Clinical Trials on Hedgehog Inhibitor

Total 537 results

Fujian Cancer Hospital

Recruiting

HRQOL in Locally Advanced Thyroid Carcinoma (LATCQOL)

Thyroid Cancer | Health Related Quality of Life | Tyrosine Kinase Inhibitor

China
Hospices Civils de Lyon

Completed

Pre-operative Exposure to SGLT2 Inhibitors and Post-operative Acute Renal Failure in Cardiac Surgery (SGLT2i-PO-AKI)

Acute Kidney Injury | Cardiac Surgery | Sodium/Glucose Cotransporter Inhibitor 2

France
Enzyre B.V.
Instytut Hematologii i Transfuzjologii, Warschau, Poland

Completed

Real-life Clinical FEIBA Samples Measured Using the Version A of the HemA EnzySystem

Hemophilia A | Hemophilia A With Inhibitor

Poland
Swedish Orphan Biovitrum
Cerner Enviza

Completed

rFVIIIFc (Elocta®) ITI Chart Review in Patients With Haemophilia A

Hemophilia A With Inhibitor

France, Ireland, Italy, Norway, Germany, Kuwait, Saudi Arabia, Switzerland
Margaret Ragni
Health Resources and Services Administration (HRSA)

Terminated

The Hemophilia Inhibitor Prevention Trial

Hemophilia A Without Inhibitor

United States
Samsung Changwon Hospital

Unknown

Efficacy of Low Dose Intravenous Proton Pump Inhibitor for Peptic Ulcer Bleeding

Peptic Ulcer | Peptic Ulcer Hemorrhage | Peptic Ulcer, Acute With Hemorrhage | Proton Pump Inhibitor Overdose

Korea, Republic of
Nara Medical University
Shire

Unknown

Basic Study of Combination Therapy Based on APCC-induced FVllI Activation in Hemophilia A Patients With Inhibitors

Hemophilia A With Inhibitor

Japan
Skane University Hospital

Completed

Hemophilia Inhibitor Genetics Study (HIGS)

Hemophilia A With Inhibitor

Sweden
Ewha Womans University Mokdong Hospital

Enrolling by invitation

The Effect of SGLT-2 Inhibitor in Patient With Atrial Fibrillation and Diabetes Mellitus

Diabetes Mellitus, Type 2 | Atrial Fibrillation | SGLT-2 Inhibitor

Korea, Republic of
Haemnet
Roche Chugai

Completed

An Exploration of the Impact of Emicizumab on the Lives of People With Haemophilia and Inhibitors and Their Families (EmiandMe)

Hemophilia A With Inhibitor

United Kingdom
Schülke & Mayr GmbH

Completed

Study to Assess the Inhibition of Plaque Formation in Subjects With a Gingival Index ≤1.5

Inhibition of Plaque Formation (by Gingivitis-Index ≤1.5)

Germany
Schülke & Mayr GmbH

Completed

Study to Assess the Inhibition of Plaque Formation in Subjects With a Gingival Index ≤1.5

Inhibition of Plaque Formation (by Gingivitis-Index ≤1.5)

Austria, Germany
Novo Nordisk A/S

Completed

Survey Evaluating the Psychosocial Effects of Living With Haemophilia (HERO)

Congenital Bleeding Disorder | Haemophilia A With Inhibitors | Haemophilia B With Inhibitors | Haemophilia A | Haemophilia B | Relatives to/Carers of Patients

Spain, Canada, United Kingdom
Novo Nordisk A/S

Completed

Impact of Pain on Functional Impairment and Quality of Life in Adults With Hemophilia

Congenital Bleeding Disorder | Haemophilia A With Inhibitors | Haemophilia B With Inhibitors | Haemophilia A | Haemophilia B

United States
Nir Peled

Not yet recruiting

A Pilot Study to Understand the Impact of Therapy With Tumour Treating Fields (TTFields) in NSCLC

Non Small Cell Lung Cancer | EGFR Gene Mutation | Immune Checkpoint Inhibitor

Israel
Nanfang Hospital of Southern Medical University

Recruiting

Immune Indicator Model for Predicting Efficacy of PD-1 Monoclonal Antibody

Esophageal Squamous Cell Carcinoma | PD-1 Inhibitor

China
Chinese University of Hong Kong
Nanfang Hospital, Southern Medical University

Recruiting

PPI Infusion Versus Oral Acid Pump Inhibitors for Bleeding Peptic Ulcers

Proton Pump Inhibitors | Upper GI Bleeding

China
G.Gennimatas General Hospital
2nd Department of Cardiology, "Attikon" University Hospital, National and...

Not yet recruiting

Dapagliflozin to Prevent Atrial Fibrillation Recurrence After Transcatheter Pulmonary Venous Isolation.

Catheter Ablation | Atrial Fibrillation Recurrent | Sodium-glucose Co-transporter 2 Inhibitors | Pulmonary Venous Isolation

Greece
Susan Smyth

Completed

Early Use of Rosuvastatin in Acute Coronary Syndromes: Targeting Platelet-Leukocyte Interactions

Acute Coronary Syndrome | Angioplasty, Transluminal, Percutaneous Coronary | Hydroxymethylglutaryl-CoA Reductase Inhibitors | Blood Platelets

United States
Novo Nordisk A/S

Completed

Bioequivalence of NovoSeven® and a NovoSeven® Formulation Stable at Room Temperature in Healthy Male Subjects

Healthy | Congenital Bleeding Disorder | Haemophilia A With Inhibitors | Haemophilia B With Inhibitors | Acquired Bleeding Disorder | Acquired Haemophilia | Congenital FVII Deficiency | Glanzmann's Disease

France
West China Second University Hospital

Recruiting

Cardiac Magnetic Resonance Monitoring of Immune Checkpoint Inhibitor-related Cardiotoxicity

Immune Checkpoint Inhibitors, Cardiotoxicity

China
Penn State University

Completed

Brain Mechanisms of Overeating in Children (RO1)

Pediatric Obesity | Inhibition | Decision Making | fMRI

United States
Drexel University
Drexel Coulter Translational Research Partnership Program

Completed

Using Virtual Reality and Sensor Technology to Enhance Outcomes From Treatment for Binge Eating

Binge Eating | Inhibition (Psychology)

United States
Mansoura University

Active, not recruiting

Cardio Renal Effects of SGLT2 Inhibitors Among Lupus Nephritis Patients

Lupus Nephritis | SLE | SGLT2 Inhibitors

Egypt
Mansoura University

Active, not recruiting

SGLT2 Inhibitors Between Reno Protective Effects and Impact on Bone and Mineral Disease Among Lupus Nephritis Patients

Lupus Nephritis | BMD | SGLT2 INHIBITORS

Egypt
Gene Solutions

Recruiting

Analysis of PD-L1, TMB, MSI and ctDNA Dynamics to Predict and Monitor Response to Immunotherapy in Metastatic Cancer.

Breast Cancer | Gastric Cancer | Colorectal Cancer | Non Small Cell Lung Cancer | Advanced Cancer | Liver Cancer | Immune Checkpoint Inhibitor

Vietnam
Affiliated Hospital of Guangdong Medical University

Not yet recruiting

Safety and Efficacy Clinical Study of Severe Hemophilia B Treatment With KL001

Hemophilia B Without Inhibitor
AryoGen Pharmed Co.

Completed

Clinical Trial Comparing a Biosimilar Eptacog Alfa With Novoseven, in Patients With Hemophilia With Inhibitors

Hemophilia A or B With Inhibitor

Iran, Islamic Republic of, Turkey
Grifols Italia S.p.A
Thrombinoscope

Unknown

Thrombin Generation Assay (TGA) as Predictive Test for Haemostatic. Effectiveness of FVIII Concentrates in Haemophiliac A With Inhibitors (PredicTGA)

Severe Hemophilia A With Inhibitor

Italy
Bristol-Myers Squibb

Completed

Dose Finding Confirmation of Atazanavir With Ritonavir and Efavirenz (ATV/RTV + EFV) in Healthy Subjects

HIV Infections | Protease Inhibitor

United States
Bristol-Myers Squibb

Completed

Atazanavir Twice Daily

HIV Infections | Protease Inhibitor

United States
University Ghent
Research Foundation Flanders

Recruiting

The Effect of Cognitive Dual-task Rehabilitation on Arthrogenic Muscle Responses After ACL Reconstruction (AMIRA)

Anterior Cruciate Ligament Reconstruction | ACL Injury | Athrogenic Muscle Responses | Arthrogenic Muscle Inhibition

Belgium
Pfizer

Completed

Study To Evaluate Safety And Tolerability Of Pegaptanib Sodium In Patients With Diabetic Macular Edema

Diabetic Retinopathy | Diabetic Macular Edema | Anti- VGF Inhibitor

Spain, United Kingdom, Finland, Sweden
Peking University Third Hospital

Completed

Stereotactic Body Radiotherapy Combined With PD-1 Blockers for Locally Advanced or Locally Recurrent Pancreatic Cancer

Pancreatic Cancer | Stereotactic Body Radiotherapy | PD-1 Inhibitors

China
Second Affiliated Hospital, School of Medicine,...

Recruiting

Single-center, Prospective Cohort Study of PD-1 Inhibitors on Clinical Outcomes of Carotid Plaques in Tumor Patients

Carotid Artery Plaque | Pd-1 Inhibitors

China
Eli Lilly and Company

Active, not recruiting

A Study of Abemaciclib (LY2835219) With Abiraterone in Men With Prostate Cancer That Has Spread to Other Parts of the Body and is Expected to Respond to Hormonal Treatment (Metastatic Hormone-Sensitive Prostate Cancer) (CYCLONE 3)

Urogenital Neoplasms | Prostatic Neoplasms | Neoplasm Metastasis | Enzyme Inhibitors | Antineoplastic Agents | Hormones | Physiological Effects of Drugs | Antineoplastic Agents, Hormonal | Androgens | Hormones, Hormone Substitutes, and Hormone Antagonists | Abiraterone Acetate | Steroid Synthesis Inhibitors | Cytochrome... and other conditions

China, Canada, France, United States, Australia, Czechia, Hungary, Spain, Germany, Japan, Taiwan, Netherlands, Turkey, Mexico, Belgium, Korea, Republic of, Argentina, Romania, United Kingdom, Italy, Israel, Brazil, Poland, Greece
AstraZeneca

Completed

Safety and Efficacy of AZD4547 in Combination With Fulvestrant vs. Fulvestrant Alone in ER+ Breast Cancer Patients (GLOW)

FGFR Inhibition, Pharmacokinetics, Biomarkers | ER+ Breast Cancer

Czech Republic, Italy, United Kingdom, Hungary, Germany, Romania, Belgium, France
RenJi Hospital

Not yet recruiting

The Effect of Henagliflozin and Metformin on Myocardial Tissue-level Characteristics

Myocardial Fibrosis | Obesity | Type 2 Diabetes | Magnetic Resonance Imaging | Sodium-glucose Co-transporter-2 Inhibitor
Sun Yat-sen University

Recruiting

IC Plus Low-dose Radiation Plus Cadonilimab in LANPC

Nasopharyngeal Carcinoma | Chemotherapy | Radiotherapy | Immune Checkpoint Inhibitor

China
Fifth Affiliated Hospital, Sun Yat-Sen University

Recruiting

Radiotherapy Combined With PD-1 Monoclonal Antibody and Capecitabine in the Treatment of Nasopharyngeal Carcinoma

Nasopharyngeal Carcinoma | Capecitabine | Radiotherapy | PD-1 Inhibitor

China
BioMarin Pharmaceutical

Recruiting

Safety, Tolerability, and Efficacy Study of Valoctocogene Roxaparvovec in Hemophilia A With Active or Prior Inhibitors (GENEr8-INH)

Hemophilia A With Inhibitor | Hemophilia A With Anti Factor VIII

United States, United Kingdom, Taiwan, Israel, Korea, Republic of, South Africa, Brazil, Italy, Germany
Southern Medical University, China

Terminated

Long-Term Renoprotection of Optimal Antiproteinuric Doses of Benazepril and Losartan in Chronic Renal Insufficiency

Disease Progression | Proteinuria | Renal Insufficiency,Chronic | Dose-Response Relationship,Drug | ACE Inhibitor | Angiotensin II Type 1 Receptor Blockers

China
University Hospital, Montpellier

Not yet recruiting

Liver Cancer and Immunotherapy in the Liquid Biopsy Era (LILIPSY)

Hepatocellular Carcinoma | Liquid Biopsy | BCLC Stage B Hepatocellular Carcinoma | BCLC Stage C Hepatocellular Carcinoma | Immune Checkpoint Inhibitor
Fudan University

Recruiting

Toripalimab Based Induction Chemotherapy Followed by De-escalation Protocols in HPV-related OPSCC

Oropharyngeal Carcinoma | Immune Checkpoint Inhibitor | De-escalation

China
Xinrui Zhu

Enrolling by invitation

The Safety and Efficacy of Transarterial Chemoembolization (TACE) + Lenvatinib + Programmed Cell Death Protein 1 (PD-1) Antibody of Advanced Unresectable Hepatocellular Carcinoma

Hepatocellular Carcinoma Non-resectable | Tyrosine Kinase Inhibitor | Transarterial Chemoembolization | Immune Checkpoint Blockade

China
Pfizer

Not yet recruiting

Abrocitinib Taiwan Treatment Pattern and Real World Study in ATopiC Dermatitis (ATTRACT Registry) (ATTRACT)

Skin Diseases | Immune System Diseases | Dermatitis | Eczema | Dermatitis, Atopic | Janus Kinase Inhibitors
Yonsei University
Chong Kun Dang Pharmaceutical Corp.

Unknown

Assessment of Change in Atherosclerotic Plaque by Serial CCTA (ACROSS)

Coronary Artery Disease | Coronary Arteriosclerosis | Hydroxymethylglutaryl-CoA Reductase Inhibitors

Korea, Republic of
Shanghai Chest Hospital

Not yet recruiting

Cardiac Adverse Reactions Related to Immune Checkpoint Inhibitor in NSCLC Patients

Cardiac Event | Immune Checkpoint Inhibitor | Adverse Reactions | Non-Small Cell Lung Cancer Patients
University College, London

Unknown

The Use of Angiotensin Converting Enzyme Inhibitors and Incident Respiratory Infections, Are They Harmful or Protective?

Covid-19, Coronavirus, Angiotensin Converting Enzyme Inhibitors, Influenza, Electronic Health Records, Epidemiology, Comorbidity, Incidence, United Kingdom
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...

Unknown

rFVIIa Prophylaxis in Children With Hemophilia A and Inhibitors (ENJOIH)

Hemophilia A With Inhibitors

United States, Germany, France, Italy, Romania, Spain

Clinical Trials on Hedgehog Inhibitor

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