Clinical Trials on Eosinophilic Disorder

Total 144334 results

AstraZeneca

Completed

TrinetX Study of Hypereosinophilic Syndrome (HES) Without an Identifiable Non-haematological Secondary Cause

Hypereosinophilic Syndrome (HES)

United States
Chulalongkorn University

Completed

Vitamin D Levels in Non-immediate Drug Hypersensitivity Case-control Study

Vitamin D Deficiency | Stevens-Johnson Syndrome | Maculopapular Exanthem | Drug Reaction With Eosinophilia and Systemic Symptom | Drug-Induced Rash

Thailand
Mundipharma Research Limited

Terminated

A Study to Compare Fluticasone /Formoterol Breath Actuated Inhaler (BAI) and Ultibro in Subjects With Fixed Airflow Obstruction and Elevated Eosinophils

ACOS (Fixed Airflow Obstruction and Elevated Eosinophils)

Slovakia
National Cancer Institute (NCI)

Completed

Bortezomib and Combination Chemotherapy in Treating Younger Patients With Recurrent, Refractory, or Secondary Acute Myeloid Leukemia

Recurrent Adult Acute Myeloid Leukemia | Adult Acute Monoblastic Leukemia (M5a) | Adult Acute Monocytic Leukemia (M5b) | Adult Acute Myeloblastic Leukemia With Maturation (M2) | Adult Acute Myeloblastic Leukemia Without Maturation (M1) | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities and other conditions

United States, Canada, Australia
National Cancer Institute (NCI)

Terminated

Entinostat and Sorafenib Tosylate in Treating Patients With Advanced or Metastatic Solid Tumors or Refractory or Relapsed Acute Myeloid Leukemia

Recurrent Adult Acute Myeloid Leukemia | Unspecified Adult Solid Tumor, Protocol Specific | Adult Acute Megakaryoblastic Leukemia (M7) | Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Adult Acute Monoblastic Leukemia (M5a) | Adult Acute Monocytic Leukemia (M5b) | Adult Acute Myeloblastic... and other conditions

United States
Assistance Publique - Hôpitaux de Paris
French Vasculitis Study Group

Completed

Rituximab in Eosinophilic Granulomatosis With Polyangiitis (REOVAS)

Eosinophilic Granulomatosis With Polyangiitis (EGPA)

France
National Cancer Institute (NCI)

Completed

3-AP and Fludarabine in Treating Patients With Myeloproliferative Disorders, Chronic Myelomonocytic Leukemia, or Accelerated Phase or Blastic Phase Chronic Myelogenous Leukemia

Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Chronic Myelomonocytic Leukemia | Accelerated Phase Chronic Myelogenous Leukemia | Relapsing Chronic Myelogenous Leukemia | Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative | Philadelphia Chromosome Negative Chronic Myelogenous... and other conditions

United States
National Cancer Institute (NCI)

Terminated

Flavopiridol in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Chronic Myelogenous Leukemia

Recurrent Adult Acute Myeloid Leukemia | Adult Acute Megakaryoblastic Leukemia (M7) | Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Adult Acute Monoblastic Leukemia (M5a) | Adult Acute Monocytic Leukemia (M5b) | Adult Acute Myeloblastic Leukemia With Maturation (M2) | Adult Acute... and other conditions

United States
National Institute of Allergy and Infectious Diseases...

Completed

Reslizumab to Prevent Post-treatment Eosinophilia in Loiasis

Loiasis

United States
National Cancer Institute (NCI)

Completed

Tipifarnib in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia

Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome | Adult Acute Megakaryoblastic Leukemia (M7) | Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Adult Acute Monoblastic Leukemia (M5a) | Adult Acute Monocytic Leukemia (M5b) | Adult Acute Myeloblastic... and other conditions

United States
National Institute of Allergy and Infectious Diseases...

Completed

Anti-Interleukin-5 Antibody to Treat Hypereosinophilic Syndrome

Hypereosinophilic Syndrome

United States
National Cancer Institute (NCI)

Completed

Combination Chemotherapy With or Without PSC 833, Peripheral Stem Cell Transplantation, and/or Interleukin-2 in Treating Patients With Acute Myeloid Leukemia

Adult Acute Megakaryoblastic Leukemia (M7) | Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Adult Acute Monoblastic Leukemia (M5a) | Adult Acute Monocytic Leukemia (M5b) | Adult Acute Myeloblastic Leukemia With Maturation (M2) | Adult Acute Myeloblastic Leukemia Without Maturation... and other conditions

United States
Knopp Biosciences

Completed

Study of Dexpramipexole Chronic Sinusitis With Nasal Polyps and Eosinophilia (CS201)

Chronic Sinusitis With Nasal Polyps and Eosinophilia

United States
National Medical Research Center for Rehabilitation...
Pirogov Russian National Research Medical University; DNKOM LLC; The Orenburg...

Recruiting

Study of Efficacy and Safety of the Plasmapheresis Method With Albumin Compensation Compared With the Plasmapheresis Method Without Albumin Compensation for Aging Biomarkers Correction in Men and Women Aged 40 to 55 Years Old

Cardiovascular Diseases | Nervous System Diseases | Urologic Diseases | Diabetes | Neuromuscular Diseases | Hypercholesterolemia | Gout | Hyperbilirubinemia | Hyper IgE Syndrome | Hyper-LDL-cholesterolemia | Hyper Beta Lipoproteinemia | Hyper Eosinophilic Syndrome

Russian Federation
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

Acute Myeloid Leukemia | Polycythemia Vera | Essential Thrombocythemia | Chronic Myelomonocytic Leukemia | Myelodysplastic Syndrome | Myeloproliferative Neoplasm | Chronic Neutrophilic Leukemia | Myeloid Neoplasm | Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative | Myelodysplastic/Myeloproliferative... and other conditions

United States
Matthias Griese

Recruiting

European Management Platform for Childhood Interstitial Lung Diseases - chILD-EU Register and Biobank (chILD-EU)

Child | Pulmonary Fibrosis | Lung Diseases, Interstitial | Pulmonary Eosinophilia | Respiratory Distress Syndrome, Newborn | Pulmonary Alveolar Proteinosis

Germany, Turkey, United Kingdom
GlaxoSmithKline

No longer available

This Record Contains Information About the Mepolizumab Compassionate Use (CU) Product Activities: 104317: CU and Long-Term Access Study of Mepolizumab in HES. 201956:A Long-term Access Programme for Subjects With Severe Asthma 112562: Expanded Access for Patients With Hypereosinophilic

Hypereosinophilic Syndrome
National Cancer Institute (NCI)

Completed

Idarubicin, Cytarabine, and Tipifarnib in Treating Patients With Newly Diagnosed Myelodysplastic Syndromes or Acute Myeloid Leukemia

Chronic Myelomonocytic Leukemia | Adult Acute Megakaryoblastic Leukemia (M7) | Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Adult Acute Monoblastic Leukemia (M5a) | Adult Acute Monocytic Leukemia (M5b) | Adult Acute Myeloblastic Leukemia With Maturation (M2) | Adult Acute Myeloblastic... and other conditions

United States
GlaxoSmithKline

Completed

Prevalence of Chronic Obstructive Pulmonary Disease (COPD) and Eosinophilia Among Primary Care Patients

Pulmonary Disease, Chronic Obstructive

Brazil
University Medical Center Groningen
GlaxoSmithKline; Maastricht University

Recruiting

Drivers of Eosinophilic COPD Exacerbations (DICE)

Eosinophilia | COPD Exacerbation

Netherlands
National Institute of Allergy and Infectious Diseases...

Recruiting

Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia

Immune System Diseases | Hypersensitivity | Eosinophilia | Helminthiasis | Parasitic Disease

United States
University Medical Center Groningen
GlaxoSmithKline

Recruiting

eGPA and Local Inflammation Within the Ear, Nose and Throat Area

EGPA - Eosinophilic Granulomatosis With Polyangiitis

Netherlands
Imperial College London
AstraZeneca

Enrolling by invitation

Explore the Efficacy and Mechanism of Action of Tezepelumab in Eosinophilic Granulomatosis With Polyangiitis (RACEMATE)

EGPA - Eosinophilic Granulomatosis With Polyangiitis

United Kingdom
Avalo Therapeutics, Inc.

Completed

A Study to Evaluate the Safety and Efficacy of AVTX-002 for the Treatment of Poorly Controlled Non-Eosinophilic Asthma.

Non-Eosinophilic Asthma

United States
Novartis Pharmaceuticals

Completed

Safety and Efficacy of QAW039 in Sputum Eosinophilia and Persistent Asthma

Asthma

United Kingdom
National Cancer Institute (NCI)

Completed

Sorafenib in Treating Patients With Refractory or Relapsed Acute Leukemia, Myelodysplastic Syndromes, or Blastic Phase Chronic Myelogenous Leukemia

Previously Treated Myelodysplastic Syndrome | Recurrent Adult Acute Myeloid Leukemia | Secondary Acute Myeloid Leukemia | Recurrent Adult Acute Lymphoblastic Leukemia | Secondary Myelodysplastic Syndrome | de Novo Myelodysplastic Syndrome | Adult Acute Monoblastic Leukemia | Adult Acute Monocytic... and other conditions

United States
Chulalongkorn University
Mahidol University; Chiang Mai University; Phramongkutklao College of Medicine... and other collaborators

Unknown

Severe Cutaneous Adverse Reactions in Thailand (ThaiSCAR)

Drug Reaction With Eosinophilia and Systemic Symptoms | Toxic Epidermal Necrolysis | Acute Generalized Exanthematous Pustulosis | Steven-Johnson Syndrome | Generalized Bullous Fixed Drug Eruption

Thailand
Jiangsu HengRui Medicine Co., Ltd.

Active, not recruiting

A Study to Evaluate the Pharmacodynamic, Efficacy and Safety of SHR-1703 in Asthma Patients With Eosinophil Phenotype

Asthma With Eosinophilic Phenotype

China
McMaster University
GlaxoSmithKline; University of Manchester

Recruiting

Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases (MUCOSA)

Asthma | Eosinophilic Bronchitis | Chronic Cough

Canada
National Institute of Allergy and Infectious Diseases...
AstraZeneca

Active, not recruiting

Study to Evaluate Safety and Efficacy of Benralizumab in Subjects With Hypereosinophilic Syndrome (HESIL5R)

Hematologic Diseases | Leukocyte Disorders | Hypereosinophilia | Respiratory System Agents | Anti-Asthmatic Agents

United States
National Cancer Institute (NCI)

Completed

Vorinostat, Cytarabine, and Etoposide in Treating Patients With Relapsed and/or Refractory Acute Leukemia or Myelodysplastic Syndromes or Myeloproliferative Disorders

Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Adult Acute Megakaryoblastic Leukemia (M7) | Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Adult Acute Monoblastic Leukemia (M5a) | Adult... and other conditions

United States
Novartis Pharmaceuticals

Terminated

A Proof-of-mechanism Study of Multiple, Oral Doses of Fevipiprant (QAW039) in COPD Patients With Eosinophilia

Chronic Obstructive Pulmonary Disease

Germany, United Kingdom
National Cancer Institute (NCI)

Completed

Tanespimycin and Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Chronic Myelogenous Leukemia, Chronic Myelomonocytic Leukemia, or Myelodysplastic Syndromes

Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Adult Acute Megakaryoblastic Leukemia (M7) | Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Adult Acute Monoblastic Leukemia (M5a) | Adult Acute Monocytic Leukemia (M5b) | Adult Acute Myeloblastic Leukemia... and other conditions

United States
The First Affiliated Hospital of Guangzhou Medical...

Completed

Therapeutic Effect of Different Treatment Course With Inhaled Corticosteroids in Eosinophilic Bronchitis Patients

Eosinophilic Bronchitis

China
Viome

Terminated

Systems Biology of Gastrointestinal and Related Diseases

Obesity | Gastritis | Irritable Bowel Syndrome | Gastric Cancer | Esophageal Cancer | Gastro Esophageal Reflux | Crohn Disease | GERD | NAFLD | Ulcerative Colitis | Eosinophilic Esophagitis | Gastric Ulcer | Duodenal Ulcer | Barrett Esophagus | Intestinal Metaplasia | Colon Polyp | Lymphocytic Colitis | IBS | SIBO | Gallstone Disease | Microscopic Colitis and other conditions

United States
AstraZeneca

Completed

FAsenra Safety Trial in India (FAST)

In Adult Patients of Severe Asthma With Eosinophilic Phenotype in India

India
Kyowa Kirin Co., Ltd.

