Clinical Trials on MGMT-unmethylated Glioblastoma (GBM)

Total 101 results

University of Florida
NovoCure Ltd.

Terminated

TTFields and Pulsed Bevacizumab for Recurrent Glioblastoma

Glioblastoma | Glioblastoma Multiforme | Malignant Glioma | GBM

United States
Shayan Moosa, MD

Recruiting

Sonodynamic Therapy in Patients With Recurrent GBM (GBM 001)

Glioblastoma Multiforme | GBM | Recurrent Glioblastoma

United States
Marcelo F. Di Carli, MD, FACC

Completed

FET-PET for Evaluation of Response of Recurrent GBM to Avastin

Glioblastoma Multiforme | GBM

United States
Patrick Wen, MD
Bristol-Myers Squibb

Active, not recruiting

Surgical Nivolumab And Ipilimumab For Recurrent GBM

Glioblastoma | Glioblastoma Multiforme | GBM | Grade IV Astrocytoma

United States
Arno Therapeutics

Unknown

Study of AR-67 in Adult Patients With Recurrence of Glioblastoma Multiforme (GBM) or Gliosarcoma

Glioblastoma Multiforme | Gliosarcoma | GBM

United States, Canada
TransMolecular

Unknown

A Study of 131I-TM601 in Adults With Recurrent Malignant Glioma

Astrocytoma | Glioblastoma Multiforme | Malignant Glioma | GBM | Oligodendroglioma

United States
TransMolecular

Unknown

Safety and Dose-Finding Study of TM-601 in Adults With Recurrent Malignant Glioma

Astrocytoma | Glioblastoma Multiforme | Malignant Glioma | GBM | Oligodendroglioma

United States
Jethro Hu

Active, not recruiting

Ketogenic Diet in Combination With Standard-of-care Radiation and Temozolomide for Patients With Glioblastoma

Glioblastoma | GBM

United States
Dushu Lake Hospital Affiliated to Soochow University

Recruiting

Natural Killer (NK) Cells (XS005) Injection Combined With Stupp Regimen for Adjuvant Chemotherapy in Subjects With Primary Glioblastoma(GBM)

Glioblastoma | GBM

China
Tel Aviv Medical Center

Not yet recruiting

Lenvatinib, Pembrolizumab, and Tumor Treating Fields (TTFields) for Second-line Treatment of Glioblastoma

GBM
Northern Sydney and Central Coast Area Health Service
Merck KGaA, Darmstadt, Germany

Unknown

Temozolomide and Procarbazine With Cilengitide for Patients With Glioblastoma Multiforme Without Methylation of the MGMT Promoter Gene (ExCentric)

Newly Diagnosed Non Methylated Glioblastoma Multiforme Grade 4

Australia
Northwell Health

Recruiting

Repeated Superselective Intraarterial Cerebral Infusion (SIACI) of Bevacizumab With Temozolomide and Radiation Compared to Temozolomide and Radiation Alone in Newly Diagnosed GBM

Glioblastoma | Brain Cancer | Glioblastoma Multiforme | GBM | Glioma, Malignant | Glioblastoma, IDH-wildtype | Glioblastoma Multiforme, Adult

United States
TransMolecular

Unknown

131-I-TM-601 Study in Adults With Recurrent High-Grade Glioma

Glioblastoma Multiforme | Malignant Glioma | Gliosarcoma | GBM | Anaplastic Astrocytoma | Oligo-Astrocytoma

United States
Diffusion Pharmaceuticals Inc

Completed

Safety and Efficacy of Trans Sodium Crocetinate (TSC) With Radiation and Temozolomide in Newly Diagnosed Glioblastoma

Glioma | Glioblastoma | GBM

United States
Samus Therapeutics, Inc.

