Clinical Trials on Healthy, Hepatic Insufficiency in United Kingdom

Total 12895 results

Pfizer

Completed

A Study To Describe The Effect Of Impaired Hepatic Function Of The Pharmacokinetics Of Palbociclib

Healthy, Hepatic Insufficiency

United States
BeiGene

Completed

Safety and Pharmacokinetics of Zanubrutinib (BGB-3111) in Healthy Subjects and Those With Impaired Liver Function

Hepatic Insufficiency & Healthy Subjects

United States
Javelin Pharmaceuticals

Completed

Open-Label, Single-Dose Study to Evaluate the Safety and PK of DIC075V in Subjects With Renal Insufficiency and Hepatic Impairment Compared to Healthy Subjects and Evaluate the Safety and Pharmacokinetics of HPβCD When Administered in DIC075V Compared to Sporanox® in Healthy Subjects

Hepatic Insufficiency | Healthy | Renal Insufficiency, Chronic

United States, United Kingdom
Acerta Pharma BV
AstraZeneca

Completed

Investigate the Influence of Severe Hepatic Impairment on the Pharmacokinetics of Acalabrutinib and Its Metabolite

Hepatic Insufficiency | Healthy Subjects | Hepatic Impairment

United States
University of Edinburgh
NHS Lothian; European Society of Organ Transplantation

Completed

Liver Transplantation and Reticuloendothelial Clearance Capacity

Hepatic Insufficiency | Liver Insufficiency

United Kingdom
Imperial College London

Completed

A Phase I/II Safety and Tolerability Dose Escalation Study of Autologous Stem Cells to Patients With Liver Insufficiency

Liver Disease

United Kingdom
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study of Canagliflozin in Study Participants With Various Degrees of Impaired Hepatic (Liver) Function

Hepatic Insufficiency | Healthy

United States
Boehringer Ingelheim

Completed

A Study to Test How Different Doses of BI 685509 Are Tolerated in Patients With Liver Problems

Hepatic Insufficiency | Healthy

United States
Eli Lilly and Company

Completed

A Study of Imlunestrant (LY3484356) in Female Participants With Impaired Liver Function

Hepatic Insufficiency | Healthy

United States
Eli Lilly and Company

Recruiting

A Study of LY3437943 in Participants With Impaired and Normal Liver Function

Hepatic Insufficiency | Healthy

United States
Eli Lilly and Company

Recruiting

A Study of LY3502970 in Participants With Impaired and Normal Liver Function

Hepatic Insufficiency | Healthy

United States
University of Edinburgh
NHS Lothian

Unknown

The Relationship of Initial Liver Profile and Outcome After Transplantation

Liver Failure

United Kingdom
Eli Lilly and Company
Loxo Oncology, Inc.

Completed

Study of Pirtobrutinib (LOXO-305) in Participants With Impaired Liver Function and Healthy Participants

Hepatic Insufficiency | Healthy

United States
Imperial College London

Completed

Adult Stem Cell Therapy in Liver Insufficiency

Liver Cirrhosis

United Kingdom
Imperial College London

Completed

Brain Muscle Axis During Treatment of Hepatic Encephalopathy With L-ornithine L-aspartate

Hepatic Encephalopathy | Cirrhosis | Minimal Hepatic Encephalopathy

United Kingdom
Norgine

Completed

Real World Outcomes Study of Hepatic Encephalopathy Patients' Experience on Rifaximin (PROSPER) (PROSPER)

Hepatic Encephalopathy

United Kingdom
University of Leeds
The Leeds Teaching Hospitals NHS Trust; University of Sheffield

Unknown

Hepatectomy Risk Assessment With Functional Magnetic Resonance Imaging (HEPARIM)

Liver Failure | Hepatectomy | Liver Metastases | Liver Cancer

United Kingdom
Guy's and St Thomas' NHS Foundation Trust
King's College London

Completed

Safety and Efficacy Study of Regulatory T Cell Therapy in Liver Transplant Patients (ThRIL)

End-stage Liver Disease

United Kingdom
Quell Therapeutics Limited

Recruiting

Safety and Clinical Activity of QEL-001 in A2-mismatch Liver Transplant Patients (LIBERATE)

Liver Diseases | Liver Failure | Rejection; Transplant, Liver

Belgium, United Kingdom, Spain
Rigshospitalet, Denmark

Completed

A Study of the Effect of Plasmaexchange in Patients With Acute Liver Failure

Acute Liver Failure

Denmark, Finland, United Kingdom
Novartis Pharmaceuticals

Completed

Pharmacokinetic Study of Icenticaftor in Participants With Hepatic Impairment

Hepatic Failure

United States
Biotie Therapies Inc.
Acorda Therapeutics

Terminated

Study to Investigate the Influence of Hepatic Insufficiency on the Pharmacokinetics of Tozadenant

Hepatic Impairment

United States
Pfizer
Medivation, Inc.

Completed

Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [Pf-01913539] In Subjects With Hepatic Impairment And Normal Hepatic Function

Hepatic Failure

United States
Atea Pharmaceuticals, Inc.

Recruiting

Study of Bemnifosbuvir in Subjects With Normal and Impaired Hepatic Function

Hepatic Impairment | Healthy Volunteer

United States
Eli Lilly and Company
Loxo Oncology, Inc.

