Clinical Trials on Leptin Deficiency in Czechia

Total 87 results

Charles University, Czech Republic

Recruiting

Immune Homeostasis in Sepsis and Septic Shock (IMHOTEP)

Sepsis | Immune Deficiency | Immunologic Paralysis | Immunologic Suppression

Czechia
Thomayer University Hospital
Masaryk University

Recruiting

Czech AATD Registry

Alpha-1-antitrypsin Deficiency

Czechia
Charles University, Czech Republic

Unknown

Fluid Responsiveness in Septic Shock Evaluated by Caval Ultrasound Doppler Examination (FRIEND)

Septic Shock | Vein Collapsibility | Intravascular Doppler | Volume Responsiveness in Septic Shock

Czechia
University Hospital Hradec Kralove
University Hospital Pilsen

Completed

Effect of Fluid Challenge on Glycocalyx

Sepsis | Septic Shock | Surgery | Endothelial Dysfunction | Anesthesia

Czechia
University Hospital Ostrava

Completed

Bioelectrical Impedance in Monitoring Hyperhydration and Polyneuromyopathy in Critically Ill Patients

Septic Shock | Respiratory Insufficiency | Hypoxemia | Chronic Obstructive Pulmonary Disease Exacerbation | Lung Ventilator | Hyperhydration | Respiratory Distress Syndrome, Acute

Czechia
University Hospital Ostrava

Completed

Control of Fever in Septic Patients (COVERSEP)

Sepsis | Septic Shock | Severe Sepsis

Czechia
University Hospital Ostrava

Recruiting

MAnual Lymphatic DrAinage to iMprove the outcomE of Patients After Septic Shock (MADAME)

Sepsis | Septic Shock | Inflammatory Response | Multiorgan Failure

Czechia
Charles University, Czech Republic

Completed

Propafenone Versus Amiodarone in Septic Shock (PRASE)

Septic Shock | Supraventricular Arrhythmia

Czechia
Brno University Hospital

Unknown

Early Identification of Sepsis in Children

Sepsis | Shock, Septic | SIRS | Sepsis, Severe

Czechia
University Hospital Ostrava
University Hospital Olomouc; University of Ostrava; Palacky University; Technical...

Completed

Specific miRNAs in Sepsis and Nephrotoxic Antibiotic Treatment

Sepsis | Septic Shock | Acute Kidney Injury

Czechia
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...
Charles University, Czech Republic

Unknown

Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients (ENTERPRISE)

Sepsis | Critical Illness | Septic Shock | Acid-Base Imbalance | Respiratory Acidosis | Respiratory Alkalosis

Italy, Czechia
Octapharma

Recruiting

Safety and Efficacy of Fibryga in Congenital Fibrinogen Deficiency

Congenital Fibrinogen Deficiency

Germany, Czechia
OPKO Health, Inc.

Completed

MOD-4023 (Long-Lasting Human Growth Hormone (hGH)) Study in Growth Hormone Deficient Adults (GHDA)

Adult Growth Hormone Deficiency

Czechia, Hungary, Israel, Serbia, Slovakia, Slovenia
Faculty Hospital Kralovske Vinohrady

Completed

The Epidemiology, Management and Comorbidities in Alopecia Areata in Czech Republic

Infections | Multiple Sclerosis | Autoimmune Diseases | Diabetes Mellitus, Type 1 | Rheumatoid Arthritis | Vaccine Reaction | Inflammatory Bowel Diseases | Psoriasis | Crohn Disease | Ulcerative Colitis | Down Syndrome | Atopic Dermatitis | Vitiligo | Alopecia Areata | COVID-19 Pandemic | Ankylosing Spondylitis | Lupus Erythematosus and other conditions

Czechia
Applied Therapeutics, Inc.

Active, not recruiting

Pharmacodynamic EffIcacy and Clinical Benefit of AT 007 in Patients With Sorbitol Dehydrogenase (SORD) Deficiency (INSPIRE)

Hereditary Neuropathy Caused by SORD Deficiency

United States, United Kingdom, Czechia, Italy
Glycomine, Inc.

Active, not recruiting

Natural History Study Protocol in PMM2-CDG (CDG-Ia)

Phosphomannomutase 2 Deficiency

United States, Spain, Portugal, Belgium, Czechia, France, Italy, Netherlands, Poland
Anders Perner
Rigshospitalet, Denmark; Scandinavian Critical Care Trials Group; Centre for...

Active, not recruiting

The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial (CLASSIC)

Septic Shock

Sweden, Denmark, Belgium, Czechia, Italy, Norway, Switzerland, United Kingdom
Novartis Pharmaceuticals

Completed

A Two-part Single- and Repeat-dose Study of CSJ137 in Anemic Chronic Hemodialysis Patients

Anemia, Iron-Deficiency

Czechia, Israel, United States, United Kingdom
Octapharma

Completed

Study of Octanorm Subcutaneous IG in Patients With PID

Primary Immune Deficiency Disorder

United States, Canada, Czechia, Hungary, Poland, Russian Federation, Slovakia
Pharvaris Netherlands B.V.

Recruiting

Extension Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema (RAPIDe-2)

Hereditary Angioedema | Hereditary Angioedema Type I | Hereditary Angioedema Type II | Hereditary Angioedema Types I and II | Hereditary Angioedema Attack | Hereditary Angioedema With C1 Esterase Inhibitor Deficiency | Hereditary Angioedema - Type 1 | Hereditary Angioedema - Type 2 | C1 Esterase Inhibitor... and other conditions

United States, Bulgaria, Czechia, Hungary, Spain, France, Germany, Poland, Canada, Israel
Alexion Pharmaceuticals

Completed

Safety, Tolerability and Pharmacokinetics of SBC-102 (Sebelipase Alfa) in Adult Participants With Lysosomal Acid Lipase Deficiency

Lysosomal Acid Lipase Deficiency | Cholesterol Ester Storage Disease(CESD) | LAL-Deficiency

France, United States, United Kingdom, Czechia
Zymenex A/S
European Commission

Completed

The Natural History of Alpha-Mannosidosis (HUE-MAN)

Alpha Mannosidosis

Czechia, Germany, Norway, United Kingdom
Masaryk Hospital Krajská zdravotní a.s.

Completed

Estimation of Coagulation Factor XIII Activity Based on the Initial Plasma Fibrinogen Level in Trauma

Coagulation Disorder | Multiple Trauma | Coagulation Defect; Acquired | Coagulation Factor Deficiency

Czechia
Alexion Pharmaceuticals

Completed

Extension Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of SBC-102 (Sebelipase Alfa) in Adult Subjects With Lysosomal Acid Lipase Deficiency

Lysosomal Acid Lipase Deficiency | LAL-Deficiency | Cholesterol Ester Storage Disease (CESD)

France, United Kingdom, United States, Canada, Czechia
Faes Farma, S.A.

Completed

Efficacy and Safety of Calcifediol vs Placebo in Subjects With Vitamin D Deficiency (WORFEROL)

Vitamin D Deficiency | Vitamin D Insufficiency

Spain, France, Bulgaria, Czechia, Italy, Serbia, Slovakia
Teva Branded Pharmaceutical Products R&D, Inc.

Terminated

Study of TV-1106 in Growth Hormone-Deficient Adults

Growth Hormone Deficiency

United States, Austria, Czechia, Greece, Hungary, Italy, Russian Federation
Novo Nordisk A/S

Completed

A Single Dose Trial in Growth Hormone Deficient Children Investigating Safety, Pharmacokinetics and Pharmacodynamics of Long Acting Growth Hormone

Growth Hormone Disorder | Growth Hormone Deficiency in Children

Israel, Denmark, Belgium, Spain, Macedonia, The Former Yugoslav Republic of, Turkey, United Kingdom, France, Slovenia, Czech Republic
Vifor Pharma
ICON Clinical Research; American Regent, Inc.

Completed

Ferric Carboxymaltose (FCM) Assessment in Subjects With Iron Deficiency Anaemia and Non-dialysis-dependent Chronic Kidney Disease (NDD-CKD) (FIND-CKD)

Chronic Kidney Disease | Iron Deficiency Anaemia

United Kingdom, United States, Australia, Austria, Belgium, Czech Republic, Denmark, France, Germany, Greece, Italy, Netherlands, Norway, Poland, Portugal, Romania, Spain, Sweden, Turkey
BioCryst Pharmaceuticals

Active, not recruiting

Open-label Berotralstat Access to HAE Patients Previously Enrolled in Berotralstat Studies (APeX-A)

Hereditary Angioedema | HAE

France, North Macedonia, Poland, Korea, Republic of, Slovakia, South Africa, Czechia
The Faculty Hospital Na Bulovce

Completed

Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures

Small Bowel Obstruction | Acute Appendicitis | Perforated Gastroduodenal Ulcer

Czech Republic
Novartis Pharmaceuticals

Completed

Study of Efficacy of CDZ173 in Patients With APDS/PASLI

Common Variable Immunodeficiency (CVID), APDS / PASLI

Germany, Russian Federation, Ireland, Italy, United Kingdom, Belarus, Netherlands, Czechia, United States
Teva Branded Pharmaceutical Products R&D, Inc.

Completed

Safety, Tolerability and Efficacy of Weekly TV-1106 in Adults With Growth Hormone Deficiency

Growth Hormone Deficiency

United States, Czechia, Germany, Greece, Hungary, Israel, Serbia, Slovakia, Slovenia
Pfizer

Completed

Cross Over Convenience And Preference Study Of New Mark VII Compared To Genotropin Pen In Pediatric And Adult Subjects (CHOOSE)

Growth Hormone Deficiency

United Kingdom, Czech Republic, Germany, Netherlands, Slovakia, Sweden, Turkey
Alexion

Recruiting

Lysosomal Acid Lipase (LAL) Deficiency Registry (ALX-LALD-501)

Wolman Disease | Cholesterol Ester Storage Disease | Lysosomal Acid Lipase Deficiency | Acid Cholesteryl Ester Hydrolase Deficiency, Type 2 | Acid Lipase Deficiency | LIPA Deficiency | LAL-Deficiency

France, Belgium, United States, Spain, Germany, Greece, Israel, Italy, Slovenia, United Kingdom, Brazil, Canada, Denmark, Australia, Croatia, Czechia, Ireland, Mexico, Netherlands, Poland, Portugal, Saudi Arabia
Pharming Technologies B.V.

Completed

A Phase 2 HAE Prophylaxis Study With Recombinant Human C1 Inhibitor

Hereditary Angioedema

United States, Canada, Czechia, Italy, Macedonia, The Former Yugoslav Republic of, Romania, Serbia
Pharming Technologies B.V.

Recruiting

C1 Inhibitor Registry in the Treatment of Hereditary Angioedema (HAE) Attacks

Hereditary Angioedema

Germany, Bulgaria, Croatia, Czechia, France, Hungary, Italy, North Macedonia, Poland, Slovakia, Norway, Slovenia, Sweden
Pharvaris Netherlands B.V.

Completed

Dose-ranging Study of Oral PHA-022121 for Acute Treatment of Angioedema Attacks in Patients With Hereditary Angioedema (RAPIDe-1)

Hereditary Angioedema | Hereditary Angioedema Type I | Hereditary Angioedema Type II | Hereditary Angioedema Types I and II | Hereditary Angioedema Attack | Hereditary Angioedema With C1 Esterase Inhibitor Deficiency | Hereditary Angioedema - Type 1 | Hereditary Angioedema - Type 2 | C1 Esterase Inhibitor... and other conditions

Bulgaria, United States, Spain, Israel, Germany, Canada, Czechia, France, Hungary, Italy, Netherlands, Poland, United Kingdom
AstraZeneca

Completed

A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab™) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock

Septic Shock | Severe Sepsis

Czech Republic, France, Spain, Finland, Canada, Australia, Belgium
Grifols Therapeutics LLC

Completed

Efficacy, Pharmacokinetics, Safety, and Tolerability of IGSC 20% in Subjects With Primary Immunodeficiency

Primary Immunodeficiency

Spain, France, Germany, United Kingdom, Australia, Czechia, Hungary, Poland, Sweden
Eli Lilly and Company

Completed

Efficacy and Safety of Drotrecogin Alfa (Activated) in Adult Patients With Septic Shock

Sepsis

Italy, United Kingdom, United States, Germany, Spain, Belgium, France, Australia, Czech Republic, Netherlands, Canada, Mexico, New Zealand, Finland, Portugal, Brazil, India, Switzerland
Baxalta now part of Shire
Baxalta Innovations GmbH, now part of Shire

Completed

Post-Authorization Safety, Tolerability and Immunogenicity Evaluation of HyQvia in Pediatric PIDD Subjects

Primary Immunodeficiency Diseases (PID)

Denmark, United Kingdom, Czechia, France, Greece, Hungary, Slovakia, Sweden
CSL Behring

Completed

Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency.

Emphysema | Alpha 1-proteinase Inhibitor Deficiency

Australia, Canada, Czech Republic, Denmark, Estonia, Finland, Germany, Ireland, Poland, Romania, Sweden
Novartis Pharmaceuticals

Recruiting

Study to Evaluate the Efficacy, Safety and Tolerability of MAS825 in Patients With Monogenic IL-18 Driven Autoinflammatory Diseases, Including NLRC4-GOF, XIAP Deficiency, or CDC42 Mutations (MASter-1)

NLRC4-GOF, AIFEC (Autoinflammation With Infantile Enterocolitis), XIAP Deficiency, CDC42 Mutations

Spain, France, United States, Canada, Japan, United Kingdom, Turkey, Czechia, Italy
Pharming Technologies B.V.

Completed

Safety of Ruconest in 2-13 Year Old Hereditary Angioedema (HAE) Patients

Hereditary Angioedema

Israel, Italy, United States, Czechia, Germany, Hungary, Poland, Romania, Slovakia, North Macedonia
Ascendis Pharma A/S

Completed

Safety, PK/PD (Pharmacokinetics/Pharmacodynamics) and Efficacy of ACP-001 Weekly Versus Daily hGH in Children With Growth Hormone Deficiency (GHD)

Growth Hormone Deficiency (GHD)

Egypt, Turkey, Germany, Poland, France, Hungary, Russian Federation, Ukraine, Belarus, Bulgaria, Czech Republic, Greece, Romania, Slovenia
Astria Therapeutics, Inc.

Recruiting

A Study of STAR-0215 in Participants With Hereditary Angioedema

Hereditary Angioedema

United States, United Kingdom, Canada, Germany, Bulgaria, Czechia
Agios Pharmaceuticals, Inc.

Active, not recruiting

A Study to Evaluate the Efficacy and Safety of Mitapivat in Pediatric Participants With Pyruvate Kinase Deficiency (PKD) Who Are Regularly Transfused, Followed by a 5-Year Extension Period (ACTIVATE-KidsT)

Pediatric Pyruvate Kinase Deficiency | Pediatric Hemolytic Anemia

United States, Spain, Denmark, Turkey, Netherlands, Czechia, United Kingdom, Germany, Canada, Switzerland
American Regent, Inc.
Duke Clinical Research Institute

Completed

Randomized Placebo-controlled Trial of FCM as Treatment for Heart Failure With Iron Deficiency (HEART-FID)

Heart Failure | Iron-deficiency

United States, Canada, Australia, Bulgaria, Georgia, New Zealand, Latvia, Hungary, Poland, Czechia, Lithuania, Russian Federation, Ukraine
PedNet Haemophilia Research Foundation
Lund University Hospital

Recruiting

The European Paediatric Network for Haemophilia Management ( PedNet Registry) (PedNet)

Factor IX Deficiency | Factor VIII Deficiency

Norway, Austria, Belgium, Canada, Czechia, Denmark, Finland, France, Germany, Greece, Ireland, Israel, Italy, Netherlands, Portugal, Spain, Sweden, Switzerland, United Kingdom
Takeda

Completed

Efficacy and Safety of Dexlansoprazole MR Compared to Placebo on Maintaining Healing in Subjects With Healed Erosive Esophagitis

Esophagitis, Peptic | Esophagitis, Reflux

United States, Canada, Czech Republic, Lithuania, Slovakia, Latvia, Estonia, Australia

Clinical Trials on Leptin Deficiency in Czechia

Sponsors and Collaborators

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CROs by country

CROs in Albania

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Drug Interventions

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