Clinical Trials on Hereditary Cancer in United Kingdom

Total 25075 results

University College, London
Medical Research Council; Moorfields Eye Hospital NHS Foundation Trust

Recruiting

RAFT - Clinical Trial of RAFT for Aniridia Related Keratopathy (RAFT)

Aniridia

United Kingdom
GenSight Biologics

Active, not recruiting

Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year (REFLECT)

Leber Hereditary Optic Neuropathy

Belgium, Spain, United States, France, United Kingdom, Taiwan, Italy
St George's, University of London
University College London Hospitals

Unknown

Effect of Orthoses and Underfoot Vibration on Balance in Neuropathy

Peripheral Neuropathy | CMT - Charcot-Marie-Tooth Disease | Hereditary Peripheral Neuropathy | CMT1A

United Kingdom
Liminal BioSciences Ltd.

Completed

Safety and Tolerability of PBI-4050 and Its Effects on the Biomarkers in Subjects With Alström Syndrome

Diabetes | Inflammation and Fibrosis

United Kingdom
University of Oxford
University College, London; Moorfields Eye Hospital NHS Foundation Trust

Completed

REP1 Gene Replacement Therapy for Choroideremia (REGENERATE)

Choroideremia

United Kingdom
University of Oxford

Completed

Safety and Efficacy of the Alpha AMS Subretinal Implant (OX-RI)

Retinitis Pigmentosa

United Kingdom
Santhera Pharmaceuticals

Completed

Historical Case Record Survey of Visual Acuity Data From Patients With Leber's Hereditary Optic Neuropathy (LHON)

Leber's Hereditary Optic Neuropathy (LHON)

Belgium, Netherlands, France, Germany, Norway, United Kingdom, Italy
Abramson Cancer Center at Penn Medicine

Enrolling by invitation

Sequential EHR Based Interventions to Increase Genetic Testing for Breast and Ovarian Cancer Predisposition

Ovarian Cancer | Genetic Predisposition to Disease | Breast Cancer Female | Hereditary Diseases | Gene Mutation-Related Cancer | Hereditary Breast and Ovarian Cancer | Hereditary Cancer Syndrome

United States
MeiraGTx UK II Ltd
Syne Qua Non Limited

Completed

Long-Term Follow-Up Gene Therapy Study for Leber Congenital Amaurosis OPTIRPE65 (Retinal Dystrophy Associated With Defects in RPE65)

Eye Diseases | Retinal Diseases | Eye Diseases, Hereditary | Leber Congenital Amaurosis (LCA)

United States, United Kingdom
Pharvaris Netherlands B.V.

Completed

Dose-ranging Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema (RAPIDe-1)

Hereditary Angioedema | Hereditary Angioedema Type I | Hereditary Angioedema Type II | Hereditary Angioedema Types I and II | Hereditary Angioedema Attack | Hereditary Angioedema With C1 Esterase Inhibitor Deficiency | Hereditary Angioedema - Type 1 | Hereditary Angioedema - Type 2 | C1 Esterase Inhibitor... and other conditions

Bulgaria, United States, Spain, Israel, Germany, Canada, Czechia, France, Hungary, Italy, Netherlands, Poland, United Kingdom
Mundipharma Research Limited

Terminated

A Study to Assess the Safety and Tolerability of Oxycodone Hydrochloride 50mg/mL Administered as an Infusion

Severe Caner Pain

United Kingdom
Imperial College London

Completed

Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs

Hereditary Hemorrhagic Telangiectasia | Pulmonary Arteriovenous Malformations

United Kingdom
Imperial College London

Terminated

Iron Deficiency and Hereditary Haemorrhagic Telangiectasia

Hereditary Haemorrhagic Telangiectasia

United Kingdom
National Cancer Institute (NCI)

Recruiting

Collection of Serum and Tissue Samples From Patients With Biopsy-Proved or Suspected Malignant Disease

Kidney Cancer | Bladder Cancer | Renal Cancer | Malignant Neoplasms | Hereditary Neoplastic Syndromes

United States
University of Oxford
Moorfields Eye Hospital NHS Foundation Trust; Oxford University Hospitals NHS...

Completed

TES for the Treatment of RP (TESOLAUK)

Retinitis Pigmentosa

United Kingdom
King's College London
University of Oxford; Neuroscience Technologies S.L.P

Unknown

Painful Channelopathies Study (PCS)

Chronic Pain | Hereditary Sensory and Autonomic Neuropathies | Erythromelalgia | Pain Insensitivity, Congenital

United Kingdom
Ambry Genetics
Beth Israel Deaconess Medical Center; HonorHealth Research Institute; University...

Completed

Utilizing a Multi-gene Testing Approach to Identify Hereditary Pancreatic Cancer

Pancreatic Ductal Adenocarcinoma

United States
University College, London

Not yet recruiting

Coloured-light in Retinitis Pigmentosa. (CLIRP)

Retinitis Pigmentosa

United Kingdom
MeiraGTx UK II Ltd

Completed

Natural History Study for Achromatopsia

Achromatopsia

United Kingdom
Vanderbilt University Medical Center
National Cancer Institute (NCI)

Completed

Collecting Information From Patients and Family Members With Hereditary Colorectal Cancer Syndromes or Who Are at High Risk of Developing Colorectal Cancer

Colorectal Cancer | Precancerous Condition | Hereditary Non-polyposis Colon Cancer

United States
Fox Chase Cancer Center
National Cancer Institute (NCI)

Completed

Educational CD-ROM Compared With Standard Informed Consent for Patients With Colorectal Cancer or a Family History of Colorectal Cancer

Colorectal Cancer | Hereditary Non-polyposis Colon Cancer

United States
Leeds Cancer Centre at St. James's University Hospital

Unknown

Identifying Gene Mutations in Patients With Melanoma and in Families With a History of Hereditary Melanoma

Melanoma (Skin) | Hereditary Multiple Melanoma

United Kingdom
National Cancer Institute (NCI)

Completed

Phase I-II Multiple-Dose Safety and Efficacy Study of a Selective Inhibitor of Cyclooxygenase - 2 (SC-58635) in Hereditary Non-Polyposis Colorectal Cancer (HNPCC) Patients and Carriers

Colorectal Neoplasm | Hereditary Nonpolyposis

United States
Imperial College London
British Heart Foundation

Active, not recruiting

Studies of White Blood Cells Derived From HHT Patients

Telangiectasia, Hereditary Hemorrhagic

United Kingdom
National Human Genome Research Institute (NHGRI)

Completed

Is it Feasible?: Self-Affirmation for Hereditary Breast and Ovarian Cancer Genetic Counseling

Breast Cancer

United States
Intellia Therapeutics

Active, not recruiting

NTLA-2002 in Adults With Hereditary Angioedema (HAE) (NTLA-2002)

Hereditary Angioedema

France, New Zealand, Germany, United Kingdom, Netherlands, Australia
Moorfields Eye Hospital NHS Foundation Trust
Bayer

Completed

Aflibercept for Macular Oedema With Underlying Retinitis Pigmentosa (AMOUR) Study (AMOUR)

Retinitis Pigmentosa | Macular Oedema

United Kingdom
National Human Genome Research Institute (NHGRI)

Completed

Psychosocial Aspects of Genetic Testing for Hereditary Nonpolyposis Colon Cancer

HNPCC | Hereditary Nonpolyposis Colon Cancer

United States
Shire

Completed

A European Post-Authorisation Observational Study Of Patients With Hereditary Angioedema

Hereditary Angioedema (HAE)

Germany, Spain, United Kingdom, France, Italy, Belgium
Santhera Pharmaceuticals

Completed

Study to Assess the Efficacy and Safety of Raxone in LHON Patients (LEROS)

Leber's Hereditary Optic Neuropathy (LHON)

United States, United Kingdom, Spain, Poland, Austria, Belgium, Bulgaria, Germany, Italy, Portugal
Imperial College London
British Heart Foundation

Recruiting

Molecular Studies on Hereditary Haemorrhagic Telangiectasia Families

Telangiectasia, Hereditary Hemorrhagic

United Kingdom
Imperial College London

Completed

Study of Histological Samples From Patients With Hereditary Haemorrhagic Telangiectasia

Telangiectasia, Hereditary Hemorrhagic

United Kingdom
Imperial College London
Hammersmith Hospitals NHS Trust

Completed

Investigation of Coagulation Parameters in Hereditary Haemorrhagic Telangiectasia

Telangiectasia, Hereditary Hemorrhagic

United Kingdom
Imperial College London

Completed

Investigation of Plasma Proteins in Patients With Hereditary Haemorrhagic Telangiectasia and PAVMs

Telangiectasia, Hereditary Hemorrhagic

United Kingdom
Imperial College London

Withdrawn

Study of Endothelial Cells in Patients With Hereditary Haemorrhagic Telangiectasia

Telangiectasia, Hereditary Hemorrhagic

United Kingdom
National Cancer Institute (NCI)

Active, not recruiting

Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Cancer

Cancer | Hereditary Neoplasms | Genetic Predisposition to Cancer | Environment

United States
Astellas Institute for Regenerative Medicine

Completed

A Follow up Study to Determine the Safety and Tolerability of Sub-retinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial (hESC-RPE) Cells in Patients With Stargardt's Macular Dystrophy (SMD)

Stargardt's Macular Dystrophy

United Kingdom
Institute of Cancer Research, United Kingdom
Cancer Research UK; National Institute for Health Research, United Kingdom

Completed

Magnetic Resonance Imaging Screening in Li Fraumeni Syndrome (SIGNIFY)

Li-Fraumeni Syndrome

United Kingdom
Cardiff University
National Institute for Social Care and Health Research

Completed

Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) (BIMA)

Graves' Ophthalmopathy

United Kingdom
KalVista Pharmaceuticals, Ltd.

Completed

A Phase II, Cross-over Clinical Trial Evaluating the Efficacy and Safety of KVD900 in the On-demand Treatment of Angioedema Attacks in Adult Subjects With Hereditary Angioedema Type I or II

Hereditary Angioedema

United States, Austria, Czechia, Germany, Hungary, Italy, Netherlands, North Macedonia, Poland, United Kingdom
University of Utah
University of Witwatersrand, South Africa

Completed

A Novel Mutation of the Spectrin Gene

Hereditary Elliptocytosis (HE) | Hereditary Pyropoikilocytosis (HPP)

United States
Imperial College London
The Margaret Hayton HHT Fund

Recruiting

Case Notes Review on Patients With Hereditary Haemorrhagic Telangiectasia

Telangiectasia, Hereditary Hemorrhagic

United Kingdom
National Cancer Institute (NCI)

Recruiting

Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer

Stomach Neoplasms | Stomach Cancer | Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) | Hereditary Diffuse Gastric Cancer (HDGC) | Familial Diffuse Gastric Cancer

United States
National Cancer Institute (NCI)

Recruiting

Rare Tumors and Cancer Predisposition in Individuals and Families

Cancer | Hereditary Neoplasms | Genetic Predisposition to Cancer | Environment

United States
University of Southern California
Stanford University

Completed

Cancer Genetics Hereditary Cancer Panel Testing (HCP)

Hereditary Breast and Ovarian Cancer

United States
University of Leicester
Children's Cancer and Leukaemia Group; Gesellschaft fur Padiatrische Onkologie... and other collaborators

Unknown

Chemotherapy Before and After Surgery in Treating Children With Wilm's Tumor

Kidney Cancer

United Kingdom, Germany, France, Netherlands
Astellas Institute for Regenerative Medicine

Completed

Safety and Tolerability of Sub-retinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial (hESC-RPE) Cells in Patients With Stargardt's Macular Dystrophy (SMD)

Stargardt's Macular Dystrophy

United Kingdom
Royal Marsden NHS Foundation Trust

Unknown

Feasibility of a Molecular Characterisation Approach to Treatment (FOrMAT)

Advanced Gastrointestinal Cancers

United Kingdom
National Eye Institute (NEI)

Completed

Evaluation and Treatment of Patients With Inherited Eye Diseases

Hereditary Eye Disease

United States
National Eye Institute (NEI)

Completed

Screening for Studies on Inherited Eye Diseases

Hereditary Eye Disease

United States

Clinical Trials on Hereditary Cancer in United Kingdom

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Zimbabwe

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

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