Clinical Trials on Hepatic Disease in United Kingdom

Total 146866 results

Imperial College London

Completed

Brain Muscle Axis During Treatment of Hepatic Encephalopathy With L-ornithine L-aspartate

Hepatic Encephalopathy | Cirrhosis | Minimal Hepatic Encephalopathy

United Kingdom
Delcath Systems Inc.

Unknown

Registry Protocol- Melphalan Percutaneous Hepatic Perfusion for the Treatment of Unresectable Hepatic Malignancy

Hepatic Malignant Neoplasm Primary Non-Resectable

United Kingdom
Imperial College London

Completed

A Phase I/II Safety and Tolerability Dose Escalation Study of Autologous Stem Cells to Patients With Liver Insufficiency

Liver Disease

United Kingdom
Norgine

Completed

Real World Outcomes Study of Hepatic Encephalopathy Patients' Experience on Rifaximin (PROSPER) (PROSPER)

Hepatic Encephalopathy

United Kingdom
University of Edinburgh
NHS Lothian

Unknown

The Relationship of Initial Liver Profile and Outcome After Transplantation

Liver Failure

United Kingdom
University of Edinburgh
NHS Lothian; European Society of Organ Transplantation

Completed

Liver Transplantation and Reticuloendothelial Clearance Capacity

Hepatic Insufficiency | Liver Insufficiency

United Kingdom
Guy's and St Thomas' NHS Foundation Trust
King's College London

Completed

Safety and Efficacy Study of Regulatory T Cell Therapy in Liver Transplant Patients (ThRIL)

End-stage Liver Disease

United Kingdom
Imperial College London
University of London; Royal College of Physicians; Paddington Charitable Estates...

Completed

Brain Imaging in Patients With Chronic Liver Disease and Functional Impairment.

Hepatic Encephalopathy | Cirrhosis

United Kingdom
King's College Hospital NHS Trust
King's College London

Completed

Randomised Controlled Trial of Mechanistic Effects of Rifaximin in Cirrhosis and Chronic Hepatic Encephalopathy (RIFSYS)

Liver Cirrhosis | Hepatoencephalopathy, Early Fatal Progressive

United Kingdom
University of Leeds
The Leeds Teaching Hospitals NHS Trust; University of Sheffield

Unknown

Hepatectomy Risk Assessment With Functional Magnetic Resonance Imaging (HEPARIM)

Liver Failure | Hepatectomy | Liver Metastases | Liver Cancer

United Kingdom
zr Pharma & GmbH

Completed

Rucaparib Hepatic Impairment Study in Patients With a Solid Tumor

Neoplasms

United Kingdom, Poland, Slovakia
Imperial College London

Completed

Adult Stem Cell Therapy in Liver Insufficiency

Liver Cirrhosis

United Kingdom
University College, London
Medical Research Council; Royal Free Hospital NHS Foundation Trust; ViiV Healthcare

Completed

Adding MAraViroc &/or METformin for Hepatic Steatosis in People Living With HIV (MAVMET)

Hepatic Steatosis | HIV-1-infection

United Kingdom
University of Nottingham
Mediplus Ltd UK; Enteric healthcare technology Co-operative

Completed

Evaluation of 'Melody' Paracentesis Device for Ascites Therapy (EMPATHY)

Ascites Hepatic | Cirrhosis and Chronic Liver Disease

United Kingdom
St George's, University of London
King's College Hospital NHS Trust

Recruiting

S100A8/A9 and Innate Immunity in Liver Disease

Infections | Cirrhosis, Liver | Ascites Hepatic | Immune Suppression | Liver Failure, Acute on Chronic

United Kingdom
GlycoMimetics Incorporated

Completed

A Study to Evaluate the Effect of IV Doses of Rivipansel in Subjects With Moderate Hepatic Impairment and in Healthy Subjects With Normal Hepatic Function

Moderate Hepatic Impairment | Normal Hepatic Function

United States
Quell Therapeutics Limited

Recruiting

Safety and Clinical Activity of QEL-001 in A2-mismatch Liver Transplant Patients (LIBERATE)

Liver Diseases | Liver Failure | Rejection; Transplant, Liver

Belgium, United Kingdom, Spain
Imperial College London
Royal Brompton & Harefield NHS Foundation Trust

Completed

Haemostatic Markers in Cardiopulmonary Bypass

Cardiopulmonary Bypass Surgery | Unfractionated Heparin

United Kingdom
University of Leicester
University of Nottingham; University Hospitals, Leicester

Recruiting

Tissue Models for Invasive Disease (TIMID) (TIMID)

Spleen; Septic

United Kingdom
Rigshospitalet, Denmark

Completed

A Study of the Effect of Plasmaexchange in Patients With Acute Liver Failure

Acute Liver Failure

Denmark, Finland, United Kingdom
Novartis Pharmaceuticals

Completed

Effect of Hepatic Impairment on LDK378 Pharmacokinetics

Normal Hepatic Function | Impaired Hepatic Function

United States
Pfizer

Recruiting

A Study to Learn About the Study Medicine (Called Lorlatinib) in People With Liver Dysfunction

Healthy Volunteers | Moderate Hepatic Impairment | Severe Hepatic Impairment

United States
Novartis Pharmaceuticals

Completed

Evaluation of Hepatic Function Impairment on the Pharmacokinetics of LEE011

Normal Hepatic Function | Impaired Hepatic Function

United States
King's College London

Unknown

Microcirculatory Guided Goal Directed Fluid Therapy in Septic Shock; a Feasibility Study (MICRORESUS)

Septic Shock

United Kingdom
Trio Medicines Ltd.
Ferring Pharmaceuticals

Completed

Effect of Repeated Doses of YF476, Omeprazole and Placebo on Stomach Acidity in Healthy Volunteers

Reflux Oesophagitis

United Kingdom
Novartis Pharmaceuticals

Completed

Effect of Hepatic Impairment on LDE225..

Normal Hepatic Function | Impaired Hepatic Function

Belgium, Germany, Israel, Bulgaria, United States
Janssen Research & Development, LLC

Completed

A Study to Assess the Effects of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine

Hepatic Impairment | Normal Hepatic Function

United States
Trio Medicines Ltd.
Ferring Pharmaceuticals

Completed

Safety, Tolerability and Pharmacokinetics of Single Rising Doses of YF476, a Gastrin Antagonist, in Healthy Men

Reflux Oesophagitis

United Kingdom
Trio Medicines Ltd.
Ferring Pharmaceuticals

Completed

Effect of Single Doses of YF476 on Stomach Acidity Compared With Ranitidine and Placebo in Fasted and Fed States

Reflux Oesophagitis

United Kingdom
Agios Pharmaceuticals, Inc.

Completed

A Pharmacokinetic Study of Mitapivat in Participants With Moderate Hepatic Impairment Compared to Matched Healthy Control Participants With Normal Hepatic Function

Moderate Hepatic Impairment

United States
Trio Medicines Ltd.
Ferring Pharmaceuticals

Completed

Effect of 5, 10 or 25 mg of YF476 Daily for 14 Days on Stomach Acidity in Healthy Volunteers

Reflux Oesophagitis

United Kingdom
Bausch Health Americas, Inc.

Terminated

Steady-State Pharmacokinetics of Rifaximin 550 mg Tablets in Healthy and Hepatically Impaired Subjects

Severe Hepatic Impairment

United States
Takeda

Completed

Pharmacokinetics, Safety and Tolerability of Vortioxetine in Normal Hepatic Function or Severe Hepatic Impairment

Severe Hepatic Impairment

United States
Eisai Inc.

Completed

A Pharmacokinetic and Safety Study of E7080 in Subjects With Mild (10 mg), Moderate (10 mg), and Severe Hepatic Impairment (5 mg) and Normal Hepatic Function (10 mg)

Hepatic Impairment | Hepatic Function

United States
Pfizer

Completed

Evaluate Severe Hepatic Impairment on Dacomitinib PK

Severe Hepatic Impairment

United States
Genfit

Completed

Nitazoxanide Pharmacokinetic Parameters in Hepatic Impaired Patients

Liver Diseases | Moderate Hepatic Impairment | Severe Hepatic Impairment

United States
Novartis Pharmaceuticals

Completed

Pharmacokinetic Study of Icenticaftor in Participants With Hepatic Impairment

Hepatic Failure

United States
Daiichi Sankyo, Inc.

Completed

A Study of Quizartinib Pharmacokinetics in Participants With Moderate Hepatic Impairment

Hepatic Impairment | Moderate Impaired Hepatic Function

United States
Merck Sharp & Dohme LLC

Completed

Belzutifan (MK-6482) Hepatic Impairment Study (MK-6482-020)

Moderate Hepatic Impairment

United States
Ethicon, Inc.

Completed

The EVARREST® Paediatric Mild/Moderate Liver and Soft Tissue Bleeding Study

Hemorrhage | Soft Tissue Bleeding | Hepatic Parenchyma Bleeding

United Kingdom, Belgium
Biotie Therapies Inc.
Acorda Therapeutics

Terminated

Study to Investigate the Influence of Hepatic Insufficiency on the Pharmacokinetics of Tozadenant

Hepatic Impairment

United States
The University of Texas Medical Branch, Galveston

Terminated

Evaluation of Mechanisms Responsible for Coma in Patients Affected by Fulminant, Acute and Chronic Hepatic Failure

Acute and Chronic Hepatic Failure With Developing Coma

United States
Pfizer
Medivation, Inc.

Completed

Study To Evaluate The Pharmacokinetics, Safety, And Tolerability Of Dimebon [Pf-01913539] In Subjects With Hepatic Impairment And Normal Hepatic Function

Hepatic Failure

United States
AdventHealth

Completed

Endoscopic Ultrasound Guided Liver Biopsy

Hepatic Cancer | Hepatic Carcinoma | Hepatic Neoplasm

United States
Pfizer

Completed

A Study To Describe The Effect Of Impaired Hepatic Function Of The Pharmacokinetics Of Palbociclib

Healthy, Hepatic Insufficiency

United States
KBP Biosciences
Covance

Completed

Pharmacokinetics of KBP-5074 in Patients With Moderate Hepatic Impairment

Healthy | Moderate Hepatic Impairment

United States
BeiGene

Completed

Safety and Pharmacokinetics of Zanubrutinib (BGB-3111) in Healthy Subjects and Those With Impaired Liver Function

Hepatic Insufficiency & Healthy Subjects

United States
Manchester University NHS Foundation Trust
University of Manchester

Recruiting

Strong Albumin Solutions in Patients With Septic Shock (SWIPE2)

Sepsis | Septic Shock | Shock, Toxic

United Kingdom
University of Edinburgh
Becton, Dickinson and Company; Technology Strategy Board, United Kingdom

Completed

Immune Failure in Critical Therapy (INFECT) Study (INFECT)

Sepsis | Septic Shock

United Kingdom
EQRx International, Inc.

Completed

An Open-Label, Single-Dose, Parallel-Group Study of the Pharmacokinetics and Safety of EQ143

Severe Hepatic Impairment

United States

Clinical Trials on Hepatic Disease in United Kingdom

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