Terminated

Study of Icapamespib (PU-AD) in Patients With Recurrent Malignant Glioma (Glio)

Recurrent Glioblastoma Multiforme (GBM) | Grade 3 Isocitrate Dehydrogenase (IDH) Wildtype Astrocytoma | Grade 3 or 4 Astrocytoma | Glioblastoma Surgery

United States
Nader Sanai
Eli Lilly and Company; Barrow Neurological Institute; Ivy Brain Tumor Center

Recruiting

LY3214996 Plus Abemaciclib in Recurrent Glioblastoma Patients

Glioma | Glioblastoma | GBM

United States
Nader Sanai
Barrow Neurological Institute; Ivy Brain Tumor Center; QED Therapeutics

Terminated

Infigratinib in Recurrent High-Grade Glioma Patients

Glioma | Glioblastoma | GBM

United States
Icahn School of Medicine at Mount Sinai

Completed

Avelumab With Laser Interstitial Therapy for Recurrent Glioblastoma

Glioblastoma | GBM

United States
St. Joseph's Hospital and Medical Center, Phoenix
Barbara Ann Karmanos Cancer Institute; American Society of Clinical Oncology; Translational Genomics Research Institute and other collaborators

Completed

A Phase 0 Study of AZD1775 in Recurrent GBM Patients

Glioblastoma | GBM

United States
CANbridge Life Sciences Ltd.

Unknown

To Evaluate the Efficacy and Safety of CAN008 Combined With Re-irradiation (rRT) for Treating Patients With Recurrent Glioblastoma (GBM)

GBM
H. Lee Moffitt Cancer Center and Research Institute
Merck Sharp & Dohme LLC

Completed

Pembrolizumab and Vorinostat Combined With Temozolomide for Newly Diagnosed Glioblastoma

Glioblastoma | Brain Tumor | GBM

United States
University of Florida
National Cancer Institute (NCI)

Completed

Vaccine Therapy for the Treatment of Newly Diagnosed Glioblastoma Multiforme (ATTAC-II)

Glioblastoma | Glioblastoma Multiforme | Malignant Glioma | GBM | Astrocytoma, Grade IV

United States
Northwell Health

Recruiting

Surgical Tissue Flap to Bypass the Blood Brain Barrier in Glioblastoma

Glioblastoma | Brain Cancer | Glioblastoma Multiforme | High Grade Glioma | GBM | Glioma, Malignant | Glioblastoma Multiforme, Adult

United States
Northwell Health

Suspended

Laparoscopically Harvested Omental Free Tissue Autograft to Bypass the Blood Brain Barrier (BBB) in Human Recurrent Glioblastoma Multiforme (rGBM)

Glioma | Glioblastoma | Brain Cancer | Glioblastoma Multiforme | GBM | Glioma, Malignant | Glioblastoma Multiforme of Brain

United States
Northwell Health

Recruiting

Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM)

Glioma | Glioblastoma | Brain Cancer | Glioblastoma Multiforme | High Grade Glioma | GBM | Glioma, Malignant | Glioblastoma Multiforme of Brain

United States
Tel-Aviv Sourasky Medical Center

Unknown

The Effect of Escitalopram on Mood, Quality of Life and Cognitive Functioning in Glioblastoma Patients (Cipralex&GBM)

Depression | GBM

Israel
Baylor College of Medicine
The Methodist Hospital Research Institute; Center for Cell and Gene Therapy...

Terminated

Administration of CMV-Specific Cytotoxic T Cells in Patients With Glioblastoma Multiforme (COGLI)

Brain Cancer | Glioblastoma Multiforme | GBM

United States
Abramson Cancer Center at Penn Medicine
National Cancer Institute (NCI); National Institutes of Health (NIH); NovoCure...

Recruiting

WBSI Guided Personalized Delivery of TTFields

GBM | Tumor, Brain | Glioma Glioblastoma Multiforme

United States
Kintara Therapeutics, Inc.
Sun Yat-sen University

Active, not recruiting

Safety Study of VAL-083 and Radiotherapy in Patients With Newly Diagnosed GBM Having Unmethylated MGMT Expression

Glioma | Glioblastoma | Brain Cancer | Glioblastoma Multiforme | GBM

China
Northwell Health

Active, not recruiting

Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM

Glioblastoma | Brain Cancer | Glioblastoma Multiforme | GBM

United States
Istari Oncology, Inc.
National Cancer Institute (NCI); Duke University; Brain Tumor Research Charity...

Completed

PVSRIPO for Recurrent Glioblastoma (GBM) (PVSRIPO)

Glioma | Glioblastoma | Malignant Glioma | GBM

United States
Amsterdam UMC, location VUmc

Recruiting

A Phase II/III Study of High-dose, Intermittent Sunitinib in Patients With Recurrent Glioblastoma Multiforme (STELLAR)

Glioblastoma | Glioblastoma Multiforme | GBM | Glioblastoma, Adult | Recurrent Brain Tumor

Netherlands
Northwell Health

Recruiting

Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM (CAPTEM)

Cancer | Glioblastoma | Brain Cancer | Brain Tumor | Brain Tumor, Primary | Brain Tumor Adult | Glioma of Brain | Glioblastoma, Adult | Glioblastoma Multiforme (GBM)

United States
Kintara Therapeutics, Inc.

Active, not recruiting

Study of VAL-083 in Patients With MGMT Unmethylated, Bevacizumab-naive Glioblastoma in the Adjuvant or Recurrent Setting

Glioma | Glioblastoma | Brain Cancer | Glioblastoma Multiforme | GBM

United States
DelMar Pharmaceuticals, Inc.

Terminated

VAL-083 Phase 3 Study in Temozolomide-Avastin (Bevacizumab) Recurrent GBM (STAR-3)

Glioma | Glioblastoma | Brain Cancer | Glioblastoma Multiforme | GBM

United States
Northwest Biotherapeutics

Active, not recruiting

Study of a Drug [DCVax®-L] to Treat Newly Diagnosed GBM Brain Cancer (GBM)

Glioma | Glioblastoma | Brain Cancer | Brain Tumor | Glioblastoma Multiforme | GBM | Grade IV Astrocytoma

United States, Germany, Canada, United Kingdom
DelMar Pharmaceuticals, Inc.

Completed

Safety Study of VAL-083 in Patients With Recurrent Malignant Glioma

Glioma | Glioblastoma | Brain Cancer | Glioblastoma Multiforme | GBM

United States
National Cancer Institute (NCI)

Completed

GW572016 to Treat Recurrent Malignant Brain Tumors

Glioma | Brain Tumor | Glioblastoma Multiforme | Gliosarcoma | GBM | GS

United States
University Hospital, Basel, Switzerland

Recruiting

Advanced Diffusion MRI to Differentiate Tumor Recurrence From Pseudoprogression in Patients With Glioblastoma and Brain Metastases (AiD-GLIO)

Glioblastoma (GBM)

Switzerland
Patrick Y. Wen, MD
Massachusetts General Hospital; Dana-Farber Cancer Institute; Brigham and Women... and other collaborators

Terminated

Plerixafor (AMD3100) and Bevacizumab for Recurrent High-Grade Glioma

High Grade Glioma: Glioblastoma (GBM) | High Grade Glioma: Gliosarcoma | Anaplastic Astrocytoma (AA) | Anaplastic Oligodendroglioma (AO) | Mixed Anaplastic Oligoastrocytoma (AOA)

United States
Proximagen, LLC

Terminated

Phase 1/2 Study of USL311 +/- Lomustine in Advanced Solid Tumors or Relapsed/Recurrent Glioblastoma Multiforme (GBM)

Solid Tumors (Phase 1) | Relapsed/Recurrent GBM (Phase 2)

United States, Spain
Henry Ford Health System

Recruiting

Adenovirus Mediated Suicide Gene Therapy With Radiotherapy in Progressive Astrocytoma.

