Clinical Trials on Gene Insertions in Canada

Total 3063 results

Laval University

Completed

Impact of a Short-Term High Fat or Low Fat Diet on Intestinal Genes Expression Involved in the Cholesterol and Fatty Acid Metabolism (DGENES)

Gene Expression

Canada
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

Lung-MAP: Talazoparib in Treating Patients With HRRD Positive Recurrent Stage IV Squamous Cell Lung Cancer

BRCA1 Gene Mutation | BRCA2 Gene Mutation | Recurrent Squamous Cell Lung Carcinoma | Stage IV Squamous Cell Lung Carcinoma AJCC v7 | BRIP1 Gene Mutation | PALB2 Gene Mutation | ATM Gene Mutation | ATR Gene Mutation | CHEK2 Gene Mutation | NBN Gene Mutation | RAD51 Gene Mutation | CHEK1 Gene Mutation | FANCA Gene... and other conditions

United States, Canada
University Health Network, Toronto
Bayer; AstraZeneca; Amgen; AnHeart Therapeutics Inc.; Applied Health Research Centre and other collaborators

Recruiting

CAnadian CAncers With Rare Molecular Alterations (CARMA) - Basket Real-world Observational Study (BROS) (CARMA-BROS)

Cancer | Malignancies Multiple | Malignant Solid Tumor | Cancer, Therapy-Related | Molecular Sequence Variation | Genetic Alteration | Gene Fusion | Receptor Tyrosine Kinase Gene Mutation | RTK Family Gene Mutation | Ras (Kras or Nras) Gene Mutation

Canada
Women's College Hospital
Canadian Institutes of Health Research (CIHR); London Health Sciences Centre; H. Lee Moffitt Cancer Center and Research Institute and other collaborators

Unknown

Cancer Prevention in Women With a BRCA Mutation

Breast Cancer | Ovarian Cancer | BRCA1 Gene Mutation | BRCA2 Gene Mutation

Canada
University Health Network, Toronto
AbbVie; Celgene

Terminated

Study of Enasidenib and Venetoclax in IDH2-Mutated Blood Cancers

Acute Myeloid Leukemia | Relapsed Cancer | Refractory Cancer | IDH2 Gene Mutation

Canada
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

Lung-MAP: AZD4547 as Second-Line Therapy in Treating FGFR Positive Patients With Recurrent Stage IV Squamous Cell Lung Cancer

Recurrent Squamous Cell Lung Carcinoma | Stage IV Squamous Cell Lung Carcinoma AJCC v7 | FGFR1 Gene Amplification | FGFR2 Gene Amplification | FGFR2 Gene Mutation | FGFR3 Gene Mutation | FGFR1 Gene Mutation | FGFR3 Gene Amplification

United States, Canada
Maisonneuve-Rosemont Hospital

Active, not recruiting

RSA and Clinical Comparison of Anatomical and Mechanical Alignment in Total Knee Replacement

Personal Satisfaction | Genu Varum

Canada
QED Therapeutics, Inc.
Helsinn Healthcare SA

Terminated

Phase 3 Study of BGJ398 (Oral Infigratinib) in First Line Cholangiocarcinoma With FGFR2 Gene Fusions/Translocations

FGFR2 Gene Mutation | Advanced Cholangiocarcinoma

Korea, Republic of, United States, Belgium, Spain, Taiwan, China, United Kingdom, France, Canada, Germany, Thailand, Italy, Portugal, Australia, Puerto Rico
Bayer

Recruiting

Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body (ON-TRK)

Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion

United States, Austria, Denmark, Germany, Italy, Norway, Spain, United Kingdom, Brazil, Russian Federation, Switzerland, Taiwan, Canada, China, Australia, Greece, Belgium, Sweden, Korea, Republic of, France, Argentina, Finland, Ireland and more
AstraZeneca
Merck Sharp & Dohme LLC; Myriad Genetic Laboratories, Inc.

Active, not recruiting

Assessment of the Efficacy and Safety of Olaparib Monotherapy Versus Physicians Choice Chemotherapy in the Treatment of Metastatic Breast Cancer Patients With Germline BRCA1/2 Mutations. (OlympiAD)

Breast Cancer Metastatic | BRCA 1 Gene Mutation | BRCA 2 Gene Mutation

Italy, Spain, United States, Czechia, Romania, France, Korea, Republic of, United Kingdom, Hungary, Japan, Peru, Poland, Russian Federation, Turkey, China, Taiwan, Bulgaria, Switzerland, Mexico
Day One Biopharmaceuticals, Inc.

