Clinical Trials on Hereditary Cancer Syndromes

Total 86233 results

National Cancer Institute (NCI)

Active, not recruiting

Clinical, Laboratory, and Epidemiologic Characterization of Individuals and Families at High Risk of Cancer

Cancer | Hereditary Neoplasms | Genetic Predisposition to Cancer | Environment

United States
National Cancer Institute (NCI)

Recruiting

Acceptance and Commitment Therapy for Caregivers of Children With a RASopathy: An Internal Pilot Feasibility Study and Follow-up Randomized Controlled Trial

Neurofibromatosis 1 | Noonan Syndrome | Legius Syndrome | Cardiofaciocutaneous Syndrome | Costello Syndrome

United States
University Hospital, Ghent
Centre Hospitalier Universitaire Vaudois; University Ghent; Hopital Lariboisière and other collaborators

Completed

PIPAC Nab-pac for Stomach, Pancreas, Breast and Ovarian Cancer (PIPAC-nabpac)

Breast Cancer Stage IV | Peritoneal Carcinomatosis | Ovarian Cancer Stage IIIC | Ovarian Cancer Stage IV | Breast Cancer Stage IIIB | Breast Cancer Stage IIIc | Ovarian Cancer Stage IIIB | Stomach Cancer Stage III | Stomach Cancer Stage IV With Metastases | Pancreas Cancer, Stage III | Pancreas Cancer, Stage...

Belgium
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

Culturally-Informed Counseling in Latinas at High Risk for Hereditary Breast or Ovarian Cancer

BRCA1 Syndrome | BRCA2 Syndrome | No Evidence of Disease | Hereditary Ovarian Carcinoma | Hereditary Female Breast Carcinoma

United States
University of Utah
University of Witwatersrand, South Africa

Completed

A Novel Mutation of the Spectrin Gene

Hereditary Elliptocytosis (HE) | Hereditary Pyropoikilocytosis (HPP)

United States
National Cancer Institute (NCI)

Completed

Familial Prostate Cancer

Prostatic Neoplasms | Neoplastic Syndromes, Hereditary

United States
Medical University of Vienna
University of Vienna; Griffith University

Recruiting

Brown Adipose Tissue Activity in Gilbert's Syndrome

Gilbert Syndrome

Austria
Assistance Publique - Hôpitaux de Paris

Active, not recruiting

Liquid Biopsies for the Personalized Management of Patients With Hereditary Diffuse Gastric Cancer (LISA-HDGC)

Hereditary Diffuse Gastric Cancer

France
National Cancer Institute (NCI)

Recruiting

Rare Tumors and Cancer Predisposition in Individuals and Families

Cancer | Hereditary Neoplasms | Genetic Predisposition to Cancer | Environment

United States
Genethon

Completed

Immunity Against AAV in Crigler Najjar Patient

Crigler Najjar Syndrome

France
Eastern Cooperative Oncology Group
National Cancer Institute (NCI)

Completed

Tretinoin With or Without Fenretinide in Treating Patients With Dysplastic Nevus Syndrome

Melanoma (Skin)

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...
Johns Hopkins University; National Cancer Institute (NCI)

Completed

Using High Resolution Function Imaging To Detect Melanoma and Dysplastic Nevi

Melanoma

United States
John Kirkwood

Completed

Pilot Study Evaluating Sulforaphane in Atypical Nevi-Precursor Lesions

Melanoma | Atypical Nevi

United States
BioCryst Pharmaceuticals

Approved for marketing

Oral Berotralstat Expanded Access Program

Hereditary Angioedema | Prophylaxis | HAE
University Hospital, Grenoble

Terminated

Determination of Specific Biomarkers of Acute Attack of Angioedema Within Pediatric Population (BRADYKID)

Healthy Volunteers | Hereditary Angioedema

France
Pharming Technologies B.V.

Completed

Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema

Genetic Disorders

Netherlands
University of British Columbia
Children's & Women's Health Centre of British Columbia; Vancouver Foundation; Circle of Care

Terminated

Establishing the Genetic Profile of Multiple Hereditary Exostoses (HME) in Families of BC

Exostoses, Multiple Hereditary

Canada
Istituto Ortopedico Rizzoli

Completed

Height, Ulnar Length and Forearm Function in Multiple Hereditary Exostoses

Exostoses, Multiple Hereditary

Italy
BioCryst Pharmaceuticals

Completed

A Long Term Safety Study of BCX7353 in Hereditary Angioedema (APeX-S)

Hereditary Angioedema | Prophylaxis | HAE

Austria, Denmark, France, Germany, Hungary, Israel, Italy, North Macedonia, Poland, Switzerland, United Kingdom, United States, Australia, Hong Kong, Korea, Republic of, New Zealand, Serbia, Slovakia, South Africa, Spain
Pharming Technologies B.V.

Completed

A Study of the Safety and Immunogenicity of Repeated rhC1INH Administration (OPERA)

Hereditary Angioedema | Genetic Disorders

Netherlands, Romania
Pharming Technologies B.V.

Completed

Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema

Genetic Disorders

Netherlands
Pharming Technologies B.V.

Completed

Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema

Hereditary Angioedema | Angioneurotic Edema

Netherlands
Pharming Technologies B.V.

Completed

Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema

Hereditary Angioedema | Genetic Disorders | Angioneurotic Edema

Netherlands, Romania
University of Cambridge

Completed

Biopsy Technique for Endoscopic Surveillance of Hereditary Diffuse Gastric Cancer

Hereditary Diffuse Gastric Cancer

United Kingdom
National Eye Institute (NEI)

Completed

Natural History and Genetic Studies of Usher Syndrome

Retinitis Pigmentosa | Usher Syndrome | Retinitis Pigmentosa Syndromic | Congenital Deafness | Retinitis Pigmentosa and Deafness

United States
University of Basel
National Cancer Center, Korea; University Hospital, Geneva; Swiss National Science... and other collaborators

Recruiting

The DIALOGUE Study: Swiss-Korean Billateral Collaboration (DIALOGUE)

Breast Cancer | Ovarian Cancer | Hereditary Cancer

Switzerland
Centre Hospitalier Universitaire Dijon

Unknown

Type 1 Multiple Endocrine Neoplasia Cohort Study (MEN1-GTEcohort)

Type 1-Multiple Endocrine Neoplasia Syndrome

France
National Cancer Institute (NCI)

Recruiting

Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer

Stomach Neoplasms | Stomach Cancer | Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS) | Hereditary Diffuse Gastric Cancer (HDGC) | Familial Diffuse Gastric Cancer

United States
Assistance Publique - Hôpitaux de Paris

Unknown

New Phototherapy Device to Treat Patients With Crigler-Najjar Disease (DRAP)

Children | Crigler Najjar Syndrome

France
IRCCS San Raffaele

Recruiting

Impact of Sensory, Motor and Vestibular Deficit on the Postural Stability of CMT Patients (EquiCMT)

Hereditary Neuropathy

Italy
National Eye Institute (NEI)

Completed

Evaluation and Treatment of Patients With Inherited Eye Diseases

Hereditary Eye Disease

United States
National Eye Institute (NEI)

Completed

Screening for Studies on Inherited Eye Diseases

Hereditary Eye Disease

United States
NorthShore University HealthSystem
National Cancer Institute (NCI); Wake Forest University Health Sciences; Van... and other collaborators

Completed

Clinical Validity and Utility of Genomic-targeted Chemoprevention of PCa: Aim 4a

Prostate Cancer | Prostate Cancer, Familial | Hereditary Prostate Cancer
Centre Hospitalier Universitaire Saint Pierre
Université Libre de Bruxelles

Withdrawn

Study on the Efficacy of Infiltration of Upper Cluneal Nerves in Chronic Pain Related to Cluneal Syndrome

Nerve Entrapment Syndrome | Cluneal Syndrome

Belgium
ProQR Therapeutics

Active, not recruiting

Study to Evaluate the Efficacy Safety and Tolerability of Ultevursen in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene (Sirius)

Eye Diseases | Retinitis Pigmentosa | Eye Diseases, Hereditary | Vision Disorders | Retinal Disease | Eye Disorders Congenital | Usher Syndrome Type 2 | Deaf Blind

United States, Netherlands, United Kingdom, Germany
ProQR Therapeutics

Terminated

Study to Evaluate the Efficacy Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene With Early to Moderate Vision Loss (Celeste)

Eye Diseases | Retinitis Pigmentosa | Eye Diseases, Hereditary | Vision Disorders | Retinal Disease | Eye Disorders Congenital | Usher Syndrome Type 2 | Deaf Blind

United States, United Kingdom
National Human Genome Research Institute (NHGRI)

Recruiting

Study of Chediak-Higashi Syndrome

Chediak-Higashi Syndrome

United States
Haramaya Unversity

Completed

Poorly Differentiated Adenocarcinoma of the Jejunum in a Patient With Peutz-Jeghers Syndrome: A Case Report

Peutz-Jeghers Syndrome

Ethiopia
University of British Columbia

Suspended

Gene Mutations and Orthopaedic Symptoms Correlation of Multiple Hereditary Exostoses: Multicentre Project

Exostoses, Multiple Hereditary

Canada
Penn State University

Withdrawn

C1-INH Compared to Placebo at the Time of Prodromal Symptoms for Hereditary Angioedema (HAE) Exacerbation

Hereditary Angioedema
ProQR Therapeutics

Completed

Study to Evaluate Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene (Stellar)

Eye Diseases | Retinitis Pigmentosa | Eye Diseases, Hereditary | Vision Disorders | Retinal Disease | Eye Disorders Congenital | Usher Syndrome Type 2 | Deaf Blind

United States, Canada, France
The University of Texas Health Science Center at...
National Institute of General Medical Sciences (NIGMS)

Recruiting

Genetic Analysis of Pheochromocytomas, Paragangliomas and Associated Conditions

Kidney Neoplasms | Bone Cancer | Thyroid Neoplasms | Pheochromocytoma | Paraganglioma | Other Cancer | Inherited Cancer Syndrome | Associated Conditions

United States
Charles Mel Wilcox, MD
Takeda Pharmaceuticals North America, Inc.

Completed

Treatment of Zollinger-Ellison Syndrome With Prevacid

Zollinger-Ellison Syndrome | Multiple Endocrine Neoplasia
Charite University, Berlin, Germany

Completed

Safety and Tolerability of Rilonacept in Muckle-Wells Syndrome (MWS) or Schnitzler Syndrome (SchS) (ACCILTRA1)

Schnitzler Syndrome | Muckle-Wells Syndrome

Germany
Sanofi

Active, not recruiting

A Study to Determine the Long-Term Safety, Tolerability and Biological Activity of SAR421869 in Patients With Usher Syndrome Type 1B

Usher's Syndrome

United States, France
Lei Li

Unknown

MSI in Circulatory DNA of Endometrial Cancer

Lynch Syndrome | Endometrial Cancer | Microsatellite Instability | Circulating Tumor Cell

China
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Completed

Alemtuzumab, Fludarabine Phosphate, and Total-Body Irradiation Followed by a Donor Stem Cell Transplant in Treating Patients With Immunodeficiency or Other Nonmalignant Inherited Disorders

Immunodeficiency Syndrome | Non-Cancer Diagnosis

United States
October 6 University

Completed

Effect of Chitosan Phonophoresis On Cubital Tunnel Syndrome

Cubital Tunnel Syndrome | Ulnar Nerve Entrapment at Elbow | Ulnar Nerve Compression | Ulnar Nerve Entrapment Syndrome

Egypt
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

Neurovisual Function in CHARGE Syndrome

CHARGE Syndrome

Italy
Universitaire Ziekenhuizen KU Leuven
KU Leuven; Universiteit Antwerpen

Recruiting

UZ/KU Leuven Program for Post-mortem Tissue Donation to Enhance Research (UPTIDER)

Breast Cancer | Hereditary Diseases

Belgium

Clinical Trials on Hereditary Cancer Syndromes

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Costa Rica

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations