Clinical Trials on Hereditary Cancer Syndromes in United Kingdom

Total 38167 results

Myriad Genetic Laboratories, Inc.
Myriad Genetics, Inc.

Completed

Impact of a Process Intervention on Screening and Testing Outcomes for Common Hereditary Cancer Syndromes

Hereditary Cancer

United States
InheRET, Inc
University of Michigan

Enrolling by invitation

Inherited Risk Evaluation Tool (InheRET): Identifying Patients at Increased Risk for Hereditary Disease

Hereditary Cancer-Predisposing Syndrome

United States
Scripps Health
J. Craig Venter Institute

Completed

Biomarker Monitoring in TP53 Mutation Carriers

Li-Fraumeni Syndrome | Hereditary Cancer Syndromes | TP53 Gene Germline Mutation Carrier

United States
Weill Medical College of Cornell University

Recruiting

Chatbot to Maximize Hereditary Cancer Genetic Risk Assessment

Gynecologic Cancer | Hereditary Cancer Syndrome

United States
Royal Marsden NHS Foundation Trust

Recruiting

Inherited Cancer Early Diagnosis (ICED) Study (ICED)

Lynch Syndrome | Familial Adenomatous Polyposis | Hereditary Diffuse Gastric Cancer | Peutz-Jeghers Syndrome | Cowden Syndrome | Li Fraumeni Syndrome | MutYH-associated Polyposis | SMAD4 Gene Mutation

United Kingdom
London North West Healthcare NHS Trust

Completed

Magnification Narrow Band Imaging Colonoscopy for Hereditary Non-Polyposis Colorectal Cancer Surveillance

Colorectal Neoplasms, Hereditary Nonpolyposis

United Kingdom
Imperial College London

Enrolling by invitation

Colonoscopy Check-up in People With Lynch Syndrome

Lynch Syndrome

United Kingdom
Institute of Cancer Research, United Kingdom
Cancer Research UK; National Institute for Health Research, United Kingdom

Completed

Magnetic Resonance Imaging Screening in Li Fraumeni Syndrome (SIGNIFY)

Li-Fraumeni Syndrome

United Kingdom
Weill Medical College of Cornell University
National Cancer Institute (NCI)

Recruiting

Discovering New Targets for Colorectal and Endometrial Cancer Risk Reduction

Colorectal Cancer | Endometrial Cancer | Hereditary Cancer Syndromes

United States
John Carroll University
University Hospital Southampton NHS Foundation Trust

Active, not recruiting

Development and Validation of an Online Neurobehavioral Evaluation Tool for PTEN Patients

PTEN Hamartoma Tumor Syndrome

United States, United Kingdom
National Cancer Institute (NCI)

Recruiting

Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease

Kidney Cancer | Bladder Cancer | Renal Cancer | Malignant Neoplasms | Hereditary Neoplastic Syndromes

United States
Dana-Farber Cancer Institute
National Cancer Institute (NCI); Baylor College of Medicine; City of Hope Medical...

Recruiting

Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress (LiFT_UP)

TP53 Gene Mutation | Li-Fraumeni Syndrome | Hereditary Cancer Syndrome | Mosaicism | Clonal Hematopoiesis

United States
Takeda

Recruiting

A Study in Adults With Hereditary Angioedema (HAE) Who Currently Receive Icatibant at Home

Hereditary Angioedema (HAE)

United Kingdom
Takeda

Recruiting

A Study of Lanadelumab in Teenagers and Adults With Hereditary Angioedema (HAE)

Hereditary Angioedema (HAE)

United Kingdom
Liminal BioSciences Ltd.

Terminated

Open-Label Rollover Study of PBI 4050 in Subjects With Alström Syndrome

Alström Syndrome

United Kingdom
BioCryst Pharmaceuticals

Completed

A Drug-Drug Interaction Study to Evaluate Drug Transporter Interactions

Hereditary Angioedema

United Kingdom
KalVista Pharmaceuticals, Ltd.

Completed

Phase 1 Crossover Study in Healthy Subjects to Evaluate the PK Profile of KVD824 Following Single and Multiple Doses of Modified Release (MR) Formulations

Hereditary Angioedema

United Kingdom
KalVista Pharmaceuticals, Ltd.

Completed

A Single Dose Safety, Tolerability, Pharmacokinetic and Food Effect Study of KVD900 in Healthy Volunteers

Hereditary Angioedema

United Kingdom
BioCryst Pharmaceuticals

Completed

A Relative Bioavailability Study of Two Formulations of BCX7353

Hereditary Angioedema

United Kingdom
BioCryst Pharmaceuticals

Completed

First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BCX7353 in Healthy Western and Japanese Volunteers

Hereditary Angioedema

United Kingdom
Kaiser Permanente
Dana-Farber Cancer Institute; Columbia University; Emory University; University... and other collaborators

Active, not recruiting

Cancer Health Assessments Reaching Many (CHARM)

Hereditary Cancer Syndrome

United States
KalVista Pharmaceuticals, Ltd.

Completed

A Single and Multiple Doses Safety, Tolerability, Pharmacokinetics and Food Effect Study of KVD824 in Healthy Volunteers

Hereditary Angioedema

United Kingdom
BioCryst Pharmaceuticals

Completed

A Study of the Relative Bioavailability of a New Formulation of BCX4161 and the Effect of Food on BCX4161

Hereditary Angioedema

United Kingdom
University of Cambridge

Completed

Biopsy Technique for Endoscopic Surveillance of Hereditary Diffuse Gastric Cancer

Hereditary Diffuse Gastric Cancer

United Kingdom
BioCryst Pharmaceuticals

Completed

An Open-label Drug-Drug Interaction Study to Evaluate the Effect of BCX7353 on Cytochrome P450 Enzyme Activity Using Probe Substrates

Hereditary Angioedema

United Kingdom
BioCryst Pharmaceuticals

Completed

Study to Determine How BCX4161 is Metabolized and Eliminated by the Body

Hereditary Angioedema

United Kingdom
University of Pittsburgh

Completed

Hereditary Colorectal and Associated Tumor Registry Study

Lynch Syndrome | Hereditary Diffuse Gastric Cancer | FAP | Peutz-Jeghers Syndrome | Juvenile Polyposis Syndrome

United States
Johns Hopkins University
National Human Genome Research Institute (NHGRI)

Completed

Genetic Risk: Whether, When, and How to Tell Adolescents

Huntington Disease | Hereditary Cancer | Hereditary Breast and Ovarian Cancer | Hereditary Non-polyposis Colon Cancer | Hereditary Non-Polyposis Colorectal Cancer Syndrome

United States
Novartis Pharmaceuticals

Completed

A Phase I/II Study of BEZ235 in Patients With Advanced Solid Malignancies Enriched by Patients With Advanced Breast Cancer

Breast Cancer | Advanced Solid Tumors | Cowden Syndrome

Netherlands, Spain, Germany, United Kingdom, United States
Abramson Cancer Center at Penn Medicine

Enrolling by invitation

Sequential EHR Based Interventions to Increase Genetic Testing for Breast and Ovarian Cancer Predisposition

Ovarian Cancer | Genetic Predisposition to Disease | Breast Cancer Female | Hereditary Diseases | Gene Mutation-Related Cancer | Hereditary Breast and Ovarian Cancer | Hereditary Cancer Syndrome

United States
Massachusetts General Hospital
National Cancer Institute (NCI); Boston Medical Center

Completed

Development and Implementation of Electronic Decision Aids for Genetic Testing in Inherited Cancer Syndromes

Genetic Testing

United States
M.D. Anderson Cancer Center

Recruiting

Evaluation of Hereditary Cancer Educational Videos

Hereditary Cancer

United States
St George's, University of London

Terminated

Intrauterine Levonorgestrel and Observation or Observation Alone in Preventing Atypical Endometrial Hyperplasia and Endometrial Cancer in Women With Hereditary Non-Polyposis Colorectal Cancer or Lynch Syndrome

Endometrial Cancer | Hereditary Non-polyposis Colon Cancer (hmsh2, hmlh1, hpms1, hpms2)

United Kingdom
Cambridge University Hospitals NHS Foundation Trust

Completed

Gastrectomy, Eating Behaviour and GLP-1

Gastric Cancer | Dumping Syndrome

United Kingdom
University of Texas Southwestern Medical Center

Recruiting

CHARGE Study: CHoice ARchitecture Genetic tEsting (CHARGE)

Hereditary Cancer

United States
M.D. Anderson Cancer Center

Recruiting

Registry for Women Who Are At Risk Or May Have Lynch Syndrome

Lynch Syndrome | Hereditary Nonpolyposis Colorectal Cancer

United States
University College London Hospitals

Completed

Muscle Structure, Function and Gait in dHMN (GAIT-dHMN)

Distal Hereditary Motor Neuropathy, Type II | Distal Hereditary Motor Neuropathy, Type V | Distal Hereditary Motor Neuronopathy Type I | Distal Hereditary Motor Neuronopathy Type VI

United Kingdom
University of Aberdeen
NHS Grampian

Completed

Abdominal Cutaneous Nerve Entrapment Syndrome (ACNES)

Abdominal Pain | Abdominal Cutaneous Nerve Entrapment Syndrome

United Kingdom
PellePharm, Inc.

Completed

Trial of Patidegib Gel 2%, 4%, and Vehicle to Decrease the Number of Surgically Eligible Basal Cell Carcinomas in Gorlin Syndrome Patients

Basal Cell Nevus Syndrome

United Kingdom
Birmingham Women's and Children's NHS Foundation...
Children's Cancer and Leukaemia Group

Not yet recruiting

Nephrogreen. Appearances of Exvivo Renal Tumours Under Near-infrared (Nephrogreen)

Renal Cancer | Wilms Tumor

United Kingdom
Liminal BioSciences Ltd.

Completed

Safety and Tolerability of PBI-4050 and Its Effects on the Biomarkers in Subjects With Alström Syndrome

Diabetes | Inflammation and Fibrosis

United Kingdom
ProQR Therapeutics

Terminated

Study to Evaluate the Efficacy Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene With Early to Moderate Vision Loss (Celeste)

Eye Diseases | Retinitis Pigmentosa | Eye Diseases, Hereditary | Vision Disorders | Retinal Disease | Eye Disorders Congenital | Usher Syndrome Type 2 | Deaf Blind

United States, United Kingdom
BioCryst Pharmaceuticals

Completed

Safety and Efficacy of Oral BCX4161 as a Prophylactic Treatment for HAE (OPuS-1)

Hereditary Angioedema

Germany, United Kingdom
University of Southern California
Stanford University

Completed

Cancer Genetics Hereditary Cancer Panel Testing (HCP)

Hereditary Breast and Ovarian Cancer

United States
University of Cincinnati
National Heart, Lung, and Blood Institute (NHLBI); Rare Diseases Clinical Research...

Completed

Assessment of Safety of Air Travel in Patients With Birt-Hogg-Dube Syndrome

Birt-Hogg-Dube Syndrome

United States
Intellia Therapeutics

Enrolling by invitation

Long-Term Follow-Up (LTFU) of Subjects Treated With NTLA 2002

Hereditary Angioedema

France, New Zealand, United Kingdom, Netherlands
Georgetown University
Virginia Commonwealth University; Cornell University

Completed

Testing an Intelligent Tutoring System to Enhance Genetic Risk Assessment

Hereditary Breast and Ovarian Cancer

United States
Imperial College London

Completed

Frequency of Common Medical Conditions in People With and Without HHT

Hereditary Hemorrhagic Telangiectasia (HHT)

United Kingdom
M.D. Anderson Cancer Center
National Cancer Institute (NCI); National Institutes of Health (NIH)

Recruiting

A Phase IIa Randomized, Double-Blinded Clinical Trial of Naproxen or Aspirin for Cancer Immune Interception in Lynch Syndrome

Colorectal Cancer | Lynch Syndrome | T Cells

United States
Kaiser Permanente
M.D. Anderson Cancer Center; Dana-Farber Cancer Institute; Vanderbilt University and other collaborators

Completed

Integrating Genetic Testing for Lynch Syndrome in a Managed Care Setting (HNPCC)

Lynch Syndrome | Colon Cancer

United States

Clinical Trials on Hereditary Cancer Syndromes in United Kingdom

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