Clinical Trials on High Grade Malignant Neoplasm

Total 5440 results

M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Vemurafenib With Sorafenib Tosylate or Crizotinib in Treating Patients With Advanced Malignancies With BRAF Mutations

Metastatic Malignant Neoplasm | Advanced Malignant Neoplasm | Recurrent Malignant Neoplasm | Refractory Malignant Neoplasm | BRAF Gene Mutation

United States
National Cancer Institute (NCI)

Completed

Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors

Recurrent Childhood Medulloblastoma | Recurrent Childhood Ependymoma | Childhood Atypical Teratoid/Rhabdoid Tumor | Childhood Choroid Plexus Tumor | Childhood Craniopharyngioma | Childhood Ependymoblastoma | Childhood Grade I Meningioma | Childhood Grade II Meningioma | Childhood Grade III Meningioma | Childhood High-grade Cerebellar Astrocytoma and other conditions

United States
M.D. Anderson Cancer Center

Withdrawn

BAY1895344 and Copanlisib for the Treatment of Molecularly Selected Patients With Advanced Solid Tumors

Locally Advanced Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Metastatic Malignant Neoplasm in the Bone
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Talazoparib and Palbociclib, Axitinib, or Crizotinib for the Treatment of Advanced or Metastatic Solid Tumors, TalaCom Trial

Advanced Malignant Solid Neoplasm | Recurrent Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
Sumitomo Pharma America, Inc.

Active, not recruiting

Study of DSP-0390 in Patients With Recurrent High-Grade Glioma

Glioblastoma Multiforme | High Grade Glioma

United States, Japan
University of California, San Francisco
Merck Sharp & Dohme LLC

Recruiting

Lenvatinib Plus Pembrolizumab in Well Differentiated G3 Neuroendocrine Tumors

Neuroendocrine Tumors | High Grade Neuroendocrine Carcinoma, Any Site | Well-Differentiated Neuroendocrine Carcinoma

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

18F-FDG PET-MRI for Planning and Follow-Up of Patients With Spine Tumors Treated With Spine Stereotactic Radiosurgery

Metastatic Malignant Neoplasm in the Bone | Metastatic Malignant Neoplasm

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Rapid On Site Evaluation of Pleural Touch Preparations in Diagnosing Malignant Pleural Effusion in Patients Undergoing Pleuroscopy

Malignant Neoplasm | Malignant Respiratory Tract Neoplasm | Malignant Thoracic Neoplasm

United States, Cyprus
National Cancer Institute (NCI)

Suspended

A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

Metastatic Osteosarcoma | Localized Osteosarcoma | High Grade Osteosarcoma | Secondary Osteosarcoma

United States
National Cancer Institute (NCI)

Completed

Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors

Recurrent Childhood Medulloblastoma | Recurrent Childhood Ependymoma | Childhood Choroid Plexus Tumor | Childhood Craniopharyngioma | Childhood Ependymoblastoma | Childhood Grade I Meningioma | Childhood Grade II Meningioma | Childhood Grade III Meningioma | Childhood High-grade Cerebellar Astrocytoma | Childhood High-grade Cerebral Astrocytoma and other conditions

United States
National Cancer Institute (NCI)

Completed

Cilengitide in Treating Children With Refractory Primary Brain Tumors

Recurrent Childhood Medulloblastoma | Recurrent Childhood Ependymoma | Childhood Choroid Plexus Tumor | Childhood Craniopharyngioma | Childhood Ependymoblastoma | Childhood Grade I Meningioma | Childhood Grade II Meningioma | Childhood Grade III Meningioma | Childhood High-grade Cerebellar Astrocytoma | Childhood High-grade Cerebral Astrocytoma and other conditions

United States
AbbVie

Terminated

Rovalpituzumab Tesirine in Delta-Like Protein 3-Expressing Advanced Solid Tumors

Glioblastoma | Medullary Thyroid Cancer | Malignant Melanoma | Other Solid Tumors | Large-Cell Neuroendocrine Carcinoma | Neuroendocrine Prostate Cancer | High Grade Gastroenteropancreatic Neuroendocrine Carcinoma | Other Neuroendocrine Carcinoma

United States
National Cancer Institute (NCI)

Terminated

Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma

Recurrent Melanoma | Stage IV Melanoma | Acral Lentiginous Malignant Melanoma | Lentigo Maligna Malignant Melanoma | Nodular Malignant Melanoma | Solar Radiation-related Skin Melanoma | Superficial Spreading Malignant Melanoma

United States
University Health Network, Toronto
GlaxoSmithKline

Recruiting

Using Genetic Profile to Determine the Treatment for Patients With Ovarian Cancer Who Previously Received a PARP-inhibitor

Ovarian Cancer | Fallopian Tube Cancer | Primary Peritoneal Cancer | High Grade Serous Cancer | High Grade Endometrioid Cancer

Canada
University of California, San Francisco
National Cancer Institute (NCI); US-Latin American-Caribbean HIV/HPV-Cancer...

Recruiting

Screening Algorithms for Cervical and Anal High-Grade Squamous Intraepithelial Lesions in People With HIV in Mexico and Puerto Rico (CAMPO-101)

HIV Infection | High Grade Cervical Intraepithelial Neoplasia | AIDS-Related Anal Carcinoma | AIDS-Related Cervical Carcinoma | High Grade Anal Intraepithelial Neoplasia

Puerto Rico, Mexico
University of California, San Francisco

Completed

Hypoxia-Specific Imaging to Predict Outcomes of Chimeric Antigen Receptor T-cell Therapy

Refractory Plasma Cell Myeloma | Recurrent Diffuse Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma | Recurrent Plasma Cell Myeloma | Recurrent Malignant Neoplasm | Refractory Malignant Neoplasm | Recurrent High Grade B-Cell Lymphoma | Refractory High Grade B-Cell Lymphoma | Recurrent... and other conditions

United States
Sameek Roychowdhury

Active, not recruiting

Infigratinib for the Treatment of Advanced or Metastatic Solid Tumors in Patients With FGFR Gene Mutations

Cholangiocarcinoma | Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States
Samus Therapeutics, Inc.

Terminated

Study of Icapamespib (PU-AD) in Patients With Recurrent Malignant Glioma (Glio)

Recurrent Glioblastoma Multiforme (GBM) | Grade 3 Isocitrate Dehydrogenase (IDH) Wildtype Astrocytoma | Grade 3 or 4 Astrocytoma | Glioblastoma Surgery

United States
New Mexico Cancer Care Alliance
National Cancer Institute (NCI)

Recruiting

Engagement of American Indians of Southwestern Tribal Nations in Cancer Genome Sequencing (PE-CGS)

Malignant Neoplasm

United States
Cancer Institute and Hospital, Chinese Academy...

Not yet recruiting

NV-001 in the Treatment of Advanced Solid Tumors

Malignant Neoplasm

China
University Hospital, Essen

Recruiting

FAPI-PET for Tumor Detection

Malignant Neoplasm

Germany
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Molecular Genetics Studies of Cancer Patients and Their Relatives

Malignant Neoplasm

United States, Peru, Colombia, Mexico, Puerto Rico
Wake Forest University Health Sciences

Terminated

Developing and Validating Fertilit-e

Malignant Neoplasm

United States
University of Utah

Terminated

Multi-Tracer Positron Emission Tomography in Patients With Solid Tumors

Malignant Neoplasm

United States
Sanofi

Active, not recruiting

Evaluation of SAR408701 in Patients With Advanced Solid Tumors

Neoplasm Malignant

United States, Canada, France, Korea, Republic of, Spain
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Music Therapy Video Development in Improving Communication, Emotional Distress, and Recovery in Adolescents/Young Adults Undergoing Treatment for High-Risk Cancer and Their Parents

Malignant Neoplasm

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Attitudes and Knowledge Regarding Clinical Trials in Underserved Populations Receiving Care at the Comprehensive Cancer Center of Wake Forest University

Malignant Neoplasm

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

FLT-PET in Predicting Response to Chemotherapy in Patients With Advanced Malignancies

Malignant Neoplasm

United States
University of Southern California
National Cancer Institute (NCI)

Terminated

Clinical Model in Evaluating Clinical, Psychosocial, and Health Economic Factors in Adolescent and Young Adult Patients With Cancer

Malignant Neoplasm

United States
Roswell Park Cancer Institute

Terminated

Impact of Early Mobility on Post-Surgery Recovery in Patients Undergoing Oncologic Surgeries

Malignant Neoplasm

United States
Sanofi

Completed

Open Label Treatment Extension Study With SAR245408 or SAR245409 as a Monotherapy or as a Combination Regimen

Neoplasm Malignant

Spain, Belgium, United States, France
NatureWise Biotech & Medicals Corporation

Completed

A Safety and Pharmacokinetic Study of NBM-BMX Administered Orally to Patients With Advanced Cancer

Malignant Neoplasm

United States
Fox Chase Cancer Center
National Cancer Institute (NCI)

Completed

Next Generation Sequence Target-Directed Therapy in Treating Patients With Cancer

Malignant Neoplasm

United States
Gary Morrow
National Cancer Institute (NCI)

Completed

Multimedia Psychoeducation or Print Education in Preparing Cancer Patients for Decision Making About Clinical Trials

Malignant Neoplasm

United States
Qilu Puget Sound Biotherapeutics (dba Sound Biologics)
Pharmaceutical Research Associates

Unknown

A Study of PSB205 in Subjects With Advanced Solid Tumors

Neoplasm Malignant

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); Conquer Cancer Foundation

Completed

Resistance Training Program and Cardiovascular Exercise in Increasing Muscle Mass in Adolescent and Young Adult Stem Cell Transplant Survivors

Malignant Neoplasm

United States
Jonsson Comprehensive Cancer Center

Terminated

18F-Clofarabine PET/CT in Imaging Cancer Patients Before and After Interventions

Malignant Neoplasm

United States
Li Yu

Unknown

Clinical Study of DC-CIK Cells as a Post-remission Treatment for Malignant Tumors

Malignant Neoplasm

China
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Terminated

Early Oral Supplementation in Improving Nutritional Status in Patients Undergoing Hematopoietic Stem Cell Transplant

Malignant Neoplasm

United States
Sanofi
Merck KGaA, Darmstadt, Germany

Completed

A Safety and Efficacy Study of SAR405838 and Pimasertib in Cancer Patients

Neoplasm Malignant

Netherlands, France
Sanofi

Completed

Phase I, Dose Escalation of SAR125844 in Asian Solid Tumor Patients (SARMETA)

Neoplasm Malignant

Korea, Republic of, Japan
Sanofi
Regeneron Pharmaceuticals

Completed

A Phase I Study of Aflibercept Plus FOLFIRI (Irinotecan, 5-Fluorouracil, and Leucovorin) in Chinese Patients With Advanced Solid Malignancies

Neoplasm Malignant

China
Sanofi

Completed

Effect of SAR302503 on ECG Activity in Patients With Solid Tumors

Neoplasm Malignant

Belgium, United States
Sanofi
Regeneron Pharmaceuticals

Completed

A Study of Intravenous Aflibercept With Docetaxel in Chinese Patients With Solid Tumors

Neoplasm Malignant

China
National Cancer Institute (NCI)

Active, not recruiting

Atezolizumab in Treating Patients With Cancer Following Adoptive Cell Transfer

Hematopoietic and Lymphoid Cell Neoplasm | Unresectable Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm

United States, Canada
Tyligand Bioscience (Shanghai) Limited

Recruiting

A Study of TSN084 in Patients With Advanced Malignant Tumors

Malignant Neoplasm

China
Guangzhou First People's Hospital

Recruiting

An Observational Clinical Study Plan on the Effects of Radiotherapy on the Immune System of Patients With Malignant Tumors.

Malignant Neoplasm

China
Wuhan Union Hospital, China

Recruiting

Clinical Application of Fibroblast Activation Protein PET/MRI for Diagnosis and Staging in Malignant Tumors

Malignant Neoplasm

China
Imperial College London

Recruiting

iKnife REIMS Project (iKnife)

Neoplasms | Neoplasm Malignant

United Kingdom
University of Southern California
National Cancer Institute (NCI)

Recruiting

18F-FMAU PET/CT in Imaging Patients With Advanced Cancers

Malignant Neoplasm

United States

Clinical Trials on High Grade Malignant Neoplasm

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