Clinical Trials on End-stage Liver Disease

Total 354659 results

Nanfang Hospital of Southern Medical University
Xiangya Hospital of Central South University; Southwest Hospital, China; The... and other collaborators

Completed

A Multicenter Prospective Study of Application of Platelet Mapping in Acute-on-chronic-liver Failure in China

Platelet | Acute on Chronic Liver Failure | Thrombelastography | Multicenter Prospective Study

China
Aga Khan University
National Institute of Liver & GI Diseases, Pakistan

Not yet recruiting

Intravenous NAC Use in ACLF Patients

Acute on Chronic Liver Failure(ACLF)

Pakistan
AstraZeneca
Hospital Israelita Albert Einstein

Not yet recruiting

Brazilian Reality of Hepatocellular Carcinoma (BRA-HEP)

Hepatocellular Carcinoma | Hepatocellular Carcinoma by BCLC Stage | Hepatocellular Carcinoma Stage I | Hepatocellular Carcinoma Stage III | Hepatocellular Carcinoma Stage II

Brazil
Tongji Hospital
The First Affiliated Hospital of Nanchang University; The First Hospital of... and other collaborators

Recruiting

Avatrombopag in Patients With End-stage Liver Disease and Thrombocytopenia

Liver Failure | Decompensated Cirrhosis | Thrombocytopenia

China
Instituto Grifols, S.A.

Completed

Effects on Plasma Exchange on Functional Capacity of Serum Albumin, Circulatory Dysfunction, Renal and Cerebral Function in Cirrhotic Patients With "Acute-on-chronic Liver Failure"

Liver Failure | Liver Cirrhosis

Spain
University College London Hospitals
Medical Research Council

Unknown

Predictive Utility of DASIMAR as a Prognostic Biomarker in Acute-on-chronic Liver Failure (ACLF) (DASIMAR)

Liver Cirrhosis

United Kingdom
Sohag University

Completed

Acute-On-Chronic Liver Failure In Cirrhotic Patients

Cirrhosis, Liver

Egypt
Postgraduate Institute of Medical Education and...

Completed

Global Coagulation Assessment in Cirrhosis and ACLF

Acute-On-Chronic Liver Failure | Cirrhosis, Liver

India
Roswell Park Cancer Institute
Merck Sharp & Dohme LLC

Active, not recruiting

Sorafenib Tosylate and Pembrolizumab in Treating Patients With Advanced or Metastatic Liver Cancer

Advanced Adult Hepatocellular Carcinoma | Child-Pugh Class A | Stage III Hepatocellular Carcinoma | Stage IIIA Hepatocellular Carcinoma | Stage IIIB Hepatocellular Carcinoma | Stage IIIC Hepatocellular Carcinoma | Stage IV Hepatocellular Carcinoma | Stage IVA Hepatocellular Carcinoma | Stage IVB Hepatocellular...

United States
University of Regensburg

Completed

CNI-free de Novo Protocol in Patients Undergoing Liver Transplantation With Renal Impairment (PATRON07)

End Stage Liver Disease | Impaired Renal Function

Germany
Asian Institute of Gastroenterology, India

Unknown

Plasma Exchange in Acute on Chronic Liver Failure (PLEXAR)

Acute-On-Chronic Liver Failure | Cirrhosis, Liver
Nanfang Hospital of Southern Medical University

Completed

A Prospective Study of Application of Platelet Mapping in HBV-related Acute-on-chronic-liver Failure in China

Thrombelastography,Acute on Chronic Liver Failure, Platelet

China
European Foundation for Study of Chronic Liver...

Recruiting

Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs (CHANCE)

Liver Diseases | Liver Cirrhosis | Acute-On-Chronic Liver Failure | Liver Transplant; Complications

Spain, United States, Germany, Belgium, United Kingdom, Japan, Mexico, Taiwan, Korea, Republic of, Canada, France, Australia, Italy, Argentina, Austria, Brazil, Colombia, Czechia, Hong Kong, India, Netherlands, New Zealand, Poland, Po... and more
St. Luke's-Roosevelt Hospital Center

Completed

Transplant and Addiction Project (TAP) - 1

Substance-Related Disorders | End Stage Liver Disease | End Stage Renal Disease

United States
The Cleveland Clinic
American College of Gastroenterology

Withdrawn

Mechanism and the Effect of Midodrine on Portal Pressures in Patients With Cirrhosis

End Stage Liver Disease | Cirrhosis | Ascites | Hypotension

United States
Institute of Liver and Biliary Sciences, India

Recruiting

To Compare Relaxed Rotational Thromboelastometry Cut-offs With Standard Cut-offs for Guiding Blood Product Use Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure Patients

Liver Cirrhosis | Acute on Chronic Liver Failure

India
Hexaell Biotech Co., Ltd.

Recruiting

The Safety and Tolerability Study of HepaCure in Chinese Subjects With Acute-On-Chronic Liver Failure

Liver Failure | Hepatitis | Acute on Chronic Hepatic Failure

China
Chulalongkorn University

Recruiting

The Effects of Double Plasma Molecular Adsorption System in Acute on Chronic Liver Failure Patients

Acute-On-Chronic Liver Failure | Acute on Chronic Hepatic Failure

Thailand
Dana-Farber Cancer Institute
National Cancer Institute (NCI); Pharmavite LLC

Recruiting

Vitamin D in Patients With Stage I-III Colon Cancer or Resectable Colon Cancer Liver Metastases

Stage, Colon Cancer | Stage I-III Colon Cancer | Stage IV Colon Cancer With Resectable Liver Metastases

United States
RenJi Hospital

Not yet recruiting

Transplantation for EASL-CLIF and APASL ACLF Patients: a Retrospective Cohort Study (TEA-ACLF)

Liver Cirrhosis | Acute-On-Chronic Liver Failure | Liver Transplant; Complications
Institute of Liver and Biliary Sciences, India

Withdrawn

To Study and Compare the Clinical Course and Development of Organ Failure in Severe Acute Hepatitis Without Ascites, Non-cirrhotic and Cirrhotic Patients With Ascites [Acute on Chronic Liver Failure] and Acute Deterioration of Previously Decompensated Cirrhosis.

Cirrhosis

India
Institute of Liver and Biliary Sciences, India

Recruiting

Role of Fecal Microbiota in Predicting Graft Rejection and Sepsis Among Recipients of Living Donor Liver Transplant in First Year.

Liver Cirrhosis | Acute-On-Chronic Liver Failure | Acute Liver Failure

India
Hepa Wash GmbH

Terminated

Hepa Wash Treatment of Patients With Acute-on-Chronic Liver Failure in Intensive Care Units (HEPATICUS-1)

Acute on Chronic Hepatic Failure

Germany
Institute of Liver and Biliary Sciences, India

Completed

Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure

Acute on Chronic Hepatic Failure

India
Mexbrain

Not yet recruiting

Feasibility Pilot Study to Evaluate the Safety and Performance of the MEX-CD1 Medical Device in ACLF (MexACLF)

Multiple Organ Failure | Acute on Chronic Liver Failure

France
Asan Medical Center

Unknown

Effect of Preoperative Beta Blocker Use Postoperative Renal Function in the Patients Undergoing Liver Transplantation

End Stage Liver Disease | Acute Kidney Injury

Korea, Republic of
Steminent Biotherapeutics Inc.
Taipei Veterans General Hospital, Taiwan

Withdrawn

Safety Study of Stemchymal® in Acute Liver Failure (ALF)

Acute-On-Chronic Liver Failure | Acute Liver Failure | Stem Cells | Adult Stem Cells | Steminent

Taiwan
Pere Gines
Clinica Universidad de Navarra, Universidad de Navarra

Terminated

Allogenic Bone Marrow Mesenchymal Stem Cell Therapy in Acute-on-chronic Liver Failure (Liveradvance)

Acute on Chronic Hepatic Failure

Spain
All India Institute of Medical Sciences, New Delhi

Unknown

Assessment of Coagulation Abnormalities in Acute on Chronic Liver Failure Patients Using Thromboelastography

