Clinical Trials on Metabolic Complications

Total 77557 results

LG Life Sciences

Unknown

Post-authorization Safety Study of Euforvac-Hib Vaccine for Active Primary Immunization in Infants From 6 Weeks

Hepatitis B | Pertussis | Tetanus | Diphtheria | Haemophilus Influenza Type B
Sanofi Pasteur, a Sanofi Company
Merck Sharp & Dohme LLC

Completed

Study of PR5I, a Pediatric Combination Vaccine With Enhanced Hepatitis B Component Given Concomitantly With Prevnar®

Hepatitis B | Pertussis | Tetanus | Diphtheria | Polio

Canada
California Cancer Consortium
National Cancer Institute (NCI)

Completed

Decitabine in Treating Patients With Melanoma or Other Advanced Cancer

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Unspecified Adult Solid Tumor, Protocol Specific | Multiple Myeloma and Plasma Cell Neoplasm | Precancerous Condition

United States
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

St. John's Wort in Relieving Fatigue in Patients Undergoing Chemotherapy or Hormone Therapy for Cancer

Lymphoma | Myelodysplastic Syndromes | Leukemia | Fatigue | Chronic Myeloproliferative Disorders | Unspecified Adult Solid Tumor, Protocol Specific | Multiple Myeloma and Plasma Cell Neoplasm | Precancerous Condition

United States
Massachusetts General Hospital

Withdrawn

Treating Sleep/Wake Cycle Disturbances in Basal Ganglia Disorders With Ramelteon

Parkinson's Disease | Sleep Disorders | Dementia With Lewy Bodies | Huntington's Disease | Circadian Dysregulation

United States
NYU Langone Health
National Cancer Institute (NCI)

Completed

Combination Chemotherapy in Treating Patients With Advanced Cancer

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Unspecified Adult Solid Tumor, Protocol Specific | Multiple Myeloma and Plasma Cell Neoplasm | Precancerous Condition

United States
National Institute of Allergy and Infectious Diseases...

Completed

Learning and Behavior Problems in Children With Chronic Granulomatous Disease and Related Disorders

Chronic Granulomatous Disease | Leukocyte Disorder | Job's Syndrome | Chediak Higashi Syndrome

United States
Fairview University Medical Center

Unknown

Pilot Study of Unrelated Donor Hematopoietic Stem Cell Transplantation in Patients With Life Threatening Hemophagocytic Disorders

Hemophagocytic Lymphohistiocytosis | Graft Versus Host Disease | Chediak-Higashi Syndrome | Virus-Associated Hemophagocytic Syndrome | X-Linked Lymphoproliferative Syndrome | Familial Erythrophagocytic Lymphohistiocytosis

United States
Zhejiang University

Not yet recruiting

A Clinical Study of Anti-CD70 UCAR-T in Relapsed or Refractory Solid Tumors

Renal Cell Carcinoma | Nasopharyngeal Carcinoma | Ovarian Cancer | Cervix Cancer | Advanced Solid Tumor | Head and Neck Squamous Cell Carcinoma | Metastatic Tumor
ImmunoGen, Inc.

Not yet recruiting

A Study of Ocular Toxicity Evaluation and Mitigation During Treatment With Mirvetuximab Soravtansine in Participants With Recurrent Ovarian Cancer With High Folate Receptor-Alpha Expression

Recurrent Ovarian Cancer | Folate Receptor-Alpha Positive

United States, Spain, Australia, Belgium, Canada, France, Ireland, Italy
Baylor College of Medicine
The Methodist Hospital Research Institute; Center for Cell and Gene Therapy...

