Clinical Trials on FLCN Gene Mutation

Total 1899 results

Li Zhang, MD

Not yet recruiting

Phase III Study Comparing Osimertinib Monotherapy to Combination Therapy With Osimertinib,Carboplatin and Pemetrexed for Untreated Patients With Advanced Non-squamous Non-Small Cell Lung Cancer With Concurrent EGFR and TP53 Mutations (TOP)

Non-small Cell Carcinoma | EGFR Gene Mutation

China
Faeth Therapeutics

Active, not recruiting

Combination of Serabelisib and Insulin Suppressing Diet With or Without Nab-paclitaxel in Subjects With Advanced Solid Tumors With PIK3CA Mutations

Advanced Solid Tumor | PIK3CA Mutation | PTEN Loss of Function Mutation

United States
Cervesi Hospital, Cattolica, Italy

Recruiting

Analysis of Human Genomic DNA in Embryo's Culture Media

Single-Gene Disease

Italy
Natera, Inc.

Completed

Clinical Use of Parental Support To Detect Single Gene Mutations

Single Gene Disorders

United States
Hamad Medical Corporation
Qatar University

Completed

Gene Polymorphisms and Morphine Analgesic Consumption

Gene | Polymorphosis

Qatar
Qianqian Qu

Not yet recruiting

DKI Combined With APT for Post-treatment Assessment of Ovarian Malignancies and Correlation With XRCC2 Gene

Malignant Tumor of the Ovary | XRCC2 Gene Mutation
Second Affiliated Hospital of Nanchang University
Nanchang University

Unknown

Gefitinib With Anlotinib in Advanced Non-squamous NSCLC Patients With Uncleared Plasma ctDNA EGFRm After First-line Treatment With Gefitinib

Non-small Cell Lung Cancer | EGFR Gene Mutation

China
Murdoch Childrens Research Institute
Royal Children's Hospital; Peter MacCallum Cancer Centre, Australia

Not yet recruiting

A Trial of Targeted Therapies for Patients With Slow-Flow or Fast-Flow Vascular Malformations (TARGET-VM)

Arteriovenous Malformations | Vascular Malformations | MAP2K1 Gene Mutation | PIK3CA-related Overgrowth Spectrum | Vascular Anomalies | Lymphangioma | Lymphatic Malformation | KRAS G12D | Venous Malformation | Vascular Anomaly | KRAS G12C | PI3K Gene Mutation | Slow-Flow Vascular Malformation | Fast-Flow Vascular... and other conditions

Australia
Memorial Sloan Kettering Cancer Center

Completed

Continued Access to RXDX-105

Ovarian Cancer | Non Small Cell Lung Cancer | RET Gene Mutation | BRAF Gene Mutation

United States
Ohio State University Comprehensive Cancer Center

Completed

Pilot Study of Curcumin for Women With Obesity and High Risk for Breast Cancer

BRCA1 Gene Mutation | BRCA2 Gene Mutation | Ductal Breast Carcinoma in Situ | Atypical Ductal Breast Hyperplasia | Lobular Breast Carcinoma in Situ

United States
Istituto Scientifico Romagnolo per lo Studio e...

Unknown

Italian Non-Interventional Study of FLT3 Mutated AML Patients (FLAM)

AML | FLT3-ITD Mutation | FLT3-TKD Mutation

Italy
Karolinska Institutet

Completed

BRCA1/2 and Effect of Mifepristone on the Breast

Women With Mutations in the Breast Cancer Susceptibility Genes BRCA1,2

Sweden
University Hospital, Montpellier

Completed

Management of Women With BRCA1/2 Mutation

BRCA1 Mutation | BRCA2 Mutation

France
Sichuan Cancer Hospital and Research Institute

Not yet recruiting

Tislelizumab +Bevacizumab+pc for Untreated EGFR+ and High PD-L1 Non-squamous NSCLC

Non-squamous Non-small Cell Lung Cancer | EGFR Gene Mutation

China
Pasithea Therapeutics Corp.

Recruiting

PAS-004 in Patients With Advanced Solid Tumors

Advanced Solid Tumors | RAS Mutation | NF1 Mutation | RAF Mutation

United States
Fundación GECP

Recruiting

Neo-DIANA: Neoadjuvant Treatment for EGFR Mutated Patients

Non Small Cell Lung Cancer | EGFR Gene Mutation

Spain
Sun Yat-sen University

Recruiting

A Prospective Multicenters Clinical Cohort Study of Stratified Treatment of Chinese Children With LBL

Lymphoma, Non-Hodgkin | Pediatric Cancer | Lymphoblastic Lymphoma, Childhood | PTEN Loss | NOTCH1 Gene Mutation

China
Beijing Tiantan Hospital
Ractigen Therapeutics

Enrolling by invitation

Safety and Tolerability of RAG-17 in the Treatment of Amyotrophic Lateral Sclerosis Patients With SOD1 Gene Mutation

Gene Mutation

China
Academic and Community Cancer Research United
National Cancer Institute (NCI)

Active, not recruiting

Regorafenib, With Cetuximab or Panitumumab, for the Treatment of Unresectable, Locally Advanced, or Metastatic Colorectal Cancer

Metastatic Colorectal Adenocarcinoma | Stage IV Colorectal Cancer AJCC v8 | Stage IVA Colorectal Cancer AJCC v8 | Stage IVB Colorectal Cancer AJCC v8 | Stage IVC Colorectal Cancer AJCC v8 | Stage III Colorectal Cancer AJCC v8 | Stage IIIA Colorectal Cancer AJCC v8 | Stage IIIB Colorectal Cancer AJCC... and other conditions

United States
Abramson Cancer Center at Penn Medicine

Recruiting

BRCA1/2 Flu Vaccine

BRCA1 Mutation | BRCA2 Mutation

United States
Regeneron Pharmaceuticals

Recruiting

A Study of DB-OTO, an Adeno-associated Virus (AAV) Based Gene Therapy, in Children/Infants With Hearing Loss Due to Otoferlin Mutations (CHORD)

Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)

Spain, United Kingdom, United States
University Hospital, Ghent
Fox Chase Cancer Center; Ziekenhuis Oost-Limburg

Completed

Use of Recombinant hCG to Prevent Breast Cancer in BRCA1 and BRCA2 Carriers

BRCA1 Mutation | BRCA2 Mutation | hCG

Belgium
Wake Forest University Health Sciences
National Center for Complementary and Integrative Health (NCCIH); University... and other collaborators

Completed

Role of Polyunsaturated Fatty Acids (PUFA)-Gene Interactions in Heath Disparities

Fatty Acid-Gene Interactions

United States
Merrimack Pharmaceuticals

Completed

A Study of MM-111 in Combination With Multiple Treatments in Patients With HER2 Positive Cancer

HER-2 Gene Amplification

United States
Ullevaal University Hospital
University of Oslo

Unknown

Effect of Bilberry (European Blueberries) and Grape Polyphenols on Cognition and Blood Parameters (BLUEBERRY)

Memory | Gene Expression

Norway
Hillel Yaffe Medical Center

Unknown

Elucidating the Molecular and Biochemical Basis of the Human AhR-mutation Disease

Mutation, Point
The Netherlands Cancer Institute
Daiichi Sankyo, Inc.

Not yet recruiting

Whole Body HER3 Quantification With Radiolabelled Patritumab Deruxtecan (HER3-DXd) PET/CT

EGFR Gene Mutation | Non-Small Cell Lung Carcinoma | Advanced Non-Small Cell Squamous Lung Cancer
Jiangsu HengRui Medicine Co., Ltd.
Shanghai Chest Hospital

Unknown

Phase II Study of SHR-1210(Anti-PD-1 Antibody) Combination With Apatinib Versus Pemetrexed and Carboplatin in Subjects With KRAS Mutant Stage IV Non-squamous Non-small Cell Lung Cancer

Chemotherapy Effect | KRAS Gene Mutation | NSCLC Stage IV | PD-1 Antibody
Blueprint Medicines Corporation

Active, not recruiting

(SYMPHONY) Phase 1/2 Study Targeting EGFR Resistance Mechanisms in NSCLC

Neoplasms | Neoplasms by Histologic Type | Lung Diseases | Neoplasms by Site | Adenocarcinoma | Carcinoma | Carcinoma, Non-Small-Cell Lung | Lung Neoplasms | Respiratory Tract Neoplasms | Thoracic Neoplasms | Carcinoma, Bronchogenic | Bronchial Neoplasms | Neoplasms, Nerve Tissue | EGF-R Positive Non-Small Cell Lung... and other conditions

United States, Canada, Taiwan, Korea, Republic of, Singapore, Japan, United Kingdom, France, Netherlands, Spain
Ohio State University Comprehensive Cancer Center
ImmunoGen, Inc.; Clovis Oncology, Inc.

Active, not recruiting

Mirvetuximab Soravtansine and Rucaparib Camsylate in Treating Participants With Recurrent Endometrial, Ovarian, Fallopian Tube or Primary Peritoneal Cancer

BRCA1 Gene Mutation | BRCA2 Gene Mutation | Folate Receptor Alpha Positive | Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Recurrent Uterine Corpus Carcinoma | Recurrent Uterine Serous Carcinoma | Recurrent Uterine Carcinosarcoma | Platinum...

United States
Vanderbilt University Medical Center

Recruiting

Risk and Resilience in Pulmonary Arterial Hypertension and Genetically Susceptible Individuals (RARE-PAH)

Idiopathic Pulmonary Arterial Hypertension | Heritable Pulmonary Arterial Hypertension | Unaffected Mutation Carriers: Healthy Participants With a Known BMPR2 Gene Mutation and Normal Pulmonary Pressure and RV Function on Echo | Healthy Individuals With no Cardiopulmonary Disease

United States
Shanghai Pulmonary Hospital, Shanghai, China

Recruiting

Neoadjuvant Furmonertinib Plus Bevacizumab or Furmonertinib Monotherapy for Resectable and Potentially Resectable Stage III-IVA EGFR Mutation-Positive Lung Adenocarcinoma

EGFR Gene Mutation | Lung Adenocarcinoma Stage III | Lung Adenocarcinoma Stage IV

China
Boston Children's Hospital
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

RAD001 and Neurocognition in PTEN Hamartoma Tumor Syndrome

PTEN Gene Mutation | PTEN Hamartoma Tumor Syndrome

United States
Guangdong Provincial People's Hospital

Recruiting

Neoadjuvant Almonertinib Followed by Chemo-immunotherapy in II-IIIB EGFR-mutant NSCLC (NEOVADE)

Non Small Cell Lung Cancer | EGFR Gene Mutation

China
University of Aarhus

Recruiting

Cystic Fibrosis in the Kidney: Monitoring the Effectiveness of Elexacaftor/Tezacaftor/Ivacaftor in Urine After a Short Pause of Therapy

Cystic Fibrosis (CF) | CFTR Gene Mutation

Denmark
Nir Peled

Not yet recruiting

A Pilot Study to Understand the Impact of Therapy With Tumour Treating Fields (TTFields) in NSCLC

Non Small Cell Lung Cancer | EGFR Gene Mutation | Immune Checkpoint Inhibitor

Israel
Pusan National University Hospital

Recruiting

Feasibility of Intratumoral Washing Fluid for Detecting EGFR Mutations in Lung Cancer

Non Small Cell Lung Cancer | EGFR Gene Mutation

Korea, Republic of
Intergroupe Francophone de Cancerologie Thoracique

Recruiting

Study of Safety and Efficacy of Brigatinib Plus Chemotherapy or Brigatinib Only in Advanced ALK-Positive Lung Cancer (MASTERPROTOCOL ALK)

Non Small Cell Lung Cancer | ALK Gene Mutation

France
Dana-Farber Cancer Institute
AbbVie; Pharmacyclics LLC.

Active, not recruiting

Ibrutinib + Venetoclax in Untreated WM

Waldenstrom Macroglobulinemia | MYD88 Gene Mutation

United States
Memorial Sloan Kettering Cancer Center

Completed

Trial of Trametinib and Ponatinib in Patients With KRAS Mutant Advanced Non-Small Cell Lung Cancer

Non Small Cell Lung Cancer | KRAS Gene Mutation

United States
Children's Healthcare of Atlanta
Emory University; Brigham and Women's Hospital; University of California, San... and other collaborators

Withdrawn

Genes Mutation Pentalogy of Cantrell

Pentalogy of Cantrell | Mutations in Non-muscle Genes

United States
Dr Joanne CHIU

Recruiting

Pembrolizumab, Lenvatinib and Chemotherapy After TKIs in NSCLC

ALK Gene Rearrangement Positive | EGF-R Positive Non-Small Cell Lung Cancer | EGFR Activating Mutation | Nsclc | ROS1 Gene Rearrangement | ROS1 Positive NSCLC - Reactive Oxygen Species 1 Positive Non-Small Cell Lung Cancer

Hong Kong
Harvard School of Public Health (HSPH)

Completed

Diet Quality and Genetic Association With Body Mass Index: Results From Three Observational Studies

Gene and Diet Interaction
Technological Centre of Nutrition and Health, Spain

Completed

Effect of a Polyphenol-rich Cocoa Extract on Peripheral Blood Mononuclear Cells Gene Expression

Gene Expression | Cardiovascular Function

Spain
University Hospital, Basel, Switzerland

Recruiting

Leflunomide Treatment for MEN1 Patients - the LUMEN1 Trial (LUMEN1)

MEN1 Gene Mutation

Switzerland
Wei Xu

Recruiting

Tislelizumab Combined With Chemotherapy in the Treatment of Bone Metastases of Unknown Primary

Chemotherapy Effect | Gene Mutation-Related Cancer | Tislelizumab | Cancer of Unknown Primary | Bone Cancer Metastatic | Immune Evasion, Tumor

China
Alpha Biopharma (Jiangsu) Co., Ltd.

Completed

First Line Treatment in EGFR Mutation Positive Advanced NSCLC Patients With Central Nervous System (CNS) Metastases (BM)

Non-small Cell Lung Cancer | Brain Metastases | EGFR Gene Mutation

China, Korea, Republic of, Singapore, Taiwan
Scripps Health
J. Craig Venter Institute

Completed

Biomarker Monitoring in TP53 Mutation Carriers

Li-Fraumeni Syndrome | Hereditary Cancer Syndromes | TP53 Gene Germline Mutation Carrier

United States
Pfizer
French College of General Hospital Pneumologists (CPHG)

Completed

Descriptive Observational Study ALK-2016-CPHG (ALK2016CPHG)

NSCLC | Crizotinib | ALK Gene Rearrangement or ROS1 Gene Rearrangement

France
The First Affiliated Hospital with Nanjing Medical...

Recruiting

Lenalidomide in Combination With R-DA-EPOCH in Patients With Untreated DLBCL With MYC Rearrangement

DLBCL | Untreated | MYC Gene Rearrangement

China

Clinical Trials on FLCN Gene Mutation

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Turkmenistan

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations