Clinical Trials on Genes, BRCA1

Total 760 results

Shandong University
Fudan University; Chinese Nutrition Society

Suspended

SREBF1 Polymorphism and Egg Yolk on Cardiovascular Disease Risk in Healthy Young Adults: a Randomised, Two-period, Single Blinded, Crossover Trial

Healthy | GEN1 Gene Mutation

China
Tufts University

Completed

DHFR 19 bp Deletion Polymorphism and Folic Acid Utilization

Characterize rs70991108 Polymorphism of DHFR Gene
Eisai Inc.

Active, not recruiting

A Study of H3B-6545 in Combination With Palbociclib in Women With Advanced or Metastatic Estrogen Receptor-Positive Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer

Breast Neoplasms | Receptors, Estrogen | Genes, Erbb-2

United States, United Kingdom
Atossa Therapeutics, Inc.

Withdrawn

A Trial of the ForeCYTE Breast Aspirator for Cytological Testing of Nipple Aspirate Fluid in Women 30-55 Years Old

Breast Cancer, Preneoplastic Conditions, BRCA

Israel
University of Arkansas

Withdrawn

Pancreatic Cancer Screening of High-Risk Individuals in Arkansas

Pancreatic Neoplasms | Colorectal Neoplasms, Hereditary Nonpolyposis | BRCA1 Gene Mutation | BRCA2 Gene Mutation | Hereditary Pancreatitis | Ataxia Telangiectasia | Peutz-Jegher's Syndrome | Familial Atypical Mole-Malignant Melanoma Syndrome

United States
Sameek Roychowdhury
National Cancer Institute (NCI)

Withdrawn

Brigatinib in Treating Patients With ALK and ROS1 Gene Alterations and Locally Advanced or Metastatic Solid Cancers

Locally Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | ALK Gene Mutation | Metastatic Malignant Neoplasm in the Brain | Advanced Malignant Neoplasm | ALK Fusion Protein Expression | Metastatic Malignant Neoplasm in the Central Nervous System | ROS1 Gene Mutation | ALK Gene... and other conditions

United States
National Cancer Institute (NCI)

Recruiting

Genetic Clues to Chordoma Etiology: A Protocol to Identify Sporadic Chordoma Patients for Studies of Cancer-Susceptibility Genes

Genes | Sporadic Chordoma

United States
University of Bath
Ministry of Education, Taiwan

Completed

The Influence of Different Dietary Status on the Acute Responses to Exercise

Adipose Tissue Gene Expression
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI); Eli Lilly and Company; Genentech, Inc.; Kazia... and other collaborators

Recruiting

Genetic Testing in Guiding Treatment for Patients With Brain Metastases

Metastatic Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Brain | NTRK Family Gene Mutation | CDK Gene Mutation | PI3K Gene Mutation | ROS1 Gene Mutation | KRAS G12C Mutation

United States
Memorial Sloan Kettering Cancer Center

Active, not recruiting

Rapid Pancreatic and Ovarian Screening MR Imaging With Motion Corrected T1, T2, and Advanced Diffusion Weighted Imaging for Patients With BRCA Mutation Who Undergo Screening Breast MRI

Screening Breast MRI in Patients Who Are BRCA Mutation Carriers

United States
Istituto Clinico Humanitas
Celgene

Unknown

Prevalence and Clinical Effect of IDH1/2 Mutations in Patients With Acute Myeloid Leukemia (Euro_IDH_AML)

Acute Myeloid Leukemia | IDH2 Gene Mutation | IDH1 Gene Mutation

Italy
Mayo Clinic
National Foundation for Cancer Research

Completed

An Integrated Approach to Treating Recurrent Thoracic Carcinomas Resistant to Tyrosine Kinase Inhibitors

Lung Cancer | Adenocarcinoma of Lung | Lung Neoplasm | Pulmonary Cancer | Cancer of Lung | EGFR Genes | ALK Genes

United States
First Affiliated Hospital of Chongqing Medical...

Not yet recruiting

[68Ga]Ga-Sa-DABI-4 PET Imaging of Stimulator of Interferon Gene Expression in Cancer Patients

Cancer | Positron Emission Tomography | Stimulator of Interferon Gene

China
SUNHO（China）BioPharmaceutical CO., Ltd.

Recruiting

IAH0968 in Combination With GC for the Treatment of HER2-Positive Unresectable Advanced/Metastatic Malignant Tumors

HER2 Gene Mutation

China
Jin-Hee Ahn
Asan Medical Center

Unknown

Trastuzumab Biosimilar (Samfenet®) Plus Treatment of Physician's Choice (TPC) in Patients With HER2-positive Solid Tumor (BIOs-Her)

HER-2 Gene Amplification | HER-2 Protein Overexpression
Hoffmann-La Roche

No longer available

Expanded Access to Entrectinib for Cancers With NTRK1/2/3, ROS1, or ALK Gene Fusions

Cancers With NTRK, ROS1, or ALK Gene Fusions

United States
Intergroupe Francophone de Cancerologie Thoracique

Completed

French National Observatory of the Patients With Non-small Cell Lung (NSCLC) and Molecular Testings

Carcinoma, Non-Small-Cell Lung | KRAS Gene Mutation | ALK Gene Mutation | BRAF Gene Mutation

France
Henan Cancer Hospital
Fundamenta Therapeutics, Ltd.

