Clinical Trials on Islet Transplantation

Total 2318 results

University Hospital, Lille

Completed

Nephrologic Prognosis 10 Years After Diabetes Cell Therapy (PRONOCELDIAB)

Islet Transplantation

France
University of British Columbia
Merck Sharp & Dohme LLC

Terminated

Effect of Sitagliptin on Graft Function Following Islet Transplantation

Islet Transplantation

Canada
Frantisek Saudek

Recruiting

Novel Method of Pancreatic Islet Transplantation Into the Omentum

Islets of Langerhans Transplantation

Czechia
University of Wisconsin, Madison

Completed

Glutamine Popsicles in Bone Marrow Transplant (BMT)/Hematopoietic Stem Cell Transplant (HSCT) Patients

Bone Marrow Transplantation | Hematopoietic Stem Cell Transplantion

United States
Stanford University
University of California, San Francisco

Not yet recruiting

Islet Transplantation With Recipient T-Reg Cells or Deceased Donor Vertebral Bone Marrow Therapy

Islet Transplantation

United States
University of Wisconsin, Madison
Bristol-Myers Squibb

Withdrawn

Calcineurin Inhibitor-free, Steroid-free Immunosuppressive Regimen in Simultaneous Islet-Kidney Transplantation for Uremic Type 1 Diabetic Patients

Diabetes Mellitus, Type 1 | Kidney Transplantation | Islets of Langerhans Transplantation

United States
Vancouver Coastal Health

Withdrawn

A Comparison of Strict Glucose Control With Usual Care at the Time of Islet Cell Transplantation

Diabetes Mellitus, Type 1 | Islet Transplantation

Canada
University of Pennsylvania
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National...

Active, not recruiting

Adrenergic System in Islet Transplantation

Hypoglycemia | Type1diabetes | Islet Cell Transplantation | Hypoglycemia Unawareness

United States
AZ-VUB
Fund for Scientific Research, Flanders, Belgium; Belgian Government

Terminated

Comparison of Sirolimus Alone With Sirolimus Plus Tacrolimus in Type 1 Diabetic Recipients of Cultured Islet Cell Grafts

Type 1 Diabetes | Islet Transplantation

Belgium
Uppsala University Hospital

Completed

Imaging of Islet Transplantation With PET and MRT

Diabetes Type 1 | Islet Transplantation

Sweden
University Hospital, Grenoble
University Hospital, Bordeaux

Unknown

Quality Control of Pancreatic Islet Intended to Islet Graft Cells Intended to Stabilot Islet Graft Protocol (ISLET CHIP)

Pancreatic Islet Quality Control

France, Switzerland
Baylor Research Institute

Withdrawn

Pancreatic Islet Cell Transplantation After Kidney Transplantation - A Novel Approach to Immunosupression

Type 1 Diabetes | Islet Cell Transplantation

United States
Baylor Research Institute
Baylor Health Care System

Completed

Pancreatic Islet Cell Transplantation - A Novel Approach to Improve Islet Quality and Engraftment

Type 1 Diabetes | Islet Cell Transplantation

United States
Leiden University Medical Center

Enrolling by invitation

Clinical Outcome After Total Pancreatectomy With Islet Autotransplantation (TOPPER)

Diabetes Mellitus | Islets of Langerhans Transplantation | Pancreatitis, Chronic

Netherlands
National Center for Research Resources (NCRR)
Juvenile Diabetes Research Foundation

Unknown

hOKT3gamma1 (Ala-Ala) for the Prevention of Human Islet Allograft Failure

Islets of Langerhans Transplantation | Diabetes Mellitus, Insulin-Dependent | Diabetes Mellitus, Experimental | Transplantation, Homologous

United States
University of Minnesota

Recruiting

Intra-Portal Alone Versus Intra- and Extra-Portal Transplantation of Pancreatic Islets After Total Pancreatectomy for Chronic Pancreatitis (iSite)

Diabetes Mellitus | Chronic Pancreatitis | Islet Cell Transplantation

United States
Leiden University Medical Center

Not yet recruiting

Arginine-stimulated Prediction of Early Outcome After Islet Transplantation (ALADDIN)

Diabetes Mellitus | Islets of Langerhans Transplantation | Chronic Pancreatitis

Netherlands
National Institute of Allergy and Infectious Diseases...
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Clinical...

Completed

Extended Follow-Up After Islet Transplantation in T1D

Type 1 Diabetes (T1D) | Islet Transplantation

United States
University of Virginia
DexCom, Inc.

Completed

CGM Use in Islet Transplant Recipients

Type1 Diabetes Mellitus | Islet Transplantation

United States
Dompé Farmaceutici S.p.A

Completed

Study to Assess Efficacy & Safety of Reparixin in Pancreatic Islet Transplantation (REP0211)

Islet Transplantation in Diabetes Mellitus Type 1

United States, Czechia, Italy, Sweden, United Kingdom
McGill University Health Centre/Research Institute...
CHU de Quebec-Universite Laval

Unknown

Circulating Extracellular Vesicles Released by Human Islets of Langerhans

Type2 Diabetes | Islet Cell Transplantation | Type1 Diabetes Mellitus

Canada
Dompé Farmaceutici S.p.A

Completed

Reparixin in Pancreatic Islet Transplantation

Pancreatic Islet Transplantation in Type 1 Diabetes Mellitus

Italy, Germany
IRCCS San Raffaele

Completed

Observational Study Concerning COVID-19 Infection in Transplanted Kidney, Pancreas or Pancreatic Islet Patients

Kidney Transplant | Pancreas Tranplant | Pancreatic Islet Transplantation

Italy
Lorenzo Piemonti

Active, not recruiting

Islet Transplant Alone in OMENtum (ITA-OMEN)

Diabetes Mellitus, Type 1 | Islets of Langerhans Transplantation

Italy
Pfizer

Terminated

A Study Of Sunitinib Compared To Placebo For Patients With Advanced Pancreatic Islet Cell Tumors

Carcinoma, Islet Cell | Carcinoma, Pancreas

United States, Canada, Belgium, Spain, Australia, Germany, Korea, Republic of, Taiwan, United Kingdom, France, Italy
Astellas Pharma Europe Ltd.

Active, not recruiting

Study to Compare the Pharmacokinetics of Tacrolimus in Stable Pediatric Allograft Recipients Converted From Prograf® to Advagraf®

Liver Transplantation | Kidney Transplantation | Heart Transplantation | Lung Transplantation | Intestine Transplantation

Belgium, Czechia, France, Germany, Italy, Poland, United Kingdom
Astellas Pharma Inc
Astellas Pharma Europe B.V.

Completed

A Study to Evaluate FK778 in Kidney Transplant Patients

Kidney Transplantation | Renal Transplantation | Transplantation, Kidney | Grafting, Kidney | Transplantation, Renal

Belgium, Germany, Spain, Sweden, Italy, Switzerland, United Kingdom, Austria, France, Poland, Czech Republic, Netherlands
Astellas Pharma Europe Ltd.

Completed

A Study to Compare How the Body Absorbs and Processes Two Different Formulations of the Anti-rejection Medication Tacrolimus (Advagraf® or Prograf®) in Children Receiving an Organ Transplant, and How Safe and Effective They Are Over a Longer Period of Time

Liver Transplantation | Kidney Transplantation | Heart Transplantation

Czechia, France, Italy, Poland, United Kingdom
The Hospital for Sick Children

Completed

Pharmacogenetic Trial of Tacrolimus After Pediatric Transplantation

Liver Transplantation | Kidney Transplantation | Heart Transplantation

Canada
Astellas Pharma Europe Ltd.

Terminated

A Paediatric, Open, Follow up Study With Modigraf Examining Safety and Efficacy in de Novo Allograft Recipients (PROGRESSION)

Liver Transplantation | Kidney Transplantation | Heart Transplantation

Belgium, France, Germany, Poland, Spain, United Kingdom
Astellas Pharma Europe Ltd.

Completed

Study to Ascertain if Prolonged Release Tacrolimus (FK506E - MR4) is Safe and Effective When Used in the Long Term and in Combination With Other Immunosuppressive Drugs in Patients Who Have Received a Transplant

Liver Transplantation | Kidney Transplantation | Heart Transplantation

Spain, Australia, France, Germany, Canada, Italy, United Kingdom, Belgium, South Africa, Switzerland, Sweden, United States, Austria, Brazil, Czechia, Denmark, Finland, Hungary, Ireland, Mexico, Netherlands, New Zealand, Poland
Astellas Pharma Europe Ltd.

Completed

A Study to Determine Pharmacokinetics of Children Receiving Modigraf (Tacrolimus Granules) Following Solid Organ Transplantation (OPTION)

Liver Transplantation | Kidney Transplantation | Heart Transplantation

Belgium, France, Germany, Poland, Spain, United Kingdom
University of Nebraska

Terminated

Cadaveric Islet Transplantation in Patients With Insulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type 1 | Islets of Langerhans Transplantation

United States
Academic and Community Cancer Research United
National Cancer Institute (NCI)

Withdrawn

Dovitinib Lactate in Treating Patients With Pancreatic Neuroendocrine Tumors

Gastrinoma | Glucagonoma | Insulinoma | Pancreatic Polypeptide Tumor | Recurrent Islet Cell Carcinoma | Somatostatinoma
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Active, not recruiting

Temozolomide With or Without Capecitabine in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors

Gastrinoma | Glucagonoma | Insulinoma | Pancreatic Polypeptide Tumor | Recurrent Islet Cell Carcinoma | Somatostatinoma | Islet Cell Carcinoma

United States
ECOG-ACRIN Cancer Research Group
National Cancer Institute (NCI)

Terminated

Everolimus in Patients With Pancreatic Neuroendocrine Tumors Metastatic to the Liver Previously Treated With Surgery

Liver Metastases | Gastrinoma | Glucagonoma | Insulinoma | Pancreatic Polypeptide Tumor | Recurrent Islet Cell Carcinoma | Somatostatinoma

United States
Astellas Pharma Inc

Completed

Study to Compare the Pharmacokinetics of Tacrolimus in Adult Transplant Recipients Treated With Advagraf® or Prograf®

Heart Transplantation | Lung Transplantation | Pancreas (Including SPK) Transplantation

France, United Kingdom, Taiwan, Belgium, Italy, Austria
Emory University

Completed

Quality of Life in Pediatric Transplant Recipients

Liver Transplantation | Kidney Transplantation | Heart Transplantation | Lung Transplantation | Heart-Lung Transplantation

United States
Northwestern University
GlaxoSmithKline; National Comprehensive Cancer Network; Robert H. Lurie Cancer...

Completed

Temozolomide and Pazopanib Hydrochloride in Treating Patients With Advanced Pancreatic Neuroendocrine Tumors That Cannot Be Removed By Surgery

Recurrent Islet Cell Carcinoma | Pancreatic Alpha Cell Carcinoma | Pancreatic Beta Islet Cell Carcinoma | Pancreatic Delta Cell Carcinoma | Pancreatic G-cell Carcinoma

United States
Novartis

Completed

Conversion Trial From Mycophenolate Mofetil (MMF) to Enteric-coated Mycophenolate Sodium (EC-MPS) in Stable Transplanted Patients Suffering From Gastrointestinal (GI) Adverse Events While on Mycophenolate Mofetil Therapy (MMF) Therapy

Liver Transplantation | Kidney Transplantation

Switzerland
University of Wisconsin, Madison

Terminated

Cytokine Kinetics Test to Assess the Presence or Absence of Tolerance in Organ Transplant

Liver Transplantation | Kidney Transplantation

United States
Nantes University Hospital

Unknown

A Study To Compare Sirolimus Versus Tacrolimus In De Novo Simultaneous Pancreas- Kidney Allograft Recipients Receiving An Induction Therapy With Antithymocyte Globulin Plus Mycophenolate Mofetil Plus Corticosteroids

Kidney Transplantation | Pancreas Transplantation

France
University Hospital, Gasthuisberg
Juvenile Diabetes Research Foundation; Fund for Scientific Research, Flanders...

Unknown

Insulin Secretory Capacity in Insulin-independent Pancreas-Kidney Recipients Compared to Controls

Kidney Transplantation | Pancreas Transplantation

Belgium
National Taiwan University Hospital

Unknown

Sirolimus Blood Concentrations on Conversion From Oral Solution to Tablets

Kidney Transplantation | Immunosuppression | Transplantation

Taiwan
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Treg Cell Therapy in Liver and Kidney Transplantation - Preclinical Validation of Batches of Treg Cells Amplified in Vitro (PRE-TREG)

Liver Transplantation | Kidney Transplantation

France
Emory University

Recruiting

Immune Monitoring and Assay Development in Organ Transplant Recipients (IMP)

Organ Transplantation | Transplantation Immunology

United States
Astellas Pharma China, Inc.

Completed

A Study to Evaluate the Safety and Efficacy of a Modigraf® Based Immunosuppression Regimen in De Novo Pediatric Allograft Liver and Kidney Transplantation Recipients

Liver Transplantation | Kidney Transplantation

China
Astellas Pharma China, Inc.

Completed

A Study of Modigraf® (Tacrolimus Granules) to Evaluate the Pharmacokinetics and Long-term Safety and Efficacy in De Novo Pediatric Allograft Liver and Kidney Transplantation Recipients

Liver Transplantation | Kidney Transplantation

China
University of Nebraska

Completed

Pre-operative Evaluation of Kidney & Pancreas Transplant Patients

Kidney Transplantation | Pancreas Transplantation

United States
Rennes University Hospital

Completed

Impact of P-gp, MRP2, ENT-1 and CNT3 on the Blood Concentration / Intra-PBMC Concentration of Tacrolimus (TRANS-TAC)

Liver Transplantation | Kidney Transplantation

France

Clinical Trials on Islet Transplantation

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