Clinical Trials on Critical Illness

Total 3978 results

APR Applied Pharma Research s.a.
Lavin Consulting, LLC

Completed

Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure (COVID-AIV)

Acute Lung Injury | Corona Virus Infection | Acute Respiratory Distress Syndrome (ARDS) | Critical COVID-19 With Respiratory Failure

United States
Concordia University Wisconsin

Not yet recruiting

M4C Nutraceutical Intervention Human Health Effects Pilot (M4C Pilot)

Obesity | Weight Management | Exercise Tolerance | Cardiovascular Health | Digestive Health | General Health and Wellness | Energy and Vitality | Cognitive Function and Mental Health | Bone and Joint Health | Skin, Hair, and Nail Health | Immune Support | Sports Performance and Recovery | Sleep and Relaxation | Anti...
Pregistry
Harvard School of Public Health (HSPH)

Completed

Health and Wellbeing of Pregnant and Post-Partum Women During the COVID-19 Pandemic

Depression | COVID-19 | Pregnancy Complications | Anxiety | Mental Health Wellness 1 | Coronavirus | Ptsd

United States
National Cancer Institute (NCI)

Recruiting

Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Patients With Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial

Anatomic Stage III Breast Cancer AJCC v8 | Anatomic Stage IV Breast Cancer AJCC v8 | Advanced Malignant Solid Neoplasm | Unresectable Malignant Solid Neoplasm | Stage III Uterine Corpus Cancer AJCC v8 | Stage IV Uterine Corpus Cancer AJCC v8 | Metastatic Malignant Solid Neoplasm | Clinical Stage... and other conditions

United States
Massachusetts General Hospital
Trefler Foundation

Recruiting

Adapting the Tumor Board Model for Mental Illness and Cancer

Cancer | Breast Cancer | Head and Neck Cancer | Schizophrenia | Lung Cancer | Bipolar Disorder | Gastrointestinal Cancer | Genitourinary Cancer | Severe Major Depression

United States
AgileMD, Inc.
University of Chicago; University of Wisconsin, Madison; Department of Health... and other collaborators

Recruiting

A Rapid Diagnostic of Risk in Hospitalized Patients Using Machine Learning

COVID-19 | Sepsis | Respiratory Failure | Cardiac Arrest | Hemodynamic Instability | Septicemia | Clinical Deterioration

United States
Fundació Institut Germans Trias i Pujol
Fundació Sant Joan de Déu; Fundación FLS de Lucha Contra el Sida, las Enfermedades... and other collaborators

Completed

Assessment of the Psycho-social Impact of COVID-19 Outbreak (COM-COVID)

COVID-19 | Quality of Life | SARS-CoV 2 | Social Distance | Mental Health Wellness 1 | Psychological | SARS (Disease)

Spain
University of North Carolina, Chapel Hill
National Human Genome Research Institute (NHGRI); East Carolina University; Mission...

Active, not recruiting

North Carolina Genomic Evaluation by Next-generation Exome Sequencing, 2 (NCGENES2)

Neuromuscular Diseases | Movement Disorders | Intellectual Disability | Autism Spectrum Disorder | Microcephaly | Hearing Loss | Genetic Disease | Inborn Errors of Metabolism | Epilepsy; Seizure | Brain Malformation | Hypotonia | Development Delay | Chromosome Abnormality | Dysmorphic Features | Skeletal Dysplasia | Congenital... and other conditions

United States
National Cancer Institute (NCI)

Recruiting

Antibody Drug Conjugate ADCT-701 in Neuroendocrine Tumors and Carcinomas

Neuroendocrine Tumors | Carcinoma, Neuroendocrine | Neuroendocrine Carcinomas | Carcinoma, Adrenal Cortical | Carcinoma, Adrenocortical

United States
michal roll

Recruiting

Safety and Efficacy Study Using 5-ALA Oral Administration as an Adjuvant Therapy on the Rate of Local Tumor Recurrence in Patients Who Have Desmoids Tumors

Surgical Resection | The Aim of the Study is to Evaluate the Efficacy of Photodynamic Therapy as an | Adjuvant Therapy on the Clinical Outcome of Patients With Desmoid Tumors After

Israel
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Active, not recruiting

Testing Dabrafenib and Trametinib With or Without Hydroxychloroquine in Stage IIIC or IV BRAF V600E/K Melanoma

Locally Advanced Melanoma | Unresectable Melanoma | Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 | Clinical Stage IV Cutaneous Melanoma AJCC v8 | Pathologic Stage IV Cutaneous Melanoma AJCC v8

United States
Nemours Children's Clinic
Potentials Foundation; Walking with Giants Foundation

Recruiting

Primordial Dwarfism Registry

MOPDII | RNU4atac-opathy (e.g. MOPDI/III, Lowry-Wood Syndrome, Roifman Syndrome) | Meier-Gorlin Syndrome | Saul-Wilson Syndrome | Ligase 4 Syndrome | Microcephalic Primordial Dwarfism

United States
Unity Health Toronto
Canadian Institutes of Health Research (CIHR); University of Toronto

Recruiting

Evaluating the Impact of Resource Navigators to Support LTC and RH Staff During and Beyond COVID-19

COVID-19 | Burnout, Professional | Wellness | Vaccine Refusal | Burnout, Caregiver

Canada
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

E6201 and Dabrafenib for the Treatment of Central Nervous System Metastases From BRAF V600 Mutated Metastatic Melanoma

Metastatic Melanoma | Clinical Stage IV Cutaneous Melanoma AJCC v8 | Metastatic Malignant Neoplasm in the Brain | Metastatic Malignant Neoplasm in the Central Nervous System

United States
Emory University
National Cancer Institute (NCI)

Active, not recruiting

Cabozantinib in Combination With Atezolizumab for the Treatment of Patients With Locally Advanced, Metastatic, or Unresectable Adrenal Cortical Cancer

Adrenal Cortical Carcinoma | Stage III Adrenal Cortex Carcinoma | Stage IV Adrenal Cortex Carcinoma AJCC v8 | Unresectable Adrenal Cortex Carcinoma | Locally Advanced Adrenal Cortex Carcinoma

United States
Bulgarian Cardiac Institute

Completed

Acute Coronary Syndrome in Patients With COVID-19 (ACS-COVID)

to Find a Clinical or Laboratory Parameter, That Would Help in Distinguishing Between COVID-19 Patients With MI and IRA and Those, Who Have no IRA

Bulgaria
University of Texas Southwestern Medical Center
MedImmune LLC

Withdrawn

Study to Evaluate Bacterial Activity That Drives the Progression of Clinical Infection

Diabetic Foot Ulcer

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma

Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7 | Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Pathologic Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma... and other conditions

United States
Norwegian School of Sport Sciences
Ostfold University College; University College of Southeast Norway

Completed

Mental Health in Fitness Instructors

Weight Loss | Amenorrhea | Dietary Habits | Weight Gain | Mental Health Wellness 1 | Body Image Disturbance | Exercise Addiction | Depression, Anxiety | Body Image | Eating Disorders | Thinness | Eating Behavior | Weight Change, Body | Sexual Harassment | Leanness

Norway
Shi Yun

Recruiting

Effect and Mechanism of Jiajian Guishen Formulation on Premature Ovarian Insufficiency Based on Metabolomics (JJGS and POI)

Traditional Chinese Medicine | Metabolomics | Premature Ovarian Insufficiency | Clinical Syndrome | Mechanism

China
Medical University of Vienna
Karl Landsteiner Institute for Clinical Epilepsy Research

Recruiting

Multimodal Neuromonitoring (MMNM)

Seizures | Traumatic Brain Injury | Subarachnoid Hemorrhage | Intracerebral Hemorrhage | Cortical Spreading Depolarization and Depression | Ictal-Interictal Continuum