Not yet recruiting

Assessment of Safety and Efficacy of ThisCART19A in Adult Patients With B Cell Malignancies After Failure of Autologous Chimeric Antigen Receptor T- Cell(CAR-T) Therapy

Allogeneic, CAR-T, Protein Sequestration, Non-gene Edited

China
Zhongnan Hospital

Active, not recruiting

Effects of Metabolic Enzymes and Transporter Gene Polymorphisms on the Pharmacokinetics and Metabolism of Oral Abiraterone Acetate in Healthy Chinese Adults

Pharmacokinetic | Abiraterone Acetate | Plasma Concentration | Gene Polymorphism | Metabolic Analysis

China
Wageningen University
Dutch Diabetes Research Foundation

Completed

MyoGene: Effects of Acute Exercise on (Myokine) Gene Expression in Human Skeletal Muscle

Exercise | Muscle | Gene Expression | Myokine

Netherlands
Assistance Publique - Hôpitaux de Paris

Completed

Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene. (MetPAP)

Pulmonary Alveolar Proteinosis | Mutation Ala393Thr of the MARS Gene | mutationSer567Leu of the MARS Gene

France
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

Lung-MAP: Palbociclib as Second-Line Therapy in Treating Cell Cycle Gene Alteration Positive Patients With Recurrent Stage IV Squamous Cell Lung Cancer

CCND1 Gene Amplification | CCND2 Gene Amplification | CCND3 Gene Amplification | CDK4 Gene Amplification | Recurrent Squamous Cell Lung Carcinoma | Stage IV Squamous Cell Lung Carcinoma AJCC v7

United States
Hutchmed

Active, not recruiting

A Study of HMPL-306 in Advanced Solid Tumors With IDH Mutations

Isocitrate Dehydrogenase Gene Mutation

United States, Spain
Moshe Flugelman

Terminated

Examining B12 Deficiency Associated With C677T Mutation on MTHFR Gene in Terms of Commonness and Endothelial Function

B12 Deficiency Combined With C677T Mutation on MTHFR Gene

Israel
National Cancer Institute (NCI)

Completed

Clinical, Genetic, Behavioral, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Breast/Ovarian Cancer

Familial Ovarian Cancer | Familial Breast Cancer | BRCA1-associate Malignancies | BRCA2-associated Malignancies

United States
Federation Francophone de Cancerologie Digestive

Recruiting

Cohort of Tumors With POLE/D1 Mutation

Tumors | POLD1 Gene Mutation | POLE Exonuclease Domain Mutation

France
Calithera Biosciences, Inc

Completed

A Study of Telaglenastat (CB-839) in Combination With Palbociclib in Patients With Solid Tumors

NSCLC | Solid Tumors | KRAS Gene Mutation | CRC

United States
Medical University of Graz

Completed

NFAT-regulated Gene Expression After Tacrolimus

NFAT Regulated Gene Expression in Tacrolimus Treated Patients

Austria
Radboud University Medical Center

Unknown

Patient Empowerment by Group Medical Consultations (GMC)

Breast Cancer | BRCA Mutation

Netherlands
Karen-Lise Garm Spindler

Completed

OPTImal PALliative Anti-epidermal Growth Factor Receptor Treatment in Metastatic Colorectal Cancer - (OPTIPAL-II)

Colorectal Cancer Metastatic | KRAS Gene Mutation | Circulating Tumor DNA | BRAF Gene Mutation | NRAS Gene Mutation | Epidermal Growth Factor Receptor Inhibitor

Denmark
Indonesia University
Dr Cipto Mangunkusumo General Hospital

Completed

The Differences of Oocyte Maturation, Granulosa Cell Apoptosis Index Between Electroacupuncture And Sham Groups IVF

in Vitro Fertilization | Acupuncture | Oocyte Maturation | BCL2 Gene mRNA Overexpression

Indonesia
Charite University, Berlin, Germany

Unknown

RM-493 Treatment Trial in Proopiomelanocortin (POMC) Deficient Patients

Homozygous or Compound Heterozygous POMC, LEPR or PCSK1 Gene Mutation

Germany
Pharming Technologies B.V.
Laboratory Corporation of America; CMIC Co, Ltd. Japan; Axial Biotech, Inc

Recruiting

An Open-Label Study to Assess the Safety & Efficacy of Leniolisib in Japanese Patients With APDS

APDS Gene Mutation

Japan
Bayer

Recruiting

Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body (ON-TRK)

Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion

United States, Austria, Denmark, Germany, Italy, Norway, Spain, United Kingdom, Brazil, Russian Federation, Switzerland, Taiwan, Canada, China, Australia, Greece, Belgium, Sweden, Korea, Republic of, France, Argentina, Finland, Ireland and more
Bayer

Completed

Study to Assess on a Molecular Level the Influence of a 5 % Dexpanthenol Ointment in Subjects With Superficial Injuries

Wound Healing | Gene Expression | Cell Proliferation

Germany
University of Texas Southwestern Medical Center

Completed

Prospective Registry Trial for Single Port Robot-assisted Nipple Sparing Mastectomy (SPrNSM) (SPrNSM)

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage IA Breast Cancer AJCC v8 | Anatomic Stage IB Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Anatomic Stage IIB Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Prognostic... and other conditions

United States
Idience Co., Ltd.

Active, not recruiting

Basket Trial of IDX-1197, a PARP Inhibitor, in Patients With HRR Mutated Solid Tumors (VASTUS) (VASTUS)

Solid Tumors | Homologous Recombination Deficiency | Homologous Recombination Repair Gene Mutation

Korea, Republic of
Jiangsu vcare pharmaceutical technology co., LTD

Completed

Food Effect Study on the Pharmacokinetics of VC004 Capsules in Healthy Adult Subjects

Locally Advanced or Metastatic Solid Tumor Harboring an NTRK Gene Fusion

China
University of Eastern Finland
DSM Nutritional Products, Inc.

Completed

Efficiency of Vitamin D3 and 25-hydroxyvitamin D3 on Transcriptomic Changes of Low Vitamin D Responders (VitDHiD)

Vitamin D Receptor Target Gene Expression | Serum 25(OH)D Concentration

Finland
M.D. Anderson Cancer Center
Syndax Pharmaceuticals

Not yet recruiting

A Phase II Study of the Menin Inhibitor Revumenib in Leukemia Associated With Upregulation of HOX Genes

Leukemia | HOX Gene

United States
Hospital Erasto Gaertner
AstraZeneca

Completed

Frequency of EGFR and KRAS Mutations and Clinical-prognostic Correlation in Brazilian Lung Cancer Patients

Lung Neoplasms | KRAS Gene Mutation | EGFR Gene Mutation

Brazil
Centre Francois Baclesse
GFPC

Recruiting

A Study Evaluating Platinum-Pemetrexed-Atezolizumab (+/-Bevacizumab) for Patients With Stage IIIB/IV Non-squamous Non-small Cell Lung Cancer With EGFR Mutations, ALK Rearrangement or ROS1 Fusion Progressing After Targeted Therapies (GFPC 06-2018)

ALK Gene Rearrangement Positive | NSCLC Stage IV | NSCLC Stage IIIB | EGFR Gene Mutation | ROS1 Gene Mutation

France
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Durvalumab and Tremelimumab in Treating Patients With Microsatellite Stable Metastatic Colorectal Cancer to the Liver

MLH1 Gene Mutation | Stage IV Colorectal Cancer | Stage IVA Colorectal Cancer | Stage IVB Colorectal Cancer | Metastatic Carcinoma in the Liver | MSH6 Gene Mutation | PMS2 Gene Mutation

United States
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

PREDICTION OF GERMLINE BRCA 1/2 GENES FROM HEALTHY OVARIES

Ovarian Cancer | Ultrasound Therapy; Complications | BRCA Mutation

Italy
Yale University
National Institute on Drug Abuse (NIDA)

Completed

Pharmacogenetics of Cannabinoid Response

COMT Gene Polymorphism

United States
Arog Pharmaceuticals, Inc.

Available

Individual Patient Compassionate Use of Crenolanib

FLT3-ITD Mutation | FLT3/TKD Mutation | PDGFR-Alpha D842V | PDGFRA Gene Amplification

Italy
Assiut University
principle investigator

Not yet recruiting

Partial PTEN Deletion in Breast Cancer

PTEN Gene Deletion
Penn State University

Completed

Temporal Genomics Mechanisms Underlying Disease and Aging

Gene Expression in Response to Acute Stress

United States
University of Eastern Finland

Completed

The Effect of a High-dose Oral Vitamin D3 Bolus on Serum 25(OH)D3 and Vitamin D Receptor Target Gene Expression (VitDbol)

Vitamin D Receptor Target Gene Expression | Serum 25(OH)D Concentration

Finland
AbbVie

Completed

A Study to Evaluate the Safety, Pharmacokinetics and Oral Bio Availability of Veliparib in Subjects With Solid Tumors

Oncology | High Grade Serous Ovarian Cancer | BRCA Mutated | BRCA Mutated Breast Cancer

Clinical Trials on Genes, BRCA1

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