Clinical Trials on Functional Disease Present

Total 383496 results

Eli Lilly and Company

Completed

A Phase 2 Trial of ALIMTA (Pemetrexed) Plus Gemcitabine in Locally Advanced or Metastatic Transitional Cell Carcinoma of the Urothelium

Urologic Neoplasms

Finland, France, Germany
Bambino Gesù Children's Hospital IRCCS
Ministry of Health, Italy

Recruiting

Effect of Pediatric Intensive Care Unit Diaries on PICS-p (PICS-p)

Depression | Anxiety | Post Traumatic Stress Disorder | Narrative Medicine | Post Intensive Care Syndrome

Italy
Lei Li

Recruiting

Immunotherapy for Recurrent Cervical Cancer Refractory to Platinum-based Chemotherapy: Multi-Center Trial

Chemotherapy | Recurrent Cervical Carcinoma | Immune Checkpoint Inhibitors | Anti-PD-1 Antibody | Persistent Advanced Cervical Carcinoma | Albumin-bound Paclitaxel

China
Lakehead University
Northern Ontario School of Medicine

Recruiting

Hot Water Immersion Therapy for Mental Health (WITHME)

Depression | Anxiety Disorders | Post-traumatic Stress Disorder | Heat | Water Immersion

Canada
Pacific University

Completed

A Trauma Informed Adaptation of Mindfulness-Based Relapse Prevention for Women in Substance Use Treatment

Post Traumatic Stress Disorder | Substance Use Disorders

United States
Yale University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Naltrexone for Antipsychotic-Induced Weight Gain (NTX)

Schizophrenia | Schizoaffective Disorder | Schizophreniform Disorder | Bipolar Disorder | Severe Major Depression With Psychotic Features

United States
Virginia Commonwealth University

Completed

Feasibility of the Utilization of Buprenorphine in the Emergency Room to Treat Clinical Opioid Withdrawal

Drug Overdose | Opioid-use Disorder | Opioid Withdrawal

United States
Foundation Medicine
The Cleveland Clinic; Rush University Medical Center; St. Luke's Hospital and... and other collaborators

Completed

Outcomes of FoundationOne Directed Therapy in Cancer of Unknown Primary

Neoplasms, Unknown Primary | CUP | Metastatic Disease | Poorly Differentiated Adenocarcinoma | Poorly Differentiated Carcinoma | Squamous Carcinoma Poorly Differentiated

United States
Hamilton Health Sciences Corporation
Pfizer

Terminated

Sertraline in Generalized Social Phobia With Co-Occurring Anxiety and Mood Disorders

Obsessive-Compulsive Disorder | Anxiety Disorders | Phobia, Social | Major Depressive Disorder | Panic Disorder | Agoraphobia

Canada
University of Pittsburgh
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Completed

Double-blind Pilot Trial of Mirtazapine for the Treatment of Co-occurring AD/MDD. (PT-MAD)

Major Depressive Disorder | Alcohol Use Disorder

United States
US Department of Veterans Affairs

Completed

Psychiatric Advance Directives for Improved Mental Health Care

Psychotic Disorders | Schizophrenia | Bipolar Disorder | Stress Disorders, Post-traumatic | Schizoaffective

United States
Anthony Papa

Completed

Pilot Study of Behavioral Activation for Prolonged Grief

Major Depressive Disorder | Posttraumatic Stress Disorder | Prolonged Grief Disorder | Complicated Grief

United States
New York State Psychiatric Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Completed

STAR*D Alcohol: Treatment of Depression Concurrent With Alcohol Abuse

Major Depressive Disorder | Alcohol Use Disorder

United States
University of Texas Southwestern Medical Center
Stanley Medical Research Institute

Completed

A Pilot Study of Citicoline add-on Therapy in Patients With Bipolar Disorder or Major Depressive Disorder and Amphetamine Abuse or Dependence

Bipolar Disorder | Major Depressive Disorder | Amphetamine Dependence | Amphetamine Abuse

