Clinical Trials on Deficiency Diseases in United Kingdom

Total 146879 results

Intellia Therapeutics

Not yet recruiting

Long-Term Follow-Up (LTFU) of Subjects Treated With NTLA 2002

Hereditary Angioedema

France, New Zealand, United Kingdom
Alexion Pharmaceuticals

Completed

Safety, Tolerability and Pharmacokinetics of SBC-102 (Sebelipase Alfa) in Adult Participants With Lysosomal Acid Lipase Deficiency

Lysosomal Acid Lipase Deficiency | Cholesterol Ester Storage Disease(CESD) | LAL-Deficiency

France, United States, United Kingdom, Czechia
Great Ormond Street Hospital for Children NHS Foundation...

Withdrawn

Lentiviral Gene Therapy for X-Linked Chronic Granulomatous Disease (X-CGD)

Granulomatous Disease, Chronic, X-linked, Variant

United Kingdom
Imperial College London
Boehringer Ingelheim

Completed

The CogNaive Study: Assessing Changes in Neurocognitive Function in Treatment Naïve HIV-1 Positive Subjects

HIV Infections

United Kingdom
Barts & The London NHS Trust

Completed

Cardiac and Skeletal Muscle Energy Metabolism in Abnormal Growth Hormone States

Acromegaly | Growth Hormone Deficiency

United Kingdom
Vitaflo International, Ltd

Completed

Evaluation of Ketoflo (Ketoflo)

Glucose Transporter Type 1 Deficiency Syndrome | Ketogenic Dieting | Epilepsy Intractable

United Kingdom
Sourse
Citruslabs

Active, not recruiting

An Exploratory Investigation of a B12 Vitamin to Increase Energy and Focus

Mood | Energy Supply; Deficiency | B12 Deficiency Vitamin

United States
National Institute of Allergy and Infectious Diseases...

Completed

A Study to Evaluate the Effects of Giving IL-2 Alone to HIV-Positive Patients With CD4 Cell Counts of at Least 350 Cells/mm3 Who Do Not Wish to Receive Anti-HIV Therapy

HIV Infections

United Kingdom
HealthCore-NERI
Bayer; Besins Healthcare

Completed

Registry of Hypogonadism in Men (RHyMe)

Male Hypogonadism | Testosterone Deficiency | Androgen Deficiency

Italy, United Kingdom, Spain, Netherlands, Germany, Sweden
rEVO Biologics

Completed

Assess Incidence of Deep Vein Thrombosis(DVT)Following Administration of Recombinant Human Antithrombin (rhAT) to Hereditary Antithrombin(AT) Deficient Patients in High Risk Situations. (rhAT)

Antithrombin Deficiency, Congenital

France, United Kingdom, Germany, United States, Sweden, Italy
Liverpool Women's NHS Foundation Trust
University of California, Davis; University of Liverpool

Recruiting

An Exploratory Study of Increased Preterm Arginine INTake (PAINT18) (PAINT18)

Preterm | Nutritional Deficiency | Immune System and Related Disorders

United Kingdom
Kirby Institute

Completed

Pharmacokinetics of Lopinavir/Ritonavir at Three Different Doses. (ENCORE3)

Acquired Immunodeficiency Syndrome

United Kingdom
Shield Therapeutics

Recruiting

Evaluate the Safety and Efficacy of Ferric Maltol Oral Suspension vs. Ferrous Sulfate Oral Liquid in Children and Adolescents Aged 2 to 17 Years With Iron-deficiency Anaemia, With a Single Arm Study in Infants Aged 1 Month to Less Than 2 Years (FORTIS)

Iron-deficiency | Anemia

United States, United Kingdom, Puerto Rico
Texas A&M University

Unknown

Nutrition, Vision, and Cognition in Sport Study: Beef (IONSport:Beef)

Cognitive Change | Nutritional Anemia | Diet, Healthy | Nutrient Deficiency | Diet; Deficiency | Visual Spatial Processing | Dietary Deficiency | Dietary B12 Deficiency | Dietary Zinc Deficiency | Dietary Vitamin B12 Deficiency Anemia | Dietary Deficiency of Selenium and Vitamin E

United States
Gilead Sciences

Completed

SWEET: Once Daily Truvada Versus Twice Daily Combivir for the Treatment of HIV Infection

