Clinical Trials on Genes, BRCA1

Total 766 results

Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

PREDICTION OF GERMLINE BRCA 1/2 GENES FROM HEALTHY OVARIES

Ovarian Cancer | Ultrasound Therapy; Complications | BRCA Mutation

Italy
AbbVie

Completed

A Study to Evaluate the Safety, Pharmacokinetics and Oral Bio Availability of Veliparib in Subjects With Solid Tumors

Oncology | High Grade Serous Ovarian Cancer | BRCA Mutated | BRCA Mutated Breast Cancer
Yale University
National Institute on Drug Abuse (NIDA)

Completed

Pharmacogenetics of Cannabinoid Response

COMT Gene Polymorphism

United States
Arog Pharmaceuticals, Inc.

Available

Individual Patient Compassionate Use of Crenolanib

FLT3-ITD Mutation | FLT3/TKD Mutation | PDGFR-Alpha D842V | PDGFRA Gene Amplification

Italy
Jiangsu Simcere Pharmaceutical Co., Ltd.

Recruiting

An Open Label, Multi-center, Phase I Clinical Study to Evaluate the Safety, Effectiveness and Pharmacokinetic Characteristics of SIM1803-1A in Patients With Locally Advanced/Metastatic Solid Tumors With NTRK, ROS1 or ALK Gene Fusion Mutations.

Advanced or Metastatic Solid Tumors With NTRK, ROS1 or ALK Gene Fusion

China
St Vincent's Hospital, Sydney

Terminated

Activity of Seviteronel in Patients With Androgen Receptor (AR)-Positive Glioblastoma (START)

Solid Tumor | Androgen Receptor Gene Overexpression

Australia
University of Utah

Terminated

Allogeneic Stem Cell Transplantation for Multiple Myeloma and Myelofibrosis

Primary Myelofibrosis | Anemia | Thrombocytopenia | Plasma Cell Myeloma | Recurrent Plasma Cell Myeloma | IDH2 Gene Mutation | IDH1 Gene Mutation | Secondary Myelofibrosis | ASXL1 Gene Mutation | EZH2 Gene Mutation

United States
Amina Fouad Farag

Completed

Polymorphisms in ENAM, AMBN, and KLK4 Contribute to DCS.

Dental Caries Secondary to Polymorphisms | Polymorphisms in Enamel Encoding Genes

Egypt
University Medical Centre Ljubljana
University of Ljubljana, Faculty of Medicine; National Institute of Chemistry... and other collaborators

Completed

Genotype-phenotype Correlations in Children and Adults With CTNNB1 Mutation (Gen-Phe CTNNB1)

CTNNB1 Gene Mutation

Slovenia, Australia
Ege University

Completed

TGFB1 And LAMA1 Gene Polymorphisms in High Myopia

High Myopia | Gene Mutations
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Olaparib in Treating Patients With Newly Diagnosed BRCA-Mutant Ovarian, Primary Peritoneal, or Fallopian Cancer Before Surgery

BRCA1 Gene Mutation | BRCA2 Gene Mutation | Primary Peritoneal High Grade Serous Adenocarcinoma | Stage III Fallopian Tube Cancer AJCC v8 | Stage III Ovarian Cancer AJCC v8 | Stage III Primary Peritoneal Cancer AJCC v8 | Stage IIIA Fallopian Tube Cancer AJCC v8 | Stage IIIA Ovarian Cancer AJCC v8 | Stage... and other conditions

United States
University of Washington
National Cancer Institute (NCI)

Completed

Veliparib, Cisplatin, and Vinorelbine Ditartrate in Treating Patients With Recurrent and/or Metastatic Breast Cancer

Male Breast Cancer | Stage IV Breast Cancer | Triple-negative Breast Cancer | Recurrent Breast Cancer | Estrogen Receptor-negative Breast Cancer | Progesterone Receptor-negative Breast Cancer | HER2-negative Breast Cancer | Hereditary Breast/Ovarian Cancer - BRCA1 | Hereditary Breast/Ovarian Cancer...

United States
Children's Healthcare of Atlanta
Emory University; Brigham and Women's Hospital; University of California, San... and other collaborators

Withdrawn

Genes Mutation Pentalogy of Cantrell

Pentalogy of Cantrell | Mutations in Non-muscle Genes

United States
Spanish Lung Cancer Group

Terminated

Study to Evaluate Treatment Customized According to RAP80 and BRCA1 in Patients With Advanced Lung Carcinoma (BREC)

Non Small Cell Lung Cancer | BRCA1 Mutation

Spain
Peking University People's Hospital
Jiangsu Hengrui Pharmaceutical Co., Ltd.

Enrolling by invitation

Neoadjuvant Fluzoparib Combined With Camrelizumab in Germline BRCA-mutated HER2-negative Breast Cancer

Germline BRCA-mutated HER2-negative Breast Cancer

China
San Raffaele University
Unita' di Gastroenterologia - Policlinico Universitario di Bari; Unita' di... and other collaborators

Recruiting

Videocapsule Endoscopy in Lynch Syndrome

Lynch Syndrome | MLH1 Gene Mutation | MSH2 Gene Mutation | MSH6 Gene Mutation | PMS2 Gene Mutation | Lynch Syndrome II | Small Bowel Adenocarcinoma | Lynch Syndrome I

Italy
University of Chicago
Novartis

Terminated

BGJ398 in Treating Patients With FGFR Positive Recurrent Head and Neck Cancer

Head and Neck Squamous Cell Carcinoma | Recurrent Head and Neck Carcinoma | Human Papillomavirus Infection | Recurrent Oropharyngeal Squamous Cell Carcinoma | FGFR Gene Amplification | FGFR1 Gene Amplification | FGFR2 Gene Amplification | FGFR2 Gene Mutation | FGFR3 Gene Mutation | Recurrent Nasopharynx...

United States
HaoxuanZhang

Recruiting

Correlation Between Microbial Infection and Lumbar Degenerative Disease Based on High-throughput Gene Sequencing

Gene Product Sequence Variation | Lumbar Degenerative Diseases

China
Arog Pharmaceuticals, Inc.
Centre Leon Berard; Fox Chase Cancer Center

Unknown

Randomized Trial of Crenolanib in Subjects With D842V Mutated GIST

GIST With D842V Mutated PDGFRA Gene

United States, France, Spain, Italy, Germany, Norway, Poland
Betta Pharmaceuticals Co., Ltd.

Unknown

X-396 Capsule in Advanced NSCLC Patients With ROS1 Gene Rearrangement

Lung Cancer | ROS1 Gene Rearrangement

China
Azienda Socio Sanitaria Territoriale degli Spedali...

Recruiting

Quality of Sexual Function in BRCA Mutated Women (BRCA_SFQ28)

Sexual Dysfunction | Sexual Dysfunctions, Psychological | Sexual Dysfunction, Physiological | BRCA Mutation

Italy
Sohag University

Completed

Irisin Expression and Gene Polymorphism in Type II Diabetic Patients With and Without CAD (CAD)

Irisin Gene Polymorphism in Type II Diabetic Patients

Egypt
Inonu University
Anadolu University

Active, not recruiting

Inflammatory and Anti-Inflammatory Gene Expressions in Liver Transplant Patients

Infections | Immune Response | Liver Transplant; Complications | Gene Amplification

Turkey
University Hospital Inselspital, Berne
University of Zurich; University Hospital Muenster

Completed

Genetic Polymorphism of the Androgen Receptor-Gene and Sexual Function in Middle Aged Women (CAG-Libido)

Polymorphism, Genetic | Libido | Receptors, Androgen | Androgen Effect

Switzerland
Memorial Sloan Kettering Cancer Center

Completed

A Study of Mirdametinib on Its Own or in Combination With Fulvestrant in People With Solid Tumor Cancer

Breast Cancer | Metastatic Breast Cancer | Breast Cancer Stage IV | Solid Carcinoma | HER2-negative Breast Cancer | MEK1 Gene Mutation | MEK2 Gene Mutation

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Factors Influencing Cascade Testing Among Women With Hereditary Gynecological Cancers and Their Relatives

Breast Carcinoma | Fallopian Tube Carcinoma | Endometrial Carcinoma | Ovarian Carcinoma | Primary Peritoneal Carcinoma | Deleterious CDH1 Gene Mutation | Deleterious DICER1 Gene Mutation | Deleterious SMARCA4 Gene Mutation | Deleterious STK11 Gene Mutation

United States
Nanfang Hospital of Southern Medical University

Recruiting

Cancer-associated Gene Mutations in CML Treatment With TKIs by NGS

Different Gene Between Different TKIs Effection

China
Institut Bergonié

Recruiting

Cancer Risk Assessment in Patients With a Constitutional Alteration of the PTEN Gene (COCO)

PTEN Gene Mutation

France
ETOP IBCSG Partners Foundation
AstraZeneca

Active, not recruiting

Osimertinib and Locally Ablative Radiotherapy in Patients With Synchronous Oligo-metastatic EGFR Mutant NSCLC (STEREO) (STEREO)

NSCLC Stage IV | EGFR Gene Mutation

Singapore, Sweden, Korea, Republic of, Spain, Switzerland, Netherlands, Italy, Poland
Rigshospitalet, Denmark

Unknown

Clinical Importance of Carrier Status of Recessive Gene Mutations in Myopathy (CICS) (CICS)

Recessive Gene Myopathies

Denmark
Calithera Biosciences, Inc

Terminated

KEAPSAKE: A Study of Telaglenastat (CB-839) With Standard-of-Care Chemoimmunotherapy in 1L KEAP1/NRF2-Mutated, Nonsquamous NSCLC (KEAPSAKE)

Non-Small Cell Lung Cancer | Non-squamous Non-small-cell Lung Cancer | Non-Squamous Non-Small Cell Neoplasm of Lung | KEAP1 Gene Mutation | NRF2 Gene Mutation | NFE2L2 Gene Mutation

United States
Henan Cancer Hospital

Recruiting

Study of CT and MR in the Lung Cancer

MRI | Genes | Response | Lung Cancer Squamous Cell | CT

China
Second Affiliated Hospital of Guangzhou Medical...
Sun Yat-sen University; The First Affiliated Hospital of Guangzhou Medical...

