Clinical Trials on Locally Advanced

Total 6343 results

EnhancedBio USA Inc.
Zenopharm

Recruiting

ER+/HER2- Locally Advanced or Metastatic Breast Cancer (ENZENO Study) (ENZENO)

Metastatic Breast Cancer | Locally Advanced Breast Cancer | HER2-Negative | Estrogen Receptor-Positive

United States, Korea, Republic of
Nykode Therapeutics ASA
Nektar Therapeutics; Vaccibody AS

Completed

A Study to Evaluate Safety and Efficacy of Multiple Dosing With VB10.NEO and Bempegaldesleukin (NKTR-214) Immunotherapy in Patients With Locally Advanced or Metastatic Cancer (DIRECT-01)

Locally Advanced or Metastatic Solid Tumours

Germany
Assistance Publique Hopitaux De Marseille

Unknown

Precarious Elderly Patient Supported For Cancer Impact on Quality Of Life of a Domotic And Remote Assistance Approach for Elderly Patients Supported For Locally Advanced or Metastatic Cancer, Socially Isolated (PREDOMOS)

Elderly | Locally Advanced or Metastatic Cancer

France
Array BioPharma

Terminated

Safety and Efficacy of LEE011 and LGX818 in Patients With BRAF Mutant Melanoma.

Locally Advanced Metastatic BRAF Mutant Melanoma

Australia, Canada, Netherlands, United States
University Medical Center Groningen

Not yet recruiting

Evaluating PD-1/PD-L1 in Locally Advanced Rectal Cancer by Quantitative Fluorescence Molecular Endoscopy (PREDICT)

Locally Advanced Rectal Carcinoma

Netherlands
University of Hull
Hull University Teaching Hospitals NHS Trust

Not yet recruiting

Exercise for Improving Radiotherapy Efficacy in Rectal Cancer

Locally Advanced Rectal Carcinoma
Lin Chen

Recruiting

Tirelizumab Combined With Chemotherapy in the Treatment of HER-2 Negative Locally Advanced Gastric Cancer

Efficacy | Safety | HER2 Negative | Locally Advanced Gastric Carcinoma

China
Wuhan Union Hospital, China
Renmin Hospital of Wuhan University

Recruiting

Short-course Radiotherapy Followed by Fruquintinib Plus Adebrelimab and CAPOX in the Full Course Neoadjuvant Treatment of Locally Advanced Rectal Cancer: a Multicenter, Single-arm, Open-label Study

Locally Advanced Rectal Cancer

China
Beijing Friendship Hospital
Peking Union Medical College Hospital

Not yet recruiting

Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and Thymalfasin for pMMR/MSS Locally Advanced Mid-low Rectal Cancer

Locally Advanced Rectal Cancer

China
Tehran University of Medical Sciences

Not yet recruiting

Comparison of the Clinical Response of Total Neoadjuvant Treatment of Two Methods of Long-term or Short-term Chemoradiotherapy in Rectal Cancer (TEHRAN)

Locally Advanced Rectal Carcinoma
JIN JING

Not yet recruiting

Assess the Efficacy of Radiotherapy and Sequential Chemotherapy and AK104 Before TME Surgery for Local CRC（AK104-IIT-13） (AK104-IIT-13)

Locally Advanced Rectal Cancer
Shenzhen People's Hospital
Sixth Affiliated Hospital, Sun Yat-sen University; The University of Hong Kong-Shenzhen...

Recruiting

Neoadjuvant Cadonilimab Plus Chemotherapy Following Short-Course Radiotherapy in Locally Advanced Rectal Cancer (NeoCaCRT)

Locally Advanced Rectal Carcinoma

China
Sun Yat-sen University
Jiangsu Hengrui Pharmaceutical Co., Ltd.

Not yet recruiting

A Phase Ib/II Clinical Study of Camrelizumab and Apatinib Plus GP in the Treatment of Advanced Biliary Tract Cancer

Metastatic Biliary Tract Cancer | Locally Advanced Biliary Tract Cancer

China
National Cancer Center Hospital East
Japan Agency for Medical Research and Development

Recruiting

Total Neoadjuvant Therapy of SCRT+CAPOX vs SCRT+CAPOXIRI for Locally Advanced Rectal Cancer (ENSEMBLE) (ENSEMBLE)

Locally Advanced Rectal Cancer

Japan
Korean Cancer Study Group

Not yet recruiting

Gut Microbiome and Its Immune Modulation in Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer
Henan Cancer Hospital

Recruiting

Toripalimab Plus FLOT in Locally Advanced Gastric Cancer

Chemotherapy | Immune Checkpoint Inhibitor | Locally Advanced Gastric Carcinoma

China
Yonsei University

Not yet recruiting

Development of a Genome-based Platform for Personalized Treatment in Locally Advanced Rectal Cancer Patients

Locally Advanced Rectal Cancer

Korea, Republic of
Fudan University

Recruiting

Short-course Radiotherapy Based TNT Combined With PD-1 Inhibitor for Locally Advanced Rectal Cancer (TORCH)

Locally Advanced Rectal Cancer

China
Fudan University

Recruiting

Perioperative Versus Postoperative CapOX Chemotherapy for Locally Advanced Colon Cancer

Locally Advanced Colon Cancer

China
Universitätsklinikum Hamburg-Eppendorf
Servier Affaires Médicales; Clinical Trial Center North (CTC North GmbH & Co...

Terminated

Evaluating Trifluridine/Tipiracil Based Chemoradiation in Locally Advanced Rectal Cancer - The Phase I/II TARC Trial

Locally Advanced Rectal Cancer

Germany
National Cancer Institute, Egypt

Completed

Prospective Study of Short Course Radiation Therapy Followed by Neoadjuvant Chemotherapy and Surgery in Locally Advanced Rectal Cancer

Locally Advanced Rectal Carcinoma

Egypt
Pfizer

Completed

A Phase Ib/II Study of LEE011 in Combination With MEK162 in Patients With NRAS Mutant Melanoma

Locally Advanced or Metastatic NRAS Mutant Melanoma

United States, Australia, Germany, Italy, Netherlands
Fudan University

Unknown

A Study of Chinese Herbal Compound Dendrobium Huoshanense Granules in NCRT for Patients With Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer

China
Sichuan Provincial People's Hospital
Xijing Hospital

Unknown

Preoperative Stomach Cancer Induction Chemotherapy and Radiation Therapy (President)

Locally Advanced Gastric Carcinoma

China
Zhu Ji

Unknown

Tumor Response Prediction in Neoadjuvant Chemoradiation of Locally Advanced Rectal Cancer Using Metabonomics Analysis

Locally Advanced Rectal Cancer

China
Maastricht University Medical Center

Completed

Minimal Invasive Strategies for Good and Complete Response to Chemoradiation in Rectal Cancer

Locally Advanced Rectal Cancer

Netherlands
Hoffmann-La Roche

Withdrawn

A Study To Observe Treatment Patterns and Outcomes in Patients With HER2-Positive Unresectable Locally Advanced or Metastatic Breast Cancer

Breast Cancer, HER2 Positive Breast Cancer, Metastatic Breast Cancer, Locally Advanced Breast Cancer
Zhejiang Cancer Hospital

Unknown

Nimotuzumab in Combination With Chemoradiation in Patients With Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer

China
Vejle Hospital
Aarhus University Hospital

Terminated

Predictive Value of 18F-FAZA in Rectum Cancer (FAZA)

Locally Advanced Rectum Cancer

Denmark
Hummingbird Bioscience

Recruiting

Study of an Anti-HER3 Antibody, HMBD-001, With or Without Chemotherapy in Patients With Solid Tumors Harboring an NRG1 Fusion or HER3 Mutation

Pancreatic Cancer | Non-Small Cell Lung Cancer | Metastatic Solid Tumor | Locally Advanced Solid Tumor

Australia
Peking Union Medical College Hospital

Recruiting

The Value of Molecular Residual Disease Monitoring Based on ctDNA in Borderline Resectable or Locally Advanced Pancreatic Cancer (MAP-03)

Pancreatic Cancer | Locally Advanced

China
University of Oxford
Cancer Research UK; Akamis Bio

Completed

Chemoradiation With Enadenotucirev as a Radiosensitiser in Locally Advanced Rectal Cancer (CEDAR)

Locally Advanced Rectal Cancer

United Kingdom
Fundación de investigación HM
Syntax for Science, S.L

Completed

A Study to Evaluate a Chemotherapy Treatment Followed by Chemo and Radiotherapy in Patients With Rectal Cancer

Locally Advanced Rectal Cancer (LARC)

Spain
Jean-Luc Van Laethem
Celgene Corporation

Completed

Effect on Tumor Perfusion of a Chemotherapy Combining Gemcitabine and Nab-paclitaxel (Abraxane) in Pancreatic Cancer (NEOPAX-001)

Pancreatic Adenocarcinoma Resectable | Pancreatic Adenocarcinoma Metastatic | Pancreatic Adenocarcinoma Locally Advanced

Belgium
Chang-Ming Huang, Prof.

Active, not recruiting

Apatinib Combined With SOX Neoadjuvant Therapy for Locally Advanced Gastric Cancer

Neoadjuvant Therapy | SOX | Locally Advanced Gastric Cancer | Apatinib Combined

China
Tongji University
Shanghai Pulmonary Hospital, Shanghai, China

Unknown

Prevention of Locally Advanced NSCLC Radiotherapy Pneumonia by Inhaling Beclomethasone Propionate

Locally Advanced Non Small Cell Lung Cancer

China
AstraZeneca

Completed

Europe-Japan Diagnostic Study for EGFR Testing (ASSESS)

EGFR Mutation Status in aNSCLC Patients (Locally Advanced and/or Metastatic Disease) With Adenocarcinoma and Non-adenocarcinoma Histologies.

Italy, Spain, United Kingdom, Sweden, Japan, Netherlands, Germany, France
Novartis Pharmaceuticals

Completed

A Phase Ib/II Study of BEZ235 and Trastuzumab in Patients With HER2-positive Breast Cancer Who Failed Prior to Trastuzumab

Metastatic Breast Cancer (MBC) | Locally Advance Breast Cancer (LABC)

United Kingdom, Spain
Jinhua Central Hospital

Not yet recruiting

Node-sparing Radiotherapy Combined With Total Neoadjuvant CAPOX and Sintilimab for MSS Middle and Low Rectal Cancer (CASINOs)

Locally Advanced Rectal Cancer

China
The First Affiliated Hospital with Nanjing Medical...

Not yet recruiting

Evaluation of the Efficacy and Safety of Interleucin-2 Combined With PD-1 Monoclonal Antibody and CAPOX in Preoperative Neoadjuvant Therapy for Locally Advanced Rectal Cancer - a Multicenter, Single-arm, Open-label Clinical Trail

Locally Advanced Rectal Adenocarcinoma
Biocon Biologics UK Ltd

Not yet recruiting

Efficacy and Safety of the Proposed Biosimilar Pertuzumab (PERT-IJS) Versus EU-Perjeta® Along With Trastuzumab and Chemotherapy (Carboplatin and Docetaxel) as Neoadjuvant Treatment in Chemotherapy naïve Patients With Early Stage or Locally Advanced HR Negative and HER2 Positive Breast Cancer

HR Negative HER2 Positive Early Breast Cancer or Locally Advanced Breast Cancer Patients
Gustave Roussy, Cancer Campus, Grand Paris

Recruiting

Preoperative Radiotherapy And ASTX660 in Rectum Cancer (PRAAR1)

Locally-advanced Rectal Cancer

France
Vejle Hospital

Recruiting

MRI T1 Relaxation Time in Rectal Cancer

Rectal Cancer | Locally Advanced Rectal Carcinoma

Denmark
Beijing Friendship Hospital

Recruiting

Total Neoadjuvant Therapy Combined With Tislelizumab for Local Advanced of Middle and Low Rectal Cancer

Locally Advanced Rectal Cancer

China
University Hospital, Bordeaux

Recruiting

Endorectal Brachytherapy for Rectal Cancer (ICUREC)

Locally Advanced Rectal Carcinoma

France
Shanghai Changzheng Hospital

Not yet recruiting

Preoperative Pembrolizumab Plus Bevacizumab Combined With Chemotherapy in Patients With pMMR/MSS Locally Advanced Colorectal Cancer (COBP)

Locally Advanced Colorectal Cancer
University of Miami

Recruiting

SMART TNT for the Conservative Management of Locally Advanced Rectal Cancer (SMART TNT)

Locally Advanced Rectal Cancer

United States
EMD Serono Research & Development Institute, Inc.
Merck KGaA, Darmstadt, Germany; Gilead Sciences; Nektar Therapeutics

Recruiting

A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley)

Locally Advanced or Metastatic Urothelial Carcinoma

Korea, Republic of, United States, Taiwan, Australia, United Kingdom, France, Greece, Italy, Belgium, Spain, Canada, Denmark, Germany
Suzhou Suncadia Biopharmaceuticals Co., Ltd.

Recruiting

SHR-1701 in Combination With Chemotherapy and Radiotherapy in Locally Advanced Rectal Cancer

Locally Advanced Rectal Cancer

China
Sun Yat-sen University

Not yet recruiting

Fruquintinib Plus PD-1 Antibody in pMMR / MSS Locally Advanced Rectal Cancer (LARC) With High Immune Score

Locally Advanced Rectal Cancer

China

Clinical Trials on Locally Advanced

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