Clinical Trials on High-Risk Breast Cancer in United States

Total 6101 results

Memorial Sloan Kettering Cancer Center

Recruiting

A Study of Oleogel-S10 Gel for the Treatment of Radiation Dermatitis in People With Breast Cancer

Breast Cancer | Breast Cancer Stage IV | Breast Cancer Stage I | Breast Cancer Stage II | Breast Cancer Stage III | Breast Cancer Stage

United States
Harold J. Burstein, MD, PhD
Massachusetts General Hospital; Dana-Farber Cancer Institute; Beth Israel Deaconess... and other collaborators

Completed

Pegfilgrastim and Darbepoetin Alfa in Support of Adjuvant Chemotherapy for Breast Cancer

Breast Cancer | Stage I Breast Cancer | Stage II Breast Cancer

United States
Washington University School of Medicine
National Cancer Institute (NCI); National Institutes of Health (NIH); MedImmune...

Terminated

Neoantigen DNA Vaccine Alone vs. Neoantigen DNA Vaccine Plus Durvalumab in Triple Negative Breast Cancer Patients Following Standard of Care Therapy

Triple Negative Breast Cancer | Triple Negative Breast Neoplasms | TNBC - Triple-Negative Breast Cancer | Triple-negative Breast Carcinoma

United States
University of Washington
National Cancer Institute (NCI)

Completed

Trastuzumab Emtansine in Treating Patients With HER2-Positive Metastatic or Locally Advanced Breast Cancer That Cannot Be Removed by Surgery

Stage IV Breast Cancer | Recurrent Breast Carcinoma | Stage IIIB Breast Cancer | Stage IIIC Breast Cancer | HER2/Neu Positive

United States
Alison Stopeck

Recruiting

Neoadjuvant Therapy and Contrast-enhanced Mammography for Early Stage Breast Cancer

Breast Cancer | Triple Negative Breast Cancer | HER2-positive Breast Cancer | TNBC, Triple Negative Breast Cancer | Locally Advanced Breast Cancer | Neoadjuvant Chemotherapy

United States
University of Rochester
Johns Hopkins University

Completed

A Whole-food, Plant-Based Nutrition Intervention in Women With Metastatic Breast Cancer

Metastatic Breast Cancer | Breast Cancer Stage IV

United States
Nuvation Bio Inc.

Withdrawn

Study of NUV-422 in Combination With Fulvestrant in Patients With HR+HER2- aBC

Breast Cancer | Advanced Breast Cancer | Metastatic Breast Cancer | Breast Carcinoma | Cancer of Breast | Malignant Tumor of Breast | Breast Tumor | Cancer of the Breast

United States
NYU Langone Health

Completed

Trial of Nivolumab With Chemotherapy as Neoadjuvant Treatment in Inflammatory Breast Cancer (IBC)

Breast Cancer

United States
Wake Forest University Health Sciences
Merck Sharp & Dohme LLC

Completed

Pilot Study of Paclitaxel Plus Pembrolizumab in Metastatic HER2-Negative Breast Cancer (PePPy)

Male Breast Cancer | Breast - Female

United States
Massachusetts General Hospital

Recruiting

The Differential Impact of Proton Beam Irradiation Versus Conventional Radiation on Organs-at-risk in Stage II-III Breast Cancer Patients

Breast Cancer Stage II | Breast Cancer Stage III

United States
Case Comprehensive Cancer Center
National Cancer Institute (NCI); Mitaka USA, Inc.

Completed

Comparison of Use of Indocyanine Green and 99mTc-labeled Radiotracer for Axillary Lymphatic Mapping in Patients With Breast Cancer

Stage I Breast Cancer | Stage II Breast Cancer

United States
Dana-Farber Cancer Institute
Massachusetts General Hospital; Beth Israel Deaconess Medical Center; Brigham...

Completed

Preoperative Herceptin and Navelbine for Breast Cancer

Breast Cancer | Stage II Breast Cancer | Stage III Breast Cancer

United States
Western Regional Medical Center

Terminated

Neoadjuvant Hormonal Therapy Combined With Chemoimmunotherapy (Neohttp)

HER2-positive Breast Cancer | ER-positive Breast Cancer

United States
Thomas Jefferson University
National Cancer Institute (NCI)

Active, not recruiting

A Text-based Intervention in Improving Adherence to Hormone Therapy in Patients With Stage I-III Hormone Receptor Positive Breast Cancer

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage IA Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Anatomic Stage IIB Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Anatomic Stage IIIB Breast Cancer AJCC v8 and other conditions

United States
Sidney Kimmel Comprehensive Cancer Center at Johns...

Completed

Zoledronic Acid in Aromatase Inhibitor Induced Musculoskeletal Symptoms

Stage I Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IIIC Breast Cancer | Estrogen Receptor-positive Breast Cancer | Progesterone Receptor-positive Breast Cancer | Ductal Carcinoma in Situ

United States
Nippon Kayaku Co., Ltd.

Completed

Study of NK012 and Carboplatin in Solid Tumors With Dose Expansion in Triple Negative Breast Cancer

Advanced Solid Tumors | Metastatic Triple Negative Breast Cancer

United States
University of Miami

Recruiting

Discontinuation of Maintenance HER-2 Directed Therapy in Long-Term Survivors of Metastatic HER-2 Positive Breast Cancer (Free-HER)

Stage IV Breast Cancer | HER2-positive Metastatic Breast Cancer

United States
Inova Health Care Services
City of Hope Medical Center

Recruiting

Systems Biology Guided Therapy for Breast Cancer Positive for Oestrogen Receptor After Aromatase Inhibitor and CDK Inhibition (SPOCK)

Breast Cancer | Estrogen Receptor-positive Breast Cancer | HER2-negative Breast Cancer

United States
University of Wisconsin, Madison

Recruiting

Evaluation of PSMA in HER2- AR+ Metastatic Breast Cancer

Breast Cancer | Metastatic Breast Cancer | HER2-negative Breast Cancer

United States
Laura Kennedy
National Cancer Institute (NCI)

Suspended

Multiparametric MRI as a Non-Invasive Biomarker of the Tumor Microenviroment

Breast Cancer | Triple-negative Breast Cancer

United States
University of Washington
National Cancer Institute (NCI)

Completed

Vitamin D Deficiency, Muscle Pain, Joint Pain, and Joint Stiffness in Postmenopausal Women Receiving Letrozole For Stage I-III Breast Cancer

Pain | Arthralgia | Stage I Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IIIC Breast Cancer | Recurrent Breast Cancer | Musculoskeletal Complications

United States
University of Washington
AbbVie

No longer available

Expanded Access With ABT-888 (Veliparib) to Treat Metastatic Breast Cancer

Triple-Negative Breast Cancer | Metastatic Breast Cancer With BRCA 1 or BRCA 2 Genetic Mutation

United States
Mayo Clinic

Recruiting

Exploring Cultural Acceptability of Community Breast Cancer Risk Assessment Among Hispanic Women in Maricopa County

Breast Cancer | Breast Carcinoma | Breast Cancer Female

United States
Columbia University

Completed

Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer

Breast Cancer | Breast Tumors | Cancer of Breast

United States
Columbia University
National Cancer Institute (NCI); Acetylon Pharmaceuticals Incorporated

Completed

ACY-1215 + Nab-paclitaxel in Metastatic Breast Cancer

Metastatic Breast Cancer | Breast Carcinoma

United States
University of Alabama at Birmingham
GlaxoSmithKline; AbbVie; Breast Cancer Research Foundation of Alabama

Active, not recruiting

Pilot Study of Veliparib (ABT-888) and Lapatinib (Tykerb) in Patients With Metastatic, Triple Negative Breast Cancer

Metastatic Triple Negative Breast Cancer

United States
Case Comprehensive Cancer Center

Completed

Carboplatin, Nab-Paclitaxel and Pembrolizumab for Metastatic Triple-Negative Breast Cancer

Metastatic Triple Negative Breast Cancer

United States
University of Southern California
National Cancer Institute (NCI)

Terminated

Sentinel and/or Axillary Lymph Node Biopsy With or Without Axillary Reverse Mapping in Reducing Incidence and Severity of Arm Lymphedema in Stage 0-2 Patients.

Lymphedema | Stage II Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Recurrent Breast Cancer

United States
City of Hope Medical Center
National Cancer Institute (NCI); Imugene Limited

Active, not recruiting

CF33-hNIS-antiPDL1 for the Treatment of Metastatic Triple Negative Breast Cancer

Anatomic Stage IV Breast Cancer AJCC v8 | Prognostic Stage IV Breast Cancer AJCC v8 | Metastatic Triple-Negative Breast Carcinoma

United States
Washington University School of Medicine
National Cancer Institute (NCI)

Completed

BKM120 and Fulvestrant for Treating Postmenopausal Patients With Estrogen Receptor-Positive Stage IV Breast Cancer

Stage IV Breast Cancer | Recurrent Breast Cancer | Estrogen Receptor-positive Breast Cancer

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Alpelisib and Enzalutamide in Treating Patients With Androgen Receptor and PTEN Positive Metastatic Breast Cancer

Anatomic Stage III Breast Cancer AJCC v8 | Anatomic Stage IIIA Breast Cancer AJCC v8 | Anatomic Stage IIIB Breast Cancer AJCC v8 | Anatomic Stage IIIC Breast Cancer AJCC v8 | Prognostic Stage III Breast Cancer AJCC v8 | Prognostic Stage IIIA Breast Cancer AJCC v8 | Prognostic Stage IIIB Breast... and other conditions

United States
Washington University School of Medicine

Terminated

Shave Margins in Breast Conservation Therapy (SMART)

Breast Cancer | Cancer of Breast | Cancer of the Breast

United States
Mayo Clinic
National Cancer Institute (NCI)

Active, not recruiting

Hypofractionated Radiation Therapy in Treating Participants With Breast Cancer Before Surgery

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage IA Breast Cancer AJCC v8 | Anatomic Stage IB Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Prognostic Stage I Breast Cancer AJCC v8 | Prognostic Stage IA Breast Cancer AJCC v8 | Prognostic Stage IB Breast Cancer AJCC v8 | Prognostic Stage IIA Breast Cancer AJCC...

United States
iSpecimen Inc

Enrolling by invitation

Collection and Distribution of Biospecimens for Novel Research

Autoimmune Diseases | Healthy | Cancer | Infectious Disease | Blood Disease | Gastrointestinal Complication | Dermatologic Disease | Women's Health: High-Risk Pregnancy

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Acupuncture in Reducing Chemotherapy-Induced Peripheral Neuropathy in Participants With Stage I-III Breast Cancer

Anatomic Stage I Breast Cancer AJCC v8 | Anatomic Stage IA Breast Cancer AJCC v8 | Anatomic Stage IB Breast Cancer AJCC v8 | Anatomic Stage II Breast Cancer AJCC v8 | Anatomic Stage IIA Breast Cancer AJCC v8 | Anatomic Stage IIB Breast Cancer AJCC v8 | Anatomic Stage III Breast Cancer AJCC v8 | Anatomic... and other conditions

United States
University of Massachusetts, Worcester

Not yet recruiting

Continuous Glucose Monitor Use in Pregnancy

Pregnancy, High Risk | Type 2 Diabetes Treated With Insulin

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Aromatase Inhibitor Therapy With or Without Fulvestrant for the Treatment of HR Positive Metastatic Breast Cancer With an ERS1 Activating Mutation, the INTERACT Study

Anatomic Stage IV Breast Cancer AJCC v8 | Prognostic Stage IV Breast Cancer AJCC v8 | Metastatic Breast Carcinoma

United States
Mayo Clinic
National Cancer Institute (NCI)

Suspended

Optimizing Treatment of Stage IV Breast Cancer Through Real-Time Disease Monitoring

Anatomic Stage IV Breast Cancer AJCC v8 | Prognostic Stage IV Breast Cancer AJCC v8 | Metastatic Breast Carcinoma

United States
Genta Incorporated

Unknown

Tesetaxel Every 3 Weeks vs Weekly vs Capecitabine as 1st-line Therapy for Locally Advanced or Metastatic Breast Cancer

Metastatic Breast Cancer | Locally Advanced Non-resectable Breast Cancer

United States
Wake Forest University Health Sciences
National Cancer Institute (NCI)

Completed

Omega-3 Fatty Acid in Treating Patients With Stage I-III Breast Cancer

Male Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIIC Breast Cancer | Ductal Breast Carcinoma in Situ | Lobular Breast Carcinoma in Situ

United States
Washington University School of Medicine
Susan G. Komen Breast Cancer Foundation

Completed

Safety and Immunogenicity of a Personalized Polyepitope DNA Vaccine Strategy in Breast Cancer Patients With Persistent Triple-Negative Disease Following Neoadjuvant Chemotherapy

Triple Negative Breast Cancer | Triple Negative Breast Neoplasms | Triple-Negative Breast Cancer

United States
Virginia Commonwealth University
Eli Lilly and Company; Bayer

Terminated

2nd Line Treatment With Pemetrexed and Sorafenib for Recurrent or Metastatic Triple Negative Breast Cancer

Breast Cancer | Metastatic Breast Cancer | Recurrent Breast Cancer

United States
Dana-Farber Cancer Institute
Genentech, Inc.

Active, not recruiting

T-DM1+Pertuzumab in Pre-OP Early-Stage HER2+ BRCA

Breast Cancer | Stage II Breast Cancer | HER-2 Positive Breast Cancer | Stage III Breast Cancer

United States
The Methodist Hospital Research Institute

Completed

L-NMMA Plus Taxane Chemotherapy in Refractory Locally Advanced or Metastatic Triple Negative Breast Cancer Patients

Metastatic Triple Negative Breast Cancer

United States
University of Colorado, Denver

Completed

Phase I Study of MLN0128 and MLN8237 in Patients With Advanced Solid Tumors and Metastatic Triple-negative Breast Cancer

Metastatic Breast Cancer | Solid Tumors

United States
Siemens Molecular Imaging

Completed

Exploratory, Phase 0 Study of Positron Emission Tomography (PET) Imaging Agent, F-18 RGD-K5 (K5)

Melanoma | Sarcoma | Breast Cancer | Lung Cancer | High Grade Gliomas

United States
Mothaffar Rimawi
Genentech, Inc.

Terminated

Neoadjuvant Herceptin in Patients With Breast Cancer

BREAST CANCER

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Ipatasertib in Combination With Carboplatin, Carboplatin/Paclitaxel, or Capecitabine/Atezolizumab in Treating Patients With Metastatic Triple Negative Breast Cancer

Anatomic Stage IV Breast Cancer AJCC v8 | Prognostic Stage IV Breast Cancer AJCC v8 | Metastatic Triple-Negative Breast Carcinoma

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Terminated

M7824 and Eribulin Mesylate in Treating Patients With Metastatic Triple Negative Breast Cancer

Anatomic Stage IV Breast Cancer AJCC v8 | Prognostic Stage IV Breast Cancer AJCC v8 | Metastatic Triple-Negative Breast Carcinoma

United States
H. Lee Moffitt Cancer Center and Research Institute

Terminated

Immune Response and Potential Booster for Patients Who Have Received HER2-pulsed DC1

Breast Cancer | Breast Cancer, Male | HER2-positive Breast Cancer | HER-2 Gene Amplification | Breast Cancer Female | HER2 Positive Breast Carcinoma | HER-2 Protein Overexpression

United States

Clinical Trials on High-Risk Breast Cancer in United States

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