Clinical Trials on Hypotension, Orthostatic in South Africa

Total 473 results

Shire

Completed

Study to Assess the Benefit of Midodrine in the Treatment of Patients With Neurogenic Orthostatic Hypotension

Hypotension, Orthostatic

United States
Chelsea Therapeutics
Chiltern International Inc.

Completed

Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (NOH302)

Primary Autonomic Failure | Dopamine Beta Hydroxylase Deficiency | Symptomatic Neurogenic Orthostatic Hypotension (NOH) | Non-diabetic Neuropathy

United States, Australia, Canada, New Zealand
Theravance Biopharma

Terminated

Phase 3 Open-Label Extension Study of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure (OAK)

Symptomatic Neurogenic Orthostatic Hypotension

United States, Spain, Portugal, United Kingdom, France, Denmark, Ukraine, Israel, Estonia, Poland, Italy, Russian Federation, Australia, Austria, Bulgaria, Canada, Germany, New Zealand
Theravance Biopharma

Completed

Clinical Effect of Ampreloxetine (TD-9855) for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure (SEQUOIA)

Symptomatic Neurogenic Orthostatic Hypotension

United States, Spain, Israel, Hungary, Portugal, Australia, Canada, Germany, Russian Federation, Estonia, France, Italy, United Kingdom, Denmark, Poland, New Zealand, Austria, Bulgaria, Ukraine
Theravance Biopharma

Terminated

Phase 3 Clinical Effect Durability of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure (REDWOOD)

Parkinson's Disease (PD) | MSA | Symptomatic Neurogenic Orthostatic Hypotension | Pure Autonomic Failure (PAF)

United States, Spain, United Kingdom, Canada, France, Estonia, Australia, Israel, Denmark, Italy, Poland, New Zealand, Germany, Ukraine, Austria, Bulgaria, Portugal, Hungary, Russian Federation
University of Johannesburg

Completed

The Effect of a Homoeopathic Complex on Blood Pressure in Refractory Hypertension

Essential Hypertension

South Africa
Chelsea Therapeutics

Completed

Open-Label Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (NOH303)

Multiple System Atrophy | Neurogenic Orthostatic Hypotension | Dopamine Beta Hydroxylase Deficiency | Non-Diabetic Autonomic Neuropathy

United States, Australia, Canada, New Zealand
GlaxoSmithKline

Completed

Study to Determine the Bioequivalence of Two Fixed Dose Combination (FDC) Tablet Formulations of Amlodipine and Losartan FDC5/50 and FDC5/100 Under Fasting Conditions

Hypertension

South Africa
University of Witwatersrand, South Africa

Completed

Comparison Of Trabeculectomy Versus The Ex-PRESS Miniature Glaucoma Device In The Same Patient: A Prospective Randomized Study (XVT-USF)

Glaucoma

South Africa
GlaxoSmithKline

Completed

Bioequivalence Study Between GSK3542503 Hydrochlorothiazide + Amiloride Hydrochloride 50 mg: 5 mg Tablets and Reference Product in Healthy Adult Participants Under Fasting Conditions

Hypertension

South Africa
Ocular Therapeutix, Inc.

Completed

Multi-Arm Feasibility Study Evaluating OTX-TP Compared to Timolol in Treatment of Subjects With Open Angle Glaucoma

Glaucoma

South Africa
University of Cape Town
Mayo Clinic; University of Lagos, Nigeria; University of Ibadan; Aminu Kano Teaching... and other collaborators

Completed

The Pan African Pulmonary Hypertension Cohort Study (PAPUCO)

Pulmonary Hypertension

South Africa
University of Stellenbosch

Completed

A Cross-sectional Study on Intradialytic Hypertension at Four Haemodialysis Units in the Western Cape

Intradialytic Hypertension

South Africa
North-West University, South Africa
GlaxoSmithKline; Novartis; Pfizer; Boehringer Ingelheim; Medical Research Council; Medical... and other collaborators

Active, not recruiting

The African-PREDICT Study (PREDICT)

Cardiovascular Diseases | Hypertension | Health Risk Behaviors | Arterial Stiffness | Young | Renin Hypertension

South Africa
University of Witwatersrand, South Africa
Massachusetts General Hospital; Emory University; UMC Utrecht

Recruiting

iHEART-SA Intervention Study (iHEART-SA)

Hypertension | HIV

South Africa
Brigham and Women's Hospital

Recruiting

Implementation of a Combination Intervention for Sustainable Blood Pressure Control (IMPACT-BP)

Hypertension

South Africa
Boston University
World Bank (Lead institution); Republic of South Africa National Department...

Completed

Evaluation of South Africa's National Adherence Strategy (ENHANCE)

Hypertension | Diabetes | HIV | Tuberculosis

South Africa
North-West University, South Africa
Medical Research Council, South Africa; National Research Foundation of South...

Active, not recruiting

Exercise, Arterial Modulation and Nutrition in Youth South Africa Study (ExAMIN-Youth)

Hypertension | Childhood Obesity | Retinal Artery Stenosis

South Africa
Pace Clinic
University Hospital, Saarland

Completed

Renal Sympathetic Denervation Prevents Atrial Fibrillation in Patients With Hypertensive Heart Disease: a Pilot Study (RDPAF)

Hypertension | Atrial Fibrillation | Autonomic Imbalance | Hypertensive Heart Disease

South Africa
University of Cape Town
Medical University of Vienna; University of Washington

Completed

Acid-Base and Point of Care Ultrasound in Severe Preeclampsia

Pre-Eclampsia

South Africa
University of Cape Town
Stanford University

Recruiting

Point-of-care Ultrasound Abnormalities in Eclampsia

Eclampsia

South Africa
University of KwaZulu
King's College London; Department for International Development, United Kingdom and other collaborators

Completed

Strengthening Mental Health Care in Chronic Care Patients With Hypertension. A Cluster Randomised Control Trial

Depression | Hypertension

South Africa
University of Cape Town

Completed

Prevalence of Hypertensive Disease in Patients Presenting for Elective Surgery in the Western Cape, South Africa (HASS)

Hypertensive Episode

South Africa
University of Cape Town
Stanford University

Recruiting

Point-of-care Ultrasound Abnormalities in Early Onset Preeclampsia

Preeclampsia | Pulmonary Edema | Cardiac Function

South Africa
University of Cape Town

Completed

Hypertension And Surgery Study: Evaluating the Implementation of a Hypertension Guideline Protocol (HASS-2)

Hypertension | Metabolic Syndrome | Non-Compliance, Medication

South Africa
Novartis

Completed

Aliskiren and the Calcium Channel Blocker Amlodipine Combination as an Initial Treatment Strategy for Hypertension (ACCELERATE)

Hypertension

Switzerland, United Kingdom, Venezuela, France, South Africa, Greece, Canada, Costa Rica, Germany, Guatemala
University of Washington
University of Cape Town

Completed

Evaluation of Metabolic Acid-base Abnormalities in Pre-eclamptic Women Applying the Stewart-Fencl Approach

Severe Pre-eclampsia | Mild Pre-eclampsia

South Africa, United States
University of KwaZulu
King's College London; University of Oxford; University of East Anglia; University... and other collaborators

Recruiting

ENHANCE-EvideNce Led Co-created HeAlth Systems interventioNs for MLTCs CarE (ENHANCE)

Depression | Myocardial Infarction | HIV Infections | Stroke | Hypertension | Diabetes Mellitus | Asthma

South Africa
Novartis Pharmaceuticals

Completed

Dose Response of Valsartan on Sitting Systolic Blood Pressure in Children 6 Months - 5 Years of Age With High Blood Pressure

Hypertension

Sweden, Belgium, Hungary, India, Italy, Poland, Turkey, United States, Brazil, France, South Africa
Horizon Health Network
University of Manitoba; University of British Columbia; University of Michigan; Dalhousie University and other collaborators

Completed

Sonography in Hypotension and Cardiac Arrest in the Emergency Department. (SHoC-ED)

Shock | Hypotension | Point of Care Ultrasound

Canada, South Africa
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield

Completed

Chronic Thrombo-embolic Pulmonary Hypertension: Classification and Long Term Outcome

Idiopathic Pulmonary Arterial Hypertension | Chronic Thromboembolic Pulmonary Hypertension

United Kingdom
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A Phase 1, Open-Label Study of Latanoprost Acid Plasma Concentrations in Pediatric and Adult Glaucoma Patients Treated With Latanoprost.

Ocular Hypertension | Glaucoma

United States, Spain, Italy, Denmark, Portugal, South Africa
Attikon Hospital

Completed

Echocardiography and Spinal Induced Hypotension.

Spinal Anesthetic Toxicity

Greece
Gmax Biopharm Australia Pty Ltd.
Metaclinical; Syneos Heath

Completed

A Study to Investigate Safe and Tolerable Dose of GMA301 Injection in Healthy Volunteers

Pulmonary Arterial Hypertension

Australia
University of Adelaide

Unknown

Effects of Renal Sympathetic Denervation on the Cardiac and Renal Functions in Patients With Drug-resistant Hypertension Through MRI Evaluation (RDN)

Uncontrolled Hypertension

Australia
Novartis Pharmaceuticals

Completed

Study to Evaluate the Efficacy and Safety of Aliskiren Alone and in Combination With Amlodipine in Essential Hypertension

Hypertension

Sweden, United States, Peru, Russian Federation, Romania, Mexico, Panama, Spain, Denmark, Italy, Greece, South Africa, Canada, Argentina, Australia, Colombia, Finland, Taiwan
ADARx Pharmaceuticals, Inc.
ADARx Australia Pty Ltd

Recruiting

Safety, Tolerability, PK and PD of ADX-850 in Participants With Hypertension

Hypertension | Hypertension,Essential

Australia
Actelion

Recruiting

A Study Providing Treatment Access in Participants With Pulmonary Hypertension Completing a Parent Study and Having no Other Option (PLATYPUS)

Hypertension, Pulmonary

Korea, Republic of, Taiwan, Poland, Bulgaria, Ukraine, Belgium, South Africa, Belarus, Russian Federation
Attikon Hospital
Ohio State University

Recruiting

Internal Jugular Vein and Spinal-induced Hypotension

Haemodynamic Instability

Greece
Sheffield Teaching Hospitals NHS Foundation Trust

Completed

Dicrotic Notch and Hypotension at Caesarean Under Spinal Anaesthesia (DINOCS)

Hypotension

United Kingdom
Aerami Therapeutics

Completed

Safety, Tolerability, & Pharmacokinetics Study of Single & Multiple Inhaled Doses of Imatinib Inhalation Solution

Pulmonary Arterial Hypertension

Australia
Prisma Health-Upstate

Completed

Amlodipine Versus Nifedipine ER for the Management of Postpartum Hypertension

Hypertension in Pregnancy

United States
Sheffield Teaching Hospitals NHS Foundation Trust

Recruiting

Feasibility of Novel Clinical Trial Infrastructure, Design and Technology for Early Phase Studies in Patients With Pulmonary Hypertension (FIT-PH) (FIT-PH)

Pulmonary Hypertension

United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust
Actelion

Completed

Assessing the Repeatability of NT-proBNP Testing Using Laboratory and Point of Care Testing in PAH (REPEAT-PAH)

Pulmonary Artery Hypertension

United Kingdom
Alcon Research

Completed

Anecortave Acetate Safety in Patients With Open-Angle Glaucoma or Ocular Hypertension

Open-angle Glaucoma | Oular Hypertension

United States
University of Sheffield

Unknown

Anxiety Self-management Intervention for Pulmonary Hypertension

Anxiety Disorders | Anxiety | Pulmonary Arterial Hypertension | Pulmonary Hypertension

United Kingdom
Medical University of South Carolina
Ochsner Health System

Terminated

Crossover Study From Macitentan or Bosentan Over to Ambrisentan (Letairis)

Pulmonary Arterial Hypertension

United States
Sheffield Teaching Hospitals NHS Foundation Trust

Completed

The Pleth Variability Index and Hypotension at Caesarean Under Spinal.

Caesarean Section

United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust
University of Sheffield

Completed

Novel MRI Techniques in the Evaluation of Pulmonary Vascular Disease

Pulmonary Hypertension

United Kingdom
University of Athens

Unknown

Central Blood Pressure in Adolescents and Young Adults

Hypertension | Healthy

Greece

Clinical Trials on Hypotension, Orthostatic in South Africa

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