Clinical Trials on Isocitrate Dehydrogenase Gene Mutation
Total 412 results
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Kymera Therapeutics, Inc.SuspendedNon Hodgkin Lymphoma | Diffuse Large B Cell Lymphoma | DLBCL | MYD88 Gene MutationUnited States, United Kingdom
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Nanfang Hospital, Southern Medical UniversityRecruitingAcute Lymphoblastic Leukemia | Philadelphia Chromosome | Adult ALL | Philadelphia-Positive ALL | IKZF1 Gene MutationChina
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Alliance for Clinical Trials in OncologyNational Cancer Institute (NCI); GlaxoSmithKline; Genentech, Inc.; Brain Science...RecruitingIntracranial Meningioma | Recurrent Meningioma | NF2 Gene MutationUnited States
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SwanBio Therapeutics, Inc.Active, not recruitingAMN | AMN Gene Mutation | X-ALDUnited States, Netherlands, Germany
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Lei LiCompletedEpithelial Ovarian Cancer | BRCA1 Mutation | BRCA2 Mutation | Homologous Recombination Deficiency | Prognosis | Chinese | Homologous Recombination GenesChina
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Shirish GadgeelMerck Sharp & Dohme LLCWithdrawnNon Small Cell Lung Cancer | PD-L1 Gene Mutation | Advanced Lung Non-Small Cell Carcinoma
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TriHealth Inc.TriHealth Cancer Institute; TriHealth Surgical Institute; TriHealth Ultrasound... and other collaboratorsWithdrawnMelanoma (Skin) | Tumor Skin | BRAF Gene Mutation | Melanoma Stage IIIb-IVM1a | Metastasis SkinUnited States
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RWJ Barnabas Health at Jersey City Medical CenterUnknownLynch Syndrome | Endometrial Cancer | Somatic Mutation | Cancer Gene MutationUnited States
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Centro di Riferimento Oncologico - AvianoRecruitingNon Small Cell Lung Cancer Metastatic | ALK Gene MutationItaly
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Hunan Province Tumor HospitalRecruitingNon Small Cell Lung Cancer | EGF-R Positive Non-Small Cell Lung Cancer | RET Gene Mutation | MET AmplificationChina
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Fudan UniversityRecruitingDiffuse Large B Cell Lymphoma, Gene MutationChina
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Xiuning LeM.D. Anderson Cancer Center; Eli Lilly and CompanyActive, not recruitingNon Small Cell Lung Cancer | Metastatic Cancer | Advanced Cancer | EGFR Gene MutationUnited States
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Turning Point Therapeutics, Inc.TerminatedNon-Small Cell Lung Cancer | NSCLC | Non Small Cell Lung Cancer | Advanced Solid Tumor | Metastatic Solid Tumor | ALK Gene MutationUnited States, Australia, Korea, Republic of
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Escape Bio, Inc.Momentum Pharma; Science 37TerminatedPatients With Parkinson's Disease (PD) Caused by the p.Gly2019Ser (G2019S) Pathogenic Mutation of the Leucine-Rich Repeat Kinase 2 (LRRK2) GeneUnited States
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The Affiliated Hospital of Xuzhou Medical UniversityRecruitingType 2 Diabetes Mellitus | Genetic Mutations | Gene Polymorphisms | Susceptibility, GeneticChina
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Regeneron PharmaceuticalsNot yet recruitingAmyotrophic Lateral Sclerosis (ALS) | Mutation in the Superoxide Dismutase-1 (SOD1) Gene
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Memorial Sloan Kettering Cancer CenterRecruitingBladder Cancer | Recurrent Bladder Cancer | FGFR3 Gene MutationUnited States
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Hospices Civils de LyonRecruitingFamilial Mediterranean Fever | MEFV Gene MutationFrance
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Heinrich-Heine University, DuesseldorfCelgene Corporation; Koordinierungszentrum für Klinische Studien DüsseldorfActive, not recruitingMyelodysplastic Syndromes | Leukemia, Myeloid, Acute | Chronic Myelomonocytic Leukemia | IDH2 Gene Mutation | IDH2 R172 | IDH2 R140Germany
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Intergroupe Francophone de Cancerologie ThoraciqueCompletedNon Small Cell Lung Cancer Metastatic | HER2 Gene Mutation | Non Small Cell Lung Cancer Stage IIIFrance
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Roswell Park Cancer InstituteCelgeneWithdrawnRecurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | IDH2 Gene Mutation | Blasts Under 5 Percent of Peripheral Blood White Cells | Bone Marrow Blasts Decreased by 50 Percent or More Compared to Pretreatment LevelUnited States
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Intergroupe Francophone de Cancerologie ThoraciqueCompletedNon-small Cell Lung Cancer | Anaplastic Lymphoma Kinase Gene MutationFrance
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Calithera Biosciences, IncTerminatedNon-Small Cell Lung Cancer | Squamous Non-small-cell Lung Cancer | NFE2L2 Gene Mutation | Squamous Non-Small Cell Neoplasm of LungUnited States
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Hellenic Cooperative Oncology GroupCompletedNon Small Cell Lung Cancer | EGF-R Positive Non-Small Cell Lung Cancer | EGFR Gene Mutation
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N.N. Petrov National Medical Research Center of...RecruitingMelanoma | Lung Cancer | Pancreas Cancer | Refractory Cancer | Colorectal Cancer Recurrent | RAS Mutation | Ras (Kras or Nras) Gene MutationRussian Federation
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Kura Oncology, Inc.RecruitingAcute Myeloid Leukemia | Acute Myeloid Leukemia, in Relapse | Myeloid Sarcoma | Acute Myeloid Leukemia Recurrent | Mixed Phenotype Acute Leukemia | Mixed Lineage Acute Leukemia | Refractory AML | NPM1 Mutation | Mixed Lineage Leukemia Gene Mutation | AML With Mutated NPM1 | KMT2ArUnited States
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SWOG Cancer Research NetworkNational Cancer Institute (NCI)Active, not recruitingStage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Lung Non-Small Cell Squamous Carcinoma | Recurrent Lung Non-Small Cell Carcinoma | Deleterious BRCA1 Gene Mutation | Deleterious BRCA2 Gene Mutation | Recurrent Lung Adenocarcinoma | Loss of Heterozygosity | Recurrent... and other conditionsUnited States
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General Oncology, Inc.Myriad Genetics, Inc.RecruitingPancreatic Cancer | Pancreatic Ductal Adenocarcinoma | Pancreatic Cancer Stage IV | Breast Cancer Stage IV | BRCA1 Mutation | BRCA2 Mutation | Pancreatic Acinar Cell Carcinoma | Metastatic Pancreatic Cancer | Breast Cancer Metastatic | HER2-negative Breast Cancer | Metastatic Pancreatic Ductal Adenocarcinoma and other conditionsUnited States
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Daping Hospital and the Research Institute of Surgery...Not yet recruitingNon Small Cell Lung Cancer | Non Small Cell Lung Cancer Stage IIIB | EGFR Gene Mutation | Non-small Cell Lung Cancer Stage IV
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Daping Hospital and the Research Institute of Surgery...Not yet recruitingNon Small Cell Lung Cancer | EGFR Gene Mutation | Non-small Cell Lung Cancer Stage IV | Non Small Cell Lung Cancer Stage IIIA
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National Cancer Institute (NCI)Active, not recruitingKRAS Gene Mutation | Recurrent Lung Non-Small Cell Carcinoma | Stage IV Lung Non-Small Cell Cancer AJCC v7United States
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Enliven TherapeuticsRecruitingHER2-positive Metastatic Breast Cancer | HER2 Gene Mutation | HER2 Mutant Non-small Cell Lung Cancer | HER2 AmplificationSpain, United States, Korea, Republic of, Taiwan, Italy, Australia, France
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI); Genentech, Inc.RecruitingAcute Myeloid Leukemia | Therapy-Related Acute Myeloid Leukemia | Hematologic and Lymphocytic Disorder | Acute Myeloid Leukemia in Remission | FLT3 Gene Mutation | Minimal Residual Disease PersistenceUnited States
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Centre Leon BerardCompletedGastrointestinal Stromal Tumors | Resected Gastrointestinal Stromal Tumors | Non-metastatic | High Risk of Recurrence | KIT Gene MutationFrance
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Betta Pharmaceuticals Co., Ltd.UnknownNon Small Cell Lung Cancer Stage IIIB | EGFR Gene Mutation | Non Small Cell Lung Cancer Stage IIIAChina
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Rutgers, The State University of New JerseyNational Cancer Institute (NCI)TerminatedAcute Lymphoblastic Leukemia | Mantle Cell Lymphoma | Non-Hodgkin Lymphoma | Myelodysplastic Syndrome | Plasma Cell Myeloma | Recurrent Diffuse Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma | Minimal Residual Disease | Therapy-Related Acute Myeloid Leukemia | Therapy-Related Myelodysplastic... and other conditionsUnited States
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University Health Network, TorontoPfizerRecruitingNon-squamous Non-small-cell Lung Cancer | Stage IV Non-small Cell Lung Cancer | ROS1 Gene Rearrangement | MET Activating Mutation | MET AmplificationCanada
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Arcus Biosciences, Inc.Gilead SciencesActive, not recruitingNon Small Cell Lung Cancer | Nonsquamous Nonsmall Cell Neoplasm of Lung | Non Small Cell Lung Cancer Metastatic | Sensitizing EGFR Gene MutationUnited States, Korea, Republic of, Singapore, Taiwan
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Oncoethix GmbHCompletedTriple Negative Breast Cancer | Pancreatic Ductal Adenocarcinoma | Castrate-resistant Prostate Cancer | CRPC | NUT Midline Carcinoma | Non-small Cell Lung Cancer With Rearranged ALK Gene/Fusion Protein or KRAS Mutation
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PfizerCompletedTransthyretin Amyloidosis | Transthyretin Gene MutationsUnited States, France, Spain, Taiwan, Israel, Korea, Republic of, Denmark, Canada, Netherlands, Japan, Sweden, Brazil, Mexico, Argentina, Portugal, Belgium, Bulgaria, Cyprus, Germany, Italy, Malaysia, Romania, Saudi Arabia, Turkey, United...
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Helse Møre og Romsdal HFNot yet recruitingCarpal Tunnel Syndrome | Cardiac Amyloidosis | ATTR Amyloidosis Wild Type | ATTR Gene Mutation
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Ascentage Pharma Group Inc.Merck Sharp & Dohme LLCRecruitingMelanoma | P53 Mutation | Uveal Melanoma | Cutaneous Melanoma | Mucosal Melanoma | Malignant Peripheral Nerve Sheath Tumors | MPNST | Unresectable or Metastatic Melanoma or Advanced Solid Tumors | MDM2 Gene MutationUnited States, Australia
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Tyra Biosciences, IncRecruitingSolid Tumor | Bladder Cancer | Advanced Solid Tumor | Urothelial Carcinoma | Metastatic Urothelial Carcinoma | Solid Tumor, Adult | FGFR3 Gene Mutation | Urinary Tract Cancer | Locally Advanced Urothelial Carcinoma | Advanced Urothelial Carcinoma | Non-muscle-invasive Bladder Cancer | FGFR3 Gene Alteration | Urinary... and other conditionsAustralia, United States, France, Spain
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)Active, not recruitingLung Non-Small Cell Carcinoma | Stage III Lung Cancer AJCC v8 | Stage II Lung Cancer AJCC v8 | Stage IIA Lung Cancer AJCC v8 | Stage IIB Lung Cancer AJCC v8 | Stage IIIA Lung Cancer AJCC v8 | Stage IIIB Lung Cancer AJCC v8 | Stage IIIC Lung Cancer AJCC v8 | EGFR Gene Mutation | Unresectable Lung Non-Small... and other conditionsUnited States
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)Active, not recruitingProgressive Disease | Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Recurrent Endometrial Carcinoma | Endometrial Adenocarcinoma | Primary Peritoneal High Grade Serous Adenocarcinoma | Platinum-Resistant Ovarian Carcinoma | High Grade Ovarian... and other conditionsUnited States
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Columbia UniversityNational Institute on Aging (NIA)RecruitingLumbar Spinal Stenosis | Cardiomyopathy, Hypertrophic | Cardiac Amyloidosis | ATTR Amyloidosis Wild Type | ATTR Gene Mutation | ATTRV122I AmyloidosisUnited States
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Rutgers, The State University of New JerseyNational Institute of Neurological Disorders and Stroke (NINDS); National Institutes...RecruitingParkinson Disease | Cognitive Decline | Parkinson | Genetic Predisposition | GBA Gene MutationUnited States
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Sarah GoldbergMirati Therapeutics Inc.TerminatedLung Diseases | Carcinoma, Non-Small-Cell Lung | Lung Neoplasms | Metastatic Lung Non-Small Cell Carcinoma | PD-L1 Gene Mutation | Pembrolizumab | Stage IV Lung Non-Small Cell Cancer AJCC v7 | Advanced Treatment-Naïve PD-L1 | SitravatinibUnited States
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Royal Marsden NHS Foundation TrustPfizer; Breast Cancer NowActive, not recruitingGastric Cancer | Triple Negative Breast Cancer | Lobular Breast Carcinoma | CDH1 Gene MutationUnited Kingdom
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Stanford UniversityCompletedRecurrent Non-Small Cell Lung Carcinoma | KRAS Gene Mutation | Metastatic Malignant Neoplasm in the Brain | Stage IV Non-Small Cell Lung Cancer AJCC v7United States