Clinical Trials on Epilepsy and Focal Cortical Dysplasia II

Total 387 results

Yonsei University

Completed

A Study Investigating the Anti-epileptic Efficacy of Afinitor (Everolimus) in Patients With Refractory Seizures Who Have Focal Cortical Dysplasia Type II (FCD II)

Epilepsy and Focal Cortical Dysplasia II

Korea, Republic of
University Hospital, Strasbourg, France

Unknown

Study of Predictive Biomarkers for Rational Management of Drug-resistant Epilepsy Associated With Focal Cortical Dysplasia (SPREAD)

Focal Epilepsy | Refractory Epilepsy | Focal Cortical Dysplasia

France
The Hospital for Sick Children

Completed

Determining the Extent of Diffusion Tensor Abnormalities in Focal Cortical Dysplasia (FCP)

Epilepsy | Focal Cortical Dysplasia

Canada
Great Ormond Street Hospital for Children NHS Foundation...

Not yet recruiting

First-in-human Experience Using Novel Ultraflexible Low-impedance Electrode Arrays: an IDEAL Stage 1 Study

Epilepsy | Focal Cortical Dysplasia

United Kingdom
King's College Hospital NHS Trust
King's College London; Danish Epilepsy Centre

Recruiting

Mos-FED (Mosaicism in Focal Epilepsy Cortical Dysplasia Tissue) (MosFED)

Epilepsy | Focal Cortical Dysplasia

United Kingdom
Fondation Ophtalmologique Adolphe de Rothschild

Recruiting

Genetic and Electrophysiologic Study in Focal Drug-resistant Epilepsies (GENEPHY)

Tuberous Sclerosis | Focal Cortical Dysplasia | Hemimegalencephaly | Refractory Focal Epilepsy | Mild Malformation of Cortical Development With Oligodendroglial Hyperplasia in Epilepsy (MOGHE)

France
NYU Langone Health

Completed

A Pilot Study To Evaluate The Effects of Everolimus on Brain mTOR Activity and Cortical Hyperexcitability in TSC and FCD

Epilepsy | Tuberous Sclerosis Complex | Focal Cortical Dysplasia

United States
Neuroelectrics Corporation

Recruiting

Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy

Epilepsy | Seizures | Refractory Epilepsy | Epilepsy, Tonic-Clonic | Epilepsy in Children | Seizures, Focal | Focal Seizure

Spain, United States, France, Belgium
UCB Biopharma SRL

Terminated

An Open-label Extension Study of UCB0942 in Adult Patients With Highly Drug-resistant Focal Epilepsy

Highly Drug-resistant Focal Epilepsy

Belgium, Bulgaria, Germany, Hungary, Netherlands, Spain
UCB Biopharma S.P.R.L.
PRA Health Sciences

Completed

A Study of UCB0942 in Adult Patients With Highly Drug-resistant Focal Epilepsy

Highly Drug-resistant Focal Epilepsy

Belgium, Bulgaria, Germany, Hungary, Netherlands, Spain
Biogen

Completed

Phase 2 Efficacy, Safety, and Tolerability Study of Natalizumab in Focal Epilepsy (OPUS)

Epilepsy, Focal Seizures, Partial Seizures

United States
King's College London
King's College Hospital NHS Trust

Completed

Subcutaneous EEG: Forecasting of Epileptic Seizures (SUBER)

Epilepsies, Focal

United Kingdom
UCB Pharma GmbH

Completed

Study Evaluating Changes in Total Drug Load and Seizure Frequency Using Vimpat® (Lacosamide) in Combination Therapy (VICTOS)

Focal Epilepsy With and Without Secondary Generalization

Germany, Austria
Neurocrine Biosciences

Terminated

Extension Study to Evaluate the Safety and Tolerability of NBI-921352 When Used With Anti-seizure Medications in Adults With Focal Onset Seizures

Focal Onset Seizure | Focal Onset Epilepsy

Spain, Australia, Belgium, Czechia, France, Hungary, Italy
Neurocrine Biosciences

Completed

A Study to Investigate How Effective, Safe and Tolerable the Drug NBI-921352 is When Used With Anti-seizure Medications in Adults With Focal Onset Seizures

Focal Onset Seizure | Focal Onset Epilepsy

Spain, Belgium, Czechia, France, Italy, Australia, Hungary, United Kingdom
Rapport Therapeutics Inc.

Not yet recruiting

Study Evaluating the Safety and Efficacy of RAP-219 in Adult Participants With Refractory Focal Epilepsy

Focal Onset Seizures
University College, London
University of Liverpool

Terminated

Evaluating Dietary Intervention Before surgicaL Treatment for Epilepsy (EDIBLE)

Cortical Dysplasia

United Kingdom, France, Austria, United States, Czechia, Germany, Italy, Switzerland
GRIN Therapeutics, Inc.

Recruiting

A Study of Radiprodil on Safety, Tolerability, Pharmacokinetics, and Effect on Seizures and Behavioral Symptoms in Patients With TSC or FCD Type II

Tuberous Sclerosis Complex | Focal Cortical Dysplasia

Spain, United Kingdom, Australia, Belgium, Canada, Italy, Poland
Przemyslaw Kunert
NaoX Technologies; Warsaw Medical University Clinical Center; Departments and...

Not yet recruiting

Assessment of Patients With Drug-resistant Temporal Lobe Epilepsy With EEG Extended With Intra-auricular Electrodes

Epilepsy | Drug Resistant Epilepsy | Focal Epilepsy

Poland
Biohaven Therapeutics Ltd.

Recruiting

Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy (RISE 3)

Focal Epilepsy

United States
Yonsei University

Completed

The Effects on Cognitive Function of Levetiracetam (Keppra®) Compared to Carbamazepine (Tegretol®, Carmazepine®) as Monotherapy for Children With Partial Seizure; A Multicentric Randomized Controlled Study

Focal Epilepsy

Korea, Republic of
Mayo Clinic

Completed

Arterial Spin Labeling MRI Focal Abnormalities in Refractory Epilepsy

Focal Epilepsy

United States
Chinese University of Hong Kong

Unknown

Post-market Study of AMPA Receptor Antagonists for Epilepsy Patients in Hong Kong

Generalized Epilepsy | Focal Epilepsy | Partial Seizures, Simple

Hong Kong
University of Mississippi Medical Center

Not yet recruiting

Clinical, Translational and Biomarker-Based Female Genital HPV Induced Dysplasia and Cancer Screening Study Using Cf-HPV-DNA Blood Tests (TTMV HPV DNA)

Cervical Dysplasia, Uterine | Vaginal Dysplasia | Vulvar Dysplasia
Biohaven Therapeutics Ltd.

Recruiting

A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy (RISE 2)

Focal Epilepsy

United States
Reliev Technologies

Not yet recruiting

Seizures Detection in Real Life Setting (ECEME)

Focal Epilepsy | Epilepsy; Seizure
Boston Children's Hospital

Recruiting

Genetics of Epilepsy and Related Disorders

Epilepsy | Dravet Syndrome | Infantile Spasms | Epileptic Encephalopathy | Ohtahara Syndrome | Early Myoclonic Epileptic Encephalopathy | PCDH19-related Epilepsy and Related Conditions | KCNQ2-Related Epileptic Encephalopathy | Epilepsy of Infancy With Migrating Focal Seizures (Disorder)

United States
Cerebral Therapeutics LLC

Terminated

Study to Assess Intracerebroventricular (ICV) Delivery of CT-010 in Subjects With Focal Seizures, With Temporal Lobe Onset With or Without Secondary Generalization

Refractory Epilepsy

Israel, Australia
SK Life Science, Inc.

Completed

An Open-Label Extension Study of the Safety and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset Seizures

Epilepsy, Complex Partial | Epilepsy, Partial, Motor | Epilepsy, Simple Partial | Focal Motor Epilepsy
SK Life Science, Inc.

Completed

A Study of the Effectiveness, Safety, and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset Seizures.

Epilepsy, Complex Partial | Epilepsy, Partial, Motor | Epilepsy, Simple Partial | Focal Motor Epilepsy
Cerebral Therapeutics LLC

Terminated

Anti-Epilepsy Medication Valproate Administered Via ICV Route and Catheters and Pumps for CSF Infusion

Focal Epilepsy

Israel, Australia
UCB Biopharma S.P.R.L.

Completed

Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsy (ARISE)

Focal-Onset Seizures | Drug-resistant Epilepsy

United States, Australia, Belgium, Bulgaria, Canada, Czechia, France, Germany, Hungary, Italy, Japan, Lithuania, Mexico, Poland, Portugal, Slovakia, Spain, Turkey, United Kingdom
Eisai GmbH

Completed

ZEDEBAC: Zebinix Effects in Dependency of Baseline Conditions

Focal Epilepsy

Germany
NYU Langone Health

Not yet recruiting

Efficacy of Intersectional Short Pulse Stimulation for Terminating Seizures

Seizures | Focal Epilepsy
UCB Pharma

Completed

A Study of Brivaracetam in Subjects With Partial Onset Seizures

Epilepsy, Focal

France, Poland, United Kingdom, Belgium, Germany, Spain, Czech Republic, Finland, Netherlands
State Budgetary Healthcare Institution, National...

Enrolling by invitation

Thermocoagulation in Drug Resistant Focal Epilepsy

Epilepsy | Epilepsies, Partial | Epilepsy Intractable | Seizures, Focal

Russian Federation
University of California, San Francisco
National Institute of Neurological Disorders and Stroke (NINDS)

Completed

Epilepsy Phenome/Genome Project (EPGP)

Epilepsy | Infantile Spasms | Lennox-Gastaut Syndrome | Polymicrogyria | Localization-related Epilepsy | Periventricular Heterotopias

United States, Argentina, Australia
UCB Biopharma SRL

Terminated

A Study to Test the Efficacy and Safety of Padsevonil as Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy (DUET)

Drug-Resistant Epilepsy | Focal-Onset Seizures

United States, Australia, Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Japan, Norway, Poland, Portugal, Romania, Serbia, Slovakia, Spain, Sweden, Switzerlan... and more
UCB Biopharma SRL

Terminated

Study to Test the Safety and Efficacy of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy

Drug-Resistant Epilepsy | Focal-Onset Seizures

United States, Australia, Belgium, Bosnia and Herzegovina, Bulgaria, Canada, Croatia, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Japan, Lithuania, Mexico, Poland, Romania, Serbia, Slovakia, Spain, Turk... and more
İpek Dokurel

Active, not recruiting

Does Levetiracetam and Carbamazepine Impact the Autonomic Activity of Children With Self-limiting Focal Epilepsy? (levcbz)

Epilepsy; Syndrome, Seizures of Localized Onset

Turkey
Engrail Therapeutics INC

Withdrawn

ENACT: A Study of ENX-101 as Adjunctive Treatment in Patients With Focal Seizures (ENACT)

Focal Epilepsy

United States
Jazz Pharmaceuticals

Completed

A Study of GWP42006 in People With Focal Seizures - Part A

Epilepsy | Focal Seizures

United Kingdom, Spain, Czechia
Jazz Pharmaceuticals

Completed

A Study of GWP42006 in People With Focal Seizures - Part B

Epilepsy | Focal Seizures

Italy, Poland, United Kingdom, Spain, Hungary, Czechia
Assistance Publique Hopitaux De Marseille

Unknown

Depression, Stress and Vulnerability Factors in Drug Resistant Focal Epilepsies

Depression and Epilepsy

France
NeuroPace

Recruiting

RNS System RESPONSE Study (RESPONSE)

Epilepsy | Drug Resistant Epilepsy | Focal Epilepsy | Partial Seizure | Neurostimulator; Complications

United States
The University of Texas Health Science Center,...
National Institute of Neurological Disorders and Stroke (NINDS)

Recruiting

Breathing Rescue for SUDEP Prevention (BreatheS)

Focal Epilepsy

United States
SK Life Science, Inc.

Completed

A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures.

Epilepsy | Epilepsy, Complex Partial | Seizure Disorder | Complex Partial Seizures | Epilepsy, Focal
SK Life Science, Inc.

Completed

A Study of the Efficacy and Safety of RWJ-333369 as add-on Therapy in the Treatment of Partial Onset Seizures.

Epilepsy | Epilepsy, Complex Partial | Seizure Disorder | Complex Partial Seizures | Epilepsy, Focal
Institut National de la Santé Et de la Recherche...

Not yet recruiting

Multi-level Approach of Brain Activity Using Intracranial Electrodes in Epileptic Patients (EpiMicro)

Cognitive Function | Focal Epilepsy | Neurophysiology | Electrodes, Implanted
Hospices Civils de Lyon

Completed

Brain Maturation in Children With Localization Related Epilepsy (DYNAMAT)

Benign Childhood Epilepsy With Centro-temporal Spikes (BCECTS) | Focal Cryptogenic Epilepsy of Childhood | Cryptogenic Epilepsy of Childhood

France

Clinical Trials on Epilepsy and Focal Cortical Dysplasia II

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