Cirrhosis | Acute on Chronic Liver Failure

India
UDA Centro Nacional Hepato-Bilio-Pancreático
University Hospital, Limoges; Universidad de la Republica; INSERM UMR-S850, Limoges... and other collaborators

Terminated

Study of PD/PK/PG Relationships of Tacrolimus and Cyclosporin in Liver Transplant Patients (3PIGREF)

End Stage Liver Disease | Diabetes | Toxicity | Rejection | Infection | Malignancy

Uruguay
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

Modified Immune Cells (Autologous Dendritic Cells) and a Vaccine (Prevnar) After High-Dose External Beam Radiation Therapy in Treating Patients With Unresectable Liver Cancer

Stage III Intrahepatic Cholangiocarcinoma AJCC v8 | Unresectable Hepatocellular Carcinoma | Stage III Hepatocellular Carcinoma AJCC v8 | Stage IV Hepatocellular Carcinoma AJCC v8 | Stage IV Intrahepatic Cholangiocarcinoma AJCC v8 | Unresectable Intrahepatic Cholangiocarcinoma

United States
Ruijin Hospital

Not yet recruiting

Albumin Infusion in Inpatients With Decompensated Cirrhosis

Decompensated Cirrhosis | Acute-On-Chronic Liver Failure

China
Institute of Liver and Biliary Sciences, India

Completed

Spectrum, Profile and Outcome of Infections in Patients With Cirrhosis and/ or Acute on Chronic Liver Failure

Cirrhosis | Chronic Liver Failure | Acute Liver Failure

India
University Hospital, Basel, Switzerland
Swiss National Science Foundation

Recruiting

MERTK Signalling in Monocytes/Macrophages in Patients With Liver Disease

Liver Failure | Acute-On-Chronic Liver Failure | Liver Disease | Cirrhosis of the Liver

Switzerland, United Kingdom
Dr. Alexander Supady

Recruiting

Cytokine Adsorption in Acute-on-chronic Liver Failure (CYTOHEP)

Acute-On-Chronic Liver Failure | Renal Failure

Germany
Jonel Trebicka

Completed

Predicting Acute-on-Chronic Liver Failure in Cirrhosis (PREDICT) Study (PREDICT)

Liver Cirrhosis With Acute Decompensation

Spain, Germany, Denmark, Austria, Belgium, United Kingdom, Netherlands, Switzerland, Hungary, Italy, France, Portugal, Slovakia, Turkey
Ohio State University Comprehensive Cancer Center
Varian Medical Systems

Completed

Stereotactic Body Radiation Therapy and Transarterial Chemoembolization in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery

Child-Pugh Class A | Stage IIIA Hepatocellular Carcinoma | Stage IIIB Hepatocellular Carcinoma | Stage IIIC Hepatocellular Carcinoma | Stage IVA Hepatocellular Carcinoma | Stage IVB Hepatocellular Carcinoma | Child-Pugh Class B

United States
Academisch Medisch Centrum - Universiteit van Amsterdam...
Erasmus Medical Center

Terminated

Sorafenib PK in Patients With Advanced HCC and Child-Pugh B (SORBE)

BCLC Stage C HCC | CP-B Liver Cirrhosis

Netherlands
Octapharma

Terminated

Evaluation of the Safety of Octaplas™ Versus Plasma in Patients Undergoing Orthotopic Liver Transplantation

Coagulopathy | Endstage Liver Disease

United States
Qin Ning

Recruiting

Clinical Observation of CABA System in the Treatment of End-stage Liver Disease With Inflammation

To Evaluate the Clinical Efficacy and Safety of the New ALSS

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Pembrolizumab With or Without Elbasvir/Grazoprevir and Ribavirin in Treating Patients With Advanced Refractory Liver Cancer

Stage IIIB Hepatocellular Carcinoma AJCC v7 | Stage IIIC Hepatocellular Carcinoma AJCC v7 | BCLC Stage B Hepatocellular Carcinoma | BCLC Stage C Hepatocellular Carcinoma | Hepatitis C Infection | Stage IV Hepatocellular Carcinoma AJCC v7 | Stage III Hepatocellular Carcinoma AJCC v7 | Stage IIIA Hepatocellular... and other conditions

United States
University of California, San Francisco
Johns Hopkins University; Duke University

Completed

Exercise Intervention in Liver Transplant Patients

End Stage Liver Disease | Sarcopenia | Liver Cirrhoses

United States
OHSU Knight Cancer Institute
Oregon Health and Science University; American Society of Clinical Oncology; Radiological... and other collaborators

Withdrawn

Y-90 Versus SBRT for Inoperable HCC

Hepatocellular Carcinoma | Stage III Hepatocellular Carcinoma AJCC v8 | Stage IIIA Hepatocellular Carcinoma AJCC v8 | Stage IVA Hepatocellular Carcinoma AJCC v8 | Stage IIIB Hepatocellular Carcinoma AJCC v8 | Stage IB Hepatocellular Carcinoma AJCC v8 | Stage II Hepatocellular Carcinoma AJCC v8 | Stage... and other conditions

United States
Chandan K Sen
Carotech Inc.

Completed

Human Tissue Distribution of Orally Supplemented Natural Vitamin E Tocotrienol

End Stage Liver Disease | Healthy Subjects | Morbid Obesity | Pulmonary Failure | End Stage Cardiac Failure | Recalcitrant Epilepsy Requiring Surgery

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

IRX-2, Cyclophosphamide, and Nivolumab in Treating Patients With Recurrent or Metastatic and Refractory Liver Cancer

Recurrent Hepatocellular Carcinoma | Stage IV Hepatocellular Carcinoma AJCC v8 | Stage IVA Hepatocellular Carcinoma AJCC v8 | Stage IVB Hepatocellular Carcinoma AJCC v8 | Refractory Liver Carcinoma

United States
Chinese PLA General Hospital

Recruiting

The Safety and Efficacy of Thermal Ablation Combined With Apatinib and Carilimub for Advanced Liver Cancer

BCLC Stage B Hepatocellular Carcinoma | BCLC Stage C Hepatocellular Carcinoma

China
Robin Kate Kelley
Bristol-Myers Squibb; Bayer

Active, not recruiting

Sorafenib and Nivolumab in Treating Participants With Unresectable, Locally Advanced or Metastatic Liver Cancer

Stage III Hepatocellular Carcinoma AJCC v8 | Stage IIIA Hepatocellular Carcinoma AJCC v8 | Stage IIIB Hepatocellular Carcinoma AJCC v7 | Stage IIIC Hepatocellular Carcinoma AJCC v7 | Stage IV Hepatocellular Carcinoma AJCC v8 | Stage IVA Hepatocellular Carcinoma AJCC v8 | Stage IVB Hepatocellular...

United States
National Cancer Institute (NCI)

Completed

Trametinib or Combination Chemotherapy in Treating Patients With Refractory or Advanced Biliary or Gallbladder Cancer or That Cannot Be Removed by Surgery (S1310)

Hilar Cholangiocarcinoma | Advanced Adult Hepatocellular Carcinoma | Localized Non-Resectable Adult Liver Carcinoma | Recurrent Adult Liver Carcinoma | Recurrent Gallbladder Carcinoma | Stage IV Distal Bile Duct Cancer | Unresectable Extrahepatic Bile Duct Carcinoma | Stage II Gallbladder Cancer | Stage... and other conditions

United States
Kyoto University

Withdrawn

Surgery With or Without Hepatic Arterial Chemotherapy in Treating Patients With Liver Cancer

Localized Resectable Adult Primary Liver Cancer | Stage III Childhood Liver Cancer

Japan
Nanfang Hospital of Southern Medical University
Xiangya Hospital of Central South University; Beijing Ditan Hospital; RenJi Hospital and other collaborators

Unknown

Metagenomic Next-Generation Sequencing for Diagnosis of Ascites Infection in End-stage Liver Diseases

Ascites Infection

China

Clinical Trials on End-stage Liver Disease

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