Clinical Trials on Emphysema or COPD

Total 35112 results

Beijing Municipal Science & Technology Commission

Unknown

A Clinical Evaluation of Baofeikang Granule in Combined Pulmonary Fibrosis and Emphysema Treatment

Combined Pulmonary Fibrosis and Emphysema

China
Imperial College London
Novartis; Boehringer Ingelheim; Royal Brompton & Harefield NHS Foundation Trust

Completed

Regulation of the Release of Inflammatory Mediators From Lung Macrophages.

Emphysema | COPD | Chronic Bronchitis

United Kingdom
University of Washington
National Institutes of Health (NIH)

Completed

Real-Time Support for Exercise Persistence in COPD

Pulmonary Disease, Chronic Obstructive | Emphysema | COPD | Chronic Bronchitis

United States
Columbia University
National Heart, Lung, and Blood Institute (NHLBI)

Unknown

Endothelial Dysfunction, Biomarkers, and Lung Function -Ancillary to MESA (MESA-LUNG)

Emphysema | Endothelial Dysfunction | Chronic Obstructive Pulmonary Disease (COPD)
Shanghai Chest Hospital

Not yet recruiting

A Multi-center RCT to Evaluate Subsegmental BTVA Treatment for Severe Emphysema (BTVA)

Severe Emphysema
Arrowhead Pharmaceuticals

Active, not recruiting

Study of Fazirsiran (TAK-999, ARO-AAT) in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATD)

Alpha 1-Antitrypsin Deficiency

Austria, Germany, United Kingdom
Dicerna Pharmaceuticals, Inc.

Withdrawn

An Extension Study of Belcesiran in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AATLD)

Alpha 1-Antitrypsin Deficiency

New Zealand
University of Massachusetts, Worcester
National Heart, Lung, and Blood Institute (NHLBI); University of Florida; National... and other collaborators

Completed

Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency

Alpha 1-Antitrypsin Deficiency

United States
Chelsea and Westminster NHS Foundation Trust

Unknown

Bronchoscopic Intrabullous Autologous Blood Instillation (BIABI) for Emphysema (BIABI)

Bullous Emphysema

United Kingdom
University Hospital, Saarland

Withdrawn

Lung Volume Reduction Coils for Emphysema in Alpha-1 Antitrypsin Deficiency (LuReCAA)

Emphysema | Chronic Obstructive Lung Disease | Alpha-1-Antitrypsin Deficiency

Denmark, Germany
Paragonix Technologies

Enrolling by invitation

Global Utilization And Registry Database for Improved preservAtion of doNor LUNGs (GUARDIANLUNG)

Emphysema | Pulmonary Fibrosis | Pulmonary Arterial Hypertension | Cystic Fibrosis | Interstitial Lung Disease | COPD

United States, Belgium
Applied Genetic Technologies Corp
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Safety & Efficacy Study of rAAV1-CB-hAAT for Alpha-1 Antitrypsin Deficiency

Alpha-1 Antitrypsin Deficiency

United States, Ireland
Johns Hopkins University
Centers for Medicare and Medicaid Services; Hill-Rom

Completed

Airway Clearance for Prevention of Chronic Obstructive Pulmonary Disease (COPD) Exacerbation

Emphysema | COPD | Chronic Bronchitis

United States
Thomayer University Hospital
Masaryk University

Recruiting

Czech AATD Registry

Alpha-1-antitrypsin Deficiency

Czechia
Grifols Therapeutics LLC

Recruiting

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% in Participants With Alpha1-Antitrypsin Deficiency

Alpha1-Antitrypsin Deficiency

United States
Columbia University
National Heart, Lung, and Blood Institute (NHLBI); Alpha-1 Foundation

Active, not recruiting

Alpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of Disease (A1BC)

Alpha 1-Antitrypsin Deficiency | Genetic Disease

United States
Vertex Pharmaceuticals Incorporated

Completed

Evaluation of the Efficacy and Safety of VX-864 in Subjects With the PiZZ Genotype

Alpha1-Antitrypsin Deficiency

United States, Germany, Canada, Ireland, Sweden, United Kingdom
Grifols Therapeutics LLC
Grifols Japan K.K.

Completed

Safety and Pharmacokinetics of Alpha-1 MP (Alpha1-proteinase Inhibitor (Human), Modified Process) in Participants With Alpha1-Antitrypsin Deficiency

Alpha1-Antitrypsin Deficiency

Japan
Baxalta now part of Shire

Completed

GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study

Alpha1-antitrypsin Deficiency

United States, Canada
Baxalta now part of Shire

Terminated

Aralast alpha1-proteinase Inhibitor Surveillance Study

Alpha1-antitrypsin Deficiency

United States
Mayo Clinic
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Home Pulmonary Rehabilitation for COPD

Emphysema | Chronic Obstructive Pulmonary Disease (COPD)

United States
Imperial College London

Completed

Leukocyte Function in Chronic Obstructive Pulmonary Disease (COPD)

Emphysema | COPD | Chronic Bronchitis

United Kingdom
University Health Network, Toronto
Novartis

Completed

Study Comparing Simulect Plus Standard Immunosuppression to Standard Immunosuppression Alone for the Prevention of Acute Rejection and Bronchiolitis Obliterans in Lung Transplant

Emphysema | COPD | Alpha-1 Antitrypsan Deficiency

Canada
University of Florida
Alpha-1 Foundation

Enrolling by invitation

Alpha-1 Foundation DNA and Tissue Bank

Alpha 1 Antitrypsin Deficiency

United States
Grifols Therapeutics LLC
Grifols Japan K.K.

Completed

Long-term Safety of Alpha1-Proteinase Inhibitor (Human) in Japanese Subjects With Alpha1 Antitrypsin Deficiency (GTI1401-OLE)

Alpha1-Antitrypsin Deficiency

Japan
Baxalta now part of Shire
Arriva Pharmaceuticals, Inc.

Completed

Safety Study of an Aerosolized, Recombinant Alpha 1-Antitrypsin in Subjects With Alpha 1-Antitrypsin Deficiency

Alpha1-antitrypsin Deficiency

United States
Baxalta now part of Shire
Arriva Pharmaceuticals, Inc.

Completed

Study of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Subjects With Alpha 1-Antitrypsin Deficiency

Alpha1-antitrypsin Deficiency

United States
Grifols Therapeutics LLC

Completed

A Study to Assess Safety and PK of Liquid Alpha₁-Proteinase Inhibitor (Human) in Treating Alpha₁-Antitrypsin Deficiency

Alpha₁-Antitrypsin Deficiency

United States
Takeda

Recruiting

Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis)

Alpha1-Antitrypsin Deficiency

United States, Poland
Takeda
Takeda Development Center Americas, Inc.

Recruiting

Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein

Alpha1-Antitrypsin Deficiency

United States, Belgium, Switzerland, Canada, Australia, Germany, United Kingdom, Austria, France, Spain, Portugal, Italy, Poland, Brazil
Alnylam Pharmaceuticals

Terminated

A Study of an Investigational Drug, ALN-AAT, in Healthy Adult Subjects and Patients With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

Antitrypsin Deficiency Liver Disease

United Kingdom
Soroka University Medical Center

Unknown

Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery

Post Cardiac Surgery Systemic Inflammatory Response
University Hospital, Basel, Switzerland

Recruiting

Comparison Between the Non-powered AEON™ Endostapler and Echelon FLEX™ Powered Plus Stapler With Regards to the Closure of Lung Tissue After Lung Resection in the Presence of Severe Lung Emphysema (Stapler)

Lung Resection | Postoperative Air Leak

Switzerland
Università Vita-Salute San Raffaele

Recruiting

Laboratory Biomarkers and Pulmonary Interstitial Emphysema in ARDS (PIE-ARDS) (PIE-ARDS)