Recruiting

Interleukin-15 Armored Glypican 3-specific Chimeric Antigen Receptor Expressed in Autologous T Cells for Solid Tumors

Solid Tumor | Liposarcoma | Rhabdomyosarcoma | Wilms Tumor | Malignant Rhabdoid Tumor | Yolk Sac Tumor | Liver Cell Carcinoma | Embryonal Sarcoma of the Liver

United States
Jason J. Luke, MD

Recruiting

Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors

Melanoma | Cervical Cancer | Hepatocellular Carcinoma | Gastric Cancer | Colorectal Cancer | NSCLC | Advanced Solid Tumors | Cholangiocarcinoma | Bladder Cancer | Renal Cancer | Anal Cancer | Merkel Cell Carcinoma | HNSCC

United States
Apollomics Inc.

Recruiting

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors (SPARTA)

Gastric Cancer | Pancreatic Cancer | NSCLC | Lung Cancer | Brain Tumor | Glioblastoma Multiforme | Advanced Cancer | Colon Cancer | Solid Tumors | Thyroid Cancer | Renal Cancer | Gastroesophageal Junction Adenocarcinoma | EGFR Gene Mutation | MET Amplification | HGF | MET Alteration | MET Fusion | Exon 14 Skipping

United States, Spain, France, United Kingdom, Taiwan, Australia, Finland, Italy, Singapore, Hungary, Canada, Puerto Rico, Russian Federation
Pfizer

Completed

Study to Test the Safety and Tolerability of PF-07257876 in Participants With Selected Advanced Tumors.

Ovarian Cancer | Non-Small Cell Lung Cancer | Squamous Cell Carcinoma of the Head and Neck

United States, Spain
Peloton Therapeutics, Inc., a subsidiary of Merck...

Active, not recruiting

A Phase 2 Study of Belzutifan (PT2977, MK-6482) for the Treatment of Von Hippel Lindau (VHL) Disease-Associated Renal Cell Carcinoma (RCC) (MK-6482-004)

VHL - Von Hippel-Lindau Syndrome | VHL Gene Mutation | VHL Syndrome | VHL Gene Inactivation | VHL-Associated Renal Cell Carcinoma | VHL-Associated Clear Cell Renal Cell Carcinoma

United States, Denmark, United Kingdom, France
Seagen Inc.

Terminated

A Study of SGN-ALPV in Advanced Solid Tumors

Uterine Cervical Neoplasms | Stomach Neoplasms | Testicular Neoplasms | Carcinoma, Non-Small-Cell Lung | Ovarian Neoplasms | Endometrial Neoplasms | Gastroesophageal Junction Carcinoma

United States, Canada, Spain, Sweden, United Kingdom
University Health Network, Toronto
Merck Sharp & Dohme LLC

Active, not recruiting

Study of the Effects of Pembrolizumab in Patients With Advanced Solid Tumors (INSPIRE)

Advanced Solid Tumors | Triple Negative Breast Cancer | Epithelial Ovarian Cancer | Malignant Melanoma | Squamous Cell Cancer of Head and Neck

Canada
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

CBM588 in Combination With Nivolumab and Cabozantinib for the Treatment of Advanced or Metastatic Kidney Cancer

Metastatic Renal Cell Carcinoma | Metastatic Clear Cell Renal Cell Carcinoma | Advanced Clear Cell Renal Cell Carcinoma | Stage III Renal Cell Cancer AJCC v8 | Stage IV Renal Cell Cancer AJCC v8 | Metastatic Sarcomatoid Renal Cell Carcinoma | Advanced Renal Cell Carcinoma | Unresectable Renal Cell... and other conditions

United States
Children's National Research Institute
Bristol-Myers Squibb

Active, not recruiting

Neoadjuvant Dual Checkpoint Inhibition and Cryoablation in Relapsed/Refractory Pediatric Solid Tumors

Melanoma | Hepatocellular Carcinoma | Osteosarcoma | Ewing Sarcoma | Neuroblastoma | Rhabdomyosarcoma | Wilms Tumor | Hepatoblastoma | Relapsed Pediatric Solid Tumor | Refractory Pediatric Solid Tumor

United States
Celldex Therapeutics

Completed

A Study of the PD-L1xCD27 Bispecific Antibody CDX-527 in Patients With Advanced Malignancies

Renal Cell Carcinoma | Breast Cancer | Head and Neck Cancer | Gastric Cancer | Esophageal Cancer | Ovarian Cancer | Fallopian Tube Cancer | Cholangiocarcinoma | Non-small Cell Lung Cancer | Primary Peritoneal Carcinoma | Hepatic Cancer | Bladder Urothelial Carcinoma | Other Solid Tumors | MSI-H Colorectal Cancer

United States
Chinese University of Hong Kong

Recruiting

Safety and Efficacy of Fecal Microbiota Transplantation

Alcohol Dependence | Multiple Sclerosis | Obesity | Diabetes Mellitus | Hepatic Encephalopathy | Irritable Bowel Syndrome | Constipation | Celiac Disease | Crohn Disease | Ulcerative Colitis | Liver Disease | Idiopathic Thrombocytopenic Purpura | Clostridium Difficile Infection | Alopecia | Autism | Multiple Organ Dysfunction... and other conditions

Hong Kong
University of Arkansas

Withdrawn

Pancreatic Cancer Screening of High-Risk Individuals in Arkansas

Pancreatic Neoplasms | Colorectal Neoplasms, Hereditary Nonpolyposis | BRCA1 Gene Mutation | BRCA2 Gene Mutation | Hereditary Pancreatitis | Ataxia Telangiectasia | Peutz-Jegher's Syndrome | Familial Atypical Mole-Malignant Melanoma Syndrome

United States
Masonic Cancer Center, University of Minnesota

Recruiting

Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies

Common Variable Immunodeficiency | Chronic Granulomatous Disease | Hemophagocytic Lymphohistiocytosis | Wiskott-Aldrich Syndrome | X-linked Lymphoproliferative Disease | Langerhan's Cell Histiocytosis | Chediak-Higashi Syndrome | Griscelli Syndrome | Bare Lymphocyte Syndrome | SCID | Omenn's Syndrome | Reticular... and other conditions

United States
National Cancer Institute (NCI)

Withdrawn

Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study

Hematopoietic and Lymphoid Cell Neoplasm | Lynch Syndrome | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Recurrent Lymphoma | Recurrent Malignant Solid Neoplasm | Recurrent Neuroblastoma | Refractory Neuroblastoma | Recurrent Primary Central Nervous System Neoplasm | Refractory Primary Central... and other conditions

United States, Canada
Fairview University Medical Center

Terminated

Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies

Immunologic Deficiency Syndromes | Common Variable Immunodeficiency | Severe Combined Immunodeficiency | Chronic Granulomatous Disease | Hemophagocytic Lymphohistiocytosis | Wiskott-Aldrich Syndrome | Graft Versus Host Disease | X-linked Agammaglobulinemia | Chediak-Higashi Syndrome | Virus-Associated... and other conditions

United States
Luye Pharma Group Ltd.

Not yet recruiting

A Phase 1, SAD Study to Evaluate the Safety and Tolerability of LY03017

Negative Symptoms of Schizophrenia | Hallucinations and Delusions Associated With Alzheimer's Disease Psychosis | Hallucinations and Delusions Associated With Parkinson Disease Psychosis

China
prof. dr. Koen Van Laere
Universitaire Ziekenhuizen KU Leuven; KU Leuven; University Hospital, Ghent; Fund...

Not yet recruiting

[18F]-MFBG Versus [123I]-MIBG and [18F]-PE2I in PD vs. MSA and DBL vs. AD

Parkinson Disease | Alzheimer Disease | Dementia With Lewy Bodies | MSA - Multiple System Atrophy

Belgium
Pauls Stradins Clinical University Hospital

Recruiting

Telemedical Assistance in Automatic Titration of Oxygen for Intensive Care Patients (Smartassistant)

Pneumonia | Interstitial Lung Disease | Chronic Obstructive Lung Disease | Obesity Hypoventilation Syndrome (OHS)

Latvia
Kliniken Beelitz GmbH

Recruiting

Evaluation of the Efficacy of a Two-week EMST on Dysphagia in Parkinsonian Patients (EMST-PS)

Parkinson Disease | Multiple System Atrophy | Progressive Supranuclear Palsy

Germany
Kliniken Beelitz GmbH
Hannover Medical School; University Hospital Muenster; Medical University Innsbruck and other collaborators

Recruiting

Systematic Assessment of Laryngopharyngeal Function in Patients With MSA, PD, and 4repeat Tauopathies (FEEMSA)

Parkinson Disease | Multiple System Atrophy | Progressive Supranuclear Palsy

Germany, Austria, Israel, Italy, Poland, Spain, Japan, Korea, Republic of
Loxo Oncology, Inc.
Eli Lilly and Company

Recruiting

A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors (LIBRETTO-121)

Soft Tissue Sarcoma | Medullary Thyroid Cancer | Papillary Thyroid Cancer | Infantile Fibrosarcoma | Infantile Myofibromatosis

United States, Australia, Japan, Canada, Germany, Korea, Republic of, France, Spain, United Kingdom, Denmark, Italy
Shanghai Mental Health Center

Recruiting

The China Longitudinal Aging Study of Cognitive Impairment

Depression | Anxiety | Alzheimer Disease | Mild Cognitive Impairment | Dementia, Vascular | Dementia With Lewy Bodies | Dementia Frontal

China
University College, London
University of Oxford; Newcastle University; University of Cambridge; University... and other collaborators

Recruiting

PROgressive Supranuclear Palsy CorTico-Basal Syndrome Multiple System Atrophy Longitudinal Study UK (PROSPECT-M)

Corticobasal Degeneration | Multiple System Atrophy (MSA) | Progressive Supranuclear Palsy (PSP)

United Kingdom
Grand Valley State University

Active, not recruiting

Pediatric Powered Wheelchair Standing Devices: An Exploratory Study

Cerebral Palsy | Spinal Cord Injuries | Spinal Muscular Atrophy | Genetic Disease | Spina Bifida | Development Delay

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Frequency of Cachexia in Ambulatory Cancer Patients and Psychological Burden in Patients and Their Primary Caregivers

Advanced Malignant Solid Neoplasm | Recurrent Lymphoma | Recurrent Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Recurrent Plasma Cell Myeloma | Caregiver | Recurrent Leukemia

United States
Thomas Jefferson University
Independence Blue Cross

Active, not recruiting

Telehealth-enabled Integrated Palliative Care for People With Dementia (IBC)

Alzheimer Disease | Frontotemporal Degeneration | Vascular Dementia | Dementia of Alzheimer Type | Lewy Body Dementia | Mixed Dementia | Vascular Cognitive Impairment

United States
Sanofi Pasteur, a Sanofi Company

Completed

Study to Evaluate the Immune Response After Booster Vaccination With Tdap-IPV Vaccine (Against Tetanus, Diphtheria, Pertussis and Poliomyelitis) in Children Who Received Different Pertussis Primary Vaccine Regimens in Republic of South Africa

Pertussis Immunisation | Diphtheria Immunisation | Tetanus Immunisation | Poliomyelitis Vaccine

South Africa
Air Liquide Santé International

Completed

Study Evaluating Telemonitoring and Experimentation in Telemedicine for the Improvement of Healthcare Pathways (ETAPES Program) Compared to Standard of Care in Patients With Chronic Respiratory Failure Receiving Non-invasive Home Ventilation (e-VENT)

Chronic Obstructive Pulmonary Disease (COPD) | Obesity Hypoventilation Syndrome (OHS) | Chronic Respiratory Failure With Hypercapnia

France
University of Florida
National Institute on Aging (NIA); Aster Labs, Inc

Completed

Accurate WiFi-Based Localization of Dementia Patients For Caregiver Support:

Lewy Body Dementia With Behavioral Disturbance | Dementia, Vascular | Alzheimer Dementia

United States
National Institute of Neurological Disorders and...

Completed

Clinical Correlates of COVID-19 Pandemic in Patients With Functional Movement Disorder (FMD) and Parkinson's Disease (PD)

COVID-19 | Parkinson's Disease | Functional Movement Disorders

United States
University of Colorado, Denver

Completed

Defining Phenotypes of Movement Disorders :Parkinson's Plus Disorders (PD), Essential Tremor (ET), Cortical Basal Degeneration (CBD), Multiple Systems Atrophy (MSA), Magnetoencephalography. (PHENO)

Parkinson Disease | Supranuclear Palsy, Progressive | Multiple System Atrophy | Corticobasal Degeneration | Essential Tremor

United States
Mitsubishi Tanabe Pharma Corporation
The Research Foundation for Microbial Diseases of Osaka University

Completed

Confirmatory Study of BK1310 in Healthy Infants

Pertussis | Tetanus | Diphtheria | Bacterial Meningitis | Poliomyelitis

Japan
Public Health England
Department of Health, United Kingdom; Institute of Child Health, London, England

Completed

Hepatitis B Vaccination in Infants (Infanrix)

Pneumococcal Disease | Meningococcal Disease | Diphtheria, Tetanus and Pertussis | Haemophilus Influenzae Serotype b Disease | Hepatitis b

United Kingdom
GlaxoSmithKline

Completed

Safety and Immunogenicity of a Booster Dose of New Formulations of GlaxoSmithKline Biologicals' DTPa-HBV-IPV/Hib Vaccine (GSK217744)

Hepatitis B | Tetanus | Diphtheria | Acellular Pertussis | Poliomyelitis | Haemophilus Influenzae Type b

Finland, Dominican Republic
Fondazione Don Carlo Gnocchi Onlus
University of Milano Bicocca; Università Carlo Cattaneo , Castellanza

Unknown

An Innovative Disease-net Management Model for Non-communicable Diseases (SIDERA^B) (SIDERA^B)

Chronic Obstructive Pulmonary Disease (COPD) | Chronic Heart Failure (CHF) | Parkinson Disease (PD)

Italy
Reha Rheinfelden

Withdrawn

Feasibility of Two New Software Modules for the Rehabilitation of Patients With Neuromuscular Upper Limb Impairments

Stroke | Parkinson Disease | Traumatic Brain Injury | Guillain-Barre Syndrome
University of Wisconsin, Madison

Completed

"Reversibility of Cardiovascular Injury With CPAP Use: Mechanisms Involved"

Sleep Apnea, Obstructive | Hypertension | Obesity | Hypoxia | Left Ventricular Function Systolic Dysfunction | Sleep Disorders | Hypercapnia | Ventricular Hypertrophy | Right Ventricular Overload | Coronary Artery Vasospasm

United States
Guangdong Provincial People's Hospital

Completed

Epidemiology and Intervention of Obstructive Sleep Apnea Based on Community

Quality of Life | Sleep Apnea, Obstructive | Hypertension | Obesity | Diabetes | Fatigue Syndrome, Chronic | Compliance, Patient | Insomnia Chronic | Economic Problems | Health Impairment | Hyperdiploid

China
Milton S. Hershey Medical Center

Completed

Identifying Biomarkers of Parkinson's Disease Using Magnetic Resonance Imaging (MRI)

Parkinsonism | Parkinson's Disease (PD) | Multiple System Atrophy (MSA) | Progressive Supranuclear Palsy (PSP)

United States
GlaxoSmithKline

Completed

A Study to Assess the Immunogenicity and Safety of GSK Biologicals' Infanrix-IPV/Hib Vaccine Administered as a Three-dose Vaccination Course at 3, 4.5 and 6 Months of Age and a Booster Dose at 18 Months of Age in Healthy Infants in Russia

Hepatitis B | Pertussis | Tetanus | Diphtheria | Haemophilus Influenzae Type b

Russian Federation

Clinical Trials on Metabolic Complications

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