Clinical Trials on KRAS G13D

Total 222 results

Zeynep Kamil Maternity and Pediatric Research and...

Enrolling by invitation

Outcomes of Enhanced Recovery After Cesarean (ERAC) Protocol

Cesarean Section Complications | ERAS

Turkey
King Saud Medical City

Active, not recruiting

"Analgesic Efficacy of Combined Transversus Abdominis Plane Block and Posterior Rectus Sheath Block in Patients Undergoing Laparoscopic Appendectomy"

ERAS

Saudi Arabia
University of Thessaly

Recruiting

A Greek-designed ERAS Protocol in Elective Craniotomy (ERAS)

Craniotomy | ERAS

Greece
Turning Point Therapeutics, Inc.

Terminated

A Study of Repotrectinib in Combination With Other Anticancer Therapies for the Treatment of Subjects With KRAS-Mutant Solid Tumors

Advanced Solid Tumor | Metastatic Solid Tumor | KRAS Mutation-Related Tumors

United States
Weibing Tang

Completed

Assessment of Enhanced Recovery After Surgery Implementation at Pediatric Surgery Practices in Mainland China

ERAS

China
Amgen

Recruiting

Sotorasib Activity in Subjects With Advanced Solid Tumors With KRAS p.G12C Mutation (CodeBreak 101)

Advanced Solid Tumors | Kirsten Rat Sarcoma (KRAS) pG12C Mutation

United States, Italy, Taiwan, Spain, United Kingdom, Australia, Austria, Germany, Belgium, Japan, Netherlands, Korea, Republic of, Canada
Neogene Therapeutics, Inc.

Recruiting

A Study of NT-112 in HLA-C*08:02-Positive Adult Subjects With Unresectable, Advanced, and/ or Metastatic Solid Tumors Positive for the KRAS G12D Mutation

Endometrial Cancer | Non-small Cell Lung Cancer | Pancreatic Ductal Adenocarcinoma | Colorectal Carcinoma | Solid Tumor, Adult | KRAS G12D

United States
EPS Corporation

Completed

Achievement of Improved Survival by Molecular Targeted Chemotherapy and Liver Resection for Not Optimally Resectable Colorectal Liver Metastases (ATOM)

Liver Only Metastasis From KRAS Exon 2 Wild Type (Under Protocol 1.0-1.2 Edition) and RAS Wild Type (Under Protocol 2.0 Edition) Colorectal Cancer

Japan
UNICANCER

Completed

I-MVAC +/- Panitumumab as First-line Treatment of Advanced Urothelial Carcinoma Without H-Ras Nor K-Ras Mutations (GETUG-AFU19)

KRAS Gene Mutation | Infiltrating Urothelial Carcinoma

France
Karolinska Institutet
Ersta Hospital, Sweden

Completed

Defunctioning Stoma and Postoperative Morbidity

Loopileostomy | Fast Track Program,(Enhanced Recovery After Surgery (ERAS))

Sweden
Arbeitsgemeinschaft medikamentoese Tumortherapie
Amgen

Terminated

Concurrent Induction Chemoimmunotherapy With Epirubicine, Oxaliplatin, Capecitabine and Panitumumab in KRAs Wild-type, Resectable Type II Gastric Adenocarcinoma

KRAS Wild Type | Resectable Type II Gastric Adenocarcinoma

Austria
Lawson Health Research Institute

Not yet recruiting

Patient Reported Outcomes Targeting Early Chest Tube Removal (PROTECTR) Study (PROTECTR)

Chest Tube Removal | Lung Surgery | ERAS

Canada
Vishnevsky Center of Surgery

Recruiting

The Strategy of Implementation of the ERAS Protocol After Esophageal Surgery

Esophageal Diseases | ERAS

Russian Federation
First Affiliated Hospital of Chongqing Medical...

Enrolling by invitation

Enhanced Recovery After Surgery Exercise Improve Perioperative Frailty (EEIPF)

Frailty | ERAS

China
University Children's Hospital Basel

Completed

Human Intestinal Amino Acid Absorption and the Role of a Local RAS

Renin-Angiotensin Aldosterone System (RAS)

Switzerland
Vanderbilt University Medical Center
Edwards Lifesciences

Completed

Enhanced Recovery After Surgery in Colorectal Surgery: A Large-Scale Quality Improvement Project (ERAS)

Colorectal Surgery | Perioperative Care | Quality Improvement | ERAS

United States
University Hospital, Basel, Switzerland

Completed

RAS-Peptide-Profile Study in Healthy Male Subjects (RAS)

RAS Peptide Profile in Healthy Volunteers

Switzerland
All India Institute of Medical Sciences, Bhubaneswar

Not yet recruiting

Impact of General Anesthesia v/s Spinal Anesthesia on ERAS Parameters in Intestinal Stoma Reversal (SPIGERAS)

Anesthesia | Ileostomy - Stoma | Colostomy Stoma | ERAS | Surgical Stomas

India
Ikena Oncology

Recruiting

Study of IK-595 in RAS- or RAF-altered Advanced Tumors

Colorectal Cancer | Pancreatic Cancer | Thyroid Carcinoma | Solid Tumor, Adult | Malignant Melanoma | Non-Small Cell Lung Carcinoma | BRAF Gene Mutation | Gliomas, Malignant | Ras (Kras or Nras) Gene Mutation | CRAF Gene Mutation

United States
The Second Hospital of Shandong University

Recruiting

Lung Surgery With Enhanced Recovery VS. Lung Surgery Without Enhanced Recovery

Lung Cancer | Surgery | ERAS

China
Jacobio Pharmaceuticals Co., Ltd.

Recruiting

A Study of JAB-21822 in Patients With KRAS p.G12C Mutated Pancreatic Cancer

Pancreatic Cancer | KRAS P.G12C

China
Amgen

Completed

Determination of RAS Mutation Status in Liquid Biopsies in Subjects With RAS Wild-type.PERSEIDA Study (PERSEIDA)

RAS Wild Type mCRC

Spain
University Hospital, Toulouse

Recruiting

Early Standing in Minors Operated on for Idiopathic Scoliosis (LevPOS)

Idiopathic Scoliosis | ERAS

France
University of Utah
Pfizer

Completed

A Trial of mFOLFIRI With MEK162 in Patients With Advanced RAS (HRAS, NRAS, or KRAS) Positive Metastatic Colorectal Cancers

Advanced KRAS Positive Metastatic Colorectal Cancer

United States
Rajavithi Hospital

Completed

Compare Outcome of Enhanced Recovery After Cesarean Surgery and Conventional Care

To Determine Whether ERAS Can Reduce Length of Stay in Pregnant Women After Cesarean Section

Thailand
Affini-T Therapeutics, Inc.

Recruiting

Phase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor

Colorectal Cancer | Non-Small Cell Lung Cancer | Solid Tumor | Pancreatic Ductal Adenocarcinoma | KRAS G12V

United States
Oncolytics Biotech
Montefiore Medical Center

Completed

Study of REOLYSIN® in Combination With FOLFIRI and Bevacizumab in FOLFIRI Naive Patients With KRAS Mutant Metastatic Colorectal Cancer

KRAS Mutant Metastatic Colorectal Cancer

United States
Queen Mary University of London
AstraZeneca; Cancer Research UK

Unknown

A Study of AZD2014 in Combination With Selumetinib in Patients With Advanced Cancers (TORCMEK)

Squamous Cell Lung Cancer | Triple-Negative Breast Cancer | Non-squamous Cell Lung Cancer With KRAS Mutations | Non-squamous Cell Lung Cancer With Wild-type KRAS

United Kingdom
Seoul National University Bundang Hospital

Completed

ERAS After Bariatric Surgery in Morbidly Obese

Obesity | ERAS

Korea, Republic of
Hospital Erasto Gaertner
AstraZeneca

Completed

Frequency of EGFR and KRAS Mutations and Clinical-prognostic Correlation in Brazilian Lung Cancer Patients

Lung Neoplasms | KRAS Gene Mutation | EGFR Gene Mutation

Brazil
The Second Hospital of Shandong University

Recruiting

Minimally Invasive Lung Surgery Under ERAS With Completely Tubeless Protocol Compared With That With Partially Tubeless Protocol

Lung Diseases | Surgery | ERAS

China
Karolinska Institutet

Recruiting

Optimization of Patients' Physical and Mental Status Prior to Colorectal Cancer Surgery (OPT)

Complication,Postoperative | ERAS

Sweden
Göteborg University
Sahlgrenska University Hospital, Sweden

Completed

Effects of Probiotic VSL#3 on Expression of Small Intestinal Renin-angiotensin System

the Local Renin-angiotensin System (RAS) in Small Intestinal Mucosa in Man

Sweden
ETOP IBCSG Partners Foundation
Mirati Therapeutics Inc.

Recruiting

Adagrasib in Patients With KRASG12C-mutant NSCLC Who Are Elderly or Have Poor Performance Status (ADEPPT)

NSCLC Stage IV | KRAS P.G12C

Ireland, Italy, France, Spain, United Kingdom, Belgium
The Netherlands Cancer Institute
Lustgarten Foundation

Recruiting

Combination Therapy of RMC-4630 and LY3214996 in Metastatic KRAS Mutant Cancers (SHERPA)

Colorectal Cancer | Pancreatic Cancer | Non-small Cell Lung Cancer | KRAS Mutation-Related Tumors

Netherlands
Cardiff Oncology

Completed

Onvansertib in Combination With FOLFIRI and Bevacizumab for Second Line Treatment of Metastatic Colorectal Cancer Patients With a Kras Mutation

Metastatic Colorectal Cancer | KRAS Gene Mutation

United States
Cardiff Oncology

No longer available

Expanded Access of Onvansertib With FOLFIRI and Bevacizumab for the Second-Line Treatment of Participants With KRAS-Mutated Metastatic Colorectal Cancer

Metastatic Colorectal Cancer | KRAS Gene Mutation
National and Kapodistrian University of Athens

Recruiting

Immunonutrition in ERAS Protocols in Gynecologic Oncology (NUTRIGO)

Gynecologic Cancer | Nutritional Deficiency | ERAS

Greece
Amgen

Active, not recruiting

Study to Compare AMG 510 "Proposed INN Sotorasib" With Docetaxel in Non Small Cell Lung Cancer (NSCLC) (CodeBreak 200).

KRAS p, G12c Mutated /Advanced Metastatic NSCLC

Finland, United States, Canada, Belgium, Spain, Korea, Republic of, Netherlands, United Kingdom, Australia, Denmark, Hungary, Sweden, Taiwan, Greece, Russian Federation, Switzerland, France, Italy, Japan, Poland, Brazil, Germany, Po...
Nanjing First Hospital, Nanjing Medical University

Completed

Enhanced Recovery After Surgery Protocols in Total Knee Arthroplasty Via Midvastus Approach

Knee Osteoarthritis | ERAS

China
Sanjay Gandhi Postgraduate Institute of Medical...

Recruiting

PaThERAS: ERAS Protocols in Thyroid & Parathyroid Surgery (PaThERAS)

Parathyroid Diseases | Thyroid Diseases | ERAS

India
Universiti Sains Malaysia

Completed

Kelulut Honey as an Alternate Source of Carbo-Loading in Abdominal Surgery Involving the Digestive System (Kel-Load)

Insulin Resistance | ERAS

Malaysia
M.D. Anderson Cancer Center

Not yet recruiting

A Multicenter Phase 1b/2 Study of Adagrasib, Cetuximab, and Cemiplimab for Metastatic Colorectal Cancer Harboring KRAS G12C Mutations

Metastatic Colorectal Cancer | KRAS G12C Mutations

United States
Academic and Community Cancer Research United
National Cancer Institute (NCI)

Active, not recruiting

Regorafenib, With Cetuximab or Panitumumab, for the Treatment of Unresectable, Locally Advanced, or Metastatic Colorectal Cancer

Metastatic Colorectal Adenocarcinoma | Stage IV Colorectal Cancer AJCC v8 | Stage IVA Colorectal Cancer AJCC v8 | Stage IVB Colorectal Cancer AJCC v8 | Stage IVC Colorectal Cancer AJCC v8 | Stage III Colorectal Cancer AJCC v8 | Stage IIIA Colorectal Cancer AJCC v8 | Stage IIIB Colorectal Cancer AJCC... and other conditions

United States
Assistance Publique - Hôpitaux de Paris

Recruiting

Hematological Anomalies in Children With Rasopathy (RAS-HEMATO)

RAS Mutation

France
Shanghai Chest Hospital
Novartis; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; BeiGene

Not yet recruiting

Trametinib Plus Anlotinib Combined With Tislelizumab in KRAS-mutant NSCLC

KRAS Mutation-Related Tumors | Advanced Lung Cancer | Refractory Tumor

China
Alexandria University
University of Alexandria

Recruiting

Lidocaine Infusion With ERAS Protocol for Pancreatic Cancer Surgery: Effect on Pain and Patient Immunity. (ERAS)

Lidocaine | ERAS

Egypt
University of Lausanne Hospitals

Completed

Brief Postoperative Hypnosis Intervention as Multimodal Analgesia After Major Abdominal Surgery (Hypn+ERAS)

Postoperative Pain | Hypnosis | ERAS

Switzerland
David E Gerber
Cancer Prevention Research Institute of Texas; Sagimet Biosciences Inc.

Recruiting

Phase 2 Study of TVB-2640 in KRAS Non-Small Cell Lung Carcinomas

KRAS Gene Mutation

United States
Institut du Cancer de Montpellier - Val d'Aurelle

Completed

Sorafenib in Combination With Irinotecan in Metastatic Colorectal Cancer Patients With KRAS Mutated Tumors (NEXIRI2)

Metastatic Colorectal Cancer Patients With KRAS Mutated Tumors

France

Clinical Trials on KRAS G13D

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