Clinical Trials on High Grade Malignant Neoplasm

Total 5478 results

First Affiliated Hospital, Sun Yat-Sen University
Jingchu University of Technology

Unknown

A Safety and Efficacy Study of TALEN and CRISPR/Cas9 in the Treatment of HPV-related Cervical Intraepithelial NeoplasiaⅠ

Human Papillomavirus-Related Malignant Neoplasm

China
University of California, San Francisco
Lazarex Cancer Foundation

Terminated

Impact of Phone Call About Financial Reimbursement Program on Access to Cancer Clinical Trials

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Neoplasm

United States
Children's Hospital Los Angeles
Dana-Farber Cancer Institute

Active, not recruiting

Study of MEK162 for Children With Low-Grade Gliomas

Soft Tissue Neoplasms | Low-Grade Gliomas | Malignant Neoplasms, Brain

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Caregiver Burden, Quality of Life, and Symptom Distress at Different Palliative Cancer Care Settings

Metastatic Malignant Neoplasm | Advanced Malignant Neoplasm | Recurrent Malignant Neoplasm | Locally Advanced Malignant Neoplasm

United States
M.D. Anderson Cancer Center

Recruiting

Nivolumab for the Treatment of Metastatic or Unresectable Solid Tumors With ARID1A Mutation and CXCL13 Expression

Metastatic Malignant Solid Neoplasm | Unresectable Solid Neoplasm

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

EHealth Mindful Movement and Breathing in Improving Outcomes in Participants Undergoing Gynecologic Surgery

Ovarian Carcinoma | Malignant Uterine Neoplasm | Malignant Female Reproductive System Neoplasm | Ovarian Neoplasm | Uterine Neoplasm | Female Reproductive System Neoplasm | Suspicious for Malignancy

United States
M.D. Anderson Cancer Center
Tempus AI

Active, not recruiting

Initiative for Molecular Profiling and Advanced Cancer Therapy (IMPACT II)

Metastatic Malignant Neoplasm | Recurrent Malignant Neoplasm

United States
Sonavex, Inc.

Recruiting

Observational Study of Outcomes After EchoMark and EchoSure-based Free Flap Monitoring

Malignant Neoplasm | Free Flap Transfer

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

RCT of QPS vs General Information Sheet

Caregiver | Advanced Malignant Neoplasm | Physician

United States
Northwestern University
National Cancer Institute (NCI)

Withdrawn

Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis

Breast Carcinoma | Metastatic Malignant Neoplasm in the Brain | Metastatic Malignant Neoplasm in the Leptomeninges

United States
Sun Yat-sen University

Not yet recruiting

First-line Maintenance Treatment With Fluzoparib Plus Bevacizumab in Advanced BRCA Wild Type Ovarian Cancer

Ovarian Cancer | Primary Peritoneal Cancer | High Grade Serous Adenocarcinoma of Ovary | High Grade Endometrioid Ovarian Cancer | Fallopian-tube Cancer

China
SWOG Cancer Research Network
National Cancer Institute (NCI)

Recruiting

Financial Navigation Program to Improve Understanding and Management of Financial Aspects of Cancer Care for Patients and Their Spouses (CREDIT)

Hematopoietic and Lymphoid Cell Neoplasm | Recurrent Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States, Puerto Rico
National Cancer Institute (NCI)

Completed

Mogamulizumab and Pembrolizumab in Treating Patients With Relapsed or Refractory Diffuse Large B Cell Lymphoma

Recurrent Diffuse Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma | Recurrent High Grade B-Cell Lymphoma | Refractory High Grade B-Cell Lymphoma | Recurrent Transformed B-Cell Non-Hodgkin Lymphoma | Refractory Transformed B-Cell Non-Hodgkin Lymphoma

United States
Tigris Pharmaceuticals

Completed

Safety and Efficacy of A-007 Topical Gel in the Treatment of High-Grade Squamous Intraepithelial Lesions (HSIL) of the Cervix

Cervical Intraepithelial Neoplasia | Uterine Cervical Dysplasia

United States
Mashhad University of Medical Sciences

Completed

Effect of Metformin on Decrement in Levothyroxin Dose Required for Thyroid Stimulating Hormone (TSH) Suppression in Patients With Differentiated Thyroid Cancer

Malignant Neoplasm of Thyroid Stage I | Malignant Neoplasm of Thyroid Stage II

Iran, Islamic Republic of
Atara Biotherapeutics

Recruiting

A Study to Evaluate the Safety and Preliminary Efficacy of ATA3219 in Participants With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma

High-grade B-cell Lymphoma | MCL | Diffuse Large B-cell Lymphoma (DLBCL) | Relapsed/Refractory B-cell Non-Hodgkin Lymphoma | DLBCL/High-grade B-cell Lymphoma With MYC and BCL2 Rearrangements | Anaplastic Lymphoma Kinase-Positive Large B-Cell Lymphoma | LBCL With IRF4 Rearrangement | High-grade B-cell... and other conditions

