Clinical Trials on Immune Function in Japan

Total 1342 results

Celgene
The Lymphoma Academic Research Organisation

Completed

Combined Rituximab and Lenalidomide Treatment for Untreated Patients With Follicular Lymphoma (RELEVANCE)

Follicular Lymphoma

Japan, United States
Novartis Pharmaceuticals

Completed

Special Drug Use Observational Study of Xolair in Patients With Severe to Most Severe Seasonal Allergic Rhinitis Aged ≥ 12 Years and < 18 Years Whose Symptoms Were Inadequately Controlled Despite to Conventional Therapies

Allergic Rhinitis

Japan
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany

Completed

Avelumab in First-Line Maintenance Gastric Cancer (JAVELIN Gastric 100)

Unresectable, Locally Advanced or Metastatic, Adenocarcinoma of the Stomach, or of the Gastro Esophageal Junction

United States, Spain, Italy, Australia, Russian Federation, Taiwan, Korea, Republic of, Thailand, Canada, Turkey, Germany, Romania, United Kingdom, Hungary, Brazil, France, Japan
Hoffmann-La Roche
Chugai Pharmaceutical Co.

Terminated

A Study In Neuromyelitis Optica Spectrum Disorder (NMOSD) With Satralizumab As An Intervention (SAkuraBonsai)

Neuromyelitis Optica Spectrum Disorder | NMOSD

United States, Korea, Republic of, Italy, Canada, Japan, Turkey
Institut de Recherches Internationales Servier
ADIR, a Servier Group company

Active, not recruiting

A Study to Evaluate the Long-term Safety of Patients With Advanced Lymphoid Leukemia Who Have Been Previously Administered With UCART19

Advanced Lymphoid Leukemia

United States, United Kingdom, Japan, France, Spain
SURPRISE Study Group

Completed

Success of Tocilizumab in RA Patients With Remission Induction and Sustained Efficacy After Discontinuation (SURPRISE)

Rheumatoid Arthritis

Japan
Pfizer

Terminated

A Study of the Long-Term Safety of Crisaborole Ointment, 2% in Japanese Pediatric and Adult Participants With Mild to Moderate Atopic Dermatitis

Atopic Dermatitis

Japan
Novartis Pharmaceuticals

Active, not recruiting

Safety and Preliminary Efficacy of JBH492 Monotherapy in Patients With CLL and NHL

Chronic Lymphocytic Leukemia | Non-Hodgkins Lymphoma

Finland, Spain, Korea, Republic of, Israel, Japan, Germany, Singapore
Shire

Completed

Study of C1 Inhibitor (Human) for the Prevention of Angioedema Attacks and Treatment of Breakthrough Attacks in Japanese Subjects With Hereditary Angioedema (HAE)

Hereditary Angioedema (HAE)

Japan
UCB BIOSCIENCES, Inc.
R-Pharm

Terminated

The Long-term Safety and Efficacy of CDP6038 (Olokizumab) With Active Rheumatoid Arthritis

Rheumatoid Arthritis

Japan, Korea, Republic of, Taiwan
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Completed

Efficacy, Safety, Pharmacokinetics and Immunogenicity Study of Abatacept Administered Intravenously to Treat Active Polyarticular-course Juvenile Idiopathic Arthritis in Japan

Juvenile Idiopathic Arthritis

Japan
AstraZeneca

Completed

Safety & Efficacy of Symbicort® Turbuhaler® (1, 2, and 4 x 160/4.5 µg Twice Daily) in Japanese Patients With Asthma

Asthma

Japan
Novo Nordisk A/S

Completed

GAPP 1 Survey: Global Attitudes of Patients and Physicians in Insulin Therapy for Diabetes Mellitus

Diabetes Mellitus, Type 2 | Diabetes | Diabetes Mellitus, Type 1

Spain, China, India, Russian Federation, Turkey, Germany, Japan, United Kingdom, France, United States
Novartis Pharmaceuticals

Completed

Efficacy and Safety of Ofatumumab Compared to Placebo in Patients With Relapsing Multiple Sclerosis Followed by Extended Treatment With Open-label Ofatumumab

Relapsing Multiple Sclerosis

Japan, Russian Federation
Celgene

Completed

A Japanese Phase 1/2 Study to Assess the Efficacy, Safety and Pharmacokinetics of Romidepsin in Patients With Peripheral T-cell Lymphoma (PTCL)

Lymphoma, T-cell, Peripheral

Japan
Celgene

Completed

A Phase 2 Study of Lenalidomide in Patients With Relapsed or Recurrent Adult T-cell Leukemia-lymphoma

Adult T-Cell Leukemia-Lymphoma

Japan
National Hospital Organization Nagoya Medical Center

Recruiting

ASIA Down Syndrome Acute Lymphoblastic Leukemia 2016

Acute Lymphoblastic Leukemia | Down Syndrome | Childhood Cancer

Taiwan, Thailand, Hong Kong, Singapore, Malaysia, Japan
Dermavant Sciences GmbH

Completed

A Phase 2 Study of E6005 in Patients With Atopic Dermatitis

Atopic Dermatitis

Japan
Novartis Pharmaceuticals

Active, not recruiting

Activity, Safety and Pharmacokinetics in Pediatric Subjects With Moderate and Severe Chronic Graft vs. Host Disease After Allogeneic Stem Cell Transplant

Graft vs Host Disease

Japan, Slovakia, Taiwan, Spain, Korea, Republic of, Thailand, Canada, Russian Federation, Italy, Turkey, India, Czechia, Brazil, Switzerland
AstraZeneca

Completed

A Study to Compare Severe Asthma Patients Who Start Biologics and Who do Not Start (PROSPECT)

Asthma

Japan
UCB Biopharma SRL

Terminated

A Study to Evaluate the Efficacy, Safety, and Tolerability of Rozanolixizumab in Adult Study Participants With Persistent or Chronic Primary Immune Thrombocytopenia (ITP) (myOpportunITy1)

Primary Immune Thrombocytopenia

United States, Bulgaria, France, Georgia, Greece, Hungary, Italy, Japan, Korea, Republic of, Moldova, Republic of, Poland, Romania, Russian Federation, Taiwan, Ukraine, United Kingdom
Kyoto Breast Cancer Research Network
Pfizer

Completed

Neoadjuvant Hormonal Therapy Plus Palbociclib in Operable, Hormone Sensitive and HER2-Negative Primary Breast Cancer

Hormone Receptor Positive Malignant Neoplasm of Breast | Breast Cancer Female

Taiwan, Japan, Korea, Republic of, Australia, Hong Kong
Celgene

Active, not recruiting

Efficacy and Safety of Oral Azacitidine (CC-486) Compared to Investigator's Choice Therapy in Patients With Relapsed or Refractory Angioimmunoblastic T Cell Lymphoma

Lymphoma, T-Cell

Japan
Bayer

Completed

Study for Evaluation of Efficacy and Safety of SH L 749 to Indolent B-cell Non-Hodgkin's Lymphoma

Lymphoma, B-Cell | Non-Hodgkin's Lymphoma | Lymphoma, Low-Grade

Japan
Eli Lilly and Company
Merck Sharp & Dohme LLC

Completed

A Study of Ramucirumab Plus Pembrolizumab in Participants With Gastric or GEJ Adenocarcinoma, NSCLC, Transitional Cell Carcinoma of the Urothelium, or Biliary Tract Cancer

Carcinoma, Transitional Cell | Gastric Adenocarcinoma | Non-small Cell Lung Cancer | Biliary Tract Cancer | Adenocarcinoma of the Gastroesophageal Junction

Germany, United States, Spain, United Kingdom, France, Japan
Novartis Pharmaceuticals

Completed

A Long-term Safety Study of QMF149 in Japanese Participants With Asthma

Asthma

Japan
Novartis Pharmaceuticals

Completed

Study of Pharmacokinetics, Activity and Safety of Ruxolitinib in Pediatric Patients With Grade II-IV Acute Graft vs. Host Disease

Acute Graft Versus Host Disease

Belgium, Japan, Spain, France, Korea, Republic of, Canada, Italy, Denmark
AstraZeneca

Recruiting

Tezepelumab PRO Study (TezepelumabPRO)

Asthma

Japan
Pfizer

Completed

Comparison Of 4 CP-690,550 Doses Vs. Placebo, Each Combined With Methotrexate, For The Treatment Of Rheumatoid Arthritis in Japan

Arthritis, Rheumatoid

Japan
SymBio Pharmaceuticals

Completed

Clinical Study on SyB L-0501 in Patients With Indolent B-cell Non-Hodgkin's Lymphoma or Mantle Cell Lymphoma

Non-Hodgkin's Lymphoma | Mantle Cell Lymphoma

Japan
Novartis Pharmaceuticals

Completed

Phase III B in Acute Lymphoblastic Leukemia

Acute Lymphoblastic Leukemia

Belgium, Germany, France, Austria, Canada, Italy, Japan, Norway, Spain
AbbVie

Recruiting

A Study to Assess Change in Disease Activity, Adverse Events, and How the Drug Moves Through the Body in Adult Participants Living With Human Immunodeficiency Virus (HIV) Receiving Intravenous (IV) Infusion of Budigalimab and/or ABBV-382

Human Immuno-deficiency Virus (HIV) Disease

United States, Puerto Rico, Japan, Spain, Germany, Canada, Belgium, France, Poland, South Africa, Italy
Eli Lilly and Company

Completed

A Study of Ramucirumab (LY3009806) in Combination With Capecitabine and Cisplatin in Participants With Stomach Cancer (RAINFALL)

Metastatic Gastric Adenocarcinoma | Gastroesophageal Junction Adenocarcinoma

Germany, Italy, Spain, United States, Hungary, Russian Federation, Poland, Belgium, Netherlands, France, Czechia, Mexico, Argentina, Canada, Denmark, Finland, Israel, Japan, Puerto Rico, United Kingdom
Sanofi

Completed

A Trial of Caplacizumab in Japanese Patients With Acquired Thrombotic Thrombocytopenic Purpura (aTTP)

Thrombotic Thrombocytopenic Purpura

Japan
Medtronic Bakken Research Center
Medtronic; Medtronic Japan Co., Ltd.

Completed

Mid-Q Response Study

Heart Failure | Left Bundle-Branch Block | Heart Failure NYHA Class II | Heart Failure NYHA Class III | Heart Failure NYHA Class IV | Heart Failure With Reduced Ejection Fraction (HFrEF)

Korea, Republic of, Japan, Singapore, Taiwan, Hong Kong, Indonesia, Malaysia, China, Philippines, Brunei Darussalam
University of Cincinnati
National Center for Research Resources (NCRR); Office of Rare Diseases (ORD); FDA Office of Orphan Products Development

Completed

Efficacy and Safety of Sirolimus in LAM (MILES)

Lymphangioleiomyomatosis

United States, Canada, Japan
Chiba University

Active, not recruiting

Low-dose Glucocorticoid Vasculitis Induction Study (LoVAS)

Microscopic Polyangiitis | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis | Wegener Granulomatosis

Japan
Novartis Pharmaceuticals

Terminated

A Phase I/Ib Study of NIZ985 Alone and in Combination With Spartalizumab

In Escalation: All Patients With Solid Tumors and Lymphoma | In Expansion: Melanoma, Non-small Cell Lung Cancer

United States, Italy, Taiwan, Belgium, Spain, Germany, Japan
Novartis Pharmaceuticals

Terminated

Efficacy and Safety of AIN457 (Secukinumab) in Patients With Relapsing Multiple Sclerosis

Multiple Sclerosis

Belgium, Spain, Russian Federation, France, Italy, Poland, Sweden, Turkey, Czech Republic, Japan
Insel Gruppe AG, University Hospital Bern
Swiss National Science Foundation; Mach Gaensslen Foundation; Baxalta Innovations...

Recruiting

Genotype and Phenotype Correlation in Hereditary Thrombotic Thrombocytopenic Purpura (Upshaw-Schulman Syndrome) (TTP registry)

Thrombotic Thrombocytopenic Purpura | Congenital Thrombotic Thrombocytopenic Purpura | Familial Thrombotic Thrombocytopenic Purpura | Thrombotic Thrombocytopenic Purpura, Congenital | Upshaw-Schulman Syndrome

United States, Austria, Czechia, Germany, Japan, Norway, Switzerland
AbbVie (prior sponsor, Abbott)

Completed

Drug Use Investigation of Kaletra Tablets (Once Daily Administration) on Patients With HIV-infection

Human Immunodeficiency Virus Infection

Japan
Bayer

Completed

Efficacy and Safety of Different Concentrations of ZK245186 in Atopic Dermatitis (AD)

Atopic Dermatitis

United States, Japan
AstraZeneca

Active, not recruiting

SAPHNELO Systemic Lupus Erythematosus Japan Post-Marketing Surveillance (PMS)

Lupus Erythematosus, Systemic

Japan
Pfizer

Recruiting

Elranatamab Post Trial Access Study for Participants With Multiple Myeloma (MM) (MagnetisMM15)

Multiple Myeloma

Canada, France, Japan, Australia, United States
Sobi, Inc.

Active, not recruiting

Evaluation of Avatrombopag for the Treatment of Thrombocytopenia in Japanese Adults With Chronic ITP

Immune Thrombocytopenia

Japan
AstraZeneca

Completed

Study to Evaluate the Effect of Dapagliflozin on the Incidence of Worsening Heart Failure or Cardiovascular Death in Patients With Chronic Heart Failure (DAPA-HF)

Chronic Heart Failure With Reduced Ejection Fraction (HFrEF)

United States, Canada, Denmark, United Kingdom, Czechia, Vietnam, Germany, Brazil, India, China, Japan, Taiwan, Netherlands, Bulgaria, Slovakia, Hungary, Poland, Russian Federation, Argentina, Sweden
Biogen

Completed

Extension Study to Evaluate Safety and Efficacy of Natalizumab in Japanese Participants With Relapsing-Remitting Multiple Sclerosis

Multiple Sclerosis | Relapsing-Remitting Multiple Sclerosis

Japan
Duke University

Active, not recruiting

Dose-Reduced Consolidation Radiation Therapy in Patients With Diffuse Large B-cell Lymphoma (DLBCL)

Diffuse Large B Cell Lymphoma

United States, Japan, Italy, Korea, Republic of, Czechia, Singapore
Alexion Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Efficacy and Safety of Eculizumab in Guillain-Barré Syndrome

Guillain-Barre Syndrome

Japan
AbbVie

Completed

A Study of the Safety and Tolerability of ABBV-621 in Participants With Previously-Treated Solid Tumors and Hematologic Malignancies

Cancer | Advanced Solid Tumors | Hematologic Malignancies

United States, Japan, Netherlands, Spain

Clinical Trials on Immune Function in Japan

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