United States
St. Justine's Hospital

Unknown

Prevention and Reduction of Alcohol and Drug Problems in a Clinical Psychiatric Youth Population

Conduct Disorder | Drug Abuse | Anxiety Disorder | Alcohol Abuse | Mood Disorder

Canada
Dartmouth-Hitchcock Medical Center
National Institute on Drug Abuse (NIDA)

Completed

Cognitive Therapy for PTSD in Addiction Treatment

Substance-Related Disorders | Stress Disorders, Post Traumatic

United States
Klinikum Stuttgart
Klinikum Kassel GmbH (COSS-Biobank)

Not yet recruiting

Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas (COSS-Registry)

Osteosarcoma | High Grade Sarcoma | Recurrent Osteosarcoma | Bone Sarcoma | Undifferentiated Pleomorphic Sarcoma | Bone Tumor | Extraskeletal Osteosarcoma | Osseous Sarcoma | Parosteal Osteosarcoma | Osteoblastic Osteosarcoma | Chondroblastic Osteosarcoma | Fibroblastic Osteosarcoma | Conventional Osteosarcoma | Conventional... and other conditions
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Not yet recruiting

Testing Laser Therapy for Treatment of Vaginal Dryness in Survivors of Breast Cancer, The Revitalize Trial

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage IA Breast Cancer AJCC v8 | Anatomic Stage IB Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Anatomic Stage IIB Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8 | Anatomic... and other conditions
Affiliated Hospital to Academy of Military Medical...
Cancer Institute and Hospital, Chinese Academy of Medical Sciences; Peking...

Recruiting

Phase II Trial of Tirelizumab Combined With R2-ICE Regimen in the Treatment of rrDLBCL/HGBL

Age Range ≥16 Years, Gender Unlimited | Histopathology Confirmed Diffuse Large B-cell Lymphoma or High-grade B-cell Lymphoma | Received Prior First-line Chemotherapy for DLBCL or HGBL, Failed to Reach CR for Four Cycles, or Relapsed | At Least One Positive Lesion According to the 2014... and other conditions

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Hypofractionated Partial Breast Irradiation in Treating Patients With Early Stage Breast Cancer

Invasive Breast Carcinoma | Early-Stage Breast Carcinoma | Stage I Breast Cancer AJCC v7 | Stage IA Breast Cancer AJCC v7 | Stage IB Breast Cancer AJCC v7 | Stage II Breast Cancer AJCC v6 and v7 | Stage IIA Breast Cancer AJCC v6 and v7 | Stage IIB Breast Cancer AJCC v6 and v7 | Ductal Breast Carcinoma... and other conditions

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Withdrawn

Effects of Ribociclib and Palbociclib on Tumor and Blood Characteristics in Patients With Metastatic Breast Cancer

Anatomic Stage III Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Anatomic Stage IIIB Breast Cancer AJCC v8 | Anatomic Stage IIIC Breast Cancer AJCC v8 | Prognostic Stage III Breast Cancer AJCC v8 | Prognostic Stage IIIA Breast Cancer AJCC v8 | Prognostic Stage IIIB Breast... and other conditions
Roswell Park Cancer Institute
National Cancer Institute (NCI); Cianna Medical, Inc.

Terminated

Radiation Therapy in Treating Post-Menopausal Women With Early Stage Breast Cancer Undergoing Surgery

Stage I Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIC Breast Cancer | Lobular Breast Carcinoma In Situ | Estrogen Receptor Negative | Estrogen Receptor Positive | HER2/Neu Negative | Progesterone Receptor Positive | Ductal Breast Carcinoma In Situ | Mucinous Breast Carcinoma | Tubular Breast Carcinoma and other conditions

United States
University Hospital Southampton NHS Foundation...
National Institute for Health Research, United Kingdom

Recruiting

Eye Movement Desensitisation and Reprocessing (EMDR) to Improve Mental Health Following Intensive Care Admission (EMERALD)

Critical Illness | Post Traumatic Stress Disorder | Depression, Anxiety | Eye Movement Desensitisation and Reprocessing

United Kingdom
Lei Li

Recruiting

Donafenib for Recurrent Cervical Cancer

Chemotherapy | Recurrent Cervical Carcinoma | Survival Outcomes | Targeted Therapy | Adverse Effect | Metastatic Cervical Carcinoma | Persistent Advanced Cervical Carcinoma

China
Lei Li

Recruiting

Combination of Nimotuzumab and Radiotherapy for Recurrent Uterine Cervical Squamous Carcinoma

Recurrent Cervical Carcinoma | Radiotherapy | Objective Response Rate | Overall Survival | Progression-free Survival | Epidermal Growth Factor Receptor | Nimotuzumab

China
University of Utah

Active, not recruiting

Salvage Oligometastasectomy and Radiation Therapy in Recurrent Prostate Cancer (SOAR)

Prostate Adenocarcinoma | Metastatic Malignant Neoplasm in the Bone | Metastatic Malignant Neoplasm in the Lymph Nodes | Recurrent Prostate Carcinoma | Oligometastasis | PSA Failure

United States
Arkin
Amsterdam UMC, location VUmc; Ziekenhuis Amstelland; Meander Medisch Centrum; Sinai... and other collaborators

Completed

Effectiveness of PTSD-treatment Compared to Integrated PTSD-PD-treatment in Adult Patients With Comorbid PTSD and CPD (PROSPER-C)

Posttraumatic Stress Disorder (PTSD) | Avoidant Personality Disorder | Dependent Personality Disorder | Obsessive Compulsive Personality Disorder

Netherlands
Merrimack College
Pennington Biomedical Research Center; University of Massachusetts, Worcester; Boston Medical Center Developmental and Behavioral Pediatrics Clinic and other collaborators

Completed

Expanded Game Squad for Neurodiverse Youth (NDGameSquad)

Mental Health Issue (E.G., Depression, Psychosis, Personality Disorder, Substance Abuse) | Physical Activity | Health Behavior | Developmental Disorder

United States
University of Texas at Austin

Unknown

Neuroimaging of Pavlovian Fear Conditioning Processes in Patients With Pathological Anxiety

Anxiety Disorders | Post Traumatic Stress Disorder | Panic Disorder | Social Phobia | Phobia

United States
Hugo W. Moser Research Institute at Kennedy Krieger...

Completed

National Child Traumatic Stress Network (NCTSN) Quality Improvement Initiative Database

Depression | Anxiety | ADHD | Conduct Disorder | Post Traumatic Stress Disorder

United States
University of Pittsburgh

Completed

Treatment of Young Adults With Comorbid AUD/MDD: A Pilot Medication Trial (YAAD-P)

Major Depressive Disorder | Alcohol Use Disorder

United States
Yale University
National Institute on Alcohol Abuse and Alcoholism (NIAAA)

Terminated

Zonisamide for Heavy Drinkers With Bipolar Disorder (ZNSBP)

Bipolar Disorder | Alcohol Use Disorders

United States
AstraZeneca

Completed

Recurrence Rate, Risk Factors for the Recurrence, and Quality of Life in Patients With GERD in Korea-an Observational (Refresh)

The Aim of This Study is to Investigate the Frequency and Related Risk Factors of Recurrence, and Quality of Life in Patients With GERD After Treatment With PPI

Korea, Republic of
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Durvalumab and Tremelimumab Before Surgery in Treating Patients With Hormone Receptor Positive, HER2 Negative Stage II-III Breast Cancer

Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Anatomic Stage IIB Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Anatomic Stage IIIB Breast Cancer AJCC v8 | Anatomic Stage IIIC Breast Cancer AJCC... and other conditions

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Radiation Therapy in Treating Patients With Stage 0-II Breast Cancer

Invasive Breast Carcinoma | Stage I Breast Cancer AJCC v7 | Stage IA Breast Cancer AJCC v7 | Stage IB Breast Cancer AJCC v7 | Stage II Breast Cancer AJCC v6 and v7 | Stage IIA Breast Cancer AJCC v6 and v7 | Stage IIB Breast Cancer AJCC v6 and v7 | Breast Adenocarcinoma | Ductal Breast Carcinoma In Situ and other conditions

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Withdrawn

Sapanisertib and Nivolumab for the Treatment of Stage I-IV Non-small Cell Lung Cancer in Patients Who Have Progressed on Prior PD-1/PD-L1 Inhibitor Therapy, I-OVERCOME Study

Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Lung Non-Small Cell Carcinoma | Stage III Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Stage II Lung Cancer AJCC v8 | Stage IIA Lung Cancer AJCC v8 | Stage IIB Lung Cancer AJCC v8 | Stage IIIA Lung Cancer AJCC v8 | Stage IIIB Lung... and other conditions
The University of Texas Health Science Center at...
National Institute on Aging (NIA)

Recruiting

Sex-specific Determinants of Early-phase Recovery From Skeletal Muscle Disuse (MAC)

Rehabilitation | Atrophy of Muscle Due to Disuse

United States
University of Washington
National Institute of Mental Health (NIMH)

Recruiting

Single Session Narrative Therapy Study

HIV | Substance Use | Mental Health Issue

United States
Medical University of Vienna

Recruiting

The Mere-measurement Effect of Patient-reported Outcomes

Speech Disorders | Assessment, Self | Measurement, Psychological Stress

Austria
Beijing Tiantan Hospital

Recruiting

Transauricular Vagal Nerve Stimulation Improves Postoperative Delirium in Elderly Patients (Vnstar-IIa)

Vagus Nerve Stimulation

China
Armando Santoro, MD
GlaxoSmithKline; Istituto Clinico Humanitas

Not yet recruiting

Niraparib and Temozolomide in Patients Glioblastoma (ONC-2022-001)

Glioma, Malignant

Italy
Umraniye Education and Research Hospital

Recruiting

Effects of Pericapsular Nerve Group Block Applied in Patients Undergoing Hip Fracture Surgery.

Pain, Postoperative | Hip Fractures

Turkey
University of Minnesota

Not yet recruiting

Supervised Treadmill Intervention to Reduce Inflammation and Depression Through Exercise in HIV: The STRIDE Pilot Study

Depression | Hiv
Duke University

Not yet recruiting

Open-Label Study to Evaluate the Safety, Tolerability and Efficacy of the Oncolytic HSV1 MVR-C5252 (PuMP)

Recurrent High Grade Glioma
Peking Union Medical College Hospital

Recruiting

First- Line Treatment With Durvalumab Plus XELOX Chemotherapy in Advanced Gastrointestinal Neuroendocrine Carcinoma

Gastrointestinal Neuroendocrine Carcinoma

China
University Hospital, Antwerp

Recruiting

Standardised Drug Provocation Testing in Perioperative Hypersensitivity

Hypersensitivity | Anaphylaxis | Allergic Reaction | Perioperative Complication | Immediate Hypersensitivity | Hypersensitivity, Drug | Anaphylactic Reaction

Belgium
Aveta Biomics, Inc.

Recruiting

Treatment of Patients With Recurrent High-Grade Glioma With APG-157 and Bevacizumab

Glioma | Glioblastoma Multiforme

United States
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

Effect of Preoperative Olfactory Training on Postoperative Delirium in the Elderly Undergoing Orthopedic Surgeries

Postoperative Delirium | Preoperative Olfactory Training
Elizabeth J Franzmann
Aveta Biomics, Inc.

Recruiting

A Proof of Concept Trial Investigating Safety and Efficacy of APG-157 in Oral Dysplasia

Oropharyngeal Dysplasia | Oral Cavity Dysplasia | Oral Carcinoma in Situ

United States
International Food Policy Research Institute
Bill and Melinda Gates Foundation

Recruiting

Improving Birth Outcomes in Bangladesh

Birth Weight | Gestational Weight Gain | Diet; Deficiency | Small for Gestational Age at Delivery

Bangladesh

Clinical Trials on Functional Disease Present

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Medical Conditions

Drug Interventions

CROs by country

CROs in Saudi Arabia

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Rare Diseases

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