France
Institut National de la Santé Et de la Recherche...

Recruiting

National Evaluation of Patients With PIK3CA-Related Overgrowth Spectrum (PROS) (COSY)

Vascular Malformations | PIK3CA-related Overgrowth Spectrum | Megalencephaly | Lymphatic Malformation | CLOVES Syndrome | Venous Malformation | Klippel Trenaunay Syndrome | MCAP | Macrodactyly

France

Clinical Trials on Craniofacial Dysostosis

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Denmark

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

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