Clinical Trials on Emphysema, Pulmonary

Total 8468 results

Medical University of South Carolina
National Center for Research Resources (NCRR); Alpha-1 Foundation

Completed

The Use of High Resolution Chest Computed Tomography in Alpha-1 Antitrypsin Deficiency (QUANTUM-1)

Alpha-1 Antitrypsin Deficiency

United States
Grifols Therapeutics LLC

Completed

Comparison of Pharmacokinetic, Safety, Tolerability of Alpha-1 MP and Prolastin In Alpha1-antitrypsin Deficient Adults (ChAMP)

Alpha 1-Antitrypsin Deficiency

United States
Grifols Therapeutics LLC

Completed

The Safety and Tolerability of Alpha-1 Modified Process (MP) In Subjects With Alpha-1-antitrypsin (AAT) Deficiency (STAMP)

Alpha 1-Antitrypsin Deficiency

United States, United Kingdom
University of Florida
Alpha-1 Foundation; Brantly, Mark L., M.D.

Completed

4-PBA: Will it Increase the Level of Alpha 1-Antitrypsin(AAT) in Persons With AAT Deficiency?

Alpha 1-Antitrypsin Deficiency

United States
National Center for Research Resources (NCRR)
University of Pittsburgh

Terminated

Study of Genotype and Phenotype in Patients With Alpha 1-Antitrypsin Deficiency

Alpha 1-Antitrypsin Deficiency

United States
KU Leuven
Chiesi Farmaceutici S.p.A.

Unknown

Evaluate the Effects of Formoterol and Beclomethasone Dipropionate Combination Therapy on Small Airways Function

Emphysema | COPD | Small Airway Disease

Belgium
Arrowhead Pharmaceuticals

Active, not recruiting

Study of Fazirsiran (TAK-999, ARO-AAT) in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATD)

Alpha 1-Antitrypsin Deficiency

Austria, Germany, United Kingdom
Dicerna Pharmaceuticals, Inc.

Withdrawn

An Extension Study of Belcesiran in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATLD)

Alpha 1-Antitrypsin Deficiency

New Zealand
Mereo BioPharma
Syneos Health

Completed

A 12-week Study Treating Participants Who Have alpha1-antitrypsin-related COPD With Alvelestat (MPH966) or Placebo. (ASTRAEUS)

Emphysema | Alpha 1-Antitrypsin Deficiency | COPD

United Kingdom, Belgium, United States, Denmark, Canada, Sweden, Poland, Spain
University of Massachusetts, Worcester
National Heart, Lung, and Blood Institute (NHLBI); University of Florida; National... and other collaborators

Completed

Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency

Alpha 1-Antitrypsin Deficiency

United States
Thomayer University Hospital
Masaryk University

Recruiting

Czech AATD Registry

Alpha-1-antitrypsin Deficiency

Czechia
Grifols Therapeutics LLC

Recruiting

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% in Participants With Alpha1-Antitrypsin Deficiency

Alpha1-Antitrypsin Deficiency

United States
Columbia University
National Heart, Lung, and Blood Institute (NHLBI); Alpha-1 Foundation

Active, not recruiting

Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of Disease (A1BC)

Alpha 1-Antitrypsin Deficiency | Genetic Disease

United States
Vertex Pharmaceuticals Incorporated

Completed

Evaluation of the Efficacy and Safety of VX-864 in Subjects With the PiZZ Genotype

Alpha1-Antitrypsin Deficiency

United States, Germany, Canada, Ireland, Sweden, United Kingdom
Grifols Therapeutics LLC
Grifols Japan K.K.

Completed

Safety and Pharmacokinetics of Alpha-1 MP (Alpha1-proteinase Inhibitor (Human), Modified Process) in Participants With Alpha1-Antitrypsin Deficiency

Alpha1-Antitrypsin Deficiency

Japan
Baxalta now part of Shire

Completed

GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study

Alpha1-antitrypsin Deficiency

United States, Canada
Baxalta now part of Shire

Terminated

Aralast alpha1-proteinase Inhibitor Surveillance Study

Alpha1-antitrypsin Deficiency

United States
Thunder Bay Regional Health Research Institute
Lakehead University; St. Joseph's Care Group; Thunder Bay Regional Health Sciences...

Recruiting

Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders

Bronchiectasis | Chronic Obstructive Pulmonary Disease | Asthma | Obstructive Sleep Apnea | Emphysema | Pulmonary Fibrosis | Lung Cancer | Cystic Fibrosis | Mesothelioma | Pulmonary Hypertension | Interstitial Lung Disease | Pulmonary Embolism | Lung Resection | Lung Transplant | Seasonal Allergies | Lung Infection | Asbes... and other conditions

Canada
University of Alabama at Birmingham
National Institutes of Health (NIH); Mereo BioPharma

Completed

Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency (ATALANTa)

Emphysema or COPD | Alpha-1 Antitrypsin Deficiency (AATD) | Pi*ZZ, Pi*SZ, Pi*Null, Another Rare Phenotype/Genotype Known to be Associated With Either Low or Functionally Impaired AAT Including F or I Mutations

United States
Applied Genetic Technologies Corp
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Safety & Efficacy Study of rAAV1-CB-hAAT for Alpha-1 Antitrypsin Deficiency

Alpha-1 Antitrypsin Deficiency

United States, Ireland
University of Florida
Alpha-1 Foundation

Enrolling by invitation

Alpha-1 Foundation DNA and Tissue Bank

Alpha 1 Antitrypsin Deficiency

United States
Grifols Therapeutics LLC
Grifols Japan K.K.

Completed

Long-term Safety of Alpha1-Proteinase Inhibitor (Human) in Japanese Subjects With Alpha1 Antitrypsin Deficiency (GTI1401-OLE)

Alpha1-Antitrypsin Deficiency

Japan
Baxalta now part of Shire
Arriva Pharmaceuticals, Inc.

Completed

Safety Study of an Aerosolized, Recombinant Alpha 1-Antitrypsin in Subjects With Alpha 1-Antitrypsin Deficiency

Alpha1-antitrypsin Deficiency

United States
Takeda

Recruiting

Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis)

Alpha1-Antitrypsin Deficiency

United States, Poland
Permian Health Lung Institute
The Gambia Committee on Traditional Practices Affecting the Health of Women...

Not yet recruiting

Permian Health Women's Lung Health Study (WLHS)

COPD | Lung Function Decreased | Alpha 1-Antitrypsin

Gambia
Takeda
Takeda Development Center Americas, Inc.

Recruiting

Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein

Alpha1-Antitrypsin Deficiency

United States, Belgium, Switzerland, Canada, Australia, Germany, United Kingdom, Austria, France, Spain, Portugal, Italy, Poland, Brazil
Alnylam Pharmaceuticals

Terminated

A Study of an Investigational Drug, ALN-AAT, in Healthy Adult Subjects and Patients With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

Antitrypsin Deficiency Liver Disease

United Kingdom
Soroka University Medical Center

Unknown

Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery

Post Cardiac Surgery Systemic Inflammatory Response
National University of Malaysia

Completed

Short Duration High Intensity Intrapleural Alteplase With Pulmozyme in Pleural Infection Management

Loculated Empyema

Malaysia
Baxalta now part of Shire
Arriva Pharmaceuticals, Inc.

Completed

Study of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Subjects With Alpha 1-Antitrypsin Deficiency

Alpha1-antitrypsin Deficiency

United States
Grifols Therapeutics LLC

Completed

A Study to Assess Safety and PK of Liquid Alpha₁-Proteinase Inhibitor (Human) in Treating Alpha₁-Antitrypsin Deficiency

Alpha₁-Antitrypsin Deficiency

United States
Altesa Biosciences, Inc.
Virtus Respiratory Research

Recruiting

RCT of Vapendavir in Patients With COPD and Human Rhinovirus/Enterovirus Upper Respiratory Infection

Infections | Virus Diseases | Respiratory Tract Infections | Respiratory Tract Diseases | Lung Diseases | Pulmonary Disease, Chronic Obstructive | Enterovirus Infections | Copd | Pulmonary Disease | Respiratory Disease | Respiratory Complication | Upper Respiratory Tract Infections | Respiratory Viral Infection | ... and other conditions

United Kingdom
Takeda

Enrolling by invitation

An Extension Study to Learn About the Long-Term Safety of Fazirsiran and if Fazirsiran Can Help People With Alpha-1 Antitrypsin Liver Disease

Alpha1-Antitrypsin Deficiency

United Kingdom, Germany, United States, Austria, Portugal
University of Michigan Rogel Cancer Center
CSL Behring; The Leukemia and Lymphoma Society

Completed

A Pilot Study of Alpha-1-Antitrypsin (AAT) in Steroid Refractory Acute Graft vs Host Disease

Graft vs Host Disease

United States
Heidelberg University

Terminated

Prevention of Pneumothorax Following Endoscopic Valve Therapy in Patients With Severe Emphysema

Pneumothorax

Germany
CSL Behring

Completed

Safety and Tolerability Study of Liquid Alpha1 Proteinase Inhibitor (API) in Subjects With Cystic Fibrosis

Cystic Fibrosis

Bulgaria, Hungary, Poland, United Kingdom
Thomas Decker Christensen
Odense University Hospital; Rigshospitalet, Denmark; Aalborg University Hospital

Not yet recruiting

VATS Surgery Compared to Drainage in the Treatment of Pleural Empyema (FIVERVATS)

Pleural Empyema
Azienda Ospedaliera di Padova
Hoffmann-La Roche

Unknown

Dornase Alfa and Urokinase for Kids With Pleural Empyema (DUKE)

Pleural Empyema

Italy
Z Factor Limited
Hammersmith Medicines Research; Centessa Pharmaceuticals plc

Terminated

A Single Ascending and Repeated Dose Study of Oral ZF874 in Healthy Volunteers and PiXZ Subjects

Alpha1 Anti-Trypsin Deficiency

United Kingdom
Baxalta now part of Shire

Completed

GLASSIA Infusion Rate Study

Healthy Volunteers | Alpha1-antitrypsin Deficiency

United States
RWTH Aachen University

Unknown

Liver Disease in Patients With alpha1-antitrypsin Deficiency

alpha1-antitrypsin Deficiency

Germany
Assiut University

Recruiting

Pediatric Video Assisted Thoracoscopic Surgery (VATS) in Management of Empyema (VATS)

Thoracic Empyema

Egypt
The Hospital for Sick Children
Canadian Institutes of Health Research (CIHR); Unity Health Toronto; Children... and other collaborators

Completed

Intrapleural DNase and Tissue Plasminogen Activator in Pediatric Empyema (DTPA Trial)

Pleural Empyema

Canada
Hospices Civils de Lyon

Completed

Polygen Defi-Alpha: Genetic Polymorphisms Study in Children With Alpha-1 Antitrypsin Deficiency, Included in the DEFI-ALPHA Cohort (Polygen)

Children With a Deficiency of Alpha-1 Antitrypsin

France
Washington University School of Medicine
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); N... and other collaborators

Terminated

Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency (CBZ)

Liver Cirrhosis | Alpha-1-antitrypsin Deficiency

United States
Alnylam Pharmaceuticals

Terminated

A Study of ALN-AAT02 in Healthy Participants and Participants With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

United Kingdom
BERBERI ANTOINE
Lebanese University

Completed

The Osteogenic Potential of Human Maxillary Sinus Shneiderian Membrane (HMSSM)

Sinus; Empyema, Maxillary (Chronic)

Lebanon
University of Florida

Completed

Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD)

Alpha-1 Antitrypsin Deficiency | Liver Fibrosis | AATD | AAT Deficiency

United States
Kamada, Ltd.

Completed

Phase II Study of the Safety and Efficacy of Inhaled Alpha-1 Antitrypsin (AAT ) in Cystic Fibrosis Patients

Cystic Fibrosis

Israel
Hillel Yaffe Medical Center

Unknown

Effect of Normatec Pump for Relief of Leg Edema in Patients With Right Heart Failure

Right Heart Failure | Cor Pulmonale

Israel

Clinical Trials on Emphysema, Pulmonary

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