Clinical Trials on Fructose Metabolism, Inborn Errors

Total 4323 results

Amgen

Completed

Trial Assessing Long Term USe of PCSK9 Inhibition in Subjects With Genetic LDL Disorders (TAUSSIG)

Severe Familial Hypercholesterolemia

Italy, Czechia, United States, Israel, New Zealand, South Africa, France, Spain, Australia, Belgium, Canada, Netherlands, Hong Kong, Brazil, United Kingdom, Greece, Japan, Lebanon
Organon and Co

Terminated

Investigational Drug in Patients With Hypercholesterolemia or in Patients With Sitosterolemia (0653-026)(COMPLETED)

Lipid Metabolism, Inborn Errors | Hypercholesterolemia, Familial
Korea United Pharm. Inc.

Active, not recruiting

Study to Evaluate the Safety and PK of UI018

Hyperlipemia, Mixed

Korea, Republic of
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

8-Week PK/PD Atorvastatin Study In Children And Adolescents With Heterozygous Familial Hypercholesterolemia

Pediatric Heterozygous Hypercholesterolemia

Greece, Norway, Canada
Amgen

Completed

Safety and Tolerability of Repatha® (Evolocumab) in Indian Participants With Homozygous Familial Hypercholesterolemia (RAMAN)

Homozygous Familial Hypercholesterolemia HoFH

India
Regeneron Pharmaceuticals
Sanofi

Completed

Open-Label Extension of Study R727-CL-1003 (NCT01266876) to Evaluate the Long-Term Safety and Efficacy of Alirocumab (REGN727) in Participants With Heterozygous Familial Hypercholesterolemia (HeFH)

Hypercholesterolemia | Heterozygous Familial Hypercholesterolemia

United States, Canada
Regeneron Pharmaceuticals
Sanofi

Completed

Study of Alirocumab (REGN727/SAR236553) in Patients With Heterozygous Familial Hypercholesterolemia (HeFH) Undergoing Low-density Lipoprotein (LDL) Apheresis Therapy (ODYSSEY ESCAPE)

Heterozygous Familial Hypercholesterolemia

United States, Germany
Laval University
Amgen

Completed

Lp(a) and Aortic Valve Calcification (FHLPA)

Heterozygous Familial Hypercholesterolemia

Canada
University of Manitoba

Completed

Sitosterolemia Metabolism (STAIR7002)

Sitosterolemia

Canada
Akcea Therapeutics
Ionis Pharmaceuticals, Inc.

Withdrawn

Study of AKCEA-ANGPTL3-LRX (ISIS 703802) in Patients With Homozygous Familial Hypercholesterolemia (HoFH)

Homozygous Familial Hypercholesterolemia

Canada
Amgen

Completed

Trial Evaluating PCSK9 Antibody in Subjects With LDL Receptor Abnormalities (TESLA)

Homozygous Familial Hypercholesterolemia

New Zealand, South Africa, France, United States, Spain, Belgium, Czechia, Italy, Netherlands, Hong Kong, Canada, Lebanon
Aegerion Pharmaceuticals, Inc.

Completed

Efficacy and Safety of Lomitapide in Japanese Patients With HoFH on Concurrent Lipid-Lowering Therapy

Familial Hypercholesterolemia - Homozygous

Japan
Aegerion Pharmaceuticals, Inc.
FDA Office of Orphan Products Development

Completed

A Safety and Efficacy Study of AEGR-733 to Treat Homozygous Familial Hypercholesterolemia (FH)

Homozygous Familial Hypercholesterolemia

United States, Canada, Italy, South Africa
Pfizer

Completed

A 52 Week Study To Assess The Use Of Bococizumab (PF-04950615; RN316) In Subjects With Heterozygous Familial Hypercholesterolemia (SPIRE-FH)

Heterozygous Familial Hypercholesterolemia

Canada, Netherlands, United Kingdom, United States, Spain, Poland, Finland, Norway, South Africa, Italy, Bulgaria
Laval University

Completed

Comparisons of Two Low-density Lipoprotein Apheresis Systems in Patients With Homozygous Familial Hypercholesterolemia (APHERESE)

Homozygous Familial Hypercholesterolemia

Canada
Regeneron Pharmaceuticals
Sanofi

Completed

Study of Alirocumab (REGN727/SAR236553) in Patients With heFH (Heterozygous Familial Hypercholesterolemia) Who Are Not Adequately Controlled With Their LMT (Lipid-Modifying Therapy) (ODYSSEY FH II)

Heterozygous Familial Hypercholesterolemia

United Kingdom, Netherlands, Czech Republic, Norway
Cerenis Therapeutics, SA

Completed

Effect of CER-001 on Plaque Volume in Homozygous Familial Hypercholesterolemia (HoFH) Subjects (MODE)

Homozygous Familial Hypercholesterolemia

United States, Canada, Italy, Netherlands, United Kingdom
Aegerion Pharmaceuticals, Inc.
University of Pennsylvania; Doris Duke Charitable Foundation

Completed

Safety, Tolerability and Efficacy of Microsomal Triglyceride Protein (MTP) Inhibitor

Homozygous Familial Hypercholesterolemia

United States
The University of Western Australia
National Health and Medical Research Council, Australia

Unknown

Postprandial Lipid Metabolism in Familial Hypercholesterolaemia:Effects of Fish Oils (FIFH)

Familial Hypercholesterolaemia | Hypertriglyceridaemia

Australia
Lumos Diagnostics
Aptatek Biosciences

Recruiting

PheCheck Feasibility Study

Phenylketonurias

United States
Sanofi

Recruiting

A Phase 1/Phase 2 Open-label Study to Evaluate the Safety, Tolerability, and Efficacy of a Single Intravenous Administration of SAR444836 in Adult Participants With Phenylketonuria

Phenylketonuria

Turkey, United States
Children's Hospital of Fudan University
Hedu Biotechnology (Shanghai) Co., LTD

Recruiting

Efficacy and Safety of Orally Administered Engineered Probiotics (CBT102-A) for the Treatment of Children With Phenylketonuria

Phenylketonuria

China
University Hospital, Grenoble

Recruiting

Evaluation of Capillary Blood Collection Devices (Mitra® and HemaPEN®) (MitrAlanine)

Metabolic Diseases | Phenylketonuria

France
APR Applied Pharma Research s.a.

Recruiting

Open-label, Randomized, 2-way Crossover, Monocentric, Controlled Study to Evaluate the Effect on Daily PHE Fluctuation of PKU GOLIKE Versus SoC in Patients With PKU.

Phenylketonurias

Italy
University Children's Hospital, Zurich
University Children's Hospital Basel; UChildrenVienna; Insel Gruppe AG, University...

Recruiting

Metabolic Control and Patient Well-being in Phenylketonuria: do Guidelines Make a Difference? (PKU_Guide)

Phenylketonurias

Switzerland
University Hospital, Lille

Not yet recruiting

Life With Phenylketonuria. Adult Neurological Outcome of PCU Screened Patients From 1971 to 2002. (PCU)

Phenylketonurias
Emory University
BioMarin Pharmaceutical

Recruiting

Nutritional Impacts of Palynziq on Patients With Phenylketonuria (PKU)

Phenylketonurias

United States
Vitaflo International, Ltd

Completed

Evaluation of PKU Sphere Liquid

Phenylketonurias

United Kingdom
Vitaflo International, Ltd
Johannes Gutenberg University Mainz; Kreiskliniken Reutlingen

Completed

A 16 Week Study Evaluating the Introduction of a GMP Based Protein Substitute in Participants With PKU (GMP In PKU)

Phenylketonurias

Germany
Klaus Parhofer

Terminated

Short-term Effects of Good Metabolic Control on Cognitive Function, Wellbeing, and Metabolic Parameters in Adult Patients With Phenylketonuria

