Clinical Trials on Esophageal or Gastric Leaks

Total 1135 results

The Methodist Hospital Research Institute

Completed

A Trial of Esophageal and Gastric Stenting for Leak or Perforation (ESO-stent)

Esophageal or Gastric Perforations | Esophageal or Gastric Leaks

United States
The Affiliated Hospital of Qingdao University

Recruiting

Toripalimab Combined With Anlotinib for Patients With Advanced, Relapsed, or Refractory Gastric, or Esophagogastric Junction Cancer (EGJC)

Gastric or Gastro-oesophageal Junction Carcinoma | Advanced, Relapsed Gastric or Gastro-oesophageal Junction Carcinoma | Second-line Therapy

China
AstraZeneca

Terminated

Assess the Efficacy of AZD8931 in Combination With Paclitaxel Versus Paclitaxel Alone in Patients With Gastric Cancer

Metastatic, Gastric or Gastro-oesophageal Junction, Cancer

Korea, Republic of, Spain, Taiwan, Germany, Japan
Astellas Pharma China, Inc.

Completed

A Pharmacokinetic Study of Zolbetuximab (IMAB362) in Chinese Subjects With Locally Advanced Unresectable or Metastatic Gastric or Gastro-esophageal Junction (GEJ) Adenocarcinoma

Gastric or Gastro-esophageal Junction (GEJ) Adenocarcinoma

China
Imperial College London

Active, not recruiting

The Bacterial Composition of the Stomach in Reflux Disease

Gastric Cancer | Esophagitis | Gastro Esophageal Reflux | Barrett Esophagus | Oesophageal Cancer | GORD | Oesophageal Reflux | Oesophageal Carcinoma

United Kingdom
NeoImmuneTech
Bristol-Myers Squibb

Terminated

NT-I7 in Combination With Nivolumab in Advanced Gastric, Gastro-Esophageal Junction or Esophageal Adenocarcinoma

Gastric or Gastro-esophageal Junction (GEJ) or Esophageal Adenocarcinoma (EAC)

United States, Poland
Institute of Child Health

Completed

Laparoscopy in Children: Does it Decrease the Metabolic, Endocrine and Inflammatory Stress Response to Surgery

Gastro-Oesophageal Reflux

United Kingdom
Region Skane

Completed

Paracetamol Absorption Technique as a Method for Measuring Gastric Tube Outlet

Esophagectomy | Esophageal and/or Cardia Cancer | Gastric Pull-up Reconstruction

Sweden
Hospital Universitario La Fe

Enrolling by invitation

Predictive Model to Early Diagnosis of Anastomotic Leak After Esophagectomy and Gastrectomy. (PROFUGO)

Gastric Cancer | Complication | Esophagus Cancer | Leak, Anastomotic

Spain
The Netherlands Cancer Institute

Unknown

Docetaxel, Oxaliplatin, Capecitabine, Bevacizumab and Trastuzumab in Patients With Locally Advanced or Metastatic Gastric Cancer (B-DOCT)

Metastatic Gastric Cancer | Adenocarcinoma of the Gastro-oesophageal Junction

Netherlands
Grubnik Volodymyr

Completed

Influence of Wrap Fixation Technique on the Results of Fundoplication

Gastro Oesophageal Reflux Disease
Imperial College London

Completed

Physical Activity and Gastrointestinal Investigations

Gastro-oesophageal Reflux Disease

United Kingdom
Norgine

Completed

A Three-Period Study to Investigate the Relative Bioavailability and Pharmacodynamic Profiles of a Zegerid 20mg Capsule, Zegerid 20mg Powder for Oral Suspension and Losec 20mg Capsule in Healthy Adult Volunteers Under Fasting Conditions

Acid Reflux | Gastro Oesophageal Reflux Disease

United Kingdom
Royal Marsden NHS Foundation Trust
AstraZeneca

Unknown

A Translational Study of Single Agent Olaparib in the Treatment of Advanced Oesophagogastric Cancer (SOLAR)

Gastric Cancer | Oesophageal Cancer | Gastro-Oesophageal Junction Cancer

United Kingdom
AIO-Studien-gGmbH
Taiho Pharmaceutical Co., Ltd.; Nordic Pharma SAS

Completed

Trial of S-1 Maintenance Therapy in Metastatic Esophagogastric Cancer (MATEO)

Esophageal Neoplasms | Gastric Adenocarcinoma | Esophageal Adenocarcinoma | Gastroesophageal Junction Adenocarcinoma | Gastric Neoplasm | Unresectable, Locally Advanced or Metastatic, Adenocarcinoma of the Stomach, or of the Gastro Esophageal Junction

Germany
Bristol-Myers Squibb

Completed

An Efficacy Study in Gastric and Gastroesophageal Junction Cancer Comparing Ipilimumab Versus Standard of Care Immediately Following First Line Chemotherapy

Locally Advanced (Unresectable) or Metastatic Adenocarcinoma of the Gastric and Gastro-esophageal Junction

France, Poland, Russian Federation, Taiwan, United States, Hong Kong, Spain, Germany, Italy, Japan, Korea, Republic of, Singapore
Baxter Healthcare Corporation

Completed

Efficacy and Safety of Endoscopic Injection of Fibrin Sealant Versus Endoscopic Ligature for Bleeding Esophageal Varices

Esophageal and/or Gastric Varices

Germany
Athenex, Inc.

Active, not recruiting

Ph1b Study of Oraxol in Comb. w. Ramucirumab in Patients w. Gastric, Gastro-esophageal, or Esophageal Cancers

Gastric Cancer | Esophageal Cancer | Gastro-esophageal Cancer

Taiwan, United States
University Hospital, Lille
University of Lille Nord de France

Active, not recruiting

Determinants of Patient Delay in Doctor Consultation in Oeso-gastric Cancers (DELOGAST)

Gastric Adenocarcinoma | Oesophageal Carcinoma

France
Gangnam Severance Hospital

Recruiting

Investigator-initiated Pilot Study to Investigate the Efficacy and Safety of Immuncell-LC in Combination With Nivolumab (Opdivo) in Subjects With Advanced or Recurrent Gastric Cancer

Gastro-esophageal Junction Cancer | Relapsed or Advanced Gastric Adenocarcinoma

Korea, Republic of
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of agenT-797 in Combination With Botensilimab, Balstilimab, Ramucirumab, and Paclitaxel for People With Esophageal, Gastric, or Gastro-esophageal Junction Cancer

Metastatic Gastric Adenocarcinoma | Metastatic Gastroesophageal Junction Adenocarcinoma | Unresectable Gastric Adenocarcinoma | Unresectable Gastroesophageal Junction Adenocarcinoma | Metastatic Gastric Cancer | Unresectable Esophageal Cancer | Metastatic Esophageal Carcinoma | Metastatic Gastric... and other conditions

United States
Mirai Medical
Nottingham University Hospitals NHS Trust

Completed

EndoVE endosCopic Treatment for Oesophageal and Gastric canceR (VECTOR)

Gastric Cancer | Oesophageal Cancer | Oesophageal Disease

United Kingdom
Al B. Benson, III, MD
Celgene Corporation; Big Ten Cancer Research Consortium

Completed

FOLFOX-A in the Treatment of Metastatic or Advanced Unresectable Gastric, Gastro-Esophageal Junction Adenocarcinoma

Gastric Cancer | Gastro-Esophageal Junction Adenocarcinoma

United States
Cancer Trials Ireland

Completed

A Phase II Trial of Epirubicin, Oxaliplatin and Capecitabine (EOX) Versus Docetaxel and Oxaliplatin (ElTax) in the Treatment of Advanced Gastro-oesophageal Cancer (ELECT)

Gastro Oesophageal Cancer

Ireland
University of Chicago
National Cancer Institute (NCI)

Recruiting

Genetic Analysis-Guided Irinotecan Hydrochloride Dosing of mFOLFIRINOX in Treating Patients With Locally Advanced Gastroesophageal or Stomach Cancer

Gastric Adenocarcinoma | Esophageal Adenocarcinoma | Stage IIIA Gastric Cancer | Stage IIIB Gastric Cancer | Stage IIIC Gastric Cancer | Stage IIB Gastric Cancer | Stage IIIA Esophageal Adenocarcinoma | Stage IIIB Esophageal Adenocarcinoma | Stage IIIC Esophageal Adenocarcinoma

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI); National Comprehensive Cancer Network

Completed

Pralatrexate and Oxaliplatin in Treating Patients With Unresectable or Metastatic Esophageal, Stomach, or Gastroesophageal Junction Cancer

Gastric Adenocarcinoma | Recurrent Gastric Carcinoma | Esophageal Undifferentiated Carcinoma | Gastric Squamous Cell Carcinoma | Adenocarcinoma of the Gastroesophageal Junction | Stage IV Gastric Cancer | Stage IIIB Gastric Cancer | Stage IIIC Gastric Cancer | Stage IV Esophageal Adenocarcinoma | Stage... and other conditions

United States
Hospital Universitari de Bellvitge

Completed

Trial on Delay Phenomenon Utility in Preventing Anastomotic Leakage After an Esophagectomy (APIL_2013)

Esophageal Anastomotic Leak

Spain
Showa Inan General Hospital

Withdrawn

Elemental Diets vs. Semi-solid Diets on Gastric Excretion and Gastroesophageal Regurgitation

Gastro-oesophageal Reflux

Japan
Cancer Institute and Hospital, Chinese Academy...
Beijing Friendship Hospital; Chinese PLA General Hospital; Beijing Hospital

Recruiting

Sintilimab and Nab-paclitaxel in Second-line Treatment of Advanced Gastric or Gastro-oesophageal Junction Adenocarcinoma

Advanced Gastric and Gastro-esophageal Junction Adenocarcinoma

China
Reckitt Benckiser Healthcare (UK) Limited

Completed

Clinical Investigation to Assess the Acid Neutralisation Activity of a Calcite Chewing Gum

Esophagitis | Gastro Oesophageal Reflux Disease

Ireland
Instituto Ecuatoriano de Enfermedades Digestivas

Completed

Treatment of Gastric Varices Using EUS Guided Techniques

Gastric Varix

Ecuador
Novartis Pharmaceuticals

Completed

Phase II Trial of AUY922 vs. Comparators in Advanced Gastric Cancer

Advanced Gastric Cancer | Gastro-esophageal Junction Cancer

United States, France, Italy, Taiwan, United Kingdom, Turkey, Germany, Singapore, Australia, Russian Federation, Korea, Republic of, Switzerland, Netherlands, Canada
Hoffmann-La Roche
BioLineRx, Ltd.; Halozyme Therapeutics

Active, not recruiting

A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer)

Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma

United States, United Kingdom, Australia, Korea, Republic of, Taiwan, Israel, Spain
Studio Osteopatico Busto Arsizio

Recruiting

Osteopathic Manipulative Treatment for Gastro-oesophageal Reflux Disease

Gastro-oesophageal Reflux Disease

Italy
Australasian Gastro-Intestinal Trials Group
National Health and Medical Research Council, Australia; Canadian Cancer Trials... and other collaborators

Active, not recruiting

A Study of Regorafenib in Refractory Advanced Gastro-Oesophageal Cancer (INTEGRATEIIa)

Gastro-Oesophageal Cancer

Korea, Republic of, Australia, Taiwan, New Zealand, United States, Canada, Japan
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Not yet recruiting

A Study of Anlotinib Hydrochloride Capsule Combined With AK105 Injection in Subject With Advanced Gastric and Gastro-oesophageal Junction Adenocarcinoma

Advanced Gastric and Gastro-oesophageal Junction Adenocarcinoma

China
Western Sydney Local Health District

Recruiting

The Australia and New Zealand Multicentre Upper Gastrointestinal Endoscopic Tissue Resection Study (ANZ UGI)

Gastric Cancer | Esophageal Neoplasms | Neuroendocrine Tumors | Gastric Adenocarcinoma | Cancer of Stomach | Oesophageal Cancer | Gastric Neoplasm | GIST | GI Cancer

Australia
Taiho Oncology, Inc.

Terminated

Diffuse Gastric and Esophagogastric Junction Cancer S-1 Trial (DIGEST)

Metastatic Diffuse Gastric Cancer Including Carcinoma of the Gastro-esophageal Junction

Belgium, Spain, United States, Italy, Estonia, Russian Federation, Bulgaria, Hungary, Croatia, Israel, Mexico, Poland, Portugal, Romania, South Africa, Ukraine, United Kingdom, Brazil, Germany, Argentina
Institute of Liver and Biliary Sciences, India

Withdrawn

To Compare the Efficacy of Endoscopic Ultrasound Assisted Endoscopic Glue Injection and Conventional Endoscopic Injection Therapy for Prevention of Gastric Variceal Rebleed

Bleeding Gastric Varices

India
Shanghai Zhongshan Hospital
Shandong Provincial Hospital

Completed

Hemodynamic Effects of Terlipressin and High Dose Octreotide (HEofT&O)

Gastric and Esophageal Varices

China
Kantonsspital Liestal

Completed

Feasibility, Safety and QoL After Merendino Procedure (MER)

Benign or Early Malignant Lesion of the Distal Esophagus or Gastro-esophageal Junction Requiring Surgical Resection

Switzerland
SOFAR S.p.A.

Completed

Evaluation of GERDOFF Efficacy in Combination With Proton Pump Inhibitor

Gastro-oesophageal Reflux Disease

Italy
Sanofi
Merck Sharp & Dohme LLC

Active, not recruiting

A Study of SAR444245 Combined With Other Anticancer Therapies for the Treatment of Participants With Gastrointestinal Cancer (Master Protocol) (Pegathor Gastrointestinal 203)

Hepatocellular Carcinoma | Gastric Cancer | Colorectal Cancer | Oesophageal Adenocarcinoma | Oesophageal Squamous Cell Carcinoma

Korea, Republic of, Belgium, Italy, United States, Chile, China, France, Netherlands, Spain
National Cancer Institute (NCI)

Active, not recruiting

Olaparib and Ramucirumab in Treating Patients With Metastatic or Locally Recurrent Gastric or Gastroesophageal Junction Cancer That Cannot Be Removed by Surgery

Recurrent Esophageal Carcinoma | Recurrent Gastric Carcinoma | Metastatic Gastroesophageal Junction Adenocarcinoma | Unresectable Gastroesophageal Junction Adenocarcinoma | Metastatic Esophageal Carcinoma | Metastatic Gastric Carcinoma | Stage IV Esophageal Cancer AJCC v7 | Stage IV Gastric Cancer... and other conditions

United States
Janssen-Cilag International NV

Completed

Observational Study (This Means That no Drug is Tested) in Patients Suffering of Gastroesophageal Reflux Disease. (PROFILE)

Gastroesophageal Reflux Disease | GERD | Gastro-oesophageal Reflux | Gastro-Esophageal Reflux | Esophageal Reflux
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Recruiting

Testing the Addition of Radiotherapy to the Usual Treatment (Chemotherapy) for Patients With Esophageal and Gastric Cancer That Has Spread to a Limited Number of Other Places in the Body

Clinical Stage IV Gastric Cancer AJCC v8 | Metastatic Gastric Adenocarcinoma | Clinical Stage IV Esophageal Adenocarcinoma AJCC v8 | Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8 | Clinical Stage IVA Gastric Cancer AJCC v8 | Clinical Stage IVB Esophageal Adenocarcinoma AJCC v8 | Clinical... and other conditions

United States
Fundación para la Investigación del Hospital Clínico...

Completed

Ischemic Conditioning of the Gastric Conduit in Esophageal Cancer.

Esophageal Anastomotic Leak | Tissue Pressure of Oxygen

Spain
Per Pfeiffer

Completed

Chemotherapy for Patients With Cancer of the Stomach (DOS)

First-line Treatment for Patients With Non-resectable Gastric Cancer or Cancer of the Esophagus or

Denmark
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Pembrolizumab in Treating Patients With Metastatic or Unresectable Gastroesophageal Adenocarcinoma

Clinical Stage III Gastric Cancer AJCC v8 | Clinical Stage IV Gastric Cancer AJCC v8 | Metastatic Gastroesophageal Junction Adenocarcinoma | Unresectable Gastroesophageal Junction Adenocarcinoma | Gastroesophageal Junction Adenocarcinoma | Clinical Stage III Esophageal Adenocarcinoma AJCC v8 | Clinical Stage IV Esophageal Adenocarcinoma AJCC v8 and other conditions

United States
Assiut University

Not yet recruiting

Endoscopic Ultrasound-guided Coil With Cyanoacrylate Injection Versus Balloon-Occluded Retrograde Transvenous Obliteration in Managing Patients With Gastric Varices

Gastric Varix

Clinical Trials on Esophageal or Gastric Leaks

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Saudi Arabia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

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