Clinical Trials on Hepatic Neoplasms

Total 109469 results

Istituto Clinico Humanitas

Terminated

Methylprednisolone N Acetylcysteine in Hepatic Resections (MENHIR)

Ischemic Reperfusion Injury | Liver Tumour | Insufficiency; Hepatic, Postoperative

Italy
Eisai Inc.

Completed

A Pharmacokinetic and Safety Study of E7080 in Subjects With Mild (10 mg), Moderate (10 mg), and Severe Hepatic Impairment (5 mg) and Normal Hepatic Function (10 mg)

Hepatic Impairment | Hepatic Function

United States
Incyte Corporation

Completed

To Evaluate the Safety, and Pharmacokinetics of Parscaclisib in Participants With Normal Hepatic Function and Hepatic Impairment.

Advanced Malignancies

United States
Vital Therapies, Inc.

Completed

Phase 2 Evaluation of the ELAD System in the Management of Acute Liver Failure

Fulminant Hepatic Failure

United States
Vital Therapies, Inc.

Withdrawn

Safety and Efficacy of the Extracorporeal Liver Assist Device (ELAD®) In Patients With Fulminant Hepatic Failure (FHF) (ELAD)

Fulminant Hepatic Failure

United States
Hui-Chuan Sun

Terminated

Comparative Study on Liver Resection Between Harmonic Scalpel Versus Crush-clamping Method

Hepatic Neoplasms

China
Agios Pharmaceuticals, Inc.

Completed

A Pharmacokinetic Study of Mitapivat in Participants With Moderate Hepatic Impairment Compared to Matched Healthy Control Participants With Normal Hepatic Function

Moderate Hepatic Impairment

United States
Memorial Sloan Kettering Cancer Center
Wake Forest University

Completed

A Phase II Study of Continuous Hepatic Arterial Infusion With Floxuridine (FUDR) and Dexamethasone (DEX) in Patients With Unresectable Primary Hepatic Malignancy

Hepatic Cancer

United States
RenJi Hospital
The Affiliated Hospital of Qingdao University; The First Affiliated Hospital...

Not yet recruiting

Liver Transplantation With Two-stage Liver Resection in Unresectable Liver Cancer , Metastases or Emd-stage Liver Disease (LTLR-LC)

Liver Transplant Disorder | Hepatic Cancer | End-stage Liver Disease
Bausch Health Americas, Inc.

Terminated

Steady-State Pharmacokinetics of Rifaximin 550 mg Tablets in Healthy and Hepatically Impaired Subjects

Severe Hepatic Impairment

United States
Janssen Research & Development, LLC

Completed

A Study to Assess the Effects of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine

Hepatic Impairment | Normal Hepatic Function

United States
Bristol-Myers Squibb

Recruiting

A Study to Evaluate CC-486/Onureg in Participants With Moderate or Severe Hepatic Impairment Compared With Normal Hepatic Function in Participants With Myeloid Malignancies

Hepatic Insufficiency | Neoplasms

Spain, United States, Germany, Argentina, Colombia, Greece
University of Louisville

Withdrawn

Direct Peritoneal Resuscitation Plus Conventional Resuscitation

Hepatic Cancer

United States
Cardiox Corporation

Terminated

Liver Function Assessment - Feasibility and Dosing Study

Hepatic Failure
Merck Sharp & Dohme LLC

Completed

Belzutifan (MK-6482) Hepatic Impairment Study (MK-6482-020)

Moderate Hepatic Impairment

United States
EQRx International, Inc.

Completed

An Open-Label, Single-Dose, Parallel-Group Study of the Pharmacokinetics and Safety of EQ143

Severe Hepatic Impairment

United States
Pfizer

Completed

Evaluate Severe Hepatic Impairment on Dacomitinib PK

Severe Hepatic Impairment

United States
Takeda

Completed

Pharmacokinetics, Safety and Tolerability of Vortioxetine in Normal Hepatic Function or Severe Hepatic Impairment

Severe Hepatic Impairment

United States
University Hospital, Strasbourg, France

Recruiting

Hydrodissection of the Hepatoduodenal Ligament (Duodenal)

Hepatic Lesions

France
Rennes University Hospital

Completed

Pharmacogenetic Study of Tacrolimus in Hepatic Transplant (CYPTAC'H)

Hepatic Transplantation

France
Maastricht University

Completed

Liver Glycogen Dynamics (LGD)

Hepatic Glycogen

Netherlands
Shire

Completed

Pharmacokinetics (PK) of 20 mg Teduglutide in Participants With Moderately Impaired Hepatic Function Compared to Healthy Participants

Hepatic Impairment

United States
University of Michigan Rogel Cancer Center

Completed

Assessment Of Liver Function in Patients Undergoing Hepatic Irradiation (IC-Green)

Hepatic Irradiation

United States
Assiut University

Unknown

Implication of Fluid Strategies Upon Hepatic Outcome in Hepatobiliary Surgery

Hepatic Complication
Novartis Pharmaceuticals

Completed

Pharmacokinetic Study of Icenticaftor in Participants With Hepatic Impairment

Hepatic Failure

United States
Daiichi Sankyo, Inc.

Completed

A Study of Quizartinib Pharmacokinetics in Participants With Moderate Hepatic Impairment

Hepatic Impairment | Moderate Impaired Hepatic Function

United States
Mitsubishi Tanabe Pharma Corporation

Completed

PK Study in Subjects With Severe Hepatic Impairment (MCI-186-E05 HP)

Healthy | Severe Hepatic Impairment

Czechia, Hungary, Slovakia
KBP Biosciences
Covance

Completed

Pharmacokinetics of KBP-5074 in Patients With Moderate Hepatic Impairment

Healthy | Moderate Hepatic Impairment

United States
Centre Hospitalier Universitaire de Nice

Completed

Pyrophosphate Homeostasis and Hepatic Expression of ABCC6.Pyro-TH (Pyro-TH)

Hepatic Failure

France
Rennes University Hospital

Completed

Comparison of the Variability of Hepatic Load Quantification in Iron and Fat Estimated by MRI at 1.5 and 3 Tesla (HEMOCOMPARE)

Iron Hepatic Overload | Fat Hepatic Overload

France
Biotie Therapies Inc.
Acorda Therapeutics

Terminated

Study to Investigate the Influence of Hepatic Insufficiency on the Pharmacokinetics of Tozadenant

Hepatic Impairment

United States
Tibotec BVBA

Completed

A Study of TMC207 in Patients With Moderately Impaired Hepatic Function

Moderate Hepatic Impairment
Pfizer
Medivation, Inc.

Completed

Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [Pf-01913539] In Subjects With Hepatic Impairment And Normal Hepatic Function

Hepatic Failure

United States
Jazz Pharmaceuticals

Completed

Assessment of the Single Dose Pharmacokinetics and Tolerability of Sativex in Patients With Impaired Hepatic Function and Healthy Patients

Hepatic Impairment

United States
Seagen Inc.

Completed

A Safety Study of Tucatinib in Healthy and Hepatically-Impaired Subjects

Hepatic Impairment

United States
Mansoura University

Completed

Clamp-crush Technique Versus Harmonic Scalpel in Living Donor Hepatectomy (KK_HS)

Hepatic Transplantation

Egypt
Nuh Rahbari

Completed

Stapler Hepatectomy for Elective Liver Resection (CRUNSH)

Hepatic Resection

Germany
Sunshine Lake Pharma Co., Ltd.

Completed

To Evaluate the Pharmacokinetics and Safety of Yimitasvir Phosphate Capsules in Subjects With Moderate and Severe Liver Function Impairment and in Healthy Subjects

Hepatic Impairment

China
Central Hospital, Nancy, France

Completed

Hepatic Artery From Origin to Segmental Branching: a 500 Case CT Study

Hepatic Artery

France
Janssen Research & Development, LLC

Withdrawn

A Study to Investigate the Pharmacokinetics, Safety, and Tolerability of Odalasvir and AL-335 Alone and in Combination With Simeprevir in Participants With Moderately Impaired Hepatic Function

Hepatic Impairment
Jinnah Postgraduate Medical Centre

Not yet recruiting

Efficacy of L-Ornithine L-Aspartate and Polyethylene Glycol in Cirrhotic Patients With Overt Hepatic Encephalopathy

Hepatic Encephalopathy Stage 2 | Hepatic Encephalopathy Stage 3 | Hepatic Encephalopathy Stage 4

Pakistan
Denver Health and Hospital Authority
University of Colorado, Denver; Johnson & Johnson Consumer Inc., McNeil Consumer... and other collaborators

Withdrawn

APAP-CYS Protein Adduct Concentrations in Patients With Liver-Directed Therapy Intended to Treat Hepatic Tumors

Acetaminophen Exposure

United States
BeiGene

Completed

Safety and Pharmacokinetics of Zanubrutinib (BGB-3111) in Healthy Subjects and Those With Impaired Liver Function

Hepatic Insufficiency & Healthy Subjects

United States
National Taiwan University Hospital

Unknown

Oxidative Stress and Microcirculation in Patient With Hepatic Failure Undergoing Liver Support Treatment

Liver Failure | Critical Care

Taiwan
Pfizer

Completed

A Study To Describe The Effect Of Impaired Hepatic Function Of The Pharmacokinetics Of Palbociclib

Healthy, Hepatic Insufficiency

United States
National Institutes of Health Clinical Center (CC)

Terminated

Fusion Guided Thermal Ablation Combined With External Beam Radiation for Hepatic Neoplasms

Liver Neoplasms | Liver Cancer | Hepatic Cancer

United States
Protgen Ltd

Unknown

Clinical Trial of Quantitative Detection Kit for Hsp90α in Hepatic Cancer

Liver Cancer

China
Rigshospitalet, Denmark

Completed

Cerebral Microdialysis in Patients With Fulminant Hepatic Failure

Fulminant Hepatic Failure

Denmark
Radboud University Medical Center

Completed

Penetration of Cefazolin Into Hepatic Cysts (PENTAC)

Hepatic Cyst

Netherlands
Center Eugene Marquis

Completed

Efficacy Study of Intra-hepatic Administration of Therasphere® in Association With Intravenous Chemotherapy to Treat Cholangiocarcinoma (MispheC)

Cholangiocarcinoma

France

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