Completed

A Study of Effects of Selpercatinib in Hepatically Impaired Participants and Healthy Participants

Healthy | Hepatic Impairment

United States
Imperial College London
University of London; Royal College of Physicians; Paddington Charitable Estates...

Completed

Brain Imaging in Patients With Chronic Liver Disease and Functional Impairment.

Hepatic Encephalopathy | Cirrhosis

United Kingdom
Alexion

Recruiting

Study of ALXN2050 in Participants With Hepatic Impairment

Healthy | Impaired Hepatic Function

United States
Pfizer

Recruiting

A Study to Learn About the Study Medicine (Called Lorlatinib) in People With Liver Dysfunction

Healthy Volunteers | Moderate Hepatic Impairment | Severe Hepatic Impairment

United States
King's College Hospital NHS Trust
King's College London

Completed

Randomised Controlled Trial of Mechanistic Effects of Rifaximin in Cirrhosis and Chronic Hepatic Encephalopathy (RIFSYS)

Liver Cirrhosis | Hepatoencephalopathy, Early Fatal Progressive

United Kingdom
Baylor Research Institute

Completed

Metabolomics of Liver Regeneration Following Partial Hepatectomy in Healthy Living Liver Donors

Liver Insufficiency

United States
UCB Biopharma S.P.R.L.

Terminated

A Pharmacokinetic Study of Padsevonil in Study Participants With Either Normal or Moderately Impaired Hepatic Function

Impaired Hepatic Function | Healthy Study Participants

United States
Tobira Therapeutics, Inc.

Completed

Phase 1 Study of Multiple-Dose Pharmacokinetics of Cenicriviroc in Subjects With Mild and Moderate Hepatic Impairment

Liver Insufficiency

United States
KBP Biosciences
Covance

Completed

Pharmacokinetics of KBP-5074 in Patients With Moderate Hepatic Impairment

Healthy | Moderate Hepatic Impairment

United States
Vital Therapies, Inc.

Completed

Phase 2 Evaluation of the ELAD System in the Management of Acute Liver Failure

Fulminant Hepatic Failure

United States
Pfizer

Completed

A Study To Compare Pharmacokinetics Of Dacomitinib (PF-00299804) Between Healthy Subjects And Subjects With Mild And Moderate Hepatic Impairment

Healthy | Otherwise Healthy Volunteers With Mild or Moderate Hepatic Dysfunction

United States
Vital Therapies, Inc.

Withdrawn

Safety and Efficacy of the Extracorporeal Liver Assist Device (ELAD®) In Patients With Fulminant Hepatic Failure (FHF) (ELAD)

Fulminant Hepatic Failure

United States
Cardiox Corporation

Withdrawn

Cardiox Liver Function Test Pivotal Trial (LFT-0002)

Liver Failure | Hepatic Failure

United States
St George's, University of London
King's College Hospital NHS Trust

Recruiting

S100A8/A9 and Innate Immunity in Liver Disease

Infections | Cirrhosis, Liver | Ascites Hepatic | Immune Suppression | Liver Failure, Acute on Chronic

United Kingdom
The Cleveland Clinic

Active, not recruiting

SVC and Its Relationship to CVP Measurements in Liver Transplantation

Liver Failure

United States
Virginia Commonwealth University

Withdrawn

Hepatocyte Transplantation in Liver Failure

Liver Failure

United States
Veloxis Pharmaceuticals
CTI Clinical Trial and Consulting Services; Aptuit

Completed

Pharmacokinetics of LCP-Tacro™ Once Daily and Prograf® Twice A Day in Adult De Novo Liver Transplant Patients

Liver Failure

United States
Eli Lilly and Company

Completed

A Study of Evacetrapib (LY2484595) in Participants With Hepatic (Liver) Impairment

Hepatic Insufficiency

United States
Debiopharm International SA

Completed

Evaluate the Pharmacokinetics, Safety, and Tolerability of Alisporivir in Subjects With Hepatic Impairment Compared to Healthy Subjects

Hepatic Insufficiency

United States
Pfizer

Completed

A Safety and Tolerability Study of CP-690,550 in Subjects With Hepatic Impairment and Normal Hepatic Function

Hepatic Insufficiency

United States
Merck Sharp & Dohme LLC
Celerion

Completed

The Influence of Hepatic Insufficiency on the Pharmacokinetics of Elbasvir (MK-8742) (MK-8742-009)

Hepatic Insufficiency

United States
Bristol-Myers Squibb

Completed

Hepatic Impaired Subjects Compared to Healthy Subjects Receiving Multi-dose BMS-650032

Hepatic Insufficiency

United States
M.D. Anderson Cancer Center

Unknown

Understanding Patient's Knowledge and Use of Acetaminophen

Liver Failure

United States
Bristol-Myers Squibb

Completed

Single-Dose Pharmacokinetics of BMS-790052 in Participants With Hepatic Impairment

Hepatic Insufficiency

United States
Novartis

Completed

Safety and Pharmacokinetics of Indacaterol in Healthy Subjects and Those With Impaired Liver Function

Hepatic Insufficiency

United States
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Single-Dose Pharmacokinetics and Safety of Oral Lofexidine in Hepatically-Impaired Subjects

Liver Failure

United States

Clinical Trials on Healthy, Hepatic Insufficiency in United Kingdom

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