Glioma | Glioblastoma | Astrocytoma | Malignant Glioma of Brain | Brain Cancer | Brain Tumor | Glioblastoma Multiforme | GBM | Malignant Astrocytoma

United States
Meyer Children's Hospital

Terminated

Prolonged Exposure to Doxorubicin in Patients With Glioblastoma Multiforme and Diffuse Intrinsic Pontine Glioma

Anaplastic Astrocytoma | DIPG | Gliomatosis Cerebri | Glioblastoma (GBM) | Brainstem Glioma, Pediatric | Diffuse Spinal Glioma | Bilateral Thalamic Glioma | Midline Diffuse Glioma

Italy
Ivy Brain Tumor Center
GlaxoSmithKline

Not yet recruiting

A Study Comparing Niraparib With Temozolomide in Adult Participants With Newly-diagnosed, MGMT Unmethylated Glioblastoma

Glioblastoma | Brain Tumor | GBM | Brain Neoplasms, Adult, Malignant
Northwell Health

Recruiting

Super-selective Intra-arterial Repeated Infusion of Cetuximab for the Treatment of Newly Diagnosed Glioblastoma

Glioblastoma | Brain Cancer | Brain Tumor | GBM | Brain Neoplasm | Brain Neoplasm, Malignant | EGFR Gene Overexpression

United States
Peloton Therapeutics, Inc.

Active, not recruiting

A Trial of Belzutifan (PT2977, MK-6482) Tablets In Patients With Advanced Solid Tumors (MK-6482-001)

Kidney Cancer | Clear Cell Renal Cell Carcinoma | Glioblastoma | Solid Tumor | Glioblastoma Multiforme | Advanced Solid Tumors | GBM | Solid Tumor, Adult | Solid Carcinoma | Glioblastoma, Adult | ccRCC | RCC, Clear Cell Adenocarcinoma | RCC | Renal Cell Carcinoma, Metastatic | Renal Cell Carcinoma Recurrent | Renal Cell...
Sapience Therapeutics

Recruiting

A Phase 1-2 Study of ST101 in Patients With Advanced Solid Tumors

Breast Cancer | Glioblastoma | Prostate Cancer | Brain Cancer | Glioblastoma Multiforme | GBM | Metastatic Breast Cancer | Recurrent Glioblastoma | Metastatic Melanoma | Metastatic Prostate Cancer | Prostate Cancer Metastatic | Newly Diagnosed Glioblastoma | Melanoma Stage IV | Melanoma Recurrent

United States, United Kingdom
Novartis Pharmaceuticals

Terminated

Safety and Efficacy of INC280 and Buparlisib (BKM120) in Patients With Recurrent Glioblastoma

c-MET Inhibitor; PI3K Inhibitor, PTEN Mutations, Homozygous Del. of PTEN or PTEN Neg. by IHC, c-Met Ampli. by FISH, INC280, BKM120, Buparlisib; Recurrent GBM

Spain, Switzerland, Germany, United States, Netherlands
University of Texas Southwestern Medical Center

Active, not recruiting

Abemaciclib w/Bevacizumab in Recurrent GBM Pts w/Loss of CDKN2A/B or Gain or Amplification of CDK4/6

Glioblastoma | Brain Tumor | GBM | Brain Tumor, Recurrent

United States
Tocagen Inc.

Terminated

A Study of Toca 511, a Retroviral Replicating Vector, Combined With Toca FC in Patients With Solid Tumors or Lymphoma (Toca 6)

Melanoma | Sarcoma | Lymphoma | Head and Neck Cancer | Colorectal Cancer | Pancreatic Cancer | Ovarian Cancer | Non-Small Cell Lung Cancer | Bladder Cancer | Triple Negative Breast Cancer | IDH1 Mutated Solid Tumors | IDH1 Mutated or MGMT Methylated Recurrent HGG (Not Recruiting)

United States

Clinical Trials on MGMT-unmethylated Glioblastoma (GBM)

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Canada

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations