Clinical Trials on Hepato-splenomegaly

Total 2114 results

University of Alberta
Becton, Dickinson and Company

Completed

Prospective Evaluation of PleurX Drain for Treatment of Cirrhotic Refractory Ascites

Ascites Hepatic
Axcella Health, Inc

Completed

Study of the Safety and Tolerability of AXA1665 in Subjects With Mild and Moderate Hepatic Insufficiency

Hepatic Insufficiency

United States
Celgene

Completed

Evaluate the Pharmacokinetics of CC-220 in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared With Healthy Subjects

Healthy Volunteers | Hepatic Impairment

United States
University of Manitoba

Completed

Comparative FK506 Drug Levels of Once Daily Advagraf in First Nations and Caucasian Patients With Liver Transplants

Liver Failure

Canada
Genentech, Inc.

Completed

A Study of Ipatasertib in Participants With Mild, Moderate or Severe Hepatic Impairment Compared to Healthy Participants

Hepatic Insufficiency

United States
Eli Lilly and Company

Completed

A Study of Evacetrapib (LY2484595) in Participants With Hepatic (Liver) Impairment

Hepatic Insufficiency

United States
Merck Sharp & Dohme LLC

Completed

Assessment of Pharmacokinetics of Single Dose Odanacatib (MK-0822) in Participants With Moderate Hepatic Insufficiency (MK-0822-070)

Hepatic Insufficiency
McGill University Health Centre/Research Institute...

Unknown

Preoperative Glucose Infusion: a Novel Strategy to Improve Liver Function After Liver Resection

Liver Failure | Hepatic Insufficiency

Canada
Korea University Anam Hospital
Pharmbio Korea Co., Ltd.

Unknown

The Effect of Somatostatin for Treatment of Post Hepatectomy Liver Failure (PHLF)

Liver Failure

Korea, Republic of
Debiopharm International SA

Completed

Evaluate the Pharmacokinetics, Safety, and Tolerability of Alisporivir in Subjects With Hepatic Impairment Compared to Healthy Subjects

Hepatic Insufficiency

United States
Virginia Commonwealth University

Withdrawn

Hepatocyte Transplantation in Liver Failure

Liver Failure

United States
AstraZeneca

Completed

Phase 1 PK Study of Cediranib in Single and Multiple Doses in Hepatically Impaired Patients With Solid Tumours

Hepatic Impairment | Advanced Cancer

Netherlands, Denmark
Boehringer Ingelheim

Completed

Pharmacokinetics and Pharmacodynamics of BI 1356 in Subjects With Different Degrees of Liver Impairment as Compared to Healthy Subjects

Hepatic Insufficiency
Vital Therapies, Inc.

No longer available

Use of the ELAD® in Patients With Liver Failure to Provide Expanded Access With Cost Recovery

Liver Failure
Third Affiliated Hospital, Sun Yat-Sen University

Unknown

Safety and Efficacy of Diverse Mesenchymal Stem Cells Transplantation for Liver Failure

Liver Failure

China
University Hospital, Gentofte, Copenhagen

Completed

Single Dose of 9-cis-retinoic Acid in Hepatic Patients

Hepatic Insufficiency

Denmark
Bristol-Myers Squibb

Completed

Hepatic Impaired Subjects Compared to Healthy Subjects Receiving Multi-dose BMS-650032

Hepatic Insufficiency

United States
Pfizer

Completed

A Safety and Tolerability Study of CP-690,550 in Subjects With Hepatic Impairment and Normal Hepatic Function

Hepatic Insufficiency

United States
Erasmus Medical Center

Recruiting

Treatment of Exertional Heatstroke witH icE wAter Soaked Towels (THE HEAT)

Heat Illness | Heat Exhaustion | Heat Stroke Exertional

Netherlands
Sir Run Run Shaw Hospital
Hexaell Biotech Co., Ltd

Recruiting

The Treatment of Bioartificial Liver With hiHep Cells After Extensive Hepatectomy

Hepatoma Resectable

China
University Hospital Heidelberg

Recruiting

Magnetic Resonance-guided Adaptive Stereotactic Body Radiotherapy for Hepatic Metastases (MAESTRO)

Hepatic Metastasis

Germany
Alnylam Pharmaceuticals

Completed

EXPLORE: A Natural History Study of Acute Hepatic Porphyria (AHP)

Acute Hepatic Porphyria

United States, Belgium, Bulgaria, France, Italy, Mexico, Spain, Taiwan, United Kingdom, Netherlands, Korea, Republic of, Switzerland, Czechia, Poland, Finland, Australia, Germany, Israel, Norway, South Africa
Takeda

Recruiting

A Study of TAK-279 in Adults With or Without Liver Damage

Healthy Volunteers | Hepatic Impairment

United States
Novo Nordisk A/S

Recruiting

A Research Study Looking at How a Single Dose of the Study Medicine NNC0194-0499 Behaves in Participants With Reduced Liver Function Compared to Participants With Normal Liver Function

Healthy Volunteers | Hepatic Impairment

Germany, Poland, Slovakia
University Hospital, Lille
Ministry of Health, France

Recruiting

Hepato Biliary Scintigraphy to Assess the Risk of Postoperative Liver Failure Hepatectomies (SCINTIVOL)

Hepatic Insufficiency

France
National Natural Science Foundation of China

Active, not recruiting

A Study on Relationship Between Resected Normal Liver Parenchymal Volume（RNLV）and Post-Hepatectomy Liver Failure (PHLF) (RNLV)

Liver Failure

China
Jiangxi Qingfeng Pharmaceutical Co. Ltd.

Completed

GP681 in Volunteers With Hepatic Impairment Compared With Healthy Volunteers

Healthy Volunteers | Hepatic Impairment

China
Millennium Pharmaceuticals, Inc.

Completed

A Study to Evaluate Pharmacokinetics (PK) and Safety of Oral Mobocertinib in Participants With Moderate or Severe Hepatic Impairment (HI) and Normal Hepatic Function

Healthy Volunteers | Hepatic Impairment

United States
Akdeniz University

Completed

Evaluation of HDL Subfraction Changes and HDL-Associated Enzymes in Liver Failure Patients and Healthy Donors

Liver Failure

Turkey
Pfizer

Completed

A Study to Understand How the Study Medicine (PF-07081532) is Processed in People With Liver Dysfunction

Healthy Volunteers | Hepatic Impairment

United States
Celgene
Impact Biomedicines, Inc., a wholly owned subsidiary of Celgene Corporation

Completed

A Pharmacokinetics and Tolerability Study of Fedratinib in Subjects With Moderate and Severe Hepatic Impairment

Healthy Volunteers | Hepatic Impairment

United States
Hoffmann-La Roche

Completed

A Study to Investigate the Effect of Impaired Hepatic Function on the Pharmacokinetics of Entrectinib in Volunteers With Different Levels of Hepatic Function

Hepatic Insufficiency

Hungary, Czechia, Slovakia
Denovo Biopharma LLC

Completed

A Study of LY2140023 in Hepatically-Impaired Participants

Hepatic Insufficiency

Germany, Hungary
Healthgen Biotechnology Corp.

Completed

A Study of OsrHSA in Adult Healthy Male and Female Volunteers

Ascites Hepatic

United States
Pfizer

Completed

A Study to Evaluate the Pharmacokinetics, Safety and Tolerability of PF-06651600 in Subjects With Hepatic Impairment and Healthy Volunteers

Hepatic Impairment | Healthy Participants

United States
Celgene

Completed

Pharmacogenetics Sampling of the CC-90007-CP-003 Study Cohort

Hepatic Insufficiency

United States
The University of Hong Kong

Unknown

A Prospective Randomized Controlled Trial on the Use of Cerebral Oximetry in Adult Chinese Patients Undergoing Liver Transplantation (LT)

Liver Failure

Hong Kong, China
Washington University School of Medicine
National Institute of General Medical Sciences (NIGMS)

Completed

Alfentanil: Simultaneous Testing Pilot

Evaluate Two Paradigms for Simultaneous Assessment of Hepatic and Intestinal CYP3A

United States
Eli Lilly and Company

Completed

A Study of Abemaciclib in Participants With Varying Degrees of Liver Impairment

Hepatic Insufficiency

United States
Humedics GmbH

Completed

Fast-track LiveR: Study for the Early Identification of Low-risk Patients After Partial Liver Resection by the LiMAx-test

Liver Failure

Germany
University of Edinburgh
NHS Lothian

Unknown

The Relationship of Initial Liver Profile and Outcome After Transplantation

Liver Failure

United Kingdom
USWM, LLC (dba US WorldMeds)
National Institute on Drug Abuse (NIDA)

Completed

Single-Dose Pharmacokinetics and Safety of Oral Lofexidine in Hepatically-Impaired Subjects

Liver Failure

United States
Stanley Dudrick's Memorial Hospital

Completed

Parenteral Lipid Emulsions and the Liver Function

Liver Failure

Poland
Veloxis Pharmaceuticals
CTI Clinical Trial and Consulting Services

Completed

Pharmacokinetics of LCP-Tacro in Stable Liver Transplant Patients

Liver Failure

United States
University Health Network, Toronto
University of Waterloo

Completed

SPME For Metabolomics And Concomitant Measurements Of Rocuronium Bromide Levels In Liver Transplantation

Liver Failure

Canada
H. Lundbeck A/S

Completed

Pharmacokinetics Properties of Single Oral Dosing of Lu AE58054 in Subjects With Hepatic Impairment (Mild and Moderate) and in Healthy Subjects

Heptic Impairment

Germany
Fundacion para la Formacion e Investigacion Sanitarias...

Completed

Extracorporeal Photopheresis After Liver Transplant

Hepatic Insufficiency

Spain
Boehringer Ingelheim

Completed

Pharmacokinetics, Safety and Tolerability of BIIL 284 BS in Patients With Hepatic Impairment in Comparison to Healthy Volunteers

Hepatic Insufficiency
Boehringer Ingelheim

Completed

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of Dabigatran Etexilate in Patients With Moderate Hepatic Impairment Compared to Subjects With Normal Hepatic Function

Hepatic Insufficiency
Pfizer

Completed

Evaluation Of Hepatic Impairment On AG-013736 Pharmacokinetics

Hepatic Insufficiency

United States

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