Clinical Trials on Fibrosis in United Kingdom

Total 2344 results

AlgiPharma AS

Completed

A Cross-over Study of OligoG in Subjects With Cystic Fibrosis. Fibrosis (OligoG)

Cystic Fibrosis

United Kingdom, Ireland
University of Oxford
British Heart Foundation; Oxford University Hospitals NHS Trust

Unknown

Multiparametric MR for Rapid Imaging Assessment of the Liver (RIAL)

Liver Cirrhosis | Fatty Liver

United Kingdom
Royal Marsden NHS Foundation Trust

Unknown

IH636 Grape Seed Extract in Treating Hardening of Breast Tissue in Women Who Have Undergone Radiation Therapy for Early Breast Cancer

Breast Cancer | Radiation Fibrosis

United Kingdom
University of California, San Diego

Recruiting

Comparative and Additive Diagnostic Performance of Magnetic Resonance Elastography (MRE) and Corrected-T1 (cT1) for Fibrosis and Inflammation in Nonalcoholic Steatohepatitis (NASH) Using Histology as Reference

Nonalcoholic Steatohepatitis | Nonalcoholic Fatty Liver | Liver Inflammation | Liver Fibroses

United States
Imperial College London

Completed

Post COVID-19 Interstitial Lung Disease: A Study of Genetic and Environmental Interactions (POSTCODE)

Pulmonary Fibrosis | COVID-19 Pneumonia

United Kingdom
Global Blood Therapeutics

Terminated

Study to Evaluate the Effect of GBT440 Administered to Subjects With IPF on Supplemental Oxygen at Rest (Zephyr)

Idiopathic Pulmonary Fibrosis | Hypoxemia

United Kingdom, United States
Manchester University NHS Foundation Trust

Completed

Biomarkers in HF: Circulating Biomarkers of Fibrosis and Cardiovascular Disease

Heart Failure With Preserved Ejection Fraction

United Kingdom
Boehringer Ingelheim

Completed

This Study Tests Different Doses of BI 1015550 in Patients With Idiopathic Pulmonary Fibrosis (IPF). The Study Tests How BI 1015550 is Taken up by the Body and How Well it is Tolerated.

Idiopathic Pulmonary Fibrosis

Spain, United Kingdom, Italy, Belgium, Germany, Netherlands, Finland, Denmark
Royal Free Hospital NHS Foundation Trust
Innovate UK

Active, not recruiting

CirrhoCare in COVID-19: A Pilot, Remote, Home Monitoring Study in Advanced Cirrhosis

Decompensated Cirrhosis

United Kingdom
Guerbet

Withdrawn

Evaluation of Nephrogenic Systemic Fibrosis (NSF) in Patients With Chronic Kidney Disease Following OptiMARK Injection (SHERLOC)

Renal Insufficiency | Nephrogenic Systemic Fibrosis

United States
University of Oxford

Completed

Intravenous Iron in Adults With Cystic Fibrosis

Iron-deficiency | Cystic Fibrosis

United Kingdom
Lantheus Medical Imaging

Completed

Prospective Evaluation of the Incidence of NSF in Patients With Kidney Disease Undergoing MR

Nephrogenic Systemic Fibrosis

United States
Nottingham University Hospitals NHS Trust
University of Washington; Seattle Children's Hospital; The Leeds Teaching Hospitals... and other collaborators

Active, not recruiting

CFTR Modulators and Gastrointestinal Complications (CFTR-MAGIC)

Lung Diseases | Cystic Fibrosis | Digestive System Disease | Pancreatic Disease | Distal Intestinal Obstruction Syndrome | Pancreatic Enzyme Abnormality | Gastrointestinal System Disease

United Kingdom
Imperial College London
National Institute for Health Research, United Kingdom; Imperial College Healthcare...

Withdrawn

MRI Assessment of Myocardial Fibrosis Associated With Monocyte Phenotype in End Stage Renal Failure (CM3)

Myocardial Fibrosis | Heart Failure | End Stage Renal Failure on Dialysis | Chronic Kidney Disease Stage V | Chronic Kidney Disease, Stage IV (Severe)

United Kingdom
Dr Manvir Kaur Hayer
British Heart Foundation

Unknown

Left Ventricular Fibrosis in Chronic Kidney Disease (FibroCKD)

Myocardial Fibrosis | Chronic Kidney Diseases | Cardio-Renal Syndrome | Uraemic Cardiomyopathy

United Kingdom
Gynesonics

Recruiting

Transcervical Radiofrequency Ablation of Uterine Fibroids Global Registry (SAGE)

Uterine Fibroid

Germany, Switzerland, United Kingdom
Renovo

Terminated

Juvista (Avotermin) in Breast Reduction Surgery Scars

Cicatrix | Mammaplasty

United Kingdom
Redx Pharma Plc
Simbec Research

Completed

A 3-part Study to Evaluate Safety, Tolerability, Food Effect and Drug-drug Interactions of RXC007 in Healthy Volunteers

Liver Diseases | Fibrosis | Kidney Diseases | Inflammation | Idiopathic Pulmonary Fibrosis | Non-alcoholic Steatohepatitis

United Kingdom
Queen Mary University of London

Withdrawn

Keloid Scarring: Treatment and Pathophysiology

Keloid Scar

United Kingdom
University of Edinburgh
Novartis Pharmaceuticals; NHS Lothian

Completed

Serelaxin To Lower Portal Pressure (STOPP)

Liver Cirrhosis | Hypertension, Portal

United Kingdom
University of Leicester
University Hospitals, Leicester; St George's, University of London

Recruiting

Validating Novel, Non-contrast Cardiac MRI Imaging in Haemodialysis Patients (CONFIRM)

End Stage Kidney Disease | Fibrosis Myocardial

United Kingdom
University of Nottingham
Mediplus Ltd UK; Enteric healthcare technology Co-operative

Completed

Evaluation of 'Melody' Paracentesis Device for Ascites Therapy (EMPATHY)

Ascites Hepatic | Cirrhosis and Chronic Liver Disease

United Kingdom
Oxford University Hospitals NHS Trust

Active, not recruiting

AI Assisted Detection of Chest X-Rays (AID-CXR)

Pneumoperitoneum | Pneumothorax | Cardiomegaly | Pleural Effusion | Atelectasis | Pulmonary Nodules, Solitary | Pneumothorax; Acute | Pleural Effusions, Chronic | Pulmonary Nodules, Multiple | Fibrosis Lung | Pulmonary Consolidation | Pulmonary Calcification

United Kingdom
Sonic Incytes

Active, not recruiting

The Sonic Incytes Liver Incytes System, Evaluation of Liver Fibrosis and Steatosis Versus MRE and MRI PDFF

Liver Fibroses | Non-Alcoholic Fatty Liver Disease (NAFLD) | Non-Alcoholic Steatohepatitis (NASH) | Liver Steatoses

United States
Royal Brompton & Harefield NHS Foundation Trust
King's College Hospital NHS Trust; Imperial College London

Completed

A Study of Web and Tablet-based Interactive Audiometry in Adults With CF

Cystic Fibrosis | Hearing Loss, Sensorineural

United Kingdom
Nottingham University Hospitals NHS Trust
VSL Pharmaceuticals

Terminated

VSL#3 and Spontaneous Bacterial Peritonitis

Decompensated Cirrhosis | Ascites

United Kingdom
Andreas Guenther

Active, not recruiting

Clinical Course of Interstitial Lung Diseases: European IPF Registry and Biobank (eurIPFreg)

Idiopathic Pulmonary Fibrosis | Idiopathic Interstitial Pneumonia | Interstitial Lung Diseases | Diffuse Parenchymal Lung Diseases

United Kingdom, Germany, Austria, Italy, France
Pharmaxis

Completed

Pharmacokinetics of Inhaled Mannitol in Cystic Fibrosis Patients (DPM-PK-102)

Cystic Fibrosis

Australia, United Kingdom
Guy's and St Thomas' NHS Foundation Trust
Royal Brompton & Harefield NHS Foundation Trust

Unknown

FIBRotic Interstitial Lung Disease and Nocturnal OXygen (FIBRINOX)

Obstructive Sleep Apnea | Idiopathic Pulmonary Fibrosis | Sleep Disturbance | Sleep Hypoventilation

United Kingdom
ISDIN
Digna Biotech S.L.

Completed

Open Label Extension (OLE) for the Patients Treated in the ISD002-P144-07 Study

Skin Fibrosis

United Kingdom, Spain, Italy, Poland, Germany, Hungary
King's College Hospital NHS Trust

Recruiting

Adiposity, Cardiometabolic and Neurocognitive Health Among Ethnic Groups: a Feasibility and Pilot Study (ACNH)

Cardiovascular Diseases | Obesity | Cognitive Impairment | Metabolic Disease | Hepatic Steato-Fibrosis

United Kingdom
Liminal BioSciences Ltd.

Completed

Safety and Tolerability of PBI-4050 and Its Effects on the Biomarkers in Subjects With Alström Syndrome

Diabetes | Inflammation and Fibrosis

United Kingdom
Royal Brompton & Harefield NHS Foundation Trust
University Hospital, Basel, Switzerland; Bioxydyn Ltd, Manchester

Unknown

MRI in Cystic Fibrosis and Primary Ciliary Dyskinesia

Cystic Fibrosis | Primary Ciliary Dyskinesia

United Kingdom
Trevi Therapeutics
Parexel

Completed

A Study of Nalbuphine (Extended Release) ER in Idiopathic Pulmonary Fibrosis (IPF) for Treatment of Cough (CANAL)

Cough | Idiopathic Pulmonary Fibrosis | Nalbuphine

United Kingdom
Celtaxsys, Inc.
Celerion

Completed

Phase 1 Study Assessing the Safety and Tolerability of CTX-4430 in Cystic Fibrosis Patients

Cystic Fibrosis

United Kingdom
Vicore Pharma AB
Orphan Reach

Completed

Safety, Efficacy and Pharmacokinetics of C21 in Subjects With IPF

Idiopathic Pulmonary Fibrosis

United Kingdom, India, Ukraine, Russian Federation
University of Edinburgh

Completed

Angiogenesis and Fibrosis in Myocardial Infarction

Myocardial Infarction | Fibrosis | Neovascularization, Pathologic

United Kingdom
University of Nottingham
Nottingham University Hospitals NHS Trust; Birmingham Women's and Children's... and other collaborators

Unknown

Evaluation of the High Frequency Digit Triplet Test in Cystic Fibrosis (3D-CF)

Cystic Fibrosis | Sensorineural Hearing Loss

United Kingdom
University College, London
London School of Hygiene and Tropical Medicine; CyberLiver Ltd

Recruiting

CirrhoCare- Using Smart-phone Technology to Enhance Care and Access to Treatment for Cirrhosis (CirrhoCare)

Decompensated Cirrhosis

United Kingdom
Kadmon Corporation, LLC
Quotient Sciences

Completed

Drug-drug Interaction Between Belumosudil, Itraconazole, Rifampicin, Rabeprazole, and Omeprazole in Healthy Volunteers

Autoimmune Diseases | Drug-drug Interaction | Fibrotic Disease

United Kingdom
Novartis Pharmaceuticals

Completed

An Exploratory Haemodynamic Study in Patients With Compensated Cirrhosis and Portal Hypertension

Compensated Cirrhosis and Portal Hypertension

United Kingdom
Novartis Pharmaceuticals

Terminated

Study of Pharmacodynamics, Pharmacokinetics, Safety and Tolerability of VAY736 in Patients With Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis

United States, Germany, Italy, Canada, Ireland, United Kingdom
Vertex Pharmaceuticals Incorporated

Completed

Study of VX-121 in Healthy Subjects and in Subjects With Cystic Fibrosis

Cystic Fibrosis

Netherlands, United Kingdom
NHS Greater Glasgow and Clyde

Terminated

Pathology and Imaging in Kidney Allografts (PIKA)

Fibrosis | Chronic Kidney Diseases | Renal Transplant Rejection

United Kingdom
Royal Marsden NHS Foundation Trust
Merck Sharp & Dohme LLC

Active, not recruiting

Pembrolizumab and Gemcitabine Chemotherapy in Leiomyosarcoma and Undifferentiated Pleomorphic Sarcoma (GEMMK)

Sarcoma

United Kingdom
Fibronostics USA, Inc

Completed

Clinical Performance of LIVERFASt Test Compared w/ Liver Biopsy in Patients w/ NAFLD.

Non-Alcoholic Fatty Liver Disease | Non-Alcoholic Steatohepatitis | Liver Inflammation | Liver Fibroses | Liver Steatoses

United States
Bracco Diagnostics, Inc

Completed

Evaluation of the Risk of Nephrogenic Systemic Fibrosis (NSF) in Patients With Chronic Kidney Disease Without Exposure to Gadolinium Based Contrast Agents (GBCA)

Renal Insufficiency

United States
Guy's and St Thomas' NHS Foundation Trust
King's College Hospital NHS Trust

Unknown

Paternally Inherited Phenotypes in Cholestasis (PIP-C)

Primary Sclerosing Cholangitis | Cholestasis | Primary Biliary Cirrhosis

United Kingdom
University College, London

Completed

Regression of Myocardial Fibrosis After Aortic Valve Replacement (RELIEF-AS)

Aortic Stenosis

United Kingdom
Enterprise Therapeutics Ltd

Completed

A First in Human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Doses of Inhaled ETD001 in Healthy Subjects

Cystic Fibrosis

United Kingdom

Clinical Trials on Fibrosis in United Kingdom

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