Clinical Trials on High Grade Intraepithelial Neoplasia in Canada

Total 116 results

Saint Thomas Hospital, Panama

Completed

Observational vs. Ablative Treatment for Low-grade Squamous Intraepithelial Lesions.

LSIL, Low-Grade Squamous Intraepithelial Lesions

Panama
Alan Nichol

Completed

Positron Emission Tomography (PET) With 3,4-dihydroxy-6-18F-fluoro-L-enylalanine (18F-FDOPA) Study

Cancer (High-grace Glioma)

Canada
University Health Network, Toronto

Recruiting

Circulating Tumor DNA Collection From Patients With High Grade Gliomas (m-ctDNA)

High Grade Glioma

Canada
Sunnybrook Health Sciences Centre
Merck Canada Inc.

Active, not recruiting

In the Era of the HPV Vaccine, What Are The Current HPV Subtypes Contributing to High Grade Cervical Dysplasia, Adenocarcinoma in Situ, and Early Cervical Cancer?

HSIL, High-Grade Squamous Intraepithelial Lesions | Adenocarcinoma in Situ | Early Cervical Cancer

Canada
Cellectar Biosciences, Inc.
National Cancer Institute (NCI)

Recruiting

Novel Targeted Radiotherapy in Pediatric Patients With Inoperable Relapsed or Refractory HGG

High-Grade Glioma

United States, Canada
University Health Network, Toronto
GlaxoSmithKline

Recruiting

Using Genetic Profile to Determine the Treatment for Patients With Ovarian Cancer Who Previously Received a PARP-inhibitor

Ovarian Cancer | Fallopian Tube Cancer | Primary Peritoneal Cancer | High Grade Serous Cancer | High Grade Endometrioid Cancer

Canada
National Cancer Institute (NCI)

Completed

Lapatinib in Treating Patients With Recurrent and/or Metastatic Adenoid Cystic Cancer or Other Salivary Gland Cancers

Recurrent Salivary Gland Cancer | Recurrent Adenoid Cystic Carcinoma of the Oral Cavity | High-grade Salivary Gland Carcinoma | High-grade Salivary Gland Mucoepidermoid Carcinoma | Low-grade Salivary Gland Carcinoma | Low-grade Salivary Gland Mucoepidermoid Carcinoma | Salivary Gland Acinic Cell... and other conditions

Canada
British Columbia Cancer Agency
National Cancer Institute (NCI)

Completed

Digital Colposcopy in Finding Cervical Intraepithelial Neoplasia

Cervical Cancer | Precancerous Condition

Canada
British Columbia Cancer Agency
National Cancer Institute (NCI)

Withdrawn

Digital Colposcopy in Finding Cervical Intraepithelial Neoplasia in Patients With An Abnormal Pap Smear

Cervical Cancer | Precancerous Condition

Canada
Sunnybrook Health Sciences Centre
Canadian Institutes of Health Research (CIHR); Sunnybrook Research Institute

Recruiting

Glioma Supra Marginal Incision Trial (G-SUMIT)

High Grade Glioma

Canada, United States
Centre hospitalier de l'Université de Montréal...
Canadian Institutes of Health Research (CIHR); Terry Fox Foundation

Active, not recruiting

Colposcopy Versus HPV Testing to Identify Persistent Cervical Precancers (CoHIPP)

High Grade Cervical Intra-epithelial Neoplasia

Canada
University of British Columbia
British Columbia Cancer Agency; Terry Fox Research Institute

Unknown

Efficacy of Optically-guided Surgery in the Management of Early-staged Oral Cancer - COOLS TRIAL

Oral Cancer | High-grade Precancer

Canada
Inovio Pharmaceuticals

Completed

VGX-3100 Delivered Intramuscularly (IM) Followed by Electroporation (EP) for the Treatment of HPV-16 and/or HPV-18 Related Anal or Anal/Peri-Anal, High Grade Squamous Intraepithelial Lesion (HSIL) in Individuals Seronegative for Human Immunodeficiency Virus (HIV)-1/2

Anal Neoplasm

United States, Canada
National Cancer Institute (NCI)

Completed

Cilengitide in Treating Younger Patients With Recurrent or Progressive High-Grade Glioma That Has Not Responded to Standard Therapy

Childhood High-grade Cerebellar Astrocytoma | Childhood High-grade Cerebral Astrocytoma | Recurrent Childhood Anaplastic Astrocytoma | Recurrent Childhood Anaplastic Oligoastrocytoma | Recurrent Childhood Anaplastic Oligodendroglioma | Recurrent Childhood Cerebellar Astrocytoma | Recurrent Childhood... and other conditions

United States, Canada
McGill University

Completed

Cervical And Self-Sample In Screening Study (CASSIS)

Cervical Cancer | Intraepithelial Neoplasia

Canada
Inovio Pharmaceuticals

Completed

A Study of VGX-3100 DNA Vaccine With Electroporation in Patients With Cervical Intraepithelial Neoplasia Grade 2/3 or 3 (HPV-003)

Cervical Intraepithelial Neoplasia

South Africa, United States, Korea, Republic of, Canada, Estonia, India, Georgia, Australia, Puerto Rico
Hoffmann-La Roche

Completed

A Study of Bevacizumab (Avastin) in Combination With Temozolomide (TMZ) and Radiotherapy in Paediatric and Adolescent Participants With High-Grade Glioma

High Grade Glioma

United Kingdom, Canada, Austria, Italy, Spain, Sweden, Belgium, Denmark, France, Australia, Czechia, Hungary, Netherlands, Poland
GTx

Completed

Prostate Cancer Prevention Study for Men With High Grade PIN (Prostatic Intraepithelial Neoplasia)

Preneoplastic Conditions | Prostatic Intraepithelial Neoplasia

United States, Argentina, Canada
Sunnybrook Health Sciences Centre

Completed

Overlooked Population at Risk for AIN.

Cervical Cancer | High Grade Cervical Dysplasia

Canada
Ontario Clinical Oncology Group (OCOG)
Canadian Institutes of Health Research (CIHR)

Completed

Immediate Treatment vs Colposcopic Follow-up for Biopsy-Proven CIN 1

Cervical Intraepithelial Neoplasia

Canada, Brazil
National Cancer Institute (NCI)

Active, not recruiting

Bevacizumab and Anetumab Ravtansine or Paclitaxel in Treating Patients With Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Ovarian Endometrioid Adenocarcinoma | Primary Peritoneal High Grade Serous Adenocarcinoma | Fallopian Tube Endometrioid Adenocarcinoma | Platinum-Resistant Fallopian Tube Carcinoma | Platinum-Resistant Primary Peritoneal Carcinoma | Ovarian High Grade Serous Adenocarcinoma | Platinum-Resistant... and other conditions

United States, Canada
Rigel Pharmaceuticals
Nationwide Children's Hospital

Not yet recruiting

Study of Olutasidenib and Temozolomide in HGG

Astrocytoma | High Grade Glioma | Oligodendroglioma | Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant | WHO Grade III Glioma | Metastatic Brain Tumor | Spinal Tumor | Astrocytoma, Grade III | Astrocytoma, Grade IV | IDH1 Mutation | WHO Grade IV Glioma | Thalamus Tumor | IDH1 R132 | IDH1 R132C | IDH1 R132H and other conditions

United States, Australia, United Kingdom, Canada, Germany, Netherlands
Nationwide Children's Hospital
Novartis

Not yet recruiting

Study of Ribociclib and Everolimus in HGG and DIPG

Glioblastoma | Glioblastoma Multiforme | High Grade Glioma | Anaplastic Astrocytoma | Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant | WHO Grade III Glioma | Metastatic Brain Tumor | WHO Grade IV Glioma

United States, Australia, United Kingdom, Canada, Germany, Netherlands
Nationwide Children's Hospital

Not yet recruiting

Targeted Pediatric High-Grade Glioma Therapy

Glioblastoma | Glioblastoma Multiforme | High Grade Glioma | Anaplastic Astrocytoma | Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant | WHO Grade III Glioma | Metastatic Brain Tumor | WHO Grade IV Glioma

United States, Australia, United Kingdom, Canada, Germany, Netherlands
Nationwide Children's Hospital
Pfizer

Not yet recruiting

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

Glioblastoma | Glioblastoma Multiforme | High Grade Glioma | Anaplastic Astrocytoma | Diffuse Intrinsic Pontine Glioma | WHO Grade III Glioma | WHO Grade IV Glioma | Infant Type Hemispheric Glioma | Diffuse Midline Glioma, H3K27-altered

United States, Australia, Canada, Germany, Netherlands
National Cancer Institute (NCI)

Completed

Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors

Recurrent Childhood Medulloblastoma | Recurrent Childhood Ependymoma | Childhood Atypical Teratoid/Rhabdoid Tumor | Extra-adrenal Paraganglioma | Childhood Choroid Plexus Tumor | Childhood Craniopharyngioma | Childhood Ependymoblastoma | Childhood Grade I Meningioma | Childhood Grade II Meningioma | Childhood... and other conditions

United States, Canada
McMaster University
Merck Frosst Canada Ltd.; Public Health Agency of Canada (PHAC); Juravinski Cancer...

Unknown

Randomized Trial of Vaginal Self Sampling for Human Papillomavirus (HPV)

Cervical Intraepithelial Neoplasia | Human Papillomavirus Infection

Canada
NCIC Clinical Trials Group

Completed

Vitamin E, Selenium, and Soy Protein in Preventing Cancer in Patients With High-Grade Prostate Neoplasia

Prostate Cancer | Precancerous/Nonmalignant Condition

Canada
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Reflectance Confocal Imaging in Cervical Cancer Patients

Cervical Cancer

United States, Canada
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Terminated

Spectroscopy Versus Standard Care in Cervical Cancer Patients

Cervical Cancer

United States, Canada
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Molecular Imaging for Detection of Cervical Intraepithelial Neoplasia

Cervical Cancer

United States, Canada
University Health Network, Toronto

Active, not recruiting

"Re-Stimulated" TILs And IL-2 Therapy for Platinum Resistant Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

Fallopian Tube Cancer | Primary Peritoneal Cancer | High Grade Serous Ovarian Cancer | Recurrent | Platinum-resistant

Canada
Memorial Sloan Kettering Cancer Center
Johns Hopkins University; M.D. Anderson Cancer Center; University of Colorado... and other collaborators

Completed

External Beam Radiation Therapy and Cetuximab Followed by Irinotecan and Cetuximab for Children and Young Adults With Newly Diagnosed Diffuse Pontine Tumors and High-Grade Astrocytomas

Brain Cancer

United States, Canada
University of British Columbia
British Columbia Cancer Agency; Women's Health Research Institute of British...

Completed

The SAFE Study: Satisfaction and Adherence to Follow-Up With Colposcopy Exams

Uterine Cervical Dysplasia | Uterine Cervix Cancer

Canada
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Fluorescence and Reflectance Spectroscopy During Colposcopy in Detecting Cervical Intraepithelial Neoplasia and Dysplasia in Healthy Participants With a History of Normal Pap Smears

Cervical Cancer | Precancerous Condition

United States, Canada
Sunnybrook Health Sciences Centre
GlaxoSmithKline

Recruiting

Alternative Dosing Of Niraparib To Decrease Dose Interruption In First Line Maintenance Treatment For Ovarian Cancer

Ovarian Cancer | Stage IV Ovarian Cancer | High Grade Ovarian Serous Adenocarcinoma | Stage III Ovarian Cancer

Canada
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Measurement of Digital Colposcopy for Fluorescence Spectroscopy of Cervical Intraepithelial Neoplasia

Cervical Cancer

United States, Canada, Nigeria
Sunnybrook Health Sciences Centre

Recruiting

CEST in Low-grade Glioma Study

Low-grade Glioma

Canada
University Health Network, Toronto

Active, not recruiting

Integrative Sequencing In Germline and Hereditary Tumours (INSIGHT)

Mutation | Hereditary Cancer Syndrome | High-Risk | Germline Mutation

Canada
Lawson Health Research Institute

Recruiting

Three Fraction Radiation to Induce Immuno-Oncologic Response (TRIO)

Locally Advanced Breast Cancer | High-Risk Cancer

Canada
British Columbia Cancer Agency
National Cancer Institute (NCI)

Terminated

Pilot Study In Vivo Confocal Microscopy Probe for Cervical Precancer (Confocal)

Cervical Cancer | Precancerous Condition

Canada
Nationwide Children's Hospital

Recruiting

A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

High Grade Glioma | Diffuse Intrinsic Pontine Glioma

United States, Australia, Canada, Germany
Daniel Morgenstern
The Hospital for Sick Children

Recruiting

Pilot Study of Vinblastine and Tovorafenib in Pediatric Patients With Recurrent/Progressive RAF Altered Low Grade Gliomas (VICTORY)

Low-grade Glioma

Canada
National Cancer Institute (NCI)

Active, not recruiting

Ibrutinib in Treating Patients With Relapsed or Refractory Follicular Lymphoma

Recurrent Grade 1 Follicular Lymphoma | Recurrent Grade 2 Follicular Lymphoma | Recurrent Grade 3 Follicular Lymphoma | Refractory Follicular Lymphoma | Grade 3a Follicular Lymphoma

United States, Canada, Singapore
National Cancer Institute (NCI)

Recruiting

A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma

Recurrent WHO Grade 2 Glioma | Recurrent Low Grade Astrocytoma | Refractory Low Grade Astrocytoma | Refractory Low Grade Glioma | Refractory WHO Grade 1 Glioma

United States, Canada
Sunnybrook Health Sciences Centre
Prostate Cancer Canada

Unknown

Stereotactic Pelvic Brachytherapy With HDR Boost for Dose Escalation in High Tier Intermediate and High Risk Prostate ca (SPARE)

HIGH RISK PROSTATE CANCER

Canada
AHS Cancer Control Alberta

Unknown

Conventional Versus Hypofractionated Radiation in High Risk Prostate Patients (CHIRP)

High-risk Prostate Cancer

Canada
Sergio Faria

Completed

Hypofractionated Intensity Modulated Radiation Therapy Plus Hormonal Therapy in Patients With High Risk Prostate Cancer

High Risk Prostate Cancer

Canada
British Columbia Cancer Agency
M.D. Anderson Cancer Center; National Cancer Institute (NCI); The University... and other collaborators

Completed

Combined Digital Colposcopy Analysis to Improve Cervical Precancer and Cancer Detection (MDC_Algo)

Cervical Cancer | Precancerous Condition

United States, Canada
Alberta Health services

Completed

HDCT and Stem Cell Transplantation for Mantle Cell and Relapsed Low Grade Non-hodgkin's Lymphoma

Low Grade Lymphoma

Canada

Clinical Trials on High Grade Intraepithelial Neoplasia in Canada

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