Phenylketonurias

Germany
Nutricia UK Ltd

Completed

GMP Case Studies of Tolerance, Safety and Acceptability in PKU and TYR

PKU | Tyrosinemias

United Kingdom
Cukurova University

Completed

The Effect of Nursing Empowerment Program

Phenylketonurias

Turkey
BioMarin Pharmaceutical

Completed

Kuvan®'s Effect on the Cognition of Children With Phenylketonuria (KOGNITO)

Phenylketonuria

Italy, Spain, United Kingdom, Germany
Rubius Therapeutics

Terminated

Safety and Tolerability of RTX-134 in Adults With Phenylketonuria

Phenylketonurias

United States
Ludwig-Maximilians - University of Munich
European Union

Completed

Quantitative Requirements of Docosahexaenoic Acid for Neural Function in Children With Phenylketonuria

Phenylketonuria

Germany, Italy, Spain, United Kingdom
BioMarin Pharmaceutical

Completed

Long-Term Extension of Previous rAvPAL-PEG Protocols in Subjects With PKU (PAL-003)

Phenylketonuria

United States
Synlogic

Completed

Safety and Tolerability of SYNB1618 in Healthy Adult Volunteers and Adult Subjects With Phenylketonuria (PKU)

Healthy | Phenylketonuria

United States
Assiut University

Unknown

Early Dietary Treated Patients With Phenylketonuria Can Achieve Normal Growth and Mental Development.

Phenylketonurias
Boston Children's Hospital
Brigham and Women's Hospital

Completed

MRI Spectroscopy and Neuropsychological Functioning in Phenylketonuria

Phenylketonuria

United States
Washington University School of Medicine
University of Missouri-Columbia; BioMarin Pharmaceutical

Completed

Sapropterin in Individuals With Phenylketonuria

Phenylketonuria

United States
Boston Children's Hospital
Beth Israel Deaconess Medical Center; Brigham and Women's Hospital

Completed

The Brain and Neuropsychological Functioning in Adults With Sapropterin Dihydrochloride Treated Phenylketonuria

Phenylketonuria

United States
University of Missouri-Columbia
BioMarin Pharmaceutical

Completed

The Effects of Kuvan on Functional Brain Connectivity in Individuals With Phenylketonuria (PKU)

Phenylketonuria

United States
BioMarin Pharmaceutical

Completed

Safety and Tolerability Study of rAvPAL-PEG to Treat Phenylketonuria

Phenylketonuria

United States
BioMarin Pharmaceutical

Completed

Safety and Therapeutic Effects of Sapropterin Dihydrochloride on Neuropsychiatric Symptoms in Phenylketonuria (PKU) Patients

Phenylketonuria

United States, Canada
Emory University
Atlanta Clinical and Translational Science Institute

Completed

The Effect of Supplemental Docosahexaenoic Acid (DHA) on Neurocognitive Outcomes in Teen and Adult Women With Phenylketonuria(PKU) (PKU&DHA)

Phenylketonuria

United States
The University of Texas Health Science Center,...
BioMarin Pharmaceutical

Terminated

Bone Mineral Density in Adults With Hyperphenylalaninemia on Kuvan Therapy

Phenylketonuria | Hyperphenylalaninemia

United States
Boston Children's Hospital
Beth Israel Deaconess Medical Center; Brigham and Women's Hospital

Completed

The Brain, Neurological Features and Neuropsychological Functioning in Adults With Phenylketonuria: A Pilot Study

Phenylketonuria

United States
The University of Texas Health Science Center,...
BioMarin Pharmaceutical

Completed

Bone Mineral Density in Adults With Hyperphenylalaninemia

Phenylketonurias

United States
Emory University

Terminated

Phenylketonuria, Oxidative Stress, and BH4

Phenylketonuria

United States
Merck KGaA, Darmstadt, Germany

Completed

Phase 3 Open-label Study to Evaluate the Response and Safety of Kuvan® in Subjects With Phenylketonuria

Phenylketonuria

Germany

Clinical Trials on Fructose Metabolism, Inborn Errors

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Malaysia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations