Clinical Trials on Hepatic Flow Changes

Total 13233 results

Genentech, Inc.

Completed

A Study of Ipatasertib in Participants With Mild, Moderate or Severe Hepatic Impairment Compared to Healthy Participants

Hepatic Insufficiency

United States
Eli Lilly and Company

Completed

A Study of Evacetrapib (LY2484595) in Participants With Hepatic (Liver) Impairment

Hepatic Insufficiency

United States
Merck Sharp & Dohme LLC

Completed

Assessment of Pharmacokinetics of Single Dose Odanacatib (MK-0822) in Participants With Moderate Hepatic Insufficiency (MK-0822-070)

Hepatic Insufficiency
McGill University Health Centre/Research Institute...

Unknown

Preoperative Glucose Infusion: a Novel Strategy to Improve Liver Function After Liver Resection

Liver Failure | Hepatic Insufficiency

Canada
Korea University Anam Hospital
Pharmbio Korea Co., Ltd.

Unknown

The Effect of Somatostatin for Treatment of Post Hepatectomy Liver Failure (PHLF)

Liver Failure

Korea, Republic of
Debiopharm International SA

Completed

Evaluate the Pharmacokinetics, Safety, and Tolerability of Alisporivir in Subjects With Hepatic Impairment Compared to Healthy Subjects

Hepatic Insufficiency

United States
Virginia Commonwealth University

Withdrawn

Hepatocyte Transplantation in Liver Failure

Liver Failure

United States
AstraZeneca

Completed

Phase 1 PK Study of Cediranib in Single and Multiple Doses in Hepatically Impaired Patients With Solid Tumours

Hepatic Impairment | Advanced Cancer

Netherlands, Denmark
Boehringer Ingelheim

Completed

Pharmacokinetics and Pharmacodynamics of BI 1356 in Subjects With Different Degrees of Liver Impairment as Compared to Healthy Subjects

Hepatic Insufficiency
Vital Therapies, Inc.

No longer available

Use of the ELAD® in Patients With Liver Failure to Provide Expanded Access With Cost Recovery

Liver Failure
Third Affiliated Hospital, Sun Yat-Sen University

Unknown

Safety and Efficacy of Diverse Mesenchymal Stem Cells Transplantation for Liver Failure

Liver Failure

China
University Hospital, Gentofte, Copenhagen

Completed

Single Dose of 9-cis-retinoic Acid in Hepatic Patients

Hepatic Insufficiency

Denmark
Bristol-Myers Squibb

Completed

Hepatic Impaired Subjects Compared to Healthy Subjects Receiving Multi-dose BMS-650032

Hepatic Insufficiency

United States
Pfizer

Completed

A Safety and Tolerability Study of CP-690,550 in Subjects With Hepatic Impairment and Normal Hepatic Function

Hepatic Insufficiency

United States
Nanfang Hospital, Southern Medical University

Recruiting

Prospective Cohort Study of Complications and Outcomes in Cirrhosis

Decompensated Cirrhosis | Overt Hepatic Encephalopathy | CMV Reactivation

China
University of South Florida
University of Miami; University of Alabama at Birmingham; Icahn School of Medicine... and other collaborators

Completed

Evidence-based Assessment of Medication Sensitivity in Acute Hepatic Porphyria

Porphyrias

United States
San Diego State University

Recruiting

An Intervention to Reduce Risk Factors for Adolescent Pregnancy

Behavioral Changes

United States
Shahid Beheshti University of Medical Sciences

Completed

Orthoptic Changes Following Photorefractive Keratectomy

Orthoptic Changes

Iran, Islamic Republic of
Ataturk University

Completed

Assessing Lung Dynamics and Respiratory Functions in Minimal Flow Anesthesia: A Prospective Study

Compliance, Patient | Pulmonary Function Test | Minimal Flow Anesthesia | Medium Flow Anesthesia | Peak Inspiratuar Pressure

Turkey
University Hospital Heidelberg

Recruiting

Magnetic Resonance-guided Adaptive Stereotactic Body Radiotherapy for Hepatic Metastases (MAESTRO)

Hepatic Metastasis

Germany
Ahon Pharmaceutical Co., Ltd.

Recruiting

Phase 1 Hepatic Insufficiency Trial of Methoxyethyl Etomidate Hydrochloride

Hepatic Insufficiency

China
The First Affiliated Hospital with Nanjing Medical...

Recruiting

Application of Sodium Bicarbonate Ringer's Solution in Laparoscopic Hepatectomy

Hepatic Ischemia

China
First Affiliated Hospital Xi'an Jiaotong University

Recruiting

Registry Study for Optimal Management of Liver Failure in the Chinese Population (RESOLVE-C)

Liver Failure

China
Merck Sharp & Dohme LLC

Not yet recruiting

Ulonivirine (MK-8507) in Participants With Mild or Moderate Hepatic Impairment (MK-8507-014)

Hepatic Insufficiency
Pfizer

Completed

A Study to Compare How the Study Medicine (PF-07923568) is Processed in Participants With Different Levels of Loss of Liver Function to Healthy Participants.

Liver Diseases | Hepatic Impairment

United States
Pfizer

Completed

STUDY OF PF-06882961 IN PARTICIPANTS WITH AND WITHOUT VARYING DEGREES OF HEPATIC IMPAIREMENT

Healthy Volunteers | Hepatic Impairment

United States
Takeda

Completed

A Study of Soticlestat in Adults With Liver Failure Compared to Those With Normal Liver Function

Healthy Volunteers | Hepatic Impairment

United States, Hungary
Boehringer Ingelheim

Completed

A Study to Test How Iclepertin is Taken up in the Blood of People With and Without Liver Problems

Hepatic Insufficiency

Germany
Eli Lilly and Company

Completed

A Study of Tirzepatide in Participants With Impaired Liver Function

Hepatic Insufficiency

United States
Protgen Ltd

Completed

Recombinant Human Serum Albumin in Healthy Subjects

Hepatic Ascites

China
Idorsia Pharmaceuticals Ltd.

Completed

The Effect of Reduced Liver Function on Selatogrel Pharmacokinetics

Healthy Subjects | Hepatic Impairment

Germany
Acerta Pharma BV

Completed

A Study to Evaluate the Effect of Hepatic Insufficiency on the Pharmacokinetics (PK) of ACP-196

Hepatic Insufficiency

United States
Hala Abd EL-Tawab Ibrahim Radwan

Completed

Effects of Adding Hypertonic Saline Solutions and/or Etilefrine to Standard Diuretics Therapy in Hepatic Ascites

Hepatic Ascites

Egypt
Novartis Pharmaceuticals

Completed

Pharmacokinetics (PK) of TKI258 in Cancer Patients With Normal and Impaired Hepatic Function

Hepatic Impairment | Solid Tumors

Belgium, Germany, Netherlands, Italy, Singapore, United States
M.D. Anderson Cancer Center

Unknown

Understanding Patient's Knowledge and Use of Acetaminophen

Liver Failure

United States
ObsEva SA

Completed

Safety and Pharmacokinetics Study of Linzagolix in Female Subjects With Normal and Impaired Hepatic Function

Hepatic Impairment | Healthy Participants

United States
Takeda

Completed

A Study to Evaluate the Effect of Hepatic Impairment on the Single Dose Pharmacokinetics (PK) of Intravenous TAK-954

Healthy Volunteers | Hepatic Impairment

Czechia, Slovakia
Sahlgrenska University Hospital, Sweden

Completed

Inflammation and Organ Impact During Hepatic Surgery

Hepatic Surgery

Sweden
Merck Sharp & Dohme LLC
Celerion

Completed

The Influence of Hepatic Insufficiency on the Pharmacokinetics of Elbasvir (MK-8742) (MK-8742-009)

Hepatic Insufficiency

United States
Hospital Italiano de Buenos Aires

Completed

Interstage Assessment of Remnant Liver Function in ALPPS

Liver Failure

Argentina
AstraZeneca

Completed

To Assess the Pharmacokinetics, Safety and Tolerability of Selumetinib in Patients With Hepatic Impairment and Healthy Subjects

Solid Tumors

United States
Conatus Pharmaceuticals Inc.

Completed

PK and PD Study of IDN-6556 in Subjects With Hepatic Impairment and Matched Healthy Volunteers

Liver Diseases | Digestive System Diseases | Hepatic Impairment

United States
Boehringer Ingelheim

Completed

Nintedanib in Volunteers With Hepatic Impairment Compared With Healthy Volunteers

Hepatic Insufficiency

Germany
Bristol-Myers Squibb

Completed

Single-Dose Pharmacokinetics of BMS-790052 in Participants With Hepatic Impairment

Hepatic Insufficiency

United States
Veloxis Pharmaceuticals
CTI Clinical Trial and Consulting Services; Aptuit

Completed

Pharmacokinetics of LCP-Tacro™ Once Daily and Prograf® Twice A Day in Adult De Novo Liver Transplant Patients

Liver Failure

United States
Boehringer Ingelheim

Completed

Study to Determine the Pharmacokinetics on TPV/r in Subjects With Mild and Moderate Hepatic Insufficiency

Hepatic Insufficiency
Baxter Healthcare Corporation
Baxter Innovations GmbH

Completed

Fibrin Sealant VH S/D 500 S-apr in Hepatic Resection

Bleeding (Oozing) in Hepatic Resection

Germany
University Hospital, Gentofte, Copenhagen

Completed

Pharmacokinetics of 9-cis-retinoic Acid (Alitretinoin, Toctino®) in Patients With Hepatic Disease

Hepatic Insufficiency

Denmark
Universitaire Ziekenhuizen KU Leuven

Unknown

Citrate Anticoagulation During MARS Treatment

Liver Failure

Belgium
Novartis

Completed

Safety and Pharmacokinetics of Indacaterol in Healthy Subjects and Those With Impaired Liver Function

Hepatic Insufficiency

United States

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