Clinical Trials on Malaria

Total 1327 results

National Institute of Allergy and Infectious Diseases...

Completed

CQSP in Malawi: Chloroquine and Sulfadoxine-pyrimethamine Efficacy for the Treatment of Malaria in Malawi

Malaria | Plasmodium Falciparum Malaria

Malawi
London School of Hygiene and Tropical Medicine
HealthNet TPO

Completed

Trial of Artesunate Combination Therapy in Pakistan

Uncomplicated Falciparum Malaria

Pakistan
Menzies School of Health Research
National Health and Medical Research Council, Australia; Wellcome Trust

Suspended

Safety and Preliminary Efficacy of L-arginine in Severe Falciparum Malaria (ARGISM)

Severe Falciparum Malaria

Indonesia
Institut de Recherche en Sciences de la Sante,...
European and Developing Countries Clinical Trials Partnership (EDCTP)

Completed

Additional Screening With Sensitives RDTs and Malaria (ASSERMalaria)

Plasmodium Falciparum Malaria | Malaria Diagnosis

Burkina Faso
Institute of Tropical Medicine, Belgium

Terminated

Comparative Evaluation of the Safety and the Efficacy of 2 Antimalarials Depending on HIV Status

Plasmodium Falciparum Malaria

Zambia
University of Oxford
European and Developing Countries Clinical Trials Partnership (EDCTP); Medical...

Recruiting

A Study to Assess the Experimental Malaria Vaccines RH5.2-VLP and R21

Malaria, Plasmodium Falciparum

Gambia
University of Oxford
World Health Organization

Completed

SPK Study in Afghanistan

Uncomplicated P. Falciparum Malaria

Afghanistan
Novartis Pharmaceuticals
Medicines for Malaria Venture

Completed

Efficacy, Safety and Pharmacokinetics of Artemether-lumefantrine Dispersible Tablet in the Treatment of Malaria in Infants < 5 kg

Acute Uncomplicated Falciparum Malaria

Burkina Faso, Benin, Congo, Nigeria, Togo
Oswaldo Cruz Foundation
University of Sao Paulo; Ministry of Health, Brazil; Pan American Health Organization

Completed

Effectiveness of the Association Artesunate and Mefloquine in the Treatment of Malaria by Plasmodium Falciparum

Falciparum Malaria

Brazil
Pfizer

Completed

Trial of Azithromycin Plus Chloroquine Versus Sulfadoxine-Pyrimethamine Plus Chloroquine for the Treatment of Uncomplicated Malaria in India

PLASMODIUM FALCIPARUM MALARIA

India
Ifakara Health Institute
University of Oxford

Not yet recruiting

In-vivo Transmission Model in Semi-immune Adults

Controlled Human Malaria Infection | Malaria Transmission | Induced Blood Stage Malaria Infection | Malaria Challenge

Tanzania
Mahidol University

Unknown

Comparison of Two Antimalarial Drugs Regimens in Patient With Plasmodium Vivax Malaria in Thailand

Acute Uncomplicated Malaria With P.Vivax Infection

Thailand
Muhimbili University of Health and Allied Sciences
Uppsala University; The Swedish Research Council

Not yet recruiting

Triple Artemisinin-based Combination Therapy for Delaying Drug Resistance Development - a Randomized Clinical Trial (3ACT)

Uncomplicated Plasmodium Falciparum Malaria

Tanzania
Novartis Pharmaceuticals
European and Developing Countries Clinical Trials Partnership (EDCTP)

Recruiting

Efficacy, Safety and Tolerability of KAF156 in Combination With Lumefantrine Solid Dispersion Formulation (LUM-SDF) in Pediatric Population With Uncomplicated Plasmodium Falciparum Malaria (KALUMI)

Uncomplicated Plasmodium Falciparum Malaria

Burkina Faso, Mali, Gabon
Armed Forces Research Institute of Medical Sciences...
National Center for Parasitology, Entomology, and Malaria Control (CNM); Naval...

Recruiting

Drug Combinations of Atovaquone-Proguanil (AP) With ACT (APACT)

Plasmodium Falciparum Malaria (Drug Resistant)

Cambodia
Menzies School of Health Research
Tribhuvan University, Nepal

Active, not recruiting

Short Course Radical Cure of P. Vivax Malaria in Nepal

Malaria | Malaria, Vivax | Malaria,Falciparum

Nepal
University Research Co, LLC
Duke University; United States Agency for International Development (USAID); Centers... and other collaborators

Unknown

Evaluation of the Performance of a hsRDT Versus cRDT in Reactive Case Detection of Malaria Infections

Malaria,Falciparum | Malaria Diagnosis

Myanmar
Menzies School of Health Research
Ministry of Health, Malaysia

Unknown

Artemether-lumefantrine vs Chloroquine for Uncomplicated P. Vivax Malaria in Malaysia (PRIMAL)

Plasmodium Vivax Malaria Without Complication

Malaysia
David Saunders
National Centre for Parasitology, Entomology and Malaria Control, Cambodia; Royal Cambodian Armed Forces and other collaborators

Suspended

Antimalarial Drug Resistance With Assessment of Transmission Blocking Activity

Uncomplicated Plasmodium Falciparum Malaria

Cambodia
University of Oxford

Not yet recruiting

A Study to Find Out if a Combination of 3 Medicines for the Treatment of Malaria Works as Well and is as Safe and Tolerable as Combinations of 2 Medicines (FD-TACT)

Uncomplicated Plasmodium Falciparum Malaria
Ministry of Public Health, Democratic Republic...
Centers for Disease Control and Prevention; Global Fund

Active, not recruiting

Test Efficacy Study on the Recommended Antimalarial Drugs in the Democratic Republic of the Congo (TES2022)

Uncomplicated Plasmodium Falciparum Malaria

Congo, The Democratic Republic of the
Medicines for Malaria Venture
Shin Poong Pharmaceuticals; Institute of Tropical Medicine, University of Tuebingen

Completed

Pyronaridine and Artesunate (3:1) in Children With Acute Uncomplicated Plasmodium Falciparum Malaria

Uncomplicated Plasmodium Falciparum Malaria

Gabon
Department of Medical Research, Lower Myanmar
Kangwon National University

Completed

Molecular Surveillance of Artemisinin Resistance Malaria in Myanmar

Plasmodium Falciparum Malaria | Drug Resistance

Myanmar
Centers for Disease Control and Prevention
Ministry of Health, Liberia

Completed

Efficacy of Artesunate-amodiaquine and Artemether-lumefantrine for Treatment of Plasmodium Falciparum Malaria in Liberia

Malaria | Plasmodium Falciparum | Uncomplicated Malaria

Liberia
Research Institute for Tropical Medicine, Philippines
World Health Organization

Completed

TES of Artemether-lumefantrine for Pf in the Philippines in 2017-2018 (TES)

Malaria,Falciparum | Malaria Recrudescence
Novartis Pharmaceuticals
Medicines for Malaria Venture

Completed

Efficacy and Safety of KAF156 in Combination With LUM-SDF in Adults and Children With Uncomplicated Plasmodium Falciparum Malaria

Acute Uncomplicated Plasmodium Falciparum Malaria

Thailand, Gabon, Mali, Uganda, Burkina Faso, India, Kenya, Mozambique, Vietnam
Novartis
World Health Organization; Avenue Appia 20; CH - 1211 Geneva 27; Switzerland

Completed

Evaluation of Safety and Efficacy of Artemether-Lumefantrine Tablets in African Infants and Children With Uncomplicated P. Falciparum Malaria

Plasmodium Falciparum Malaria

Kenya, Nigeria, Tanzania
University of Oxford

Completed

Mass Screening and Treatment for Reduction of Falciparum Malaria (MSAT)

Plasmodium Falciparum Malaria

Thailand
Nurex S.r.l.
Purdue University; Università degli Studi di Sassari; Vinmec Healthcare System

Unknown

Triple Antimalarial Combination to Accelerate the Parasite Clearance and to Prevent the Selection of Resistant Parasites (Artesynib)

Plasmodium Falciparum Malaria (Drug Resistant)

Vietnam
Centre Muraz
Institute of Tropical Medicine, Belgium

Completed

Artemether-lumefantrine (AL) Versus Artesunate + Amodiaquine (ASAQ) for the Treatment of Uncomplicated Falciparum Malaria in Burkina Faso (ACTE)

Uncomplicated P. Falciparum Malaria in Children

Burkina Faso
Shanghai Wanxing Bio-Pharmaceutical Co. Ltd.
PATH; World Health Organization; Xinhua Hospital, Shanghai Jiao Tong University... and other collaborators

Completed

A Study of Safety and Immunogenicity of a Malaria Vaccine Candidate

Prophylaxis Against Plasmodium Falciparum Malaria

China
Proto Pharma Ltd

Completed

Superiority of ArTiMist Versus Quinine in Children With Severe Malaria

Plasmodium Falciparum Malaria

Burkina Faso, Ghana, Rwanda
Jomaa Pharma GmbH
Centre de Recherche Médicale de Lambaréné

Unknown

Evaluation of Fosmidomycin and Piperaquine in the Treatment of Acute Falciparum Malaria (FOSPIP)

