Clinical Trials on Medically Resistant Seizures

Total 6956 results

Prelude Therapeutics

Completed

A Study of PRT2527 in Participants With Advanced Solid Tumors

Sarcoma | Non-small Cell Lung Cancer | Castrate Resistant Prostate Cancer | Solid Tumors With Known MYC Amplification | Hormone Receptor Positive HER2 Negative Breast Cancer

United States
Ascentage Pharma Group Inc.

Recruiting

Study of Safety, Pharmacokinetic and Efficacy of APG-5918 in Advanced Solid Tumors or Lymphomas

Sarcoma | Nasopharyngeal Carcinoma | Gastric Cancer | B Cell Lymphoma | Mesothelioma | Non Hodgkin Lymphoma | Ovarian Clear Cell Carcinoma | Epithelioid Sarcoma | Castrate Resistant Prostate Cancer

United States
Genelux Corporation
GOG Foundation

Recruiting

Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Platinum-doublet + Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (OnPrime, GOG-3076)

Fallopian Tube Cancer | Platinum-resistant Ovarian Cancer | Platinum-refractory Ovarian Cancer | Primary Peritoneal Cancer | High-grade Serous Ovarian Cancer | Endometrioid Ovarian Cancer | Ovarian Clear Cell Carcinoma

United States
VelosBio Inc.

Completed

A Study of Zilovertamab Vedotin (MK-2140) (VLS-101) in Participants With Solid Tumors (MK-2140-002)

Gastric Cancer | Pancreatic Cancer | NSCLC | Platinum-resistant Ovarian Cancer | Triple-negative Breast Cancer | ER-positive Breast Cancer | HER2-negative Breast Cancer | Non-squamous Non-small-cell Lung Cancer | Estrogen-receptor-positive Breast Cancer | Progesterone-receptor-positive Breast Cancer | Estrogen-receptor-negative... and other conditions

United States, Canada
Semmelweis University

Recruiting

Polycystic Ovary Syndrome, Mitochondrial Dysfunction, Obesity, Insulin Resistance Infertility (POMODORI) Cohort (POMODORI)

Obesity | Polycystic Ovary Syndrome | Insulin Resistance | Primary Ovarian Insufficiency | Infertility, Female | Mitochondrial Alteration

Hungary
Lei Li

Recruiting

HRD and Resistance to PAPPi in EOC Patients

Epithelial Ovarian Cancer | Homologous Recombination Deficiency | Homologous Recombination Repair Gene Mutation | Drug Resistance | Overall Survival | Progression-free Survival | Poly(ADP-ribose) Polymerase Inhibitor

China
University of California, Davis
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Vanderbilt...

Recruiting

Sodium Bicarbonate and Mitochondrial Energetics in Persons With CKD (Senergy-CKD)

Diabetes | Fatigue | Chronic Kidney Diseases | Insulin Resistance | Metabolic Acidosis | Physical Endurance | Mitochondrial Energetics

United States
Columbia University

Active, not recruiting

NAFLD in Adolescents and Young Adults With PCOS

Polycystic Ovary Syndrome | Metabolic Syndrome | Non-Alcoholic Fatty Liver Disease

United States
Washington University School of Medicine

Completed

Effect of Diet-induced Weight Loss on HIV-associated Metabolic Syndrome

HIV Infections | Metabolic Syndrome | HIV (Human Immunodeficiency Virus)

United States
Washington University School of Medicine
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Recruiting

Brain Health in Youth With Normal Weight, Overweight and Obesity at Risk for Type 2 Diabetes (T2D) (Metabrain)

Inflammation | Insulin Resistance | Type 2 Diabetes Mellitus in Obese | Obesity, Childhood | Type2 Diabetes | Cognitive Decline | Dysglycemia | Overweight, Childhood | Brain Structure | Microvascular Complications | Diabetes in Adolescence

United States
German Diabetes Center

Recruiting

Metabolic Phenotyping and Follow-Up of Patients With and Without Diabetes After New Onset of STEMI (DISTEMI)

Diabetes Mellitus | Insulin Resistance | Non-Alcoholic Fatty Liver Disease | ST-segment Elevation Myocardial Infarction (STEMI)

Germany
University of Nebraska

Active, not recruiting

Healthy Bones, Healthy Life: Habitual Physical Activity on Bone & Metabolic Health in Pediatric Cancer Survivors (HBHL)

Lymphoma | Leukemia | Metabolic Syndrome | Osteoporosis | Bone Loss | Pediatric ALL | Acute Lymphoblastic Leukemia, Pediatric | Osteoporosis Risk | Pediatric | Lymphoid Leukemia | Pediatric Lymphoma | Habitual Physical Activity | Precursor Cell Lymphoblastic Leukemia

United States
Kaohsiung Medical University Chung-Ho Memorial...

Completed

The Sero-Prevalence and Genetic Study for the Infectious Diseases and Metabolic Syndrome in Solomon Islands

Hypertension | Malaria | Alphavirus Infections | Parasitic Disease | Leptospirosis | Flavivirus Infection | Metabolic Syndromes

Taiwan
University of Washington
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Central Obesity and Disease Risk in Japanese Americans

Heart Diseases | Cardiovascular Diseases | Hypertension | Obesity | Diabetes Mellitus | Atherosclerosis | Insulin Resistance | Hyperinsulinism | Coronary Arteriosclerosis | Metabolic Syndrome X | Diabetes Mellitus, Non-insulin Dependent
Poznan University of Medical Sciences

Completed

Salusin-alpha - a New Factor in the Pathogenesis of Lipid Abnormalities in Hemodialysis Patients

Metabolic Syndrome | Diabetes Mellitus Type 2 | Hyperlipidemia | Renal Failure Chronic Requiring Hemodialysis

Poland
George Washington University

Not yet recruiting

Plant-based Diet for Kidney Transplant Recipients

Inflammation | Hypertension | Diabetes Mellitus | Metabolic Syndrome | Dietary Habits | Kidney Disease, Chronic | Kidney Transplant Failure | Transplant Complication
Taipei Veterans General Hospital, Taiwan

Enrolling by invitation

Breathing-based Leg Resistance Exercise Improves Wound Healing, Blood Sugar and Quality of Life for Diabetic Foot Ulcers

Hyperglycemia | Quality of Life | Diabetic Foot | Wound Healing | Resistance Exercise
Sun Yat-sen University
Shenzhen Nanshan Center for Chronic Disease Control

Recruiting

Nanshan Elderly Cohort Study (NECS)

Cardiovascular Diseases | Stroke | Hypertension | Obesity | Cancer | Type 2 Diabetes Mellitus | Death | Metabolic Syndrome | Chronic Kidney Disease | Sarcopenia

China
Chinese University of Hong Kong

Recruiting

Incidence of HANA Conditions in HIV-infected Individuals

Metabolic Syndrome | Vitamin D Deficiency | Renal Impairment | HIV | Osteoporosis | Osteopenia | Liver Fibroses

Hong Kong
University of Virginia
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Go Girls! Fitness Support Group Intervention Effectiveness Study (CBS002)

Polycystic Ovary Syndrome | Type 2 Diabetes Mellitus | Insulin Resistance | Abnormal Weight Gain | Excess Weight | Premature Adrenarche

United States
Sumitomo Pharma America, Inc.

Terminated

A Study of DSP-7888 Dosing Emulsion in Combination With Immune Checkpoint Inhibitors in Adult Patients With Advanced Solid Tumors

Fallopian Tube Cancer | Primary Peritoneal Cancer | Urothelial Carcinoma | Renal Cell Carcinoma (RCC) | Platinum-resistant Ovarian Cancer (PROC) | Serous Epithelial Ovarian Cancer

United States, Canada
National Cancer Institute (NCI)
NRG Oncology

Active, not recruiting

Comparison of Standard of Care Treatment With a Triplet Combination of Targeted Immunotherapeutic Agents

Ovarian Seromucinous Carcinoma | Recurrent Ovarian High Grade Serous Adenocarcinoma | Recurrent Platinum-Resistant Ovarian Carcinoma | Fallopian Tube Mucinous Adenocarcinoma | Recurrent Fallopian Tube Clear Cell Adenocarcinoma | Recurrent Fallopian Tube Endometrioid Adenocarcinoma | Recurrent... and other conditions

United States, Puerto Rico
Fondazione Policlinico Universitario Agostino Gemelli...