Acute Respiratory Distress Syndrome | Barotrauma

Italy
Takeda

Enrolling by invitation

An Extension Study to Learn About the Long-Term Safety of Fazirsiran and if Fazirsiran Can Help People With Alpha-1 Antitrypsin Liver Disease

Alpha1-Antitrypsin Deficiency

United Kingdom, Germany, United States, Austria, Portugal
University of Michigan Rogel Cancer Center
CSL Behring; The Leukemia and Lymphoma Society

Completed

A Pilot Study of Alpha-1-Antitrypsin (AAT) in Steroid Refractory Acute Graft vs Host Disease

Graft vs Host Disease

United States
Bastiaan Driehuys

Completed

Effects of Bevespi on Ventilation and Gas Exchange Abnormalities in COPD Assessed by 129Xe MRI (COPD)

COPD

United States
Queen's University
Ontario Lung Association

Completed

Pulmonary Gas Exchange Abnormalities in Patients With Mild COPD

COPD

Canada
Alliance of Cardiothoracic and Vascular Surgeons

Terminated

Outpatient Chest Tube Management Following Thoracic Resection Improves Patient Length of Stay and Satisfaction Without Compromising Outcomes

Pneumothorax | Lung Cancer | Subcutaneous Emphysema

United States
Z Factor Limited
Hammersmith Medicines Research; Centessa Pharmaceuticals plc

Terminated

A Single Ascending and Repeated Dose Study of Oral ZF874 in Healthy Volunteers and PiXZ Subjects

Alpha1 Anti-Trypsin Deficiency

United Kingdom
Baxalta now part of Shire

Completed

GLASSIA Infusion Rate Study

Healthy Volunteers | Alpha1-antitrypsin Deficiency

United States
RWTH Aachen University

Unknown

Liver Disease in Patients With alpha1-antitrypsin Deficiency

alpha1-antitrypsin Deficiency

Germany
Hospices Civils de Lyon

Unknown

Genetics of the Combined Pulmonary Fibrosis and Emphysema Syndrome (GENES-SEF)

Emphysema | Pulmonary Fibrosis | Healthy Subjects | Combined Pulmonary Fibrosis and Emphysema Syndrome

France
CSL Behring

Completed

Safety and Tolerability Study of Liquid Alpha1 Proteinase Inhibitor (API) in Subjects With Cystic Fibrosis

Cystic Fibrosis

Bulgaria, Hungary, Poland, United Kingdom
Rabin Medical Center

Unknown

The Value of Bronchoscopic Lung Volume Reduction by Endobronchial Valves in Patients With Single Lung Transplantation and Overinflation of the Native Lung

Native Lung Overinflation in Patients That Underwent Single Lung Transplantation Due to Emphysema

Israel
Hospices Civils de Lyon

Completed

Polygen Defi-Alpha: Genetic Polymorphisms Study in Children With Alpha-1 Antitrypsin Deficiency, Included in the DEFI-ALPHA Cohort (Polygen)

Children With a Deficiency of Alpha-1 Antitrypsin

France
University of Florida

Completed

Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD)

Alpha-1 Antitrypsin Deficiency | Liver Fibrosis | AATD | AAT Deficiency

United States
Kamada, Ltd.

Completed

Phase II Study of the Safety and Efficacy of Inhaled Alpha-1 Antitrypsin (AAT ) in Cystic Fibrosis Patients

Cystic Fibrosis

Israel
Washington University School of Medicine
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); N... and other collaborators

Terminated

Carbamazepine in Severe Liver Disease Due to Alpha-1 Antitrypsin Deficiency (CBZ)

Liver Cirrhosis | Alpha-1-antitrypsin Deficiency

United States
Alnylam Pharmaceuticals

Terminated

A Study of ALN-AAT02 in Healthy Participants and Participants With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

United Kingdom

Clinical Trials on Emphysema or COPD

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