Recruiting

Tovorafenib (DAY101) Monotherapy or in Combination With Other Therapies for Patients With Melanoma and Other Solid Tumors

Melanoma | Colorectal Cancer | Solid Tumor | Non Small Cell Lung Cancer | Bladder Cancer | Thyroid Cancer, Papillary | Pilocytic Astrocytoma | Bladder Urothelial Carcinoma | Non-Small Cell Adenocarcinoma | MEK Mutation | RAS Mutation | Pancreatic Acinar Carcinoma | RAF Mutation | CRAF Gene Amplification | RAF1 Gene Amplification and other conditions

United States, Canada, Korea, Republic of, Spain, Australia, Belgium, France
National Cancer Institute (NCI)
Glaxosmithkline Biologicals S.A.

Terminated

Dabrafenib in Treating Patients With Solid Tumors and Kidney or Liver Dysfunction

Renal Failure | Solid Neoplasm | BRAF Gene Mutation | Hepatic Complication

United States, Canada
University Health Network, Toronto
Pfizer

Recruiting

Study of Crizotinib for ROS1 and MET Activated Lung Cancer

Non-squamous Non-small-cell Lung Cancer | Stage IV Non-small Cell Lung Cancer | ROS1 Gene Rearrangement | MET Activating Mutation | MET Amplification

Canada
Regeneron Pharmaceuticals

Recruiting

A Study of DB-OTO, an Adeno-associated Virus (AAV) Based Gene Therapy, in Children/Infants With Hearing Loss Due to Otoferlin Mutations (CHORD)

Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)

Spain, United Kingdom, United States
Rhythm Pharmaceuticals, Inc.

Completed

Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers

Pro-opiomelanocortin (POMC), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) and Leptin Receptor (LepR) Gene Mutations

United States, Israel, Canada, Germany, Greece, Italy, Portugal
Circassia Limited
Adiga Life Sciences, Inc.

Completed

Evaluating the Efficacy of Ragweed-SPIRE Following Exposure to Ragweed Allergen in an Environmental Exposure Chamber

Seasonal Allergic Rhinitis

Canada
Circassia Limited
Adiga Life Sciences, Inc.

Completed

Safety Study of Ragweed-SPIRE in Subjects With Ragweed Allergies and Asthma

Asthma | Seasonal Allergic Rhinitis

Canada
Laval University

Recruiting

Immunogenicity of 2 Versus 3 Doses of Combined Hepatitis B Vaccines in 2-18 Months Old Children

Hepatitis B

Canada
McMaster University
Canadian Institutes of Health Research (CIHR)

Completed

Phase 1 Clinical Trial of the Safety and Immunogenicity of an Adenovirus-based TB Vaccine Administered by Aerosol

Tuberculosis

Canada
Laval University

Unknown

HPV Prevalence in 16-20 Year Old Males

HPV Infection

Canada
McMaster University

Terminated

Study of the Safety and Immunogenicity of an Adenovirus-based Tuberculosis Vaccine

Tuberculosis

Canada
Ottawa Hospital Research Institute
Government of Canada; Government of Nunavut

Completed

Taima TB: 3HP Study

Tuberculosis

Canada
McMaster University

Completed

Accessibility of the World Health Organization's eTB Catalogue of Recommendations

Tuberculosis

Canada
CanSino Biologics Inc.
Beijing Institute of Biotechnology; Canadian Center for Vaccinology

Unknown

Phase I/II Clinical Trial of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) in Canada

COVID-19

Canada
University of Calgary
Canadian Institutes of Health Research (CIHR); Alberta Health services

Completed

C Difficile Near-patient Diagnostics

Clostridium Difficile

Canada
Laval University

Completed

Impact of the COVID-19 Pandemic on Diet Quality and Food Insecurity: a NutriQuébec Sub-study

Eating Habits

Canada
Hamilton Health Sciences Corporation
St. Joseph's Healthcare Hamilton; McMaster University

Completed

Comparative Study of Three Different Testing Mechanisms for Clostridium Difficile

Clostridium Difficile

Canada
Queen's University
The Physicians' Services Incorporated Foundation

Terminated

Harnessing the Healthy Gut Microbiota to Cure Patients With Recurrent C. Difficile Infection

Clostridium Difficile Infection

Canada
Ryerson University
Chr Hansen

Completed

Effect of Probiotics on GBS Colonization Status During Pregnancy: A Pilot Randomized Controlled Trial

Group B Streptococcal Infection

Canada
Joseph Kim
Alberta Health services

Completed

Comprehensive Strategy to Decolonize Methicillin-resistant Staphylococcus Aureus (MRSA) in the Outpatient Setting

Methicillin-resistant Staphylococcus Aureus

Canada
Laval University
Réseau-1 Québec; Réseau de recherche en santé des populations du Québec

Unknown

Optimization of the Management of COVID-19 Through Tailored Recommendations to the Citizens (VIGIE-COVID)

COVID19 | Tailored Recommendations | Citizen Self-reported Symptoms

Canada
Jordan Feld

Recruiting

UHN Inpatient Hepatitis C & B Screening

Hepatitis B | Hepatitis C

Canada
Lawson Health Research Institute
Canadian Association of Emergency Physicians

Completed

What is the Prevalence of Methicillin-Resistant Staphylococcus Aureus in Skin and Soft Tissue Infections Presenting to the Emergency Departments of a Canadian Academic Health Care Center? (CA-MRSA)

Bacterial Infections | Gram-Positive Bacterial Infections | Staphylococcal Infections

Canada
Johann DD Pitout
Merck Sharp & Dohme LLC

Completed

International Travel and the Spread of Extended-spectrum Beta-lactamase-producing Escherichia Coli

Infection Due to Resistant Bacteria

Canada
University Health Network, Toronto

Unknown

Neurocognitive Functioning in Patients With Hepatitis C Pre- and Post-Treatment With Antiviral Medication

Hepatitis B | Hepatitis C

Canada
University of Alberta

Recruiting

Breakthrough CMV Lung Transplant -Multicentre

Cytomegalovirus Infections

Canada
Laval University
CISSS de Chaudière-Appalaches; VITAM: Research Center on Sustainable Health; Centre... and other collaborators

Recruiting

MAVIPAN: My Life and the COVID-19 Pandemic

Psychosocial Impacts of the COVID-19 Pandemic

Canada
University of Alberta

Terminated

Fecal Microbiota Transplant (FMT) Plus Fidaxomicin for Severe or Fulminant Clostridium Difficile Infection

Clostridium Difficile

Canada
Sanofi Pasteur, a Sanofi Company

Completed

Study of Two Doses of Menactra® or One Dose of Monovalent Meningococcal Group C Vaccine With Routine Immunizations

Meningitis | Meningococcal Infection

Canada
Sanofi Pasteur, a Sanofi Company

Completed

Study of Tetanus and Diphtheria Toxoids Adsorbed Combined With Component Pertussis Vaccine and Inactivated Poliomyelitis

Hepatitis B | Pertussis | Tetanus | Diphtheria | Poliomyelitis

Canada
University Health Network, Toronto
Sunnybrook Health Sciences Centre; University of Toronto

Active, not recruiting

At Home Monitoring for Patients With Covid19

Coronavirus

Canada
Mount Sinai Hospital, Canada
University of Toronto

Withdrawn

Combination Hepatitis A and B Vaccine to Induce Immunity in Non-responders

Hepatitis B

Canada
St. Joseph's Health Care London

Completed

Efficacy Study of Combined Hepatitis A and Hepatitis B Vaccine to Protect Against Hepatitis B in Hemodialysis Patients

Hepatitis B

Canada
University of Alberta
Griffith University

Recruiting

A Trial of a Peptide-based Group A Streptococcal (GAS) Vaccine Candidate in Healthy Individuals.

Group A Streptococcal Infection

Canada
Bio-K Plus International Inc.
Centre Hospitalier Pierre-Le Gardeur

Withdrawn

Evaluation of the Efficacy of Bio-K+ Cl-1285® In the Nasal Decolonization of Methicillin Resistant Staphylococcus Aureus (MRSA) Carrier Patients (MRSA)

MRSA Colonization

Canada
Hamilton Health Sciences Corporation
St. Joseph's Healthcare Hamilton; McMaster University

Completed

Comparison of Elution Swab (ESwab) and Amies Transport Swabs for Screening Patients for Methicillin Resistant Staphylococcus Aureus (MRSA) and Vancomycin Resistant Enterococci (VRE) Colonization (MRSA VRE)

Eluted Swab

Canada
Lawson Health Research Institute
London Health Sciences Foundation; Ontario Ministry of Colleges and Universities

Recruiting

Annexin A5 in Patients With Severe COVID-19 Disease (AX-COVID)

Coronavirus Infection | Sepsis

Canada
St. Joseph's Healthcare Hamilton

Withdrawn

Hydroxychloroquine to Prevent COVID-19 Disease Amongst Healthcare Workers (PROVIDE)

Corona Virus Infection

Canada
University Health Network, Toronto

Unknown

Apoptosis and Hepatitis B: The Role of Apoptosis in Patients Who Are HBeAg Negative

Hepatitis B

Canada
Tibotec Pharmaceuticals, Ireland

Completed

A Study to Investigate the Potential Pharmacokinetic Interaction Between TMC435 and Methadone

Hepatitis C

Canada

Clinical Trials on Gene Insertions in Canada

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Guatemala

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations