Clinical Trials on Hepatic Fibrosis

Total 8458 results

Boehringer Ingelheim

Completed

Nintedanib in Volunteers With Hepatic Impairment Compared With Healthy Volunteers

Hepatic Insufficiency

Germany
Bristol-Myers Squibb

Completed

Single-Dose Pharmacokinetics of BMS-790052 in Participants With Hepatic Impairment

Hepatic Insufficiency

United States
Veloxis Pharmaceuticals
CTI Clinical Trial and Consulting Services; Aptuit

Completed

Pharmacokinetics of LCP-Tacro™ Once Daily and Prograf® Twice A Day in Adult De Novo Liver Transplant Patients

Liver Failure

United States
Boehringer Ingelheim

Completed

Study to Determine the Pharmacokinetics on TPV/r in Subjects With Mild and Moderate Hepatic Insufficiency

Hepatic Insufficiency
Baxter Healthcare Corporation
Baxter Innovations GmbH

Completed

Fibrin Sealant VH S/D 500 S-apr in Hepatic Resection

Bleeding (Oozing) in Hepatic Resection

Germany
University Hospital, Gentofte, Copenhagen

Completed

Pharmacokinetics of 9-cis-retinoic Acid (Alitretinoin, Toctino®) in Patients With Hepatic Disease

Hepatic Insufficiency

Denmark
Universitaire Ziekenhuizen KU Leuven

Unknown

Citrate Anticoagulation During MARS Treatment

Liver Failure

Belgium
Novartis

Completed

Safety and Pharmacokinetics of Indacaterol in Healthy Subjects and Those With Impaired Liver Function

Hepatic Insufficiency

United States
Wake Forest University Health Sciences
Mayo Clinic; The University of Texas Health Science Center at San Antonio

Completed

Targeting Pro-Inflammatory Cells in Idiopathic Pulmonary Fibrosis: a Human Trial (IPF)

Idiopathic Pulmonary Fibrosis (IPF)

United States
Kowa Company, Ltd.

Completed

Study of Peretinoin for Suppressing Recurrence of HCV-positive HCC

Hepatic Neoplasm Malignant Recurrent

Japan
Alnylam Pharmaceuticals

Completed

EXPLORE: A Natural History Study of Acute Hepatic Porphyria (AHP)

Acute Hepatic Porphyria

United States, Belgium, Bulgaria, France, Italy, Mexico, Spain, Taiwan, United Kingdom, Netherlands, Korea, Republic of, Switzerland, Czechia, Poland, Finland, Australia, Germany, Israel, Norway, South Africa
Takeda

Recruiting

A Study of TAK-279 in Adults With or Without Liver Damage

Healthy Volunteers | Hepatic Impairment

United States
Novo Nordisk A/S

Recruiting

A Research Study Looking at How a Single Dose of the Study Medicine NNC0194-0499 Behaves in Participants With Reduced Liver Function Compared to Participants With Normal Liver Function

Healthy Volunteers | Hepatic Impairment

Germany, Poland, Slovakia
University Hospital, Lille
Ministry of Health, France

Recruiting

Hepato Biliary Scintigraphy to Assess the Risk of Postoperative Liver Failure Hepatectomies (SCINTIVOL)

Hepatic Insufficiency

France
National Natural Science Foundation of China

Active, not recruiting

A Study on Relationship Between Resected Normal Liver Parenchymal Volume（RNLV）and Post-Hepatectomy Liver Failure (PHLF) (RNLV)

Liver Failure

China
Jiangxi Qingfeng Pharmaceutical Co. Ltd.

Completed

GP681 in Volunteers With Hepatic Impairment Compared With Healthy Volunteers

Healthy Volunteers | Hepatic Impairment

China
Millennium Pharmaceuticals, Inc.

Completed

A Study to Evaluate Pharmacokinetics (PK) and Safety of Oral Mobocertinib in Participants With Moderate or Severe Hepatic Impairment (HI) and Normal Hepatic Function

Healthy Volunteers | Hepatic Impairment

United States
Akdeniz University

Completed

Evaluation of HDL Subfraction Changes and HDL-Associated Enzymes in Liver Failure Patients and Healthy Donors

Liver Failure

Turkey
Pfizer

Completed

A Study to Understand How the Study Medicine (PF-07081532) is Processed in People With Liver Dysfunction

Healthy Volunteers | Hepatic Impairment

United States
Celgene
Impact Biomedicines, Inc., a wholly owned subsidiary of Celgene Corporation

Completed

A Pharmacokinetics and Tolerability Study of Fedratinib in Subjects With Moderate and Severe Hepatic Impairment

Healthy Volunteers | Hepatic Impairment

United States
Hoffmann-La Roche

Completed

A Study to Investigate the Effect of Impaired Hepatic Function on the Pharmacokinetics of Entrectinib in Volunteers With Different Levels of Hepatic Function

Hepatic Insufficiency

Hungary, Czechia, Slovakia
Denovo Biopharma LLC

Completed

A Study of LY2140023 in Hepatically-Impaired Participants

Hepatic Insufficiency

Germany, Hungary
Healthgen Biotechnology Corp.

Completed

A Study of OsrHSA in Adult Healthy Male and Female Volunteers

Ascites Hepatic

United States
Pfizer

Completed

A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of PF-06651600 in Subjects With Hepatic Impairment and Healthy Volunteers

Hepatic Impairment | Healthy Participants

United States
Celgene

Completed

Pharmacogenetics Sampling of the CC-90007-CP-003 Study Cohort

Hepatic Insufficiency

United States
The University of Hong Kong

Unknown

A Prospective Randomized Controlled Trial on the Use of Cerebral Oximetry in Adult Chinese Patients Undergoing Liver Transplantation (LT)

Liver Failure

Hong Kong, China
Washington University School of Medicine
National Institute of General Medical Sciences (NIGMS)

Completed

Alfentanil: Simultaneous Testing Pilot

Evaluate Two Paradigms for Simultaneous Assessment of Hepatic and Intestinal CYP3A

United States
Eli Lilly and Company

Completed

A Study of Abemaciclib in Participants With Varying Degrees of Liver Impairment

Hepatic Insufficiency

United States
Humedics GmbH

Completed

Fast-track LiveR: Study for the Early Identification of Low-risk Patients After Partial Liver Resection by the LiMAx-test

Liver Failure

Germany
University of Edinburgh
NHS Lothian

Unknown

The Relationship of Initial Liver Profile and Outcome After Transplantation

Liver Failure

United Kingdom
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Single-Dose Pharmacokinetics and Safety of Oral Lofexidine in Hepatically-Impaired Subjects

Liver Failure

United States
Stanley Dudrick's Memorial Hospital

Completed

Parenteral Lipid Emulsions and the Liver Function

Liver Failure

Poland
Veloxis Pharmaceuticals
CTI Clinical Trial and Consulting Services

Completed

Pharmacokinetics of LCP-Tacro in Stable Liver Transplant Patients

Liver Failure

United States
University Health Network, Toronto
University of Waterloo

Completed

SPME For Metabolomics And Concomitant Measurements Of Rocuronium Bromide Levels In Liver Transplantation

Liver Failure

Canada
Fundacion para la Formacion e Investigacion Sanitarias...

Completed

Extracorporeal Photopheresis After Liver Transplant

Hepatic Insufficiency

Spain
Boehringer Ingelheim

Completed

Pharmacokinetics, Safety and Tolerability of BIIL 284 BS in Patients With Hepatic Impairment in Comparison to Healthy Volunteers

Hepatic Insufficiency
Boehringer Ingelheim

Completed

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Dabigatran Etexilate in Patients With Moderate Hepatic Impairment Compared to Subjects With Normal Hepatic Function

Hepatic Insufficiency
Pfizer

Completed

Evaluation Of Hepatic Impairment On AG-013736 Pharmacokinetics

Hepatic Insufficiency

United States
Vertex Pharmaceuticals Incorporated

Completed

Study of Telaprevir in Subjects With Hepatic Impairment

Hepatic Insufficiency

United States
Johns Hopkins University
Guerbet

Not yet recruiting

High Relaxivity Contrast Agent for Cardiac MR in the Myocardial Scar Assessment

Myocardial Fibrosis

United States
Echosens

Recruiting

Optimization of Spleen VCTE Examinations With FibroScan

Spleen; Fibrosis

Spain, Netherlands, Romania
Medical University of Vienna

Unknown

Association of T1-mapping and LV Strain Analysis by CMR

Myocardial Fibrosis

Austria
University of Michigan

Completed

Bladder ARFI (Acoustic Radiation Force Impulse) Study

Bladder Fibrosis

United States
Sheba Medical Center

Unknown

The Role of Gastric Content Microaspirations in the Pathogenesis of Idiopathic Pulmonary Fibrosis

IDIOPATHIC PULMONARY FIBROSIS

Israel
Centre Hospitalier Universitaire, Amiens

Unknown

Prevalence of Liver Fibrosis and Cirrhosis in Patients With Squamous Cell Carcinoma of the Head and Neck (fibr'HOM)

Squamous Cell Carcinoma of the Head and Neck | Liver Cirrhoses | Liver Fibroses

France
Aga Khan University

Unknown

Lactulose for the Prevention of Hepatic Encephalopathy in Cirrhotic Patients With Upper Gastrointestinal Hemorrhage

Encephalopathy, Hepatic | Hepatocerebral Encephalopathy | Portal-Systemic Encephalopathy | Encephalopathy, Hepatocerebral

Pakistan
Theravance Biopharma

Terminated

TD-1058 First-In-Human Study in Healthy Subjects and Subjects With Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis (IPF)

United Kingdom
University of California, San Francisco

Completed

Biomarker Discovery for Novel Drug Development in Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis (IPF)

United States
Biogen

Completed

STX-100 in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic Pulmonary Fibrosis (IPF)

United States
Liminal BioSciences Ltd.

Completed

A Phase 2 Study to Evaluate the Safety and Tolerability of PBI-4050 in Patients With Idiopathic Pulmonary Fibrosis (IPF)

Idiopathic Pulmonary Fibrosis (IPF)

Canada

Clinical Trials on Hepatic Fibrosis

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