Clinical Trials on Intra-Abdominal Hypertension in South Africa

Total 589 results

Ottawa Hospital Research Institute
Canadian Institutes of Health Research (CIHR)

Completed

High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention (FACT)

Pregnancy Complications | Preeclampsia

Canada, United Kingdom, Argentina, Australia, Jamaica
Zimmer Biomet

Recruiting

Clinical Outcomes Study of the Nexel Total Elbow

Post-traumatic Arthritis | Degenerative Arthritis | Elbow Joint Destruction | Post-traumatic Lesions | Ankylosed Joints | Advanced Rheumatoid Arthritis | Joint Instability or Loss of Motion | Acute Comminuted Articular Fracture of Elbow Joint Surfaces | Bone Loss Contributing to Elbow Instability | Bilateral...

United States, Australia, Finland, France, Germany, Italy, Netherlands, United Kingdom
Forest Laboratories

Completed

Nebivolol in Patients With Systolic Stage 2 Hypertension (NEB-MD-20)

Hypertension

United States
Bristol-Myers Squibb
Sanofi

Completed

Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy for Patients With Moderate Hypertension

Hypertension

United States, Canada, Germany, Russian Federation, France
Cynthia West

Completed

Stop Atherosclerosis in Native Diabetics Study (SANDS)

Hypertension | Cardiovascular Disease | Diabetes | Carotid Atherosclerosis | Hyperlipidemia

United States
Novartis Pharmaceuticals

Completed

An Extension Study to Evaluate the Long Term Safety, Tolerability and Efficacy of Aliskiren Compared to Enalapril in Pediatric Hypertensive Patients 6-17 Years of Age

Hypertension

United States, Hungary, Turkey, Guatemala, Slovakia, Puerto Rico, Poland
Bayer

Terminated

Efficacy and Safety of Riociguat in Patients With Symptomatic Pulmonary Hypertension (PH) Associated With Idiopathic Interstitial Pneumonias (IIP) (RISE-IIP)

Idiopathic Interstitial Pneumonias / Hypertension,Pulmonary

Belgium, Israel, Spain, United States, Switzerland, New Zealand, Greece, Portugal, Japan, Argentina, Canada, Denmark, France, Germany, Russian Federation, Turkey, Colombia, Saudi Arabia, Australia, Italy, United Kingdom
Acceleron Pharma, Inc., a wholly-owned subsidiary...

Recruiting

A Study of Sotatercept for the Treatment of Cpc-PH Due to HFpEF (MK-7962-007/A011-16) (CADENCE)

Hypertension, Pulmonary

United States, Belgium, France, Germany, Israel, Italy, Spain, Sweden, United Kingdom, Poland, Canada
The George Institute
University of Sydney

Terminated

Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial Magnetic Resonance Imaging Sub-study (TRIDENT-MRI)

Stroke | Hypertension | Cerebral Small Vessel Diseases | Vascular Dementia | Intracerebral Hemorrhage

Australia
Theravance Biopharma

Terminated

Phase 3 Open-Label Extension Study of TD-9855 for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure (OAK)

Symptomatic Neurogenic Orthostatic Hypotension

United States, Spain, Portugal, United Kingdom, France, Denmark, Ukraine, Israel, Estonia, Poland, Italy, Russian Federation, Australia, Austria, Bulgaria, Canada, Germany, New Zealand
Forest Laboratories

Completed

Efficacy and Safety of Nebivolol (Added to Lisinopril or Losartan) in Hypertensive Patients

Hypertension

United States
ReCor Medical, Inc.

Active, not recruiting

A Study of the ReCor Medical Paradise System in Clinical Hypertension (RADIANCE-HTN)

Vascular Diseases | Hypertension

United States, Netherlands, United Kingdom, Germany, France, Poland, Belgium
Mayo Clinic
Johns Hopkins University; University of Chicago; Brigham and Women's Hospital; University... and other collaborators

Completed

Multicenter Endoscopic Sleeve Gastrectomy (ESG) Trial (MERIT Trial)

Hypertension | Obesity | Diabetes Mellitus, Type 2

United States
Daiichi Sankyo, Inc.

Completed

Safety and Efficacy Study of a Triple Combination Therapy in Subjects With Hypertension

Hypertension

United States, Puerto Rico
Forest Laboratories

Completed

Study of the Efficacy and Safety of Nebivolol in Younger Patients (18 - 54 Years)

Hypertension

United States
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

A Multi-Risk Factor Strategy vs a Guideline-Based Approach in Achieving Blood Pressure and Lipid Goals in Hypertensives at Extra Risk (TOGETHER)

Hypertension | Dyslipidemia

United States
Daiichi Sankyo, Inc.

Completed

Study of Co-administration of Olmesartan Medoxomil Plus Amlodipine in Patients With Mild to Severe Hypertension

Hypertension

United States
ReCor Medical, Inc.

Active, not recruiting

The RADIANCE II Pivotal Study: A Study of the ReCor Medical Paradise System in Stage II Hypertension (RADIANCE-II)

Cardiovascular Diseases | Vascular Diseases | Hypertension

United States, United Kingdom, Netherlands, France, Ireland, Belgium, Germany, Switzerland
Daniel Benjamin
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Completed

Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of Care (PTN_POPS)

Heart Failure | Epilepsy | Pain | Pneumonia | Sepsis | Inflammation | Hypertension | Chronic Kidney Diseases | Hemophilia | Schizophrenia | Central Nervous System Infections | Nosocomial Pneumonia | Insomnia | Anxiety | Bipolar Disorder | Neutropenia | Staphylococcal Infections | Bradycardia | Seizures | Urinary Tract Infections | Pulmonary... and other conditions

United States, Canada, United Kingdom, Israel, Singapore
Cumberland Pharmaceuticals

Recruiting

Oral Ifetroban to Treat Diffuse Cutaneous Systemic Sclerosis (SSc) or SSc-associated Pulmonary Arterial Hypertension

Pathologic Processes | Skin Diseases | Autoimmune Diseases | Connective Tissue Diseases | Scleroderma, Systemic | Scleroderma, Diffuse | Scleroderma, Limited | Sclerosis, Progressive Systemic

United States, India
Mineralys Therapeutics Inc.

Recruiting

A Pivotal Study to Evaluate the Efficacy of Lorundrostat in Subjects With Uncontrolled Hypertension on a Standardized Antihypertensive Medication Regimen

Hypertension

United States
Daiichi Sankyo, Inc.
Integrium

Completed

A Dose Escalation Study of a Combination Antihypertensive Drug in the Treatment of Various Groups of Patients Who do Not Respond to Single Drug Treatment of Their High Blood Pressure (BP CRUSH)

Hypertension

United States
Chelsea Therapeutics
Chiltern International Inc.

Completed

Clinical Study of Droxidopa in Patients With Neurogenic Orthostatic Hypotension (NOH) (NOH302)

Primary Autonomic Failure | Dopamine Beta Hydroxylase Deficiency | Symptomatic Neurogenic Orthostatic Hypotension (NOH) | Non-diabetic Neuropathy

United States, Australia, Canada, New Zealand
Medtronic Vascular

Completed

SPYRAL PIVOTAL - SPYRAL HTN-OFF MED Study

Cardiovascular Diseases | Vascular Diseases | Hypertension

United States, Canada, Germany, Australia, United Kingdom, Ireland, Japan, Austria, Greece
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Clinical Utility of Caduet in Achieving Blood Pressure and Lipid Endpoints in a Specific Patient Population (CAPABLE)

Hypertension | Dyslipidemia

United States
Medtronic Vascular

Active, not recruiting

SPYRAL HTN-ON MED Study of Renal Denervation With the Symplicity Spyral™ Multi-electrode Renal Denervation System

Cardiovascular Diseases | Vascular Diseases | Hypertension

United States, Germany, Canada, Australia, United Kingdom, France, Ireland, Japan, Austria, Greece
University of Alabama at Birmingham
Medical University of South Carolina; Johns Hopkins University; University of... and other collaborators

Completed

Chronic Hypertension and Pregnancy (CHAP) Project (CHAP)

Hypertension

United States
Mineralys Therapeutics Inc.

Recruiting

Efficacy and Safety of Lorundrostat in Subjects With Uncontrolled and Resistant Hypertension

Hypertension

United States, Australia, Canada, Puerto Rico, United Kingdom
Novartis Pharmaceuticals

Completed

8-week Randomized, Open-label Study to Evaluate Food Effect on Efficacy and Safety of Oral Aliskiren 300 mg in Patients With Hypertension

Hypertension

United States, Taiwan, Italy, Slovakia, Canada, Spain, Puerto Rico
Alnylam Pharmaceuticals

Active, not recruiting

A Study to Evaluate Efficacy and Safety of ALN-AGT01 in Patients With Mild To-Moderate Hypertension (KARDIA-1) (KARDIA-1)

Hypertension

United States, Canada, United Kingdom, Puerto Rico, Ukraine
Boehringer Ingelheim

Completed

PROBE Investigation of the Safety & Efficacy of Telmisartan (Micardis®) vs Ramipril (Altace®) Using ABPM in HTN

Hypertension

United States, Canada
Boehringer Ingelheim

Completed

A Randomized, Double-blind, Placebo Controlled Comparison of Telmisartan Hydrochlorothiazide (HCT) and Valsartan HCT in Hypertension (HTN) Stage I/II Patients

Hypertension

United States
Gilead Sciences

Terminated

DORADO-AC-EX - A Long-Term Safety Extension Study to the Phase 3 DORADOC-AC Study (Protocol DAR-312) of Darusentan in Resistant Hypertension (Darusentan)

Hypertension

United States, Argentina, Australia, Brazil
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Amlodipine/Atorvastatin Combination to Reduce the Health Risk of High Blood Pressure and High Cholesterol Levels (GEMINI-AALA)

Hypertension | Hyperlipidemia

Brazil, Turkey, Taiwan, Argentina, India, Philippines, Singapore, Thailand, Australia, Chile, South Africa, Jordan, Korea, Republic of, Lebanon, United Arab Emirates, Malaysia, Peru, Israel, Indonesia, Guatemala, Hong Kong, Kuwait, ... and more
Daiichi Sankyo, Inc.

Completed

18 Week Study Evaluating Safety and Efficacy of Olmesartan, Amlodipine, and Hydrochlorothiazide, in Type 2 Diabetics

Hypertension | Type 2 Diabetes

United States
Boehringer Ingelheim

Completed

Randomized, Double-Blind, Placebo-Controlled, Forced-Titration, Comparing Telmisartan vs Valsartan. Taken Orally for Eight Weeks in Patients With Stage 1 and Stage 2 Hypertension

Hypertension

United States
AbbVie

Recruiting

Study to Assess Change in Disease Activity and Adverse Events of Ab Externo Approach for Glaucoma Gel Stent (XEN45) Implantation In Participants Aged 45 Years or Older With Open-Angle Glaucoma

Open-Angle Glaucoma

United States, Australia
Novartis Pharmaceuticals

Completed

Safety and Efficacy of Aliskiren in Pediatric Hypertensive Patients 6-17 Years of Age

Hypertension

United States, Belgium, Hungary, Turkey, Guatemala, Slovakia, Germany, Puerto Rico, Poland
Kyowa Kirin, Inc.

Completed

Study of a Monoclonal Antibody KHK4083 in Moderate Ulcerative Colitis

Digestive System Diseases | Gastrointestinal Diseases | Colonic Diseases | Intestinal Diseases | Abdominal Pain | Inflammatory Bowel Diseases | Ulcerative Colitis | Colitis | Colitis, Ulcerative | Autoimmune Disease

Hungary, Russian Federation, Serbia, United States, Poland, Czechia, Romania
Pfizer's Upjohn has merged with Mylan to form Viatris...

Completed

Caduet in an Untreated Subject Population (CUSP)

Hypertension | Dyslipidemia

United States
Takeda

Completed

Efficacy and Safety of Azilsartan Medoxomil Combined With Chlorthalidone in Participants With Moderate to Severe Hypertension

Hypertension

United States, Chile, Russian Federation, Mexico, Peru
GlaxoSmithKline

Completed

COREG MR Versus TOPROL-XL On The Lipid Profile Of Normolipidemic Or Mildly Dyslipidemic Patients With Hypertension

Hypertension

United States, Canada, Puerto Rico
The George Institute
University of Sydney

Terminated

Triple Therapy Prevention of Recurrent Intracerebral Disease EveNts Trial (TRIDENT) Cognitive Sub-Study (TRIDENT COG)

Hypertension | Cerebral Small Vessel Diseases | Dementia, Vascular | Stroke Hemorrhagic | Cognitive Decline | Intracerebral Hemorrhage

Australia, Netherlands
Forest Laboratories

Completed

Combination of Nebivolol and Valsartan Given as Free Tablets for Stage 1 or Stage 2 Hypertension

Hypertension

United States
Novartis Pharmaceuticals

Terminated

Study to Evaluate the Efficacy and Safety of the Combination of Valturna and Amlodipine or Valturna and Chlorthalidone Versus Valturna Alone in Patients With Stage 2 Hypertension and Diabetes (VALENCIA)

Hypertension | Diabetes | Stage 2 Hypertension

United States, Puerto Rico
Bristol-Myers Squibb
Sanofi

Completed

Irbesartan/Hydrochlorothiazide (HCTZ) Combination Therapy as First Line Treatment for Severe Hypertension

Hypertension

United States, Belgium, Canada, Germany, Russian Federation, France, Israel, Netherlands
Theravance Biopharma

Completed

Clinical Effect of Ampreloxetine (TD-9855) for Treating Symptomatic nOH in Subjects With Primary Autonomic Failure (SEQUOIA)

Symptomatic Neurogenic Orthostatic Hypotension

United States, Spain, Israel, Hungary, Portugal, Australia, Canada, Germany, Russian Federation, Estonia, France, Italy, United Kingdom, Denmark, Poland, New Zealand, Austria, Bulgaria, Ukraine
Gilead Sciences

Completed

DORADO-AC - Optimized Doses of Darusentan as Compared to an Active Control in Resistant Hypertension (Darusentan)

Hypertension

United States, Spain, Argentina, Australia, Belgium, Brazil, Denmark, France, Germany, New Zealand
University of Iowa

Completed

A Collaborative Model to Improve Blood Pressure (BP) Control and Minimize Racial Disparities

Hypertension | Asthma

United States
DiaSorin Inc.
ICON Clinical Research

Completed

Helicobacter Pylori Sample Collection Protocol Pre Therapy Subjects

Nausea | Abdominal Pain | Weight Loss | Helicobacter Pylori Infection | Gastric Ulcer | Stomach Ulcer | Loss of Appetite | Bloating

United States, Italy

Clinical Trials on Intra-Abdominal Hypertension in South Africa

Sponsors and Collaborators

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CROs in India

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