Clinical Trials on Hereditary Complement Deficiency Diseases in Germany

Total 638 results

Robert Bosch Gesellschaft für Medizinische Forschung...

Completed

Influence of Pharmacogenetic Factors, Paroxetine and Clarithromycin on Pharmacokinetics of Clomiphene

Anovulation | Cytochrome P450 CYP3A Enzyme Deficiency | Disorder Due Cytochrome P450 CYP2D6 Variant

Germany
Ipsen

Recruiting

Global Patient Registry to Monitor Long-term Safety and Effectiveness of Increlex® in Children and Adolescents With Severe Primary Insulin-like Growth Factor-1 Deficiency (SPIGFD).

IGF1 Deficiency

Spain, United States, Italy, France, United Kingdom, Germany, Austria, French Guiana, Poland, Sweden, Martinique
Kowa Research Institute, Inc.

Recruiting

A Study to Evaluate the Safety and Efficacy of K-321 Eye Drops After Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)

Fuchs Endothelial Corneal Dystrophy

United States, Germany, Spain, Canada, United Kingdom, Denmark
Johns Hopkins University
The Shulsky Foundation

Completed

The Natural History of the Progression of Atrophy Secondary to Stargardt Disease Type 4: PROM1-Related Macular Dystrophy (ProgStar-4)

Stargardt Disease

Germany, United States, United Kingdom
Heidelberg University

Recruiting

The Effect of Oxygen Therapy on 6MWD in PAH and CTEPH Patients With Hypoxemia (SOPHA)

Pulmonary Arterial Hypertension | Oxygen Deficiency | CTEPH

Germany
Charite University, Berlin, Germany

Completed

Morphological Analysis of the Pineal Gland in Pediatric Retinoblastoma Patients Using Magnetic Resonance Imaging

Retinoblastoma | Pineoblastoma

Germany
University Medical Center Goettingen
University Hospital Muenster; Ludwig-Maximilians - University of Munich

Completed

Biomarkers and Validation of Selected Outcome Measures (CMTNSmod)

Charcot-Marie-Tooth Disease, Type IA

Germany
Gilead Sciences

Completed

Safety Study of Once a Day ART and Opiate Substitute. (3OD)

HIV Infections

Germany
ProQR Therapeutics

Active, not recruiting

A Study to Evaluate Efficacy, Safety, Tolerability and Exposure After a Repeat-dose of Sepofarsen (QR-110) in LCA10 (ILLUMINATE) (ILLUMINATE)

Eye Diseases | Neurologic Manifestations | Eye Diseases, Hereditary | Sensation Disorders | Vision Disorders | Blindness | Leber Congenital Amaurosis | Leber Congenital Amaurosis 10 | Retinal Disease | Eye Disorders Congenital

United States, Belgium, Brazil, Canada, France, Germany, Italy, Netherlands, United Kingdom
Johann Wolfgang Goethe University Hospital

Unknown

Status of Growth Hormone/ Insulin-like Growth Factor-1 (GH/IGF-1) Axis and Growth Failure in Ataxia Telangiectasia (AT) (GHAT)

Growth Failure | Ataxia Telangiectasia

Germany
ViiV Healthcare
GlaxoSmithKline

Completed

Pharmacodynamics, Safety and Pharmacokinetics of BMS-663068, an HIV Attachment Inhibitor, in HIV-1

HIV Infections

Germany
Boehringer Ingelheim

Completed

Effect of Multiple Dosing With BI 201335 on the Pharmacokinetics of Darunavir Co-administered With Ritonavir in Healthy Male and Female Volunteers

HIV Infections

Germany
University of Rostock

Unknown

Effects of GH on Body Proportions and Final Height in X-Linked Hypophosphatemic Rickets

Growth Disorders | Hypophosphatemic Rickets | Somatropin Therapy

Germany
Genetic Immunity
Universitätsklinikum Hamburg-Eppendorf

Completed

Repeated DermaVir Immunizations in HIV-1 Infected Treatment-naïve Patients (GIEU006)

HIV Infection

Germany
Institute for Interdisciplinary Infectiology
Hoffmann-La Roche

Unknown

Cohort Study for Patients Using Fuzeon (Enfuvirtide)

HIV Infections | Antiretroviral Treatment

Germany
Kowa Research Institute, Inc.

Recruiting

A Study to Investigate the Safety and Efficacy of K-321 Eye Drops After Simultaneous Cataract Surgery and Descemetorhexis in Participants With Fuchs Endothelial Corneal Dystrophy (FECD)

Fuchs Endothelial Corneal Dystrophy

United States, United Kingdom, Spain, Germany, Canada, Denmark
Johann Wolfgang Goethe University Hospital
German Federal Ministry of Education and Research

Unknown

Gene Therapy for Chronic Granulomatous Disease (CGD)

Granulomatous Disease, Chronic

Germany
Novo Nordisk A/S

Completed

Safety and Efficacy of Long-term Somatropin Treatment in Children (GrowthWIN II)

Turner Syndrome | Growth Hormone Disorder | Growth Hormone Deficiency in Children | Genetic Disorder | Foetal Growth Problem | Small for Gestational Age | Growth Disorder | Idiopathic Short Stature

Germany
Charite University, Berlin, Germany

Completed

Safety and Tolerability of Rilonacept in Muckle-Wells Syndrome (MWS) or Schnitzler Syndrome (SchS) (ACCILTRA1)

Schnitzler Syndrome | Muckle-Wells Syndrome

Germany
University Hospital Tuebingen

Completed

Tocilizumab for the Treatment of Familial Mediterranean Fever

Familial Mediterranean Fever

Germany
National Cancer Institute (NCI)

Active, not recruiting

Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

Lynch Syndrome | Stage III Colon Cancer AJCC v8 | Colon Adenocarcinoma | DNA Repair Disorder

United States, Puerto Rico, Germany
University Hospital Heidelberg
German Cancer Research Center

Completed

Mitochondrial Effects of C18:0 Supplementation in Humans

Type2 Diabetes | Fatty Acid Deficiency | Alteration of Mitochondrial Membrane

Germany
Foundation Fighting Blindness
United States Department of Defense

Completed

A Natural History of the Progression of Stargardt Disease: Retrospective and Prospective Studies (ProgSTAR)

Stargardt Disease

United States, United Kingdom, France, Germany
rEVO Biologics

Completed

Assess Incidence of Deep Vein Thrombosis(DVT)Following Administration of Recombinant Human Antithrombin (rhAT) to Hereditary Antithrombin(AT) Deficient Patients in High Risk Situations. (rhAT)

Antithrombin Deficiency, Congenital

France, United Kingdom, Germany, United States, Sweden, Italy
Pixium Vision SA

Completed

Restoring Vision With the Intelligent Retinal Implant System (IRIS V1)in Patients With Retinal Dystrophy (IRIS-1)

Retinitis Pigmentosa | Choroideremia | Cone Rod Dystrophy

Austria, France, Germany
Regenerative Medicine Network
University of Leipzig

Completed

Examination of B Cell Responses in Human Blood

HIV Infections

Germany
Technical University of Munich

Completed

Dual Therapy With Boosted Darunavir + Dolutegravir (Dualis)

HIV-Infection

Germany
UniQure Biopharma B.V.

Completed

Glybera Registry, Lipoprotein Lipase Deficient (LPLD) Patients (GENIALL)

Lipoprotein Lipase Deficiency | Familial Hyperlipoproteinemia Type 1 | Familial Hyperchylomicronemia

Germany
AMAG Pharmaceuticals, Inc.

Completed

A Trial Comparing Ferumoxytol With Iron Sucrose for the Treatment of Iron Deficiency Anemia

Iron Deficiency Anemia

Germany, Poland, United Kingdom, Australia, France, Hungary, Italy, Korea, Republic of, Latvia, Lithuania, Romania, South Africa, Spain, Ukraine
GenSight Biologics

Completed

Efficacy Study of GS010 for Treatment of Vision Loss From 7 Months to 1 Year From Onset in LHON Due to the ND4 Mutation (REVERSE) (REVERSE)

Optic, Atrophy, Hereditary, Leber

United Kingdom, United States, Germany, Italy, France
University of Cologne

Completed

CD4 Cell Recovery in HIV-1 Patients Comparing 2 Treatment Regimes

HIV Infections | Acquired Immunodeficiency Syndrome

Germany
GenSight Biologics

Completed

Efficacy Study of GS010 for the Treatment of Vision Loss up to 6 Months From Onset in LHON Due to the ND4 Mutation (RESCUE)

Optic, Atrophy, Hereditary, Leber

United Kingdom, United States, France, Germany, Italy
Takeda

Enrolling by invitation

An Extension Study to Learn About the Long-Term Safety of Fazirsiran and if Fazirsiran Can Help People With Alpha-1 Antitrypsin Liver Disease

Alpha1-Antitrypsin Deficiency

United Kingdom, Germany, United States, Austria, Portugal
Charite University, Berlin, Germany

Completed

Growth Hormone and Glucose Metabolism (GHGMS)

Growth Hormone Deficiency

Germany
Charite University, Berlin, Germany

Unknown

Subjective Near-infrared Fluorescence Guidance in Perfusion Assessment of Ileal Pouch Formation and Ileal-pouch-anal Anastomosis

Colorectal Cancer | Crohn Disease | Ulcerative Colitis | Familial Adenomatous Polyposis | Crohn Colitis | Ileal Pouch

Germany
Bavarian Nordic
National Institutes of Health (NIH)

Completed

Single-Blind, Controlled Safety and Immunogenicity Study of Recombinant MVA Virus to Treat HIV Infection

HIV Infections

Germany
Pfizer

Terminated

A Single Dose Study to Evaluate the PK-PD Response and Safety of PHA-794428 in Children With Growth Hormone Deficiency

Growth Hormone Deficiency

France, Belgium, Germany, Israel, United Kingdom
Imperial College London
Fu Wai Hospital, Beijing, China

Completed

IV Iron Replacement for Iron Deficiency in Idiopathic Pulmonary Arterial Hypertension (IPAH) Patients

Pulmonary Arterial Hypertension | Iron Deficiency

United Kingdom, China, Germany
Bavarian Nordic

Completed

Safety and Immunogenicity Study of Recombinant Modified Vaccinia Virus Ankara (MVA) Virus to Treat HIV Infection

HIV Infections

Germany
ViiV Healthcare
GlaxoSmithKline

Completed

Study to Evaluate a HIV Drug for the Treatment of HIV Infection

HIV Infections | Infection, Human Immunodeficiency Virus

Germany
Hubert Serve, Prof., MD

Unknown

Gene Therapy for X-CGD

X-linked Chronic Granulomatous Disease

Germany
Merck KGaA, Darmstadt, Germany

Completed

An Open-label Phase 4 Study to Explore Immunogenicity of the Liquid Formulation of Saizen® in Subjects With Adult Growth Hormone Deficiency (AGHD)

Adult Growth Hormone Deficiency

United Kingdom, Germany, Australia, Sweden
Klinikum St. Georg gGmbH

Completed

Wound Healing Abnormalities in Major Abdominal Surgery (INWOUND)

Impaired Wound Healing | Factor XIII Deficiency

Germany
Second Sight Medical Products

Terminated

Argus® II Retinal Prosthesis System Post-Market Surveillance Study

Retinitis Pigmentosa | Outer Retinal Degeneration

Germany, Italy
NYU Langone Health
Universitätsklinikum Hamburg-Eppendorf

Completed

A Natural History Study of Canavan Disease

Canavan Disease

Germany, United States
Charite University, Berlin, Germany

Unknown

Objective Perfusion Rate Assessment by Near-infrared Fluorescence in Ileal Pouch Formation and Ileal-pouch-anal Anastomosis

Colorectal Cancer | Crohn Disease | Ulcerative Colitis | Familial Adenomatous Polyposis | Crohn Colitis | Ulcerative Colitis Chronic | Ulcerative Colitis in Remission | Ileal Pouch

Germany
Pfizer

Completed

Cross Over Convenience And Preference Study Of New Mark VII Compared To Genotropin Pen In Pediatric And Adult Subjects (CHOOSE)

Growth Hormone Deficiency

United Kingdom, Czech Republic, Germany, Netherlands, Slovakia, Sweden, Turkey
Amsterdam UMC, location VUmc
University Hospital, Essen; Institut Curie; Ligue contre le cancer, France

Completed

New Strategies to Detect Cancers in Carriers of Mutations in RB1 (NIRBTEST)

Retinoblastoma | Secondary Primary Malignancies After Retinoblastoma

Netherlands, France, Germany
Clara Lehmann
German Federal Ministry of Education and Research

Completed

Gut Associated Lymphatic Tissue (GALT) in HIV (Human Immunodeficiency Virus)- Infected Patients

HIV Infection

Germany
Columbia University
Ludwig-Maximilians - University of Munich; Moorfields Eye Hospital NHS Foundation... and other collaborators

Recruiting

CNGB1 and Allied Disorders

Retinitis Pigmentosa Associated With CNGB1 Mutations

United States, France, Germany, United Kingdom

Clinical Trials on Hereditary Complement Deficiency Diseases in Germany

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in China

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

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