Oral Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria
Menzies School of Health Research
Aga Khan University; University of Melbourne; Universitas Sumatera Utara; Ethiopian... and other collaborators

Recruiting

Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine (EFFORT)

Vivax Malaria | Malaria, Vivax | Plasmodium Vivax | Malaria Relapse

Cambodia, Ethiopia, Indonesia, Pakistan
University of Oxford
Mahidol Oxford Tropical Medicine Research Unit

Recruiting

A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combina-tions of 2 Anti-malarial Drugs. (DeTACT-Africa)

Plasmodium Falciparum Malaria (Uncomplicated)

Burkina Faso, Congo, The Democratic Republic of the, Gambia, Guinea, Nigeria, Niger, Rwanda, Tanzania
University of Oxford
Mahidol Oxford Tropical Medicine Research Unit

Completed

A Trial to Compare the Efficacy, Safety and Tolerability of Combinations of 3 Anti-malarial Drugs Against Combinations of 2 Anti-malarial Drugs (Asia) (DeTACT-ASIA)

Plasmodium Falciparum Malaria (Uncomplicated)

Cambodia, Bangladesh
Research Institute for Tropical Medicine, Philippines
World Health Organization

Completed

TES of Artemether-lumefantrine for Pf in the Philippines in 2015 (TES)

Malaria,Falciparum | Malaria Recrudescence
GlaxoSmithKline
Medicines for Malaria Venture

Recruiting

A Study to Investigate the Safety of GSK4024484 in Healthy Adult Participants

Malaria, Falciparum

United Kingdom
Menzies School of Health Research
University of Melbourne; Curtin University; Addis Ababa University; Fundação de... and other collaborators

Not yet recruiting

A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malaria (TADORE)

Vivax Malaria

Brazil, Ethiopia, Indonesia, Papua New Guinea
University of Oxford

Recruiting

A Phase Ia Clinical Trial to Assess the Safety and Immunogenicity of the Blood-stage Malaria Candidate Vaccines RH5.1 in Matrix-M and R78C in Matrix-M in Healthy UK Adults

Malaria, Falciparum

United Kingdom
PATH
Centers for Disease Control and Prevention; Ministry of Health, Zambia

Recruiting

Proactive Community Case Management for Malaria in Zambia (ProACT)

Malaria | Malaria, Falciparum

Zambia
University of Oxford
European and Developing Countries Clinical Trials Partnership (EDCTP); Kenya...

Recruiting

A Study to Determine if New Types of Malaria Vaccines Are Safe, Effective and Lead to Immunity in Kenyan Adults

Malaria,Falciparum

Kenya
University of Oxford
European and Developing Countries Clinical Trials Partnership (EDCTP); Kenya...

Completed

A Study to Determine if a New Malaria Vaccine is Safe and Induces Immunity Among Kenyan Adults, Young Children and Infants

Malaria,Falciparum

Kenya
University of Oxford
European and Developing Countries Clinical Trials Partnership (EDCTP); Ifakara...

Active, not recruiting

Safety and Immunogenicity of RH5.1/Matrix-M in Adults and Infants Living in Tanzania

Malaria,Falciparum

Tanzania
University Clinical Research Center, Mali
Johns Hopkins University; University of South Florida; University of Copenhagen; Tulane University and other collaborators

Active, not recruiting

Seasonal Malaria Chemoprevention With Dihydroartemisin Piperaquin vs. Sulfadoxine-pyrimethamin+Amodiaquin

Malaria,Falciparum

Mali
London School of Hygiene and Tropical Medicine

Completed

Gametocytocidal and Transmission-blocking Efficacy of PQ in Combination With AL and TQ in Combination With SPAQ in Mali (NECTAR3)

Malaria,Falciparum

Mali
Medicines for Malaria Venture
Jimma University; University of Gondar

Terminated

MMV390048 POC in Patients With P. Vivax and P. Falciparum Malaria

Malaria

Ethiopia
U.S. Army Medical Research and Development Command
United States Agency for International Development (USAID); IDRI

Completed

Trial of a Falciparum Malaria Protein (FMP012), E. Coli-expressed PfCelTOS, in Healthy Malaria-Naive Adults

Malaria

United States
Duke University
National Heart, Lung, and Blood Institute (NHLBI)

Withdrawn

Nitrite Infusion in Children With Malaria

Falciparum Malaria

Tanzania
London School of Hygiene and Tropical Medicine
Radboud University Medical Center; Malaria Research and Training Center, Bamako...

Completed

Pyronaridine-artesunate With Low Dose Primaquine for Preventing P. Falciparum Transmission (NECTAR1)

Malaria,Falciparum

Netherlands, Mali

Clinical Trials on Malaria

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