Recruiting

iCAGES-guided Precision Therapy for Cancers in Contrast to Standard Care or IHC-guided Theray

Cancer | Lung Cancer | Gene Product Sequence Variation | Gene Abnormality

China
Institut Claudius Regaud

Recruiting

Study for Characterisation of Predictive Parameters of Clonal Evolution in Subjects With GATA2 Germline Mutation (GATA-2)

GATA2 Gene Mutation

France
Shandong University

Completed

Gene Expression Profiling in Human Gastric Intestinal Metaplasia Mucosa and Duodenal Mucosa

Gastric Intestinal Metaplasia | Gene Expression Profiling | Duodenum

China
AstraZeneca
Merck Sharp & Dohme LLC; Myriad Genetic Laboratories, Inc.

Completed

Olaparib in gBRCA Mutated Pancreatic Cancer Whose Disease Has Not Progressed on First Line Platinum-Based Chemotherapy (POLO)

Metastatic Adenocarcinoma of the Pancreas | Germline BRCA1/2 Mutations and

United States, France, Italy, Spain, United Kingdom, Belgium, Canada, Germany, Korea, Republic of, Australia, Israel, Netherlands
Indiana University
Breast Cancer Research Foundation

Withdrawn

Breast Cancer BRCA1 Carriers: a Pilot Study

High-grade Serous Ovarian Cancer | BRCA1 Mutation | TNBC - Triple-Negative Breast Cancer

United States
Sheffield Children's NHS Foundation Trust

Withdrawn

Gene Expression Profiles in CML Non-responders

Gene Expression Profiles in CML Non-responders

United Kingdom
Yuhan Corporation

Active, not recruiting

Clinical Trial of YH25448 in Patients With EGFR Mutation Positive Advanced NSCLC

EGFR Gene Mutation

Korea, Republic of
Cervesi Hospital, Cattolica, Italy

Unknown

Genomic DNA in Human Blastocoele Fluid

Chromosomal Aneuploidies | Single Gene Desease

Italy
Assistance Publique Hopitaux De Marseille

Unknown

Does Chemotherapy Train the Mutation of the Pig-A Gene? (PIGA)

Breast Cancer Female

France
Sheba Medical Center
AstraZeneca

Suspended

Osimertinib for NSCLC With Uncommon EGFR Mutations (UNICORN)

Carcinoma, Non-Small-Cell Lung | Genes, erbB-1

Israel
Recursion Pharmaceuticals Inc.

Recruiting

A Study of REC-4881 in Participants With Cancers Which Have an AXIN1 or APC Mutation

Solid Tumor | APC Gene Mutation | AXIN1 Gene Mutation

United States
Pamela Munster
QuantumLeap Healthcare Collaborative

Terminated

Study of BMN-673 With Carboplatin and Paclitaxel in Patients With Advanced BRCA-mutated Solid Tumor or Triple Negative Metastatic Breast Cancer

Triple Negative Metastatic Breast Cancer | BRCA-mutated Solid Tumor

United States
National University of Malaysia

Recruiting

GREM1, HAS2 and PTGS2 Gene Expression Following the in Vitro Maturation (IVM)

in Vitro Maturation | Cumulus Cell | Increased Oocyte Death | GREM1 Gene Mutation

Malaysia
Assiut University

Unknown

PCM1-JAK2 in Therapy Related Neoplasms

Detection of PCM1-JAK2 Fusion Gene by FISH in the Two Types of t-MDS/AML and Relationship Between PCM1-JAK2 Fusion Gene and Cumulative Dose, Dose Intensity
Ikena Oncology

Recruiting

Oral TEAD Inhibitor Targeting the Hippo Pathway in Subjects With Advanced Solid Tumors

Solid Tumor | Solid Tumors, Adult | Malignant Pleural Mesothelioma (MPM) | Epithelioid Hemangioendothelioma (EHE) | NF2 Deficient Mesothelioma | Other NF2 Deficient Solid Tumors and Solid Tumors With YAP1/TAZ Fusion Genes | NF2 Deficiency | YAP1 or TAZ Gene Fusions

United States, United Kingdom
The First Hospital of Jilin University

Recruiting

Effects of Different Genetic Mutations on Prognosis in sMPLC Adenocarcinoma Patients

Gene Mutation

China
Bayer

Completed

An Observational Study to Learn More About NTRK Gene Fusion Positive in Solid Tumor in Japan

Advanced or Recurrent Solid Tumor Harboring an NTRK Gene Fusion

Japan
Aristotle University Of Thessaloniki

Completed

Androgen Receptor mRNA Expression is Positively Associated With Live Birth in Women Undergoing IVF Independently of the Type of Ovarian Response

Poor Ovarian Response | Androgen Receptor Gene Overexpression | Normal Responders | Bologna Criteria

Clinical Trials on Genes, BRCA1

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