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Genetically Modified T-cells (CMV-Specific CD19-CAR T-cells) Plus a Vaccine (CMV-MVA Triplex) for the Treatment of Intermediate or High Grade B-Cell Non-Hodgkin Lymphoma

Refractory B-Cell Non-Hodgkin Lymphoma | Recurrent B-Cell Non-Hodgkin Lymphoma | High Grade B-Cell Non-Hodgkin's Lymphoma | Intermediate Grade B-Cell Non-Hodgkin's Lymphoma

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing the Addition of an Anti-cancer Drug, Elimusertib (BAY 1895344) ATR Inhibitor, to the Chemotherapy Treatment (Gemcitabine) for Advanced Pancreatic and Ovarian Cancer, and Advanced Solid Tumors

Advanced Malignant Solid Neoplasm | Stage II Pancreatic Cancer AJCC v8 | Stage III Pancreatic Cancer AJCC v8 | Stage IV Pancreatic Cancer AJCC v8 | Metastatic Pancreatic Adenocarcinoma | Primary Peritoneal High Grade Serous Adenocarcinoma | Advanced Pancreatic Adenocarcinoma | Platinum-Resistant... and other conditions

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Consumer-Based Activity Monitor in Evaluating and Measuring Activity of Older Patients With Abdominal Cancer Undergoing Surgery

Malignant Gastrointestinal Neoplasm | Malignant Peritoneal Neoplasm

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Pro-Active Genetic Testing in Patients With Solid Tumors, Inherit Study

Malignant Solid Neoplasm | Breast Carcinoma | Digestive System Neoplasm | Skin Carcinoma | Malignant Female Reproductive System Neoplasm | Metastatic Malignant Neoplasm of Unknown Primary | Malignant Head and Neck Neoplasm | Malignant Brain Neoplasm | Malignant Central Nervous System Neoplasm | Malignant... and other conditions

United States
National Cancer Institute (NCI)

Recruiting

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

Low Grade Glioma | Low Grade Astrocytoma | Metastatic Low Grade Astrocytoma | Metastatic Low Grade Glioma

United States, Canada, Puerto Rico
Siemens Molecular Imaging

Completed

Exploratory, Phase 0 Study of Positron Emission Tomography (PET) Imaging Agent, F-18 RGD-K5 (K5)

Melanoma | Sarcoma | Breast Cancer | Lung Cancer | High Grade Gliomas

United States
National Cancer Institute (NCI)

Suspended

Testing Olaparib and AZD6738 in IDH1 and IDH2 Mutant Tumors

Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Refractory Cholangiocarcinoma

United States
National Cancer Institute, Thailand

Completed

Discordant HER2/Neu Status of Breast Cancer.

Malignant Neoplasm of Breast.

Thailand
Patrick C. Johnson, MD
AstraZeneca

Recruiting

Acalabrutinib + Liso-Cel In R/R Aggressive B-Cell Lymphomas

Refractory B-Cell Non-Hodgkin Lymphoma | Diffuse Large B-cell Lymphoma (DLBCL) | Grade 3b Follicular Lymphoma | Refractory Aggressive B-cell Lymphomas | Aggressive B-cell NHL | De Novo or Transformed Indolent B-cell Lymphoma | DLBCL, Nos Genetic Subtypes | T Cell/Histiocyte-rich Large B-cell Lymphoma and other conditions

United States
OX2 Therapeutics

Recruiting

CD200AR-L and Allogeneic Tumor Lysate Vaccine Immunotherapy for Recurrent HGG and Newly Diagnosed DMG/DIPG in Children and Young Adults

Diffuse Midline Glioma, H3 K27M-Mutant | Recurrent High Grade Glioma

United States
University of Pennsylvania
AstraZeneca; Myriad Genetics, Inc.

Recruiting

Combination ATR and PARP Inhibitor (CAPRI) Trial With AZD6738 and Olaparib in Recurrent Ovarian Cancer (CAPRI)

High Grade Serous Carcinoma

United States
Antiva Biosciences

Terminated

Study of Topical ABI-1968 in Subjects With Precancerous Anal Lesions Resulting From Human Papillomavirus (HPV) Infection

HIV Infection | Anal Cancer | Human Papilloma Virus Infection | HSIL, High-Grade Squamous Intraepithelial Lesions | Anus Neoplasm

United States, Australia
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

18F-Fluoroazomycin Arabinoside PET-CT in Diagnosing Solid Tumors in Patients

Malignant Solid Neoplasm | Malignant Breast Neoplasm | Malignant Pancreatic Neoplasm | Malignant Colorectal Neoplasm

United States
National Cancer Institute, Thailand

Completed

Discordant Hormonal Status of Breast Cancer.

Malignant Neoplasm of Breast.

Thailand
Tigris Pharmaceuticals

Completed

A Two-Stage Phase 2 Study Of A-007 Topical Gel in High-Grade Squamous Intraepithelial Lesions (HSIL) (TG-003)

Cervical Intraepithelial Neoplasia | Uterine Cervical Dysplasia

United States
National Cancer Institute (NCI)

Terminated

Photodynamic Therapy Using Lutetium Texaphyrin in Treating Patients With Cervical Intraepithelial Neoplasia

Cervical Cancer | Cervical Intraepithelial Neoplasia Grade 2 | Cervical Intraepithelial Neoplasia Grade 3

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Terminated

Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal Incontinence in Patients With Locally Advanced Rectal Cancer or Other Pelvic Cancer, the RESTORE Study

Low Anterior Resection Syndrome | Malignant Uterine Neoplasm | Rectal Carcinoma | Malignant Ovarian Neoplasm | Malignant Pelvic Neoplasm | Malignant Anal Neoplasm | Malignant Bladder Neoplasm | Malignant Cervical Neoplasm | Malignant Prostate Neoplasm | Malignant Vaginal Neoplasm | Malignant Vulvar Neoplasm

United States
Children's Oncology Group

Not yet recruiting

A Culturally-Tailored Mobile Health and Social Media Physical Activity Intervention for Improving Physical Activity in Hispanic or Latino/Latina Adolescent and Young Adult Childhood Cancer Survivors, Walking Juntos Study

Malignant Solid Neoplasm | Hematopoietic and Lymphatic System Neoplasm
OHSU Knight Cancer Institute
Oregon Health and Science University; National Center for Complementary and...

Not yet recruiting

Examining Arts as Therapy in Children With Cancer, CREATe Trial

Malignant Solid Neoplasm | Hematopoietic and Lymphatic System Neoplasm

United States
NRG Oncology
National Cancer Institute (NCI)

Not yet recruiting

Comparing Telephone Symptom Monitoring Interventions for Managing Symptoms and Psychological Distress During Oral Anti-Cancer Treatment

Malignant Solid Neoplasm | Hematopoietic and Lymphoid System Neoplasm
Mayo Clinic

Recruiting

Acceptance and Commitment Therapy and Compassion-Based Virtual Group Therapy to Improve Psychological Wellbeing in Patients With Cancer

Malignant Solid Neoplasm | Hematopoietic and Lymphoid System Neoplasm

United States
Roswell Park Cancer Institute

Recruiting

Community-Based Physical Activity Intervention for Underserved Cancer Survivors

Malignant Solid Neoplasm | Hematopoietic and Lymphoid System Neoplasm

United States
Roswell Park Cancer Institute

Recruiting

Financial Health Educational Program for Increasing Financial Literacy Among Underserved Communities in Western New York

Malignant Solid Neoplasm | Hematopoietic and Lymphoid System Neoplasm

United States
Ohio State University Comprehensive Cancer Center

Not yet recruiting

Online Tai Chi Intervention to Promote Smoking Cessation Among Cancer Survivors

Malignant Solid Neoplasm | Hematopoietic and Lymphoid System Neoplasm

United States
Douglas Johnson
Incyte Corporation

Recruiting

Itacitinib for the Treatment Steroid Refractory Immune Related Adverse Events Arising From Immune Checkpoint Inhibitors

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm

United States
Children's Oncology Group
National Cancer Institute (NCI)

Recruiting

Vincristine Pharmacokinetics in Infants

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm

United States, Australia, Canada
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

A Mobile Application, Oncpatient, to Assist Patients Undergoing Radiation Therapy

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Reproducibility and Accuracy of a Portable System for Early Detection of Cardiac Dysfunction in Childhood Cancer Survivors

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm

United States
M.D. Anderson Cancer Center

Recruiting

Exercise Program (TEAM Me) for the Improvement of Movement and Mobility in Pediatric and Adolescent and Young Adult Patients With Cancer Undergoing a Blood Stem Cell Transplant

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); Memorial Sloan Kettering Cancer Center; American...

Recruiting

Quit2Heal Smartphone App in Helping Cancer Patients Quit Smoking

Malignant Solid Neoplasm | Hematopoietic and Lymphoid System Neoplasm

United States
M.D. Anderson Cancer Center

Recruiting

Collection of Outcomes Data for Pregnant Patients With Cancer

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm

United States
Thomas Jefferson University

Withdrawn

Virtual Reality for the Improvement of Patients Understanding of Disease and Treatment (MRgRT)

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm

United States
Mayo Clinic
National Cancer Institute (NCI)

Active, not recruiting

Enhanced, EHR-facilitated Cancer Symptom Control Pragmatic Clinical Trial

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Terminated

eHealth Diet and Physical Activity Program for the Improvement of Health in Rural Latino Cancer Survivors (MiVSEEV)

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm

United States

Clinical Trials on High Grade Malignant Neoplasm

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