Completed

Study of Benralizumab (KHK4563) in Patients With Eosinophilic Chronic Rhinosinusitis

Eosinophilic Chronic Rhinosinusitis

Japan
Société des Produits Nestlé (SPN)

Completed

A Study to Monitor the Use of an Amino Acid-Based Infant Formula (EAGLE)

Short Bowel Syndrome | Cow's Milk Protein Allergy | Eosinophilic Gastrointestinal Disorders | Malabsorption/Maldigestion | Multiple Food Allergies

United States
Guangzhou Medical University

Unknown

Efficacy and Safety of add-on Montelukast to Inhaled Budesonide in the Treatment of Nonasthmatic Eosinophilic Bronchitis (NAEB)

Nonasthmatic Eosinophilic Bronchitis

China
University of Pennsylvania
University of South Florida; University of Oxford

Completed

The ANCA Vasculitis Questionnaire (AAV-PRO©) (AAV-PRO)

Vasculitis | Churg-Strauss Syndrome (CSS) | Microscopic Polyangiitis (MPA) | Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss) (EGPA) | Granulomatosis With Polyangiitis (Wegener's) (GPA) | Wegener Granulomatosis (WG) | ANCA-Associated Vasculitis (AAV)

United States
Novartis Pharmaceuticals

Withdrawn

Mechanistic Study of Anti-inflammatory Effects of Fevipiprant in Patients With Eosinophilic Asthma.

Asthma | Eosinophilia | Asthma, Bronchial | Bronchial Asthma | Physiological Effects of Drugs
National Cancer Institute (NCI)

Completed

XK469R in Treating Patients With Refractory Hematologic Cancer

Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Adult Acute Megakaryoblastic Leukemia (M7) | Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Adult Acute Monoblastic Leukemia (M5a) | Adult Acute Monocytic Leukemia (M5b) | Adult Acute Myeloblastic Leukemia... and other conditions

United States
The First Affiliated Hospital of Guangzhou Medical...

Unknown

The Effect of Bronchodilator on Eosinophilic Bronchitis and Cough Variant Asthma

Eosinophilic Bronchitis | Cough Variant Asthma

China
Peter Merkel
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and other collaborators

Recruiting

Clinical Transcriptomics in Systemic Vasculitis (CUTIS) (CUTIS)

Vasculitis | Eosinophilic Granulomatosis With Polyangiitis (EGPA) | Cryoglobulinemic Vasculitis (CV) | Drug-induced Vasculitis | IgA Vasculitis | Isolated Cutaneous Vasculitis | Granulomatosis With Polyangiitis (GPA) | Microscopic Polyangiitis (MPA) | Polyarteritis Nodosa (PAN) | Urticarial Vasculitis

United States, Canada
Chronic Obstructive Pulmonary Disease Trial Network...

Completed

Corticosteroid Reduction in COPD (Cortico-cop)

Lung Diseases, Obstructive | Pulmonary Disease, Chronic Obstructive | COPD | Glucocorticoids | Blood Eosinophil Count

Denmark
Johns Hopkins University

Completed

Benralizumab Effect on Severe Chronic Rhinosinusitis With Eosinophilic Polyposis

Chronic Rhinosinusitis (Diagnosis) | Nasal Polyps | Eosinophilia

United States
McMaster University
Novartis

Completed

Study of the Steroid Sparing Effect of Xolair (Omalizumab) in Patients With Persistent Eosinophilic Bronchitis

Eosinophilic Bronchitis | Steroid and/or Prednisone Dependent Asthma

Canada
Second Affiliated Hospital, School of Medicine,...

Unknown

Clinical Characteristics and Treatment of Chest Tightness Variant Asthma

Quality of Life | Asthma | Eosinophilia | Nitric Oxide | Airway Responsiveness | Clinical Depression | Chest Syndrome | Lung Function | Clinical Anxiety | Induced Sputum

China
AstraZeneca

Active, not recruiting

Efficacy and Safety of Benralizumab in EGPA Compared to Mepolizumab. (MANDARA)

Eosinophilic Granulomatous Vasculitis

United States, Canada, France, Italy, Israel, United Kingdom, Japan, Germany, Belgium
GlaxoSmithKline
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

A Study to Investigate Mepolizumab in the Treatment of Eosinophilic Granulomatosis With Polyangiitis

Churg-Strauss Syndrome

United States, France, Japan, Spain, Italy, Germany, Canada, Belgium, United Kingdom

Clinical Trials on Eosinophilic Disorder

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