HIV Infections

United Kingdom
Novartis Pharmaceuticals

Completed

A Two-part Single- and Repeat-dose Study of CSJ137 in Anemic Chronic Hemodialysis Patients

Anemia, Iron-Deficiency

Czechia, Israel, United States, United Kingdom
St Stephens Aids Trust

Completed

PK of Tenofovir, Emtricitabine and Efavirenz in Healthy Volunteers

HIV Infections | HIV Infection

United Kingdom
PENTA Foundation

Completed

Pharmacokinetic (PK) Study of Twice Daily vs Once Daily Lamivudine (3TC) and Abacavir (ABC) as Part of Combination Antiretroviral Therapy (ART) in HIV Infected Children (PENTA 13)

HIV Infection

United Kingdom
University of Florida

Completed

Vitamin B6 Effects for Women Taking Birth Control Pills

Vitamin B6 Deficiency

United States
Imperial College London
Fu Wai Hospital, Beijing, China

Completed

IV Iron Replacement for Iron Deficiency in Idiopathic Pulmonary Arterial Hypertension (IPAH) Patients

Pulmonary Arterial Hypertension | Iron Deficiency

United Kingdom, China, Germany
Chelsea and Westminster NHS Foundation Trust
Merck Sharp & Dohme LLC; Imperial College London; University of Liverpool

Completed

Pharmacokinetics of Plasma Doravirine Once Daily Over 72 Hours Following Drug Intake Cessation in Healthy Volunteers

Human Immunodeficiency Virus

United Kingdom
BioCryst Pharmaceuticals

Completed

Safety and Efficacy of Oral BCX4161 as a Prophylactic Treatment for HAE (OPuS-1)

Hereditary Angioedema

Germany, United Kingdom
Alexion Pharmaceuticals

Terminated

Clinical Study In Infants With Rapidly Progressive Lysosomal Acid Lipase Deficiency

Lysosomal Acid Lipase Deficiency

United Kingdom, Finland, United States, Italy
Applied Therapeutics, Inc.

Active, not recruiting

Pharmacodynamic EffIcacy and Clinical Benefit of AT 007 in Patients With Sorbitol Dehydrogenase (SORD) Deficiency (INSPIRE)

Hereditary Neuropathy Caused by SORD Deficiency

United States, United Kingdom, Czechia, Italy
Genethon
Institute of Child Health; Great Ormond Street Hospital for Children NHS Foundation...

Completed

Gene Therapy for Wiskott-Aldrich Syndrome (WAS)

Wiskott-Aldrich Syndrome

United Kingdom
Kemin Foods LC
DSM Nutritional Products, Inc.

Terminated

Effects of Lutein on Visual Function

Healthy | Nutrition Poor

United Kingdom
metaX Institut fuer Diatetik GmbH
Birmingham Children's Hospital

Completed

Acceptability and Tolerance of a Ready-to-use Protein Substitute in Tablet Form for the Dietary Management of Phenylketonuria

Phenylketonurias | Hyperphenylalaninaemia | Tetrahydrobiopterin Deficiency

United Kingdom
University of Florida
National Institutes of Health (NIH)

Completed

Vitamin B6 Dependence of One-Carbon Metabolism

Vitamin B6 Deficiency

United States
Ardea Biosciences, Inc.

Completed

Naïve HIV POC Monotherapy Trial

HIV Infections

Germany, United Kingdom
Imperial College London

Enrolling by invitation

Colonoscopy Check-up in People With Lynch Syndrome

Lynch Syndrome

United Kingdom
University of Edinburgh
NHS Lothian; DexCom, Inc.; Tandem Diabetes Care, Inc.; The Leona M. and Harry B...

Active, not recruiting

Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes

Hypoglycemia | Type 1 Diabetes | Type 1 Diabetes Mellitus With Hypoglycemia | Hypoglycemia Unawareness | Glucagon Deficiency | Insulin Hypoglycemia

United Kingdom
Imperial College London

Completed

Clinical Trial of HIV Vaccine Combinations in Healthy Men and Women (Ad4HIV)

Human Immunodeficiency Virus

United Kingdom
Vitaflo International, Ltd

Completed

Evaluation of Keyo in Children With Epilepsy (Keyo)

Intractable Epilepsy | Glucose Transporter Type 1 Deficiency Syndrome | Ketogenic Dieting

United Kingdom
Kamada, Ltd.
Syneos Health

Recruiting

Evaluate Efficacy and Safety of "Kamada-AAT for Inhalation" in Patients With AATD (InnovAATe)

Alpha 1-Antitrypsin Deficiency

United Kingdom, Sweden, Ireland, Netherlands, Belgium, Finland
Ipsen

Recruiting

Global Patient Registry to Monitor Long-term Safety and Effectiveness of Increlex® in Children and Adolescents With Severe Primary Insulin-like Growth Factor-1 Deficiency (SPIGFD).

