Clinical Trials on Health Care Decision Making in South Africa

Total 1320 results

Tenaya Therapeutics
Medical University of South Carolina; Johns Hopkins University; University of... and other collaborators

Recruiting

Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) (RIDGE)

Arrhythmogenic Right Ventricular Cardiomyopathy

United States, Italy, United Kingdom, France, Sweden, Germany
GlaxoSmithKline

Completed

A Study to Evaluate the Safety of 12 Weeks of Dosing With GW856553 and Its Effects on Inflammatory Markers, Infarct Size, and Cardiac Function in Subjects With Myocardial Infarction Without ST-segment Elevation (Solstice)

Acute Coronary Syndrome

United States, Netherlands, Canada, Germany, Australia, United Kingdom, India, Spain, Poland
Aerovate Therapeutics

Recruiting

Inhaled Imatinib Pulmonary Arterial Hypertension Clinical Trial - Follow Up Long Term Extension (IMPAHCT-FUL) (IMPAHCT-FUL)

Pulmonary Arterial Hypertension

United States, Belgium, Italy, Spain, Australia, Canada, China, Singapore, France, United Kingdom, Latvia, Mexico, Argentina, Israel, South Africa, Chile, Poland, Germany, Portugal, Colombia
Pfizer

Recruiting

Safety and Effectiveness of Giroctocogene Fitelparvovec or Fidanacogene Elaparvovec in Patients With Hemophilia A or B Respectively

Hemophilia A | Hemophilia B

Australia, United States, Turkey
Novo Nordisk A/S

Recruiting

A Research Study Looking at Mim8 in Children With Haemophilia A With or Without Inhibitors

Haemophilia A With or Without Inhibitors

India, China, Korea, Republic of, Canada, Spain, Netherlands, South Africa, United States, Israel, Poland, United Kingdom, Italy, Japan, Lithuania, Portugal, Switzerland, Taiwan
Amgen

Completed

Long-term Study of Romiplostim in Thrombocytopenic Pediatric Patients With Immune Thrombocytopenia (ITP)

Immune Thrombocytopenia

United States, Canada, Belgium, Czechia, Mexico, Turkey, Australia, Spain, France, Israel, Hungary, South Africa, Poland, Russian Federation, United Kingdom, Brazil, Switzerland
Ottawa Hospital Research Institute

Enrolling by invitation

Folic Acid Clinical Trial: Follow up of Children (FACT 4 Child)

Death | Asthma | Autism Spectrum Disorder | Pre-Eclampsia | Executive Dysfunction | Emotional Problem | Behavioural Problem

Australia, United Kingdom, Canada, Jamaica
Medtronic Cardiac Rhythm and Heart Failure

Completed

Reducing Decompensation Events Utilizing Intracardiac Pressures in Patients With Chronic Heart Failure (HF) (REDUCEhf) (REDUCEhf)

Heart Failure

United States
Imago BioSciences, Inc., a subsidiary of Merck...

Completed

Bomedemstat (IMG-7289/MK-3543) in Participants With Myelofibrosis (IMG-7289-CTP-102/MK-3543-002)

Myelofibrosis | Primary Myelofibrosis (PMF) | Post-polycythemia Vera Myelofibrosis (PPV-MF) | Post-essential Thrombocythemia Myelofibrosis (PET-MF)

Germany, United States, Australia, Italy, United Kingdom
Mezzion Pharma Co. Ltd
National Heart, Lung, and Blood Institute (NHLBI)

Unknown

A Extension Study of Udenafil in Adolescents (FUELExten)

Functional Single Ventricle Heart Disease

United States, Korea, Republic of, Canada
Ascentage Pharma Group Inc.
Merck Sharp & Dohme LLC

Recruiting

A Study of APG-115 in Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors

Melanoma | P53 Mutation | Uveal Melanoma | Cutaneous Melanoma | Mucosal Melanoma | Malignant Peripheral Nerve Sheath Tumors | MPNST | Unresectable or Metastatic Melanoma or Advanced Solid Tumors | MDM2 Gene Mutation

United States, Australia
Novartis Pharmaceuticals

Completed

Comparison of Sacubitril/Valsartan Versus Enalapril on Effect on NT-proBNP in Patients Stabilized From an Acute Heart Failure Episode. (PIONEER-HF)

Acute Heart Failure

United States
Bayer

Completed

Trial to Evaluate the Efficacy and Safety of a New Full Length Recombinant Human FVIII for Hemophilia A (Leopold I)

Hemophilia A | Blood Coagulation Disorders

Spain, Taiwan, Austria, United States, Germany, Thailand, United Kingdom, Italy, Turkey, Croatia, Serbia, Poland, Israel, Sweden, Indonesia, Argentina, Norway, South Africa, India, Hong Kong, Denmark, Pakistan
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Everolimus in Recipients of Heart Transplants to Prevent Acute and Chronic Rejection

Graft Rejection

United Kingdom, Canada, Taiwan, United States, France, Belgium, Spain, Australia, Germany, New Zealand, Argentina, Italy, Austria, Norway, Puerto Rico
Seoul National University Hospital
Asan Medical Center; Johannes Gutenberg University Mainz; Gyeongsang National... and other collaborators

Active, not recruiting

CoHOrt of Cerebral CavernOus maLformATion: multicEnter Prospective Observational Study (CHOCOOATE)

Intracerebral Hemorrhage | Cerebral Cavernous Malformation

Korea, Republic of
UK Kidney Association

Recruiting

National Registry of Rare Kidney Diseases (RaDaR)

Vasculitis | AL Amyloidosis | Tuberous Sclerosis | Fabry Disease | Cystinuria | Focal Segmental Glomerulosclerosis | IgA Nephropathy | Bartter Syndrome | Pure Red Cell Aplasia | Membranous Nephropathy | Atypical Hemolytic Uremic Syndrome | Autosomal Dominant Polycystic Kidney Disease | Cystinosis | Nephronophthisis | BK Nephropathy and other conditions

United Kingdom
Genzyme, a Sanofi Company

Active, not recruiting

Long-term Safety and Efficacy Study of Fitusiran in Patients With Hemophilia A or B, With or Without Inhibitory Antibodies to Factor VIII or IX (ATLAS-OLE)

Hemophilia

China, Hungary, Turkey, Canada, Korea, Republic of, United States, Australia, Denmark, France, Germany, India, Ireland, Israel, Italy, Japan, Malaysia, South Africa, Taiwan, Ukraine, United Kingdom
LimFlow, Inc.

Completed

PROMISE I Early Feasibility Trial of the LimFlow Stent Graft System

Critical Limb Ischemia | Chronic Limb-Threatening Ischemia

United States
Hoffmann-La Roche

Completed

A Study of Dalcetrapib in Patients Hospitalized For An Acute Coronary Syndrome (Dal-ACUTE)

Coronary Heart Disease

Netherlands, United States, United Kingdom, Czechia
Human Genome Sciences Inc.

Completed

Study of Mapatumumab in Combination With Bortezomib (Velcade) and Bortezomib Alone in Subjects With Relapsed or Refractory Multiple Myeloma

Multiple Myeloma

United States, Canada, Australia, India
ARYx Therapeutics

Unknown

Comparison of ATI-5923, a Novel Vitamin K Antagonist, With Warfarin in Patients Requiring Chronic Anticoagulation (EmbraceAC)

Myocardial Infarction | Atrial Fibrillation | Atrial Flutter | Cardiomyopathy | Venous Thromboembolic Disease

United States
Vascutek Ltd.

Terminated

Vascutek Anaconda™ Abdominal Aortic Aneurysm (AAA) Post-Market Surveillance Registry

Abdominal Aortic Aneurysm

United Kingdom, Australia, New Zealand, Germany, France, Italy, Spain
Hoffmann-La Roche

Completed

Efficacy, Safety, and Tolerability Study of Pirfenidone in Combination With Sildenafil in Participants With Advanced Idiopathic Pulmonary Fibrosis (IPF) and Intermediate or High Probability of Group 3 Pulmonary Hypertension

Idiopathic Pulmonary Fibrosis

Hungary, Belgium, Germany, Netherlands, Italy, Israel, Spain, Canada, South Africa, Turkey, Czechia, Egypt, Greece
Medical University of South Carolina
Ohio State University; University of Texas Southwestern Medical Center; University...

Recruiting

Comparison of 24-hours Versus 72-hours of Octreotide Infusion in Preventing Early Rebleed From Esophageal Varices (LOVARB)

Upper Gastrointestinal Bleeding | Liver Cirrhoses | Esophageal Varices | Bleeding Esophageal Varices

United States
Acceleron Pharma Inc. (a wholly owned subsidiary...

Completed

A Study of Sotatercept for the Treatment of Pulmonary Arterial Hypertension (PAH) (PULSAR)

Pulmonary Arterial Hypertension

Spain, United States, Israel, Australia, Germany, United Kingdom, France, Brazil
Takeda

Completed

Safety and Efficacy of TAK-442 in Subjects With Acute Coronary Syndromes

Acute Coronary Syndrome

United States, Belgium, Germany, Bulgaria, India, South Africa, Netherlands, Korea, Republic of, Canada, Chile, Peru, Russian Federation, Argentina, Hungary, Romania, Brazil, Estonia, Serbia, United Kingdom
Novartis Pharmaceuticals

Completed

Safety of Repeat Doses of IV Serelaxin in Subjects With Chronic Heart Failure (RELAX-REPEAT)

Chronic Heart Failure

Germany, United States, Spain, Italy, Norway, Netherlands, Turkey, Russian Federation, Sweden, Finland, Czech Republic, Romania, Australia
Pfizer

Recruiting

Open-Label Extension Study of Marstacimab in Hemophilia Participants With or Without Inhibitors

Hemophilia A | Hemophilia B

Hong Kong, Spain, Serbia, Turkey, United States, China, Mexico, South Africa, India, Japan, Croatia, Korea, Republic of, Oman, Taiwan, Italy, Canada, France
Abbott Medical Devices

Completed

Left Atrial Pressure Monitoring to Optimize Heart Failure Therapy (LAPTOP-HF)

Heart Failure

United States, New Zealand
Boehringer Ingelheim

Completed

Open Label Study Telmisartan and Amlodipine in Hypertension

Hypertension

Belgium, Canada, Denmark, Finland, France, Korea, Republic of, Netherlands, Norway, Philippines, South Africa, Sweden, Taiwan
Bioverativ Therapeutics Inc.
Swedish Orphan Biovitrum

Completed

Study to Evaluate the Safety, Pharmacokinetics and Efficacy of Recombinant Factor VIII Fc Fusion Protein (rFVIIIFc) in Previously Treated Subjects With Severe Hemophilia A

Severe Hemophilia A

United States, United Kingdom, Spain, Hong Kong, Israel, New Zealand, Sweden, Australia, Brazil, Japan, Austria, Belgium, Italy, India, Switzerland, Canada, France, Germany, South Africa
Lantheus Medical Imaging

Completed

A Trial to Determine Radiation Exposure to Organs and Assess the Safety of CARDIOLITE® in Pediatric Subjects

Kawasaki Disease

United States, Taiwan, Canada
Astellas Pharma Europe B.V.

Completed

Study Evaluating Safety, Tolerability and Efficacy of YM150 in Subjects With Acute Coronary Syndromes (RUBY-1)

Acute Coronary Syndrome

Poland, Colombia, Germany, Korea, Republic of, South Africa, Czech Republic, Netherlands, Hungary, Russian Federation, Mexico, Romania, Argentina, Ukraine, Denmark, Slovakia, Belgium, India, Brazil, Australia, Canada, France
Ottawa Hospital Research Institute
Canadian Institutes of Health Research (CIHR)

Completed

High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention (FACT)

Pregnancy Complications | Preeclampsia

Canada, United Kingdom, Argentina, Australia, Jamaica
Millennium Pharmaceuticals, Inc.

Completed

Phase 2 Study to Evaluate the Oral Combination of Ixazomib (MLN9708) With Cyclophosphamide and Dexamethasone in Patients With Newly Diagnosed or Relapsed and/or Refractory Multiple Myeloma

Multiple Myeloma

United States, Poland, Greece, Australia, Sweden
ReCode Therapeutics

Recruiting

Study Evaluating the Safety and Tolerability of RCT1100 in Healthy and PCD Subjects

Primary Ciliary Dyskinesia

United Kingdom, United States, Australia, New Zealand
MedImmune LLC

Completed

A Study to Evaluate the Immunogenicity of Quadrivalent Live Attenuated Influenza Vaccine (LAIV) in Children (LAIV)

Healthy or Stable Chronic Illness

United States
Seagen Inc.
Genentech, Inc.

Completed

Study of SGN-40, Lenalidomide, and Dexamethasone in Patients With Multiple Myeloma

Multiple Myeloma

United States
Alaunos Therapeutics

Unknown

A Phase II Trial of ZIO-101 in Advanced Multiple Myeloma: Protocol SGL2001b

Multiple Myeloma

United States
Xcyte Therapies

Completed

Xcellerated T CellsTM in Patients With Multiple Myeloma

Multiple Myeloma

United States
Novartis Pharmaceuticals

Completed

Pharmacokinetic Effects of QTI571 on Sildenafil and Bosentan in Pulmonary Arterial Hypertension Participants

Pulmonary Arterial Hypertension

Germany, Belgium, United States, Lithuania, United Kingdom, Italy, Australia
Bayer

Completed

A Trial to Compare Prophylaxis Therapy to On-demand Therapy With a New Full Length Recombinant FVIII in Patients With Severe Hemophilia A (Leopold II)

Hemophilia A

China, United States, Ukraine, Taiwan, Mexico, Thailand, Romania, Colombia, Turkey, Serbia, Russian Federation, South Africa, Japan, Indonesia, Argentina, Czech Republic, India, Slovakia
Abbott Medical Devices

Completed

AMPLATZER Duct Occluder II Clinical Study (ADO II)

Patent Ductus Arteriosus

United States
Sanofi Pasteur, a Sanofi Company

Completed

Immunogenicity and Safety of a Quadrivalent Meningococcal Conjugate Vaccine When Administered Concomitantly With Routine Pediatric Vaccines in Healthy Infants and Toddlers in the US

Healthy Volunteers (Meningococcal Infection)

United States, Puerto Rico
United Therapeutics

Active, not recruiting

ADAPT - A Patient Registry of the Real-world Use of Orenitram® (ADAPT)

Pulmonary Arterial Hypertension

United States
Kaiser Permanente

Completed

Electronic Support for Pulmonary Embolism Emergency Disposition (eSPEED)

Pulmonary Embolism

United States
Bayer

Completed

A Trial to Study Neladenoson Bialanate Over 20 Weeks in Patients With Chronic Heart Failure With Reduced Ejection Fraction (PANTHEON)

Heart Failure

United States, Israel, Spain, Poland, Japan, Italy, Belgium, Bulgaria, Germany, Greece, Netherlands
Novartis Pharmaceuticals

Completed

Extension Study of Efficacy and Safety of LTP001 in Pulmonary Arterial Hypertension Participants

Pulmonary Arterial Hypertension

Spain, Germany, Poland, United Kingdom, Netherlands, Argentina, United States
Bayer

Completed

A Trial to Study Neladenoson Bialanate Over 20 Weeks in Patients With Chronic Heart Failure With Preserved Ejection Fraction (PANACHE)

Heart Failure

United States, Spain, Israel, Belgium, Japan, Italy, Austria, Bulgaria, Germany, Greece, Poland, Portugal
Novartis Pharmaceuticals

Completed

Efficacy, Safety and Tolerability of Serelaxin When Added to Standard Therapy in AHF (RELAX-AHF-2)

Acute Heart Failure

Germany, United States, Colombia, Romania, South Africa, Italy, Austria, Belgium, Czechia, Hungary, Turkey, United Kingdom, Switzerland, Australia, France, Israel, Netherlands, Sweden, Spain, Argentina, Bulgaria, Ireland, Denmark, Mexico and more

Clinical Trials on Health Care Decision Making in South Africa

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