Clinical Trials on Focal Epilepsy With and Without Secondary Generalization

Total 538 results

UCB Pharma GmbH

Completed

Study Evaluating Changes in Total Drug Load and Seizure Frequency Using Vimpat® (Lacosamide) in Combination Therapy (VICTOS)

Focal Epilepsy With and Without Secondary Generalization

Germany, Austria
University Hospital Schleswig-Holstein

Completed

Lacosamid-i.v.-Register (LCM)

Epilepsy With Partial Onset Seizures With or Without Secondary Generalization

Germany
UCB Biopharma S.P.R.L.
Pharm Research Associates (UK) Ltd.

Completed

Study to Look at How Effective Briviact is as add-on Treatment for Patients With Epilepsy With Partial Onset Seizures (BASE)

Epilepsy With POS With or Without Secondary Generalization

Denmark, Germany, Hungary, Ireland, Italy, Netherlands, Norway, Spain, United Kingdom
UCB Biopharma SRL

Enrolling by invitation

A Study to Test the Safety/ Efficacy of Brivaracetam (BRV) Used as Adjunctive Treatment in Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization

Epilepsy | Partial Seizures With or Without Secondary Generalization

China, Japan
UCB Biopharma SRL

Completed

A Study to Evaluate the Efficacy and Safety of Brivaracetam in Study Participants (>=16 to 80 Years of Age) With Epilepsy

Epilepsy | Partial Seizures With or Without Secondary Generalization

China, Japan, Malaysia, Philippines, Singapore, Taiwan, Thailand
UCB Biopharma S.P.R.L.

Completed

A Study to Evaluate the Safety and Tolerability of Intravenous Brivaracetam (BRV) as Replacement for Oral Brivaracetam in Japanese Subjects >=16 Years of Age With Partial Seizures With or Without Secondary Generalization

Epilepsy | Partial Seizures With or Without Secondary Generalization

Japan
Whanin Pharmaceutical Company

Completed

Clinical Trial for Zebinix (Eslicarbazepine Acetate) in Healthy Korean and Caucasian Adult

Partial-onset Seizures With or Without Secondary Generalisation

Korea, Republic of
UCB Pharma

Completed

A Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel Group Trial to Investigate the Efficacy and Safety of SPM 927 (200mg/Day and 400mg/Day) as Adjunctive Therapy in Subjects With Partial Seizures With or Without Secondary Generalization

Partial Seizures With or Without Secondary Generalization

Germany
University of North Carolina, Chapel Hill
Focused Ultrasound Foundation

Recruiting

A Pilot Study: Focused Ultrasound Thalamotomy for the Prevention of Secondary Generalization in Focal Onset Epilepsy

Partial Seizures With Secondary Generalization

United States
Valexfarm

Completed

Remegal Fixed Dose as Adjunctive Therapy in Patients With Partial Seizures

Epilepsy | Complex Partial Seizures | Simple Partial Seizures | Partial Seizures With Secondary Generalization

Russian Federation
Eisai Co., Ltd.

Completed

Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adult Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Seizures) or Primary Generalized Tonic-clonic Seizures (FYC01S)

Partial Seizures (With or Without Secondary Generalized Seizures) | Primary Generalized Tonic-clonic Seizures

Japan
Eisai Co., Ltd.

Completed

Investigation of the Clinical Safety and Efficacy of Long-term Treatment With Fycompa Tablets in Adolescence Epilepsy Patients With Partial-onset Seizures (With or Without Secondary Generalized Seizures) or Primary Generalized Tonic-clonic Seizures (FYC02T)

Partial Seizures (With or Without Secondary Generalized Seizures) | Primary Generalized Tonic-clonic Seizures

Japan
Boston Children's Hospital

Recruiting

Genetics of Epilepsy and Related Disorders

Epilepsy | Dravet Syndrome | Infantile Spasms | Epileptic Encephalopathy | Ohtahara Syndrome | Early Myoclonic Epileptic Encephalopathy | PCDH19-related Epilepsy and Related Conditions | KCNQ2-Related Epileptic Encephalopathy | Epilepsy of Infancy With Migrating Focal Seizures (Disorder)

United States
Neuroelectrics Corporation

Recruiting

Pivotal-Safety and Therapeutic Measures of tDCS in Patients With Refractory Focal Epilepsy

Epilepsy | Seizures | Refractory Epilepsy | Epilepsy, Tonic-Clonic | Epilepsy in Children | Seizures, Focal | Focal Seizure

Spain, United States, France, Belgium
Hospices Civils de Lyon

Completed

Brain Maturation in Children With Localization Related Epilepsy (DYNAMAT)

Benign Childhood Epilepsy With Centro-temporal Spikes (BCECTS) | Focal Cryptogenic Epilepsy of Childhood | Cryptogenic Epilepsy of Childhood

France
Theranica

Completed

Migraine With and Without Aura Response to Remote Electrical Neuromodulation (REN) Treatment

Migraine Without Aura | Migraine With Aura

Israel
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Eletriptan Provides Consistent Migraine Relief: Results Of A Within-Patient Multiple-Dose Study

Migraine Without Aura | Migraine With Aura

Spain, France, Italy, Netherlands, Turkey, Belgium, Hungary, Czechia, Denmark, Germany, Greece, Norway, Portugal, Sweden
UCB Biopharma S.P.R.L.
PRA Health Sciences

Completed

A Study of UCB0942 in Adult Patients With Highly Drug-resistant Focal Epilepsy

Highly Drug-resistant Focal Epilepsy

Belgium, Bulgaria, Germany, Hungary, Netherlands, Spain
UCB Biopharma SRL

Terminated

An Open-label Extension Study of UCB0942 in Adult Patients With Highly Drug-resistant Focal Epilepsy

Highly Drug-resistant Focal Epilepsy

Belgium, Bulgaria, Germany, Hungary, Netherlands, Spain
Biogen

Completed

Phase 2 Efficacy, Safety, and Tolerability Study of Natalizumab in Focal Epilepsy (OPUS)

Epilepsy, Focal Seizures, Partial Seizures

United States
California Medical Clinic for Headache

Unknown

Preventive Treatment of Episodic and Chronic Migraine

Chronic Migraine | Migraine Without Aura | Migraine With Aura

United States
King's College London
King's College Hospital NHS Trust

Completed

Subcutaneous EEG: Forecasting of Epileptic Seizures (SUBER)

Epilepsies, Focal

United Kingdom
Danish Headache Center

Recruiting

The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.

Headache | Migraine Without Aura | Migraine With Aura

Denmark
Neurocrine Biosciences

Completed

A Study to Investigate How Effective, Safe and Tolerable the Drug NBI-921352 is When Used With Anti-seizure Medications in Adults With Focal Onset Seizures

Focal Onset Seizure | Focal Onset Epilepsy

Spain, Belgium, Czechia, France, Italy, Australia, Hungary, United Kingdom
Neurocrine Biosciences

Terminated

Extension Study to Evaluate the Safety and Tolerability of NBI-921352 When Used With Anti-seizure Medications in Adults With Focal Onset Seizures

Focal Onset Seizure | Focal Onset Epilepsy

Spain, Australia, Belgium, Czechia, France, Hungary, Italy
Rapport Therapeutics Inc.

Not yet recruiting

Study Evaluating the Safety and Efficacy of RAP-219 in Adult Participants With Refractory Focal Epilepsy

Focal Onset Seizures
Przemyslaw Kunert
NaoX Technologies; Warsaw Medical University Clinical Center; Departments and...

Not yet recruiting

Assessment of Patients With Drug-resistant Temporal Lobe Epilepsy With EEG Extended With Intra-auricular Electrodes

Epilepsy | Drug Resistant Epilepsy | Focal Epilepsy

Poland
Biohaven Therapeutics Ltd.

Recruiting

Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy (RISE 3)

Focal Epilepsy

United States
Yonsei University

Completed

The Effects on Cognitive Function of Levetiracetam (Keppra®) Compared to Carbamazepine (Tegretol®, Carmazepine®) as Monotherapy for Children With Partial Seizure; A Multicentric Randomized Controlled Study

Focal Epilepsy

Korea, Republic of
Chinese University of Hong Kong

Unknown

Post-market Study of AMPA Receptor Antagonists for Epilepsy Patients in Hong Kong

Generalized Epilepsy | Focal Epilepsy | Partial Seizures, Simple

Hong Kong
Mayo Clinic

Completed

Arterial Spin Labeling MRI Focal Abnormalities in Refractory Epilepsy

Focal Epilepsy

United States
Reliev Technologies

Not yet recruiting

Seizures Detection in Real Life Setting (ECEME)

Focal Epilepsy | Epilepsy; Seizure
Sehat Medical Complex

Completed

Effects of Resistance Sprint Training With and Without Power Training on Sprint and Agility Performance

Resistance Sprint Training With and Without Power

Pakistan
Biohaven Therapeutics Ltd.

Not yet recruiting

Long-term Safety and Tolerability of BHV-7000

Focal Epilepsy
Biohaven Therapeutics Ltd.

Recruiting

A Study to Determine if BHV-7000 is Effective and Safe in Adults With Refractory Focal Onset Epilepsy (RISE 2)

Focal Epilepsy

United States
Cerebral Therapeutics LLC

Terminated

Study to Assess Intracerebroventricular (ICV) Delivery of CT-010 in Subjects With Focal Seizures, With Temporal Lobe Onset With or Without Secondary Generalization

Refractory Epilepsy

Israel, Australia
University Hospital, Strasbourg, France

Unknown

Study of Predictive Biomarkers for Rational Management of Drug-resistant Epilepsy Associated With Focal Cortical Dysplasia (SPREAD)

Focal Epilepsy | Refractory Epilepsy | Focal Cortical Dysplasia

France
SK Life Science, Inc.

Completed

An Open-Label Extension Study of the Safety and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset Seizures

Epilepsy, Complex Partial | Epilepsy, Partial, Motor | Epilepsy, Simple Partial | Focal Motor Epilepsy
SK Life Science, Inc.

Completed

A Study of the Effectiveness, Safety, and Tolerability of Carisbamate as Add-On Therapy in Patients With Partial Onset Seizures.

Epilepsy, Complex Partial | Epilepsy, Partial, Motor | Epilepsy, Simple Partial | Focal Motor Epilepsy
Eisai GmbH

Completed

ZEDEBAC: Zebinix Effects in Dependency of Baseline Conditions

Focal Epilepsy

Germany
UCB Biopharma S.P.R.L.

Completed

Study to Test the Efficacy and Safety of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adults With Drug-resistant Epilepsy (ARISE)

Focal-Onset Seizures | Drug-resistant Epilepsy

United States, Australia, Belgium, Bulgaria, Canada, Czechia, France, Germany, Hungary, Italy, Japan, Lithuania, Mexico, Poland, Portugal, Slovakia, Spain, Turkey, United Kingdom
Cerebral Therapeutics LLC

Terminated

Anti-Epilepsy Medication Valproate Administered Via ICV Route and Catheters and Pumps for CSF Infusion

Focal Epilepsy

Israel, Australia
NYU Langone Health

Not yet recruiting

Efficacy of Intersectional Short Pulse Stimulation for Terminating Seizures

Seizures | Focal Epilepsy
UCB Pharma

Completed

A Study of Brivaracetam in Subjects With Partial Onset Seizures

Epilepsy, Focal

France, Poland, United Kingdom, Belgium, Germany, Spain, Czech Republic, Finland, Netherlands
UCB Biopharma SRL

Terminated

A Study to Test the Efficacy and Safety of Padsevonil as Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy (DUET)

Drug-Resistant Epilepsy | Focal-Onset Seizures

United States, Australia, Belgium, Bosnia and Herzegovina, Bulgaria, Croatia, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Japan, Norway, Poland, Portugal, Romania, Serbia, Slovakia, Spain, Sweden, Switzerlan... and more
UCB Biopharma SRL

Terminated

Study to Test the Safety and Efficacy of Padsevonil as Adjunctive Treatment of Focal-onset Seizures in Adult Subjects With Drug-resistant Epilepsy

Drug-Resistant Epilepsy | Focal-Onset Seizures

United States, Australia, Belgium, Bosnia and Herzegovina, Bulgaria, Canada, Croatia, Czechia, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Japan, Lithuania, Mexico, Poland, Romania, Serbia, Slovakia, Spain, Turk... and more
State Budgetary Healthcare Institution, National...

Enrolling by invitation

Thermocoagulation in Drug Resistant Focal Epilepsy

Epilepsy | Epilepsies, Partial | Epilepsy Intractable | Seizures, Focal

Russian Federation
Engrail Therapeutics INC

Withdrawn

ENACT: A Study of ENX-101 as Adjunctive Treatment in Patients With Focal Seizures (ENACT)

Focal Epilepsy

United States
İpek Dokurel

Active, not recruiting

Does Levetiracetam and Carbamazepine Impact the Autonomic Activity of Children With Self-limiting Focal Epilepsy? (levcbz)

Epilepsy; Syndrome, Seizures of Localized Onset

Turkey
Jazz Pharmaceuticals

Completed

A Study of GWP42006 in People With Focal Seizures - Part B

Epilepsy | Focal Seizures

Italy, Poland, United Kingdom, Spain, Hungary, Czechia

Clinical Trials on Focal Epilepsy With and Without Secondary Generalization

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