Recruiting

PROtocol of Metabolic and Cryptogenic livEr Disease regisTry for intEgration of Omic Studies (PROMETEO)

Obesity | Diabetes | Fatty Liver | Metabolic Syndrome | Cirrhosis | NASH - Nonalcoholic Steatohepatitis | Liver Cancer | NAFLD - Nonalcoholic Fatty Liver Disease | HCC - Hepatocellular Carcinoma

Italy
Temple University
The Comprehensive NeuroAIDS Center (CNAC) at Temple University

Terminated

Liraglutide for HIV-associated Neurocognitive Disorder

HIV Infection | Obesity | Overweight | Metabolic Syndrome | Diabetes Mellitus Type 2

United States
National Cancer Institute (NCI)
NRG Oncology

Recruiting

Testing Different Amounts of the Combination of Drugs M1774 and ZEN-3694 for the Treatment of Recurrent Ovarian and Endometrial Cancer

Ovarian Endometrioid Adenocarcinoma | Endometrial Carcinoma | Endometrial Clear Cell Adenocarcinoma | Endometrial Endometrioid Adenocarcinoma | Ovarian Clear Cell Adenocarcinoma | Ovarian High Grade Serous Adenocarcinoma | Platinum-Resistant Ovarian Carcinoma | Endometrial Low Grade Endometrioid... and other conditions

United States
National Cancer Institute (NCI)

Active, not recruiting

Randomized Trial of Topotecan With M6620, an ATR Kinase Inhibitor, in Small Cell Lung Cancers and Small Cell Cancers Outside of the Lungs

Extensive Stage Lung Small Cell Carcinoma | Limited Stage Lung Small Cell Carcinoma | Platinum-Resistant Lung Small Cell Carcinoma | Platinum-Sensitive Lung Small Cell Carcinoma | Bladder Small Cell Neuroendocrine Carcinoma | Extrapulmonary Small Cell Neuroendocrine Carcinoma | Recurrent Lung... and other conditions

United States
University of Aarhus
Danish Cardiovascular Academy (DCA); Danish Diabetes Academy; Sygesikringen Danmark and other collaborators

Recruiting

Polyamine Treatment in Elderly Patients With Coronary Artery Disease (PolyCAD)

Myocardial Infarction | Cardiovascular Diseases | Quality of Life | Inflammation | Hypertension | Obesity | Diabetes Mellitus, Type 2 | Cognitive Impairment | Metabolic Syndrome | Ischemic Heart Disease | Dietary Habits | Diastolic Dysfunction | Cognition Disorder | Hypertensive Heart Disease

Denmark
Pacific Coast Family Medical Group

Enrolling by invitation

Disease Prevention in Clinical Practice Base on Patient Specific Physiology (STOPDISEASE)

Cancer | Atherosclerosis | Atrial Fibrillation | Insulin Resistance | Dementia | PreDiabetes | Type2 Diabetes | NASH - Nonalcoholic Steatohepatitis | Diastolic Dysfunction | Carotid Plaque
Institut de Recerca Biomèdica de Lleida
Diputació de Lleida; Jaume Arnó Renal Foundation; Unit of Detection and Treatment... and other collaborators

Active, not recruiting

The ILERVAS Project: Assessing the Prevalence of Subclinical Vascular Disease and Hidden Kidney Disease (ILERVAS)

Chronic Kidney Diseases | Atherosclerosis | Metabolic Syndrome | PreDiabetes | Subclinical Disease and/or Syndrome

Spain
Stanford University

Completed

Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar or Schizophrenia Illness

Obesity | Schizophrenia | Metabolic Syndrome | Bipolar Disorder | Weight Gain | Ketogenic Dieting | Psychotropic Agents Causing Adverse Effects in Therapeutic Use | Brain Metabolic Disorder

United States
Manuel Luque Ramírez
Instituto de Salud Carlos III

Completed

Phlebotomy and Polycystic Ovary Syndrome

Hyperandrogenism | Metabolic Cardiovascular Syndrome

Spain
Jeffrey L Zitsman, MD

Completed

LAGB as a Treatment for Morbid Obesity in Adolescents

Obstructive Sleep Apnea Syndrome | Metabolic Syndrome | Insulin Resistance | Morbid Obesity | Nonalcoholic Fatty Liver Disease

United States
John Sievenpiper
Canadian Institutes of Health Research (CIHR); Canada Research Chairs Endowment... and other collaborators

Unknown

Meta-Analyses of the Effect of Vegetable Protein for Animal Protein on Cardiometabolic Risk

Hypertension | Obesity | Cardiovascular Disease | Diabetes | Overweight | Metabolic Syndrome | Dyslipidemia | Kidney Injury | Prediabetes | Gout | Dysglycemia | Kidney Disease | Non-alcoholic Fatty Liver Disease (NAFLD)

Canada
Ascendis Pharma Oncology Division A/S

Recruiting

A Study to Investigate Safety and Tolerability of TransCon IL-2 β/γ Alone or in Combination With Pembrolizumab and/or Chemotherapy or TransCon TLR7/8 Agonist in Adult Participants With Locally Advanced or Metastatic Solid Tumor Malignancies (IL Believe)

Advanced Solid Tumor | Metastatic Solid Tumor | Platinum-resistant Ovarian Cancer | Locally Advanced Solid Tumor | Post Anti-PD-1 Melanoma | 2L+ Cervical Cancer | Neoadjuvant Melanoma | Neoadjuvant Non-Small Cell Lung Cancer | Post Anti-PD-(L)1 Non-Small Cell Lung Cancer | Post Anti-PD-(L)1 Small Cell...

United States, Australia, Korea, Republic of
University of Novi Sad
Merck Sharp & Dohme LLC

Recruiting

Neuroinflammation and Neurodegeneration in HIV-positive Subjects Switched and Initially Treated With INSTI

Metabolic Syndrome | Aging | HIV I Infection | HIV Associated Lipodystrophy

Serbia
Rennes University Hospital
Ministry of Health, France

Completed

Quantification of Liver Iron Overload and Steatosis Using Magnetic Resonance Imaging (SURFER)

Hepatitis B | Hepatitis C | Iron Overload | Metabolic Syndrome X | Alcohol Abuse

France, Spain
South Tyneside and Sunderland NHS Foundation Trust
Newcastle-upon-Tyne Hospitals NHS Trust; South Tees Hospitals NHS Foundation... and other collaborators

Completed

ObeSity Related Colorectal Adenoma Risk (OSCAR)

Obesity | Colorectal Cancer | Metabolic Syndrome | Colorectal Neoplasm | Colorectal Adenoma | Liver Fibrosis | Non-Alcoholic Fatty Liver Disease

United Kingdom
University of Aarhus

Completed

Body Composition, Bone Mineral Density, Insulin Sensitivity and Echocardiographic Measurements in Klinefelter Syndrome

Cardiovascular Disease | Diabetes | Metabolic Syndrome | Osteoporosis | Klinefelter Syndrome

Denmark
University of Missouri-Columbia
American Society for Metabolic and Bariatric Surgery

Recruiting

Impact GLP-1 Agonists Following Bariatric

Hypertension | Diabetes Mellitus | Metabolic Syndrome | Morbid Obesity | Obstructive Sleep Apnea of Adult

United States
Institut National de la Santé Et de la Recherche...
Centre Hospitalier Universitaire de Nice

Not yet recruiting

CHronic Hepatopathies Associated With ALcohol Consumption aNd metAbolic Syndrome (CHALNA2)

Hepatocellular Carcinoma | Cirrhosis, Liver | Non-Alcoholic Fatty Liver Disease | Non-Alcoholic Steatohepatitis | Alcohol-related Liver Disease
Karolinska Institutet
Karolinska University Hospital; Peking University

Recruiting

Acupuncture or Metformin for Insulin Resistance in Women With PCOS (PIAII)

Polycystic Ovary Syndrome | Hyperandrogenism | Insulin Resistance

Sweden, China
Blueprint Medicines Corporation

Active, not recruiting

(SYMPHONY) Phase 1/2 Study Targeting EGFR Resistance Mechanisms in NSCLC

Neoplasms | Neoplasms by Histologic Type | Lung Diseases | Neoplasms by Site | Adenocarcinoma | Carcinoma | Carcinoma, Non-Small-Cell Lung | Lung Neoplasms | Respiratory Tract Neoplasms | Thoracic Neoplasms | Carcinoma, Bronchogenic | Bronchial Neoplasms | Neoplasms, Nerve Tissue | EGF-R Positive Non-Small Cell Lung... and other conditions

United States, Canada, Taiwan, Korea, Republic of, Singapore, Japan, United Kingdom, France, Netherlands, Spain
Wake Forest University Health Sciences

Completed

Habitual Diet and Avocado Trial (HAT)

Cardiovascular Diseases | Diabetes | Metabolic Syndrome | Liver Fat | Cardiovascular Risk Factor | Diet Habit | Dietary Modification | High Cholesterol | Triglycerides High | Low-density-lipoprotein-type | HDL Cholesterol, Low Serum | High Blood Sugar | Intra-abdominal Fat | High Density Lipoprotein Deficiency

United States
Weill Medical College of Cornell University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Growth Hormone and/or Rosiglitazone for HIV-Associated Increased Abdominal Fat and Insulin Resistance

HIV Infections | Insulin Resistance | Body Weight Changes | Metabolic Syndrome X | HIV-Associated Lipodystrophy Syndrome

United States
University of Sao Paulo General Hospital
InCor Heart Institute

Unknown

Sleep Apnea Syndrome on Acromegaly: Impact of the Treatment on the Carbohydrates Metabolism.

Insulin Resistance | Obstructive Sleep Apnea | Acromegaly

Brazil
858 Therapeutics, Inc.

Recruiting

A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies (ERADIC8)

Breast Cancer | Gastric Cancer | Colorectal Cancer | Ovarian Cancer | Prostate Cancer | Endometrial Cancer | Epithelial Ovarian Cancer | BRCA1 Mutation | BRCA2 Mutation | Advanced or Metastatic Solid Tumors | ER+ Breast Cancer | Castrate Resistant Prostate Cancer | BRCA Mutation

United States
Cancer Research UK
Hummingbird Bioscience

Recruiting

HMBD-001 in Advanced HER3 Positive Solid Tumours

Melanoma | Cervical Cancer | Gastric Cancer | Pancreatic Cancer | Ovarian Cancer | Hepatocellular Carcinoma (HCC) | Bladder Cancer | Triple Negative Breast Cancer | Endometrial Cancer | Castration-resistant Prostate Cancer | Non-small Cell Lung Cancer (NSCLC) | Oesophageal Cancer | RAS Wild Type Colorectal Cancer | Squamous Cell Cancer of the Head and Neck

United Kingdom
Tempest Therapeutics

Completed

TPST-1120 as Monotherapy and in Combination With Nivolumab in Subjects With Advanced Cancers

Sarcoma | Renal Cell Carcinoma | Hepatocellular Carcinoma | Colorectal Cancer | Pancreatic Cancer | Squamous Cell Carcinoma of Head and Neck | Cholangiocarcinoma | Non-small Cell Lung Cancer | Urothelial Carcinoma | GastroEsophageal Cancer | Triple-Negative Breast Cancer | Metastatic Castration Resistant Prostate...

United States
Exelixis

Recruiting

Study of XB002 in Subjects With Solid Tumors (JEWEL-101)

Cervical Cancer | Pancreatic Cancer | Non Small Cell Lung Cancer | Triple Negative Breast Cancer | Endometrial Cancer | Epithelial Ovarian Cancer | Metastatic Castration-resistant Prostate Cancer | Hormone Receptor-positive Breast Cancer | SCCHN | Esophageal SCC | Tissue Factor-Expressing Solid Tumors

United States, Spain, Australia, Belgium, France, Italy, Netherlands, United Kingdom, Korea, Republic of
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

DS3201 and Ipilimumab for the Treatment of Metastatic Prostate, Urothelial and Renal Cell Cancers

Metastatic Clear Cell Renal Cell Carcinoma | Castration-Resistant Prostate Carcinoma | Metastatic Prostate Carcinoma | Stage IV Prostate Cancer AJCC v8 | Stage IV Renal Cell Cancer AJCC v8 | Metastatic Malignant Solid Neoplasm | Metastatic Urothelial Carcinoma | Stage IVA Prostate Cancer AJCC v8 | Stage... and other conditions

United States

Clinical Trials on Medically Resistant Seizures

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Drug Interventions

CROs by country

CROs in Mauritania

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