Clinical Trials on Down Syndrome (DS)

Total 33991 results

Parc de Salut Mar

Completed

Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool

Down Syndrome (DS)

Spain
Centre Hospitalier Universitaire Dijon

Unknown

Prevalence and Risk Factors of Reventilation Syndrome in a Population of Patients Under Ventilation for Whatever Reason (DEVENTILATION)

Prevalence of and Factors Associated With Reventilation Syndrome (DS)

France
Takeda

Completed

A Study of Soticlestat as an Add-on Therapy in Children and Young Adults With Dravet Syndrome

Dravet Syndrome (DS)

China, Canada, France, Hungary, Poland, United States, Spain, Greece, Australia, Brazil, Serbia, Germany, Italy, Japan, Latvia, Netherlands, Ukraine, Russian Federation
Odense University Hospital

Completed

Use of eHealth in Communication With Patients About Prenatal Diagnosis (HIIP)

Health Knowledge, Attitudes, Practice | Downs Syndrome

Denmark
Takeda

Recruiting

A Study of Soticlestat as an Add-on Therapy in Children and Adults With Dravet Syndrome or Lennox-Gastaut Syndrome

Lennox Gastaut Syndrome (LGS) | Dravet Syndrome (DS)

United States, China, Spain, France, Belgium, Australia, Brazil, Canada, Germany, Greece, Hungary, Italy, Japan, Latvia, Netherlands, Poland, Serbia, Mexico, Russian Federation, Ukraine
Takeda

Not yet recruiting

A Study on Dravet Syndrome (DS) and Lennox-Gastaut Syndrome (LGS) in Children, Teenagers and Adults in Portugal (DRALEGA-PT)

Dravet Syndrome (DS) | Lennox-Gastaut Syndrome (LGS)
Takeda

Recruiting

A Study to Gather Information About Overall Occurrence and New Cases of Dravet and Lennox-Gastaut Syndromes in Children, Teenagers and Adults in Spain (DRALEGA)

Dravet Syndrome (DS) | Lennox-Gastaut Syndrome (LGS)

Spain
Rachel G. Greenberg, MD, MB, MHS
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Not yet recruiting

Guanfacine for Hyperactivity in Children With Down Syndrome (HYPEbeGONE_DS) (HYP01)

Hyperactivity in Children With Down Syndrome | Impulsivity in Children With Down Syndrome

United States
Takeda

Recruiting

A Study Evaluating Soticlestat in Participants With Dravet Syndrome or Lennox-Gastaut Syndrome Who Have Been Exposed to Fenfluramine

Dravet Syndrome (DS) | Lennox-Gastaut Syndrome (LGS)

United Kingdom, Denmark
Takeda

Active, not recruiting

A Study of Soticlestat in Adults and Children With Rare Epilepsies (Endymion 1)

Epilepsy | Dravet Syndrome (DS) | Lennox-Gastaut Syndrome (LGS)

United States, Canada, Australia, China, Israel, Poland, Spain, Portugal
Riphah International University

Completed

Manual Ankle Rocking Training on Postural Control and Foot Function in Children With Down Syndrome

Down S Syndrome

Pakistan
Hoffmann-La Roche

Completed

A Molecular and Functional Brain Imaging Study in Individuals With Down Syndrome and Healthy Controls Following Single Dose RG1662

Healthy Volunteer, Down Syndrome

United Kingdom
Cairo University

Completed

Interaction Effects of Vitamin D Supplementation and Aerobic Exercises on Balance and Physical Performance in Children With Down Syndrome

Children With Down Syndrome

Egypt
Institute of Child Health

Completed

Vitamins and Minerals for Children With Downs Syndrome

Trisiomy 21 (Down Syndrome)

United Kingdom
Vanderbilt University Medical Center
National Institute on Deafness and Other Communication Disorders (NIDCD)

Recruiting

Predictors of Speech Ability in Down Syndrome

Speech Intelligibility Intervention in Down Syndrome

United States
National Cancer Institute (NCI)

Active, not recruiting

Lenalidomide and Dexamethasone With or Without Bortezomib in Treating Patients With Previously Untreated Multiple Myeloma

DS Stage I Multiple Myeloma | DS Stage II Multiple Myeloma | DS Stage III Multiple Myeloma

United States, Saudi Arabia, Puerto Rico
Marmara University

Completed

Investigation of the Effect of Stair Activity on Lumbal Paravertebral Mechanical Properties in Amputes.