Austria
Janssen Research & Development, LLC

Completed

A Study to Characterize the Clinical Course of Pregnant Women and Children at High Risk for Early Onset Severe Hemolytic Disease of the Fetus and Newborn

Erythroblastosis, Fetal | Early Onset Severe Hemolytic Disease of the Fetus and Newborn (EOS-HDFN)

United States, Canada, Netherlands, Belgium, Australia, Germany, Spain, Sweden, United Kingdom
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Low Dose Ipilimumab With Pembrolizumab in Treating Patients With Melanoma That Has Spread to the Brain

Metastatic Melanoma | Clinical Stage IV Cutaneous Melanoma AJCC v8 | Pathologic Stage IV Cutaneous Melanoma AJCC v8 | Metastatic Malignant Neoplasm in the Brain

United States
University of Michigan
National Cancer Institute (NCI)

Completed

Why do Oral Contraceptives Prevent Ovarian Cancer?

Ovarian Cancer Risk | Risk-reducing Surgery | Fallopian Tube Fimbriae | Ovarian Cortical Inclusion Cysts

United States, Canada
University Hospital, Clermont-Ferrand
I-SITE Cap 20-25 project

Recruiting

Evaluation of Impaired Mobility in Chronic Illness Constitution of a Cohort (EVALMOB)

Parkinson Disease | Joint Osteoarthritis | Atherosclerosis of the Distal Arteries, Without Gangrene | Chronic Obstructive Pulmonary Disease, Unspecified | Obesity, Unspecified

France
University Hospital, Clermont-Ferrand

Completed

Towards the Use of Instrumented Tests for Screening the Risk of Falling in Patients With Chronic Illness. (DETECACTI)

Parkinson Disease | Joint Osteoarthritis | Atherosclerosis of the Distal Arteries, Without Gangrene | Chronic Obstructive Pulmonary Disease, Unspecified | Obesity, Unspecified

France
National Taiwan University Hospital

Recruiting

Taiwan Associated Genetic and Nongenetic Small Vessel Disease (TAG-SVD)

Stroke | Magnetic Resonance Imaging | Fabry Disease | Cerebral Small Vessel Diseases | Cadasil | HTRA1-Related Autosomal Dominant Cerebral Angiopathy | COL4A1-Related Brain Small Vessel Disease With Haemorrhage | Next-generation Sequencing

Taiwan
Second Affiliated Hospital, School of Medicine,...

Recruiting

Clinical Features and Outcome in Patients With Osseomuscular Type of Wilson's Disease

Clinical Features and Outcome

China
University of Michigan
Medical University of South Carolina; National Institute of Neurological Disorders... and other collaborators

Recruiting

Sleep for Stroke Management and Recovery Trial (Sleep SMART)

Stroke | Sleep Apnea, Obstructive | Ischemic Stroke | Sleep Apnea | Telemedicine | TIA | Randomized Clinical Trial | CPAP | Home Sleep Apnea Test | Multicenter Trial

United States
Fred Hutchinson Cancer Center
Amazon.com Services LLC

Recruiting

Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma or Hormone Receptor Positive Her2 Negative Metastatic Refractory Breast Cancer

Anatomic Stage IV Breast Cancer AJCC v8 | Prognostic Stage IV Breast Cancer AJCC v8 | Metastatic Cutaneous Melanoma | Unresectable Cutaneous Melanoma | Clinical Stage III Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 | Pathologic Stage IIID Cutaneous Melanoma AJCC... and other conditions

United States
Roswell Park Cancer Institute
Incuron

Terminated

CBL0137 in Treating Patients With Advanced Extremity Melanoma or Sarcoma

Clinical Stage III Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 | Clinical Stage IV Cutaneous Melanoma AJCC v8 | Pathologic Stage IV Cutaneous Melanoma AJCC v8 | Stage III Soft Tissue Sarcoma of the Trunk and... and other conditions

United States
Tjhin Wiguna
Fakultas Kedokteran Universitas Indonesia

Not yet recruiting

Mental Health Assessment Among Community Member During the Covid-19 Pandemic in Indonesia (New)

Depression | Anxiety | Mental Health Wellness 1 | Behavior Problem | Mental Stress | Emotional Problem

Indonesia
Assiut University

Not yet recruiting

Clinical Profile and Out Come of Children With Wilson's Disease

Clinical Outcome in WILSON Disease
Nebraska Methodist Health System

Active, not recruiting

De-Escalation Protocol Of HPV Mediated Oropharyngeal Squamous Cell Carcinoma

Oropharynx Cancer | HPV-Mediated (P16-Positive) Oropharyngeal Carcinoma by AJCC V8 Clinical Stage

United States
Centre Hospitalier Universitaire, Amiens

Completed

Relationship Between Alzheimer Disease and Diminution of the Three Macular Nervous Retinal Layers (RETEVAL)

Alzheimer Disease | Lewy Body Disease | Retina | Optical Coherence Tomography | Cortical Atrophy | Optical Coherence Tomography Angiography | Retinal Thickening | Retinal Nerve Fibres Layer

France
Mayo Clinic

Recruiting

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors (PNeoVCA)

Metastatic Renal Cell Carcinoma | Anatomic Stage III Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Anatomic Stage IIIB Breast Cancer AJCC v8 | Anatomic Stage IIIC Breast Cancer AJCC v8 | Prognostic Stage III Breast Cancer AJCC v8 | Prognostic Stage IIIA Breast Cancer AJCC v8 and other conditions

United States
Shanghai Jiao Tong University School of Medicine

Recruiting

Treatment of Advanced Endocrine Tumor With Iindividualized mRNA Neoantigen Vaccine (mRNA-0523-L001)

Medullary Thyroid Cancer | Pancreatic Neuroendocrine Tumor | Adrenal Cortical Carcinoma | Thymic Neuroendocrine Carcinoma

China
Instituto Nacional de Cancerologia de Mexico

Completed

Nitroglycerin Plus Intracranial Radiotherapy for Brain Metastases in NSCLC Patients

Phase II Clinical Trial | Ninety-six Histologically Confirmed NSCLC Patients With BM | Randomized 1:1 to Received TN Plus WBR or Only WBR | ICPFS Evaluated by Two Blinded and Independent Radio-oncologist With MRI

Mexico
Podimetrics, Inc.

Unknown

Patient Empowerment Study

Quality of Life | Diabetic Foot | Diabetes Complications | Mental Health Wellness 1 | Ulcer Foot

United States
Molecular NeuroImaging
Life Molecular Imaging SA

Completed

Evaluation of [18F]MNI-815 as a Potential PET Radioligand for Imaging Tau Protein in the Brain of Patients With Tauopathies

Alzheimer's Disease (AD) | Progressive Supranuclear Palsy (PSP) | Frontal Temporal Dementia (FTD) | Cortical Basal Syndrome (CBS)

United States
Mayo Clinic

Recruiting

A Vaccine (PDS0101) Alone or in Combination With Pembrolizumab for the Treatment of Locally Advanced Human Papillomavirus-Associated Oropharynx Cancer

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8 | Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8 | Human Papillomavirus-Related Carcinoma | Locally Advanced Oropharyngeal Carcinoma

United States
Mayo Clinic
National Institute on Aging (NIA)

Recruiting

Molecular and Structural Imaging in Alzheimer's Disease: A Longitudinal Study

Alzheimer Disease | Alzheimer Disease, Early Onset | Amnestic Mild Cognitive Disorder | Atypical Alzheimer's Disease | Logopenic Progressive Aphasia (LPA) | Posterior Cortical Atrophy (PCA) | Amnestic Disorder | Amnestic Symptoms

United States
Alliance for International Medical Action
Institut National de la Santé Et de la Recherche Médicale, France; University... and other collaborators

Recruiting

Lassa Fever Clinical Course and Prognostic Factors in Nigeria (LASCOPE)

Pregnancy Complications | Acute Kidney Injury | Coma | Acute Kidney Failure | Lassa Fever | Lassa Virus Infection

Nigeria
M.D. Anderson Cancer Center

Recruiting

Plinabulin in Combination With Radiation/Immunotherapy in Patients With Select Advanced Cancers After Progression on PD-1 or PD-L1 Targeted Antibodies

Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Advanced Malignant Solid Neoplasm | Stage III Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Stage III Renal Cell Cancer AJCC v8 | Stage IV Renal Cell Cancer AJCC v8 | Stage IIIA Lung Cancer AJCC v8 | Stage IIIB Lung Cancer AJCC v8 | Clinical Stage III Cutaneous Melanoma AJCC v8 and other conditions

United States
Maastricht University Medical Center

Enrolling by invitation

Reproductive Options in Inherited Skin Diseases (REPRO-ISD)

Tuberous Sclerosis | Basal Cell Nevus Syndrome | Cutis Laxa | Epidermolysis Bullosa | Ichthyosis | Ectodermal Dysplasia | Albinism | Xeroderma Pigmentosum | Birt-Hogg-Dube Syndrome | Palmoplantar Keratoses

Netherlands
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Withdrawn

Nutritional Supplementation in Reducing Complications in Patients With Locally Advanced Esophageal Cancer Undergoing Chemotherapy, Radiation Therapy, and/or Surgery

Clinical Stage III Esophageal Adenocarcinoma AJCC v8 | Clinical Stage III Esophageal Squamous Cell Carcinoma AJCC v8 | Pathologic Stage III Esophageal Adenocarcinoma AJCC v8 | Pathologic Stage III Esophageal Squamous Cell Carcinoma AJCC v8 | Pathologic Stage IIIA Esophageal Adenocarcinoma... and other conditions

United States
Maastricht University Medical Center

Recruiting

Qualitative Study in Patients With Genodermatoses and Healthcare Professionals on Reproductive Counselling

Quality of Life | Tuberous Sclerosis | Basal Cell Nevus Syndrome | Cutis Laxa | Epidermolysis Bullosa | Ichthyosis | Ectodermal Dysplasia | Albinism | Birt-Hogg-Dube Syndrome | Palmoplantar Keratoses

Netherlands
Universidad del Norte

Unknown

Piperacillin/Tazobactam Versus Carbapenems in Non-bacteremic UTI Due to -ESBL-producing Enterobacteriaceae (CAPITIS)

Urinary Tract Infections | Enterobacteriaceae Infections | Clinical Trial | Carbapenem | Klebsiella Pneumoniae Infection | Infection Due to ESBL Bacteria | Escherichia Coli Infection | Drug Resistance, Bacterial

Colombia
Seoul National University Hospital
Samsung Medical Center; Asan Medical Center; Chonnam National University Hospital and other collaborators

Recruiting

Development of Clinical Evidence for Optimal Management of Adrenal Diseases Based on Real-World Data

Primary Aldosteronism | Cushing Syndrome | Pheochromocytoma | Adrenal Cortical Carcinoma | Adrenal Tumor

Korea, Republic of
National Cancer Institute (NCI)

Suspended

A Study Evaluating Whether Pembrolizumab Alone or in Combination With CMP-001 Improves Efficacy in Patients With Operable Melanoma

Clinical Stage III Cutaneous Melanoma AJCC v8 | Melanoma of Unknown Primary | Pathologic Stage IIIB Cutaneous Melanoma AJCC v8 | Pathologic Stage IIIC Cutaneous Melanoma AJCC v8 | Pathologic Stage IIID Cutaneous Melanoma AJCC v8 | Recurrent Cutaneous Melanoma

United States

Clinical Trials on Critical Illness

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