IGF1 Deficiency

Spain, United States, Italy, France, United Kingdom, Germany, Austria, French Guiana, Poland, Sweden, Martinique
Bio Products Laboratory

Completed

A Study to Investigate Bio Product Laboratory Ltd (BPL's) Factor X in the Prophylaxis of Bleeding in Children <12 Years

Factor X Deficiency

United Kingdom
International AIDS Vaccine Initiative
University of Nairobi; Medical Research Council-Oxford

Completed

A Phase IIA Trial to Evaluate the Safety and Immunogenicity of a DNA HIV-1 Vaccine Followed by an MVA HIV-1 Vaccine in HIV-uninfected Volunteers

HIV Infections

United Kingdom, Kenya
St Stephens Aids Trust

Terminated

Pre-Exposure Prophylaxis Using TMC278LA

HIV Infections

United Kingdom
Oklahoma State University Center for Health Sciences

Active, not recruiting

Food and Alcohol Behavior Study: Meaningful Enhancement (FAB:ME)

Folate Deficiency

United States
ViiV Healthcare
GlaxoSmithKline

Completed

GSK3640254 First Time in Human (FTIH) Study in Healthy Volunteers

HIV Infections | Infection, Human Immunodeficiency Virus

United Kingdom
Guy's and St Thomas' NHS Foundation Trust
King's College London; Newcastle University; University of Cambridge

Completed

XPAND Trial: Enhancing XP Photoprotection Activities - New Directions (XPAND)

Xeroderma Pigmentosum

United Kingdom
Mead Johnson Nutrition

Withdrawn

Evaluation of Fatty Acid Levels and Growth in Infants Fed Amino Acid Based (AA) Formulas

Cow's Milk Allergy | Intolerance to Extensively Hydrolyzed Formulas | Intolerance to Breast Milk

United Kingdom
Takeda

Enrolling by invitation

An Extension Study to Learn About the Long-Term Safety of Fazirsiran and if Fazirsiran Can Help People With Alpha-1 Antitrypsin Liver Disease

Alpha1-Antitrypsin Deficiency

United Kingdom, Germany, United States, Austria, Portugal
Chelsea and Westminster NHS Foundation Trust
Gilead Sciences; Imperial College London

Terminated

Efficacy, Tolerability and Acceptability of Biktarvy by TPLWH

Human Immunodeficiency Virus

United Kingdom
ViiV Healthcare
GlaxoSmithKline

Completed

Bioavailability of BMS-626529 in Healthy Subjects From Prototype Low Dose Extended Release Formulations (Part 1) and Prototype Extended Release Multi-particulate Formulations (Part 2) of BMS-663068 Relative to 600 mg Extended Release Tablet

Infection, Human Immunodeficiency Virus

United Kingdom
ViiV Healthcare
GlaxoSmithKline

Completed

Relative Bioavailability Study With BMS-955176

Infection, Human Immunodeficiency Virus

United Kingdom
Pennington Biomedical Research Center

Recruiting

Meals to Improve Absorption of Iron Supplements

Iron-deficiency | Iron Deficiency Anemia | Iron Deficiency Anemia Treatment

United States
Pfizer

Terminated

A Single Dose Study to Evaluate the PK-PD Response and Safety of PHA-794428 in Children With Growth Hormone Deficiency

Growth Hormone Deficiency

France, Belgium, Germany, Israel, United Kingdom
Baylor College of Medicine
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Oral Iron Versus Oral Iron Plus a Web-based Behavioral Intervention in Young Children (IRONCHILD)

Iron-deficiency | Iron Deficiency Anemia

United States
University of California, San Francisco
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Tufts... and other collaborators

Completed

The Effect of SLC19A3 Inhibition on the Pharmacokinetics of Thiamine

Vitamin B1 Deficiency | Thiamine Deficiency

United States

Clinical Trials on Deficiency Diseases in United Kingdom

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Hungary

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Rare Diseases

Drug Interventions

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