Stair up and Down, Amputation | Amputation,Stair up and Down

Turkey
National Cancer Institute (NCI)

Completed

Bortezomib and Pegylated Liposomal Doxorubicin Hydrochloride in Treating Patients With Previously Untreated Symptomatic Multiple Myeloma

DS Stage I Plasma Cell Myeloma | DS Stage II Plasma Cell Myeloma | DS Stage III Plasma Cell Myeloma

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Bortezomib and Vorinostat in Treating Patients With Multiple Myeloma Who Have Undergone Autologous Stem Cell Transplant

DS Stage I Plasma Cell Myeloma | DS Stage II Plasma Cell Myeloma | DS Stage III Plasma Cell Myeloma

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Study of Blood Samples From Newborns With Down Syndrome

Myeloid Proliferations Associated With Down Syndrome

United States, Canada, Australia, Puerto Rico
Eastern Mediterranean University

Completed

Cognitive Orientation to Daily Occupational Performance and Conductive Education Approaches on Down Syndrome

Down Syndrome, Trisomy 21

Cyprus
Institut Jerome Lejeune
Fondation Jérôme Lejeune

Completed

Pilot Study of Auto-immune Abnormalities Associated With Down Syndrome (IMMUTRI)

Down Syndrome With and Without Auto Immune Abnormalities

France
Boston Children's Hospital

Completed

JASPER Intervention in Down Syndrome

Down Syndrome, Trisomy 21

United States
National Cancer Institute (NCI)

Active, not recruiting

Lenalidomide and Dexamethasone With or Without Thalidomide in Treating Patients With Multiple Myeloma

DS Stage I Multiple Myeloma | DS Stage II Multiple Myeloma | DS Stage III Multiple Myeloma

United States
Albert Einstein College of Medicine
National Cancer Institute (NCI)

Terminated

Desipramine Hydrochloride and Filgrastim For Stem Cell Mobilization in Patients With Multiple Myeloma Undergoing Stem Cell Transplant

Refractory Plasma Cell Myeloma | DS Stage II Plasma Cell Myeloma | DS Stage III Plasma Cell Myeloma | DS (Durie/Salmon) Stage I Plasma Cell Myeloma

United States
Albert Einstein College of Medicine
National Cancer Institute (NCI)

Completed

Busulfan, Melphalan, and Bortezomib Before First-Line Stem Cell Transplant in Treating Patients With Multiple Myeloma

Refractory Plasma Cell Myeloma | DS Stage I Plasma Cell Myeloma | DS Stage II Plasma Cell Myeloma | DS Stage III Plasma Cell Myeloma

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Lenalidomide, Dexamethasone, and Clarithromycin in Treating Patients Who Have Undergone Stem Cell Transplant for Multiple Myeloma

Refractory Plasma Cell Myeloma | DS Stage I Plasma Cell Myeloma | DS Stage II Plasma Cell Myeloma | DS Stage III Plasma Cell Myeloma

United States
Children's Oncology Group
National Cancer Institute (NCI)

Active, not recruiting

Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome

Acute Myeloid Leukemia | Down Syndrome | Myelodysplastic Syndrome | Myeloproliferative Neoplasm | Myeloid Leukemia Associated With Down Syndrome

United States, Canada, Saudi Arabia, Puerto Rico, Australia, New Zealand
Mayo Clinic
National Cancer Institute (NCI)

Completed

Carfilzomib and Melphalan Before Stem Cell Transplant in Treating Patients With Multiple Myeloma

Refractory Plasma Cell Myeloma | DS Stage I Plasma Cell Myeloma | DS Stage II Plasma Cell Myeloma | DS Stage III Plasma Cell Myeloma

United States
National Cancer Institute (NCI)

Withdrawn

RO4929097 After Autologous Stem Cell Transplant in Treating Patients With Multiple Myeloma

Refractory Plasma Cell Myeloma | DS Stage I Plasma Cell Myeloma | DS Stage II Plasma Cell Myeloma | DS Stage III Plasma Cell Myeloma

United States
Children's Oncology Group
National Cancer Institute (NCI)

Recruiting

A Study to Learn More About the Health of Persons With Down Syndrome After Treatment for Acute Leukemia

Down Syndrome | Myeloid Leukemia Associated With Down Syndrome | B Acute Lymphoblastic Leukemia Associated With Down Syndrome

United States
Ultragenyx Pharmaceutical Inc

Available

Expanded Access to Triheptanoin

Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)
SWOG Cancer Research Network
National Cancer Institute (NCI)

Active, not recruiting

S1211 Bortezomib, Dexamethasone, and Lenalidomide With or Without Elotuzumab in Treating Patients With Newly Diagnosed High-Risk Multiple Myeloma

DS Stage I Plasma Cell Myeloma | DS Stage II Plasma Cell Myeloma | DS Stage III Plasma Cell Myeloma

United States
Radboud University Medical Center

Completed

Sodium Lactate Infusion in GLUT1DS Patients

Epilepsy | Ketogenic Dieting | Lactic Acid Blood Increased | GLUT1DS1 | GLUT1 Deficiency Syndrome | GLUT1DS2

Netherlands
Adrian Lacy
Ultragenyx Pharmaceutical Inc

Completed

An Open-Label Trial of Triheptanoin in Patients With Glucose Transporter Type-1 Deficiency Syndrome (GLUT1DS)

Glucose Transporter Type-1 Deficiency Syndrome (Glut1 DS)

United States
Ultragenyx Pharmaceutical Inc

Completed

Phase 2 Study of Triheptanoin (UX007) for the Treatment of Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)

Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)

United States, Spain, Australia, France, Israel, Italy, United Kingdom
National Cancer Institute (NCI)

Active, not recruiting

Lenalidomide in Treating Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplant

Smoldering Multiple Myeloma | Refractory Multiple Myeloma | DS Stage I Multiple Myeloma | DS Stage II Multiple Myeloma | DS Stage III Multiple Myeloma

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Bortezomib, Melphalan, and Total-Body Irradiation Before Stem Cell Transplant in Treating Patients With Multiple Myeloma

Refractory Plasma Cell Myeloma | DS Stage I Plasma Cell Myeloma | DS Stage II Plasma Cell Myeloma | DS Stage III Plasma Cell Myeloma

United States
National Cancer Institute (NCI)

Completed

Vismodegib After Stem Cell Transplant in Treating Patients With High-Risk First Remission or Relapsed Multiple Myeloma

Refractory Plasma Cell Myeloma | DS Stage I Plasma Cell Myeloma | DS Stage II Plasma Cell Myeloma | DS Stage III Plasma Cell Myeloma

United States
LuMind IDSC Foundation
Alzheimer's Disease Cooperative Study (ADCS)

Active, not recruiting

Down Syndrome Clinical Trials - Study of Alzheimer's Disease in Down Syndrome (LIFE-DSR)

Alzheimer's Disease in Down Syndrome

United States
Ziauddin University

Completed

Down Syndrome and Effects of Foot Muscle Exercise

Pes Planus Down Syndrome Patients

Pakistan
Ultragenyx Pharmaceutical Inc

Terminated

Crossover Study to Assess the Efficacy and Safety of UX007 in the Treatment of Movement Disorders Associated With Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)

Glucose Transporter Type 1 Deficiency Syndrome (Glut1 DS)

United States, Spain, France, Germany, Italy, United Kingdom
University Hospital of Split

Completed

Indicators of Growth, Nutritional Status and Comorbide Disorders of Newborns With Down Syndrome (DownSy)

Down Syndrome,Auxological Indexes, Auxological Parametars, Intrauterine Growth Restriction

Croatia
Damascus University

Completed

Evaluation of a New Design of Crowns in the Posterior Teeth

Broken Down Molars | IPS-emmax Crowns

Syrian Arab Republic
Cairo University

Not yet recruiting

Performance of Injectable Composite Versus Dual Cured Cement in Cementation of Indirect Restoration: A Clinical Trial

Cementation Teeth | Badly Broken Down Vital Teeth
Vanderbilt University Medical Center
Vanderbilt Kennedy Center

Recruiting

Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition

Alzheimer Disease | Down Syndrome | Down Syndrome, Partial Trisomy 21

United States
Riphah International University

Completed

Treadmill Training With and Without Weighted Ankle Cuffs on Gait Parameters

Down's Syndrome

Pakistan
Riphah International University

Recruiting

Effect of Virtual Video Reality Gaming on Fine Motor Skills in Children With Down's Syndrome

Fine Motor Skills | Down's Syndrome

Pakistan
Hasan Kalyoncu University

Recruiting

Effects of Orofacial Therapy and Therapeutic Yoga in Children With Down Syndrome

Down Syndrome

Turkey
Riphah International University

Recruiting

Effects of Maze Activities in Down's Syndrome

Down Syndrome

Pakistan

Clinical Trials on Down Syndrome (DS)

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Sri Lanka

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

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