Clinical Trials on Impaired Liver Function

Total 18778 results

Novartis Pharmaceuticals

Completed

Study of Efficacy and Safety of MAS825 in Patients With COVID-19 (MAS-COVID)

COVID-19 Pneumonia, Impaired Respiratory Function

United States
Novartis Pharmaceuticals

Completed

Study of Efficacy and Safety of DV890 in Patients With COVID-19 Pneumonia

COVID-19 Pneumonia, Impaired Respiratory Function

Germany, India, Spain, Russian Federation, Mexico, Netherlands, Peru, Brazil, Hungary, Argentina, Denmark, South Africa
Bausch Health Americas, Inc.

Completed

Pharmacokinetics, Safety, and Tolerability of Methylnaltrexone (MNTX) in Subjects With Impaired Renal Function

Renal Impairment

United States
Xuzhou Central Hospital
The Affiliated Hospital of Xuzhou Medical University

Not yet recruiting

rTMS in the Prevention and Treatment of Postoperative Executive Dysfunction

Functional Magnetic Resonance Imaging | Executive Function Disorder
Novartis Pharmaceuticals

Completed

Pharmacokinetics Study of Asciminib in Subjects With Impaired Renal Function Compared to Matched Healthy Volunteers

Renal Impairment

Germany, Bulgaria
Zhejiang Medicine Co., Ltd.

Unknown

Pharmacokinetics Study of Nemonoxacin Malate Capsules in Subjects With Severe Impaired Renal Function

Kidney Dysfunction

China
GlaxoSmithKline

Completed

A Phase I Topotecan Study in Subjects With Cancer and Impaired Renal Function

Solid Tumours

United States, Korea, Republic of, Netherlands
NicOx

Completed

A Pharmacokinetics and Safety Study of Naproxcinod in Subjects With Impaired Renal Function (HCT3012-X-106)

Renal Failure

United States
Ligand Pharmaceuticals
CyDex Pharmaceuticals, Inc.

Withdrawn

Comparison of Captisol-Enabled™ Iohexol and Omnipaque™ in Patients With Impaired Renal Function Undergoing Coronary Angiography

Contrast-induced Nephropathy
Yuzuncu Yıl University

Completed

The Effects of Low Flow and Normal Flow Desflurane Anesthesia

Anesthesia | Geriatric | Liver Functions | Kidney Functions

Turkey
National Hepatology & Tropical Medicine Research...

Completed

Role of Branched-chain Amino Acids Infusion as Adjunct Therapy Post Liver Surgery for Patients in Intensive Care Unit

Liver Function Post BCAA Infusion

Egypt
Exelixis

Completed

A Single-Dose Study to Assess the Pharmacokinetics of Cabozantinib (XL184) Capsules in Subjects With Impaired Renal Function

Healthy | Renal Impairment

United States
Eli Lilly and Company
CoLucid Pharmaceuticals

Completed

Study of Oral Lasmiditan in Participants With Normal and Impaired Renal Function

Migraine

Canada
RenJi Hospital

Completed

Dexmedetomidine and Liver Transplantation

Dexmedetomidine, Liver Transplantation, Allograft Function, Survival

China
AstraZeneca

Recruiting

Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function (BalanceD-HF)

Heart Failure and Impaired Kidney Function

Spain, France, Germany, Italy, United States, Argentina, Czechia, Vietnam, Peru, China, Philippines, Austria, Canada, Japan, Malaysia, Poland, Taiwan, Thailand, Brazil, Finland, Greece, Israel, Mexico, United Kingdom, Turkey, Colombia, Slov... and more
Nhat Nhat Pharmaceutical Company

Unknown

TONKA Versus Legalon for Lowering Hepatic Enzymes in Liver Function Disorder Patients.

Liver Function Failure

Vietnam
National Cancer Institute, Egypt

Enrolling by invitation

Desflurane and Sevoflurane in Pediatrics With Elevated Liver Enzymes

Liver Functions Tests

Egypt
Gilead Sciences

Completed

Pharmacokinetics of Bictegravir in Adults With Normal and Impaired Renal Function

HIV

United States, New Zealand
University of Copenhagen
Rigshospitalet, Denmark; Glostrup University Hospital, Copenhagen

Completed

Effects of Exercise Training on Cardiovascular Health in Middle-aged Women

Cardiovascular Diseases | Metabolic Diseases | Blood Platelet Disorders | Menopause | Cardiac Function Impaired

Denmark
Bayer

Completed

A Study to Evaluate the Pharmacokinetics (How it Moves Into, Through and Out From the Body) of a New Gadolinium-based Contrast Agent (GBCA) After Injection and How Safe it is in Participants With Normal and Impaired Renal Function

Contrast Enhancement in Magnetic Resonance Imaging

United States
Eisai Inc.

Completed

An Open-Label Study to Assess the Pharmacokinetics and Safety of HALAVEN in Subjects With Cancer Who Also Have Impaired Renal Function

Unspecified Adult Solid Tumor, Protocol Specific

United States
Richever Enterprise Co., Ltd.

Unknown

Clinical Study for Development of Oral Galactose Single Point (OGSP) Solution (G.S.P. Oral Solution®)

Galactose Single Point (GSP), Residual Liver Function
Brugmann University Hospital

Completed

Validation of Kinocardiography, New Technology for Cardiac Linear and Torsional Contractility Measurement, to Assess Heart Failure Patient With Low Ejection Fraction

Impaired Left Ventricular Ejection Fraction

Belgium
Institut Claudius Regaud

Completed

A Study Evaluating Chemotherapy With Fractionated Cisplatin/Gemcitabine Versus Carboplatin/Gemcitabine in the Treatment of Advanced or Metastatic Urothelial Cancer With Impaired Renal Function. (VEFORA)

Metastatic Urothelial Cancer | Advanced Urothelial Cancer

France
University of Cologne

Unknown

Longterm Follow-up After Remote Ischemic Preconditioning for Prevention of Contrast-induced Nephropathy (RenProLong)

Impaired Renal Function

Germany
Université de Sherbrooke
Centre hospitalier de l'Université de Montréal (CHUM); Réseau de bio-imagerie...

Completed

MRE-IA in Liver Disease and Neurovascular Imaging (MRE-IA)

Diffuse and Focal Liver Diseases, Cerebral Function

Canada
Amgen

Completed

Study to Evaluate the Safety, Tolerability and Pharmacokinetics of AMG 986 Administered Orally to Healthy Volunteers and Participants With Severely Impaired Renal Function

Heart Failure

United States
Taipei City Hospital

Completed

The Effect of Chinese Herbal Formula (KSY) on HCV Carrier With Abnormal Liver Function

Liver Function

Taiwan
US Department of Veterans Affairs

Completed

Extension of the MIME Robotic System for Stroke Rehabilitation

Stroke | Impaired Upper Extremity Function

United States
Mansoura University

Completed

Monitoring Living Donor Liver Functions by Thromboelastometry (TGF)

THROMBELASTOGRAPHY and Liver Graft Functions

Egypt
National Defense Medical Center, Taiwan
Tri-Service General Hospital; Cardinal Tien Hospital

Completed

GSP as an Novel Indicator for Residual Liver Function in Patients With Fatty Liver (GSP)

Galactose Single Point (GSP), Residual Liver Function
Neurocrine Biosciences

Completed

Safety, Tolerability, and Pharmacokinetics of a Single Dose of NBI-98854 in Subjects With Mild,Moderate, or Severe Hepatic Insufficiency

Safety, Tolerability, and PK of NBI-98854 in Hepatically Impaired Subjects

United States
Instituto Mexicano del Seguro Social

Completed

Dexamethasone and Respiratory Function After Mastectomy (Dexa-mama)

Respiratory; Disorder, Functional, Impaired

Mexico
Damanhour University

Completed

Linezolid Pharmacokinetics In Patients With Impaired Renal Function (PPT6) (LZDPPT6)

Renal Failure | Impaired Renal Function
Andres Duarte-Rojo

Completed

Controlled Attenuation Parameter (CAP) in Liver Allografts

Liver Disease | Early Allograft Dysfunction | Liver Steatosis | Liver Transplant | Primary Non-function

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Terminated

An Open Label Pharmacokinetic Study Of Gabapentin In Japanese Subjects With Renal Impairment Including Hemodialysis

PK Properties Of Gabapentin In Subjects With Impaired Renal Function

Japan
Assistance Publique - Hôpitaux de Paris

Recruiting

Evaluation of the Metrological Reliability of Connected Objects in the Measurement of Medical Physiological Parameters (EVALEXPLO)

Respiratory; Disorder, Functional, Impaired

France
Jayla Bostic

Completed

Efficacy of Osteopathic Manipulation on Breathing Mechanics in a Healthy Population: A Randomized Controlled Study

Respiratory Function Impaired

United States
Mustafa Kemal University
The Scientific and Technological Research Council of Turkey

Completed

Cardiopulmonary Assesments in Mood Disorders

Mood Disorders | Physical Inactivity | Respiratory Function Impaired

Turkey
Karolinska Institutet
Danderyd Hospital

Completed

Platelet Function in Diabetic Patients With and Without Renal Impairment, and the Effects of Lipid Lowering Treatment (PLAUDIT)

Diabetes Mellitus | Impaired Renal Function

Sweden
Eisai Inc.

Completed

A Pharmacokinetic and Safety Study of E7080 in Subjects With Mild (10 mg), Moderate (10 mg), and Severe Hepatic Impairment (5 mg) and Normal Hepatic Function (10 mg)

Hepatic Impairment | Hepatic Function

United States
Peking University Third Hospital

Recruiting

Assessment of Remnant Liver Function in ALPPS by Gd-EOB-DTPA Enhanced MRI

Liver Function Failure | Liver Malignant Tumors

China
Federal University of Vicosa

Completed

Eccentrically Reinforced Resistance Training vs. Traditional Resistance Training in Sedentary Older Women

Depression | Executive Function | Physical Functional Performance

Brazil
Merck Sharp & Dohme LLC

Completed

Pharmacokinetics of Anacetrapib (MK0859) in Subjects With Impaired Renal Function (MK-0859-038)

Dyslipidemia
Bezmialem Vakif University
Nuh Naci Yazgan University

Recruiting

Core Stabilization Training on Chest Expansion, Functional Capacity, Trunk Muscle Endurance in Hearing-Impaired Children

Respiration | Functional Capacity | Hearing Impaired Children | Endurance | Core Stabilization

Turkey
Janssen Research & Development, LLC

Completed

A Study to Assess the Effects of Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of Intranasally Administered Esketamine

Hepatic Impairment | Normal Hepatic Function

United States
AstraZeneca

Terminated

The Study Will Evaluate Average 24-hr Sodium Excretion During Dapagliflozin Treatment in Patients With Type 2 Diabetes Mellitus With Preserved or Impaired Renal Function or Non-diabetics With Impaired Renal Function. (DAPASALT)

Diabetes Mellitus, Type 2 | Kidney Function Tests

Netherlands, Sweden
Novartis Pharmaceuticals

Completed

Efficacy, Safety and Tolerability of Everolimus in Combination With Reduced Exposure Cyclosporine or Tacrolimus in Paediatric Liver Transplant Recipients.

Renal Function | Liver Transplant

United States, Germany, Spain, Belgium, France, Hungary, Australia, Sweden, Italy, Canada, United Kingdom, Denmark
HULYA KESKIN

Completed

Effect of Exercise on Liver Cirrhosis

Liver Function Tests

Turkey
Novartis Pharmaceuticals

Terminated

A Dose-escalation Pharmacokinetic Study of Intravenous ASA404 in Adult Advanced Cancer Patients With Impaired Renal Function and Patients With Normal Renal Function

Metastatic Cancer

United States

Clinical Trials on Impaired Liver Function

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Medical Conditions

Drug Interventions

CROs by country

CROs in Gambia

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Rare Diseases

Drug Interventions

Dietary Supplements

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