Clinical Trials on Microangiopathies thrombotiques

Total 546 results

Bristol-Myers Squibb

Completed

Study to Evaluate Safety and Efficacy in Adult Subjects With ITP (ITP)

Immune Thrombocytopenic Purpura

United States, Australia, United Kingdom, Canada, Georgia, Moldova, Republic of, Poland, Russian Federation
Rigel Pharmaceuticals

Completed

A Efficacy and Safety Study of R935788 in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP) (FIT)

Immune Thrombocytopenic Purpura

United States, Australia, United Kingdom, Canada, Italy, Denmark, Hungary, Netherlands
Eisai Inc.

Terminated

A Phase 3, Multicenter, Randomized, Double-blind,Active-controlled, Parallel-group Trial With an Open-labelExtension Phase to Evaluate the Efficacy and Safety of OralE5501 Versus Eltrombopag, in Adults With Chronic ImmuneThrombocytopenia (Idiopathic Thrombocytopenic Purpura)

Idiopathic Thrombocytopenic Purpura

United States
CSL Behring

Completed

A Safety Study of Intravenous Immunoglobulin in Patients With Chronic Immune Thrombocytopenic Purpura (ITP)

Immune Thrombocytopenic Purpura

Serbia, Romania, Bulgaria
Genzyme, a Sanofi Company

Terminated

Safety Study of GMA161 in Patients With Idiopathic Thrombocytopenic Purpura (ITP)

Idiopathic Thrombocytopenic Purpura

United States
Eisai Inc.

Completed

A Study to Evaluate the Relative Bioavailability and Intra-Subject Variability of Two Lots of E5501 40 mg Tablets Administered Twice as Single Oral Doses to Healthy Subjects

Idiopathic Thrombocytopenia Purpura

United States
Henri Mondor University Hospital

Completed

Efficacy and Safety of Rituximab Given at Fixed Dose (1000 mg on Days 1 and 15) Compared to the Standard Regimen in Adult's Immune Thrombocytopenia

Primary Immune Thrombocytopenia
GlaxoSmithKline

Completed

Outcomes Comparison of Chronic Immune Thrombocytopenic Purpura (ITP) Patients Switched to Eltrombopag and Romiplostim

Immune Thrombocytopenic Purpura
Henri Mondor University Hospital
Paris 12 Val de Marne University

Completed

Eltrombopag and Romiplostim Used Alternatively in Patients With Immune Thrombopenia (ITP): Efficacy and Safety.

Immune Thrombocytopenia | Thrombopoietin Receptor Agonist
CSL Behring

Completed

Treatment of Chronic Immune Thrombocytopenic Purpura (ITP) With Intravenous Immunoglobulin IgPro10

Immune Thrombocytopenic Purpura

Poland, Ukraine, Germany, Russian Federation, Italy, United Kingdom
Cooperative Study Group A for Hematology

Unknown

Helicobacter Pylori Immune Thrombocytopenic Purpura (HpyloriITP)

Immune Thrombocytopenic Purpura

Korea, Republic of
Institute of Hematology & Blood Diseases Hospital...
Henan Cancer Hospital; Tianjin Medical University Second Hospital; The Second... and other collaborators

Recruiting

Avatrombopag in the Treatment of Pediatric Immune Thrombocytopenia

Immune Thrombocytopenia | Treatment

China
Institute of Hematology & Blood Diseases Hospital...

Recruiting

A Prospective, One-arm and Open Clinical Study of Obinutuzumab in the Treatment of Pediatric Primary Immune Thrombocytopenia (ITP)

Immune Thrombocytopenia | Treatment

China
Mario Negri Institute for Pharmacological Research

Recruiting

Functional Implications of Rare Gene Mutations in aHUS Open the Door to Personalized Therapy (aHUS-iPSC-EC)

Atypical Hemolytic Uremic Syndrome

Italy
Gruppo Italiano Malattie EMatologiche dell'Adulto

Recruiting

Biologic Characterization of Patients With ITP

Immune Thrombocytopenia

Italy
Sanofi

Recruiting

Caplacizumab and Immunosuppressive Therapy Without Firstline Therapeutic Plasma Exchange in Adults With Immune-mediated Thrombotic Thrombocytopenic Purpura (MAYARI)

Thrombotic Thrombocytopenic Purpura

Italy, Belgium, France, Greece, United States, Austria, Canada, Czechia, Germany, Japan, Netherlands, Spain, United Kingdom
Peking University People's Hospital
Beijing Friendship Hospital; Beijing Hospital; The First Affiliated Hospital... and other collaborators

Recruiting

The Combination of Iguratimod and Danazol as the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia

Immune Thrombocytopenia | ITP

China
Peking University People's Hospital
Shanghai Zhongshan Hospital; Qilu Hospital of Shandong University; The Affiliated... and other collaborators

Recruiting

Machine-learning Based Prediction Model in Primary Immune Thrombocytopenia

Immune Thrombocytopenia | ITP

China
Baylor College of Medicine
Boston Children's Hospital; University of California, San Francisco

Active, not recruiting

Eltrombopag vs Standard Front Line Management for Newly Diagnosed Immune Thrombocytopenia (ITP) in Children

Immune Thrombocytopenia

United States
Rigel Pharmaceuticals

Terminated

Observational Study of Fostamatinib as Second Line Therapy in Adult Patients With Immune Thrombocytopenia (ITP) and Insufficient Response to a Prior Therapy

Immune Thrombocytopenia | ITP

United States
Boston Children's Hospital
Baylor College of Medicine; Children's Hospital of Philadelphia; Columbia University and other collaborators

Completed

Association of Platelet Parameters With Bleeding Severity in Children With ITP (ITP-APPS)

Immune Thrombocytopenia

United States
Swedish Orphan Biovitrum

Active, not recruiting

An Observational, Multicenter Study to Evaluate the Use and Effectiveness of Doptelet® in Patients With ITP (ADOPT)

Immune Thrombocytopenia | ITP

Croatia, Czechia, Germany, Italy, Netherlands, Norway, Spain, Switzerland, United Kingdom
Novartis Pharmaceuticals

Completed

Drug Use Investigation for REVOLADE (ITP)

Purpura, Thrombocytopaenic, Idiopathic
Shandong University
The Second Hospital of Hebei Medical University; The Affiliated Hospital of... and other collaborators

Completed

A Multicenter Study on Recombinant Human Thrombopoietin in Management of ITP in Pregnancy

Pregnancy | Immune Thrombocytopenia

China
Eisai Inc.

Completed

Efficacy and Safety of Oral E5501 Plus Standard of Care for the Treatment of Thrombocytopenia in Adults With Chronic Immune Thrombocytopenia (Amendment 02)

Immune Thrombocytopenia | Chronic Thrombocytopenia

Poland, Ukraine, Belgium, Bulgaria, South Africa, Netherlands, New Zealand, Singapore, Australia, Slovakia, Czechia
Shandong University
Shandong Provincial Hospital; Qianfoshan Hospital; Traditional Chinese Medicine... and other collaborators

Unknown

The Association Between Platelet Reactivity and Bleeding Risk in Adult ITP

Immune Thrombocytopenia

China
Peking University People's Hospital

Unknown

Thrombocytopenia in Gestational Period

Pregnancy | Immune Thrombocytopenia
Shandong University

Unknown

Recombinant Human Thrombopoietin (rhTPO) in Management of Immune Thrombocytopenia (ITP) in Pregnancy

Pregnancy | Immune Thrombocytopenia

China
GlaxoSmithKline

Completed

A Longitudinal 2-year Bone Marrow Study of Eltrombopag in Previously Treated Adults, With Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP)

Purpura, Thrombocytopaenic, Idiopathic

Italy, Germany, Hong Kong, Korea, Republic of, United States, Pakistan, Russian Federation, India, Czech Republic, Hungary, France
GlaxoSmithKline

Completed

SB-497115 (Oral Thrombopoietin Receptor Agonist) Versus Placebo In Adults With Refractory Immune Thrombocytopenic Purpura (ITP)

Purpura, Thrombocytopaenic, Idiopathic

Thailand, Korea, Republic of, United Kingdom, New Zealand, Germany, Greece, Hong Kong, Pakistan, Poland, Romania, Russian Federation, Slovenia, Taiwan
St. Olavs Hospital
Norwegian University of Science and Technology

Withdrawn

Prophylactic Plasma Infusion Therapy for Congenital Thrombotic Thrombocytopenic Purpura

Purpura, Thrombotic Thrombocytopenic
Assiut University

Not yet recruiting

Immune Markers in Pediatric ITP on Second Line Therapy

ITP - Immune Thrombocytopenia
Sohag University

Not yet recruiting

Assessment of Serum interleukin10 Level in Patients With Immune Thrombocytopenic Purpura at Sohag University Hospital

Immune Thrombocytopenic Purpura

Egypt
Institute of Biophysics and Cell Engineering of...
Belarusian Research Center for Pediatric Oncology, Hematology and Immunology

Not yet recruiting

Assesment of the Functional Activity of Platelets for the Differential Diagnosis of Thrombocytopathies

Hemorrhagic Disorders | Immune Thrombocytopenia | Acute Leukemia | Thrombocytopathy
Novartis Pharmaceuticals

Recruiting

A Study of Efficacy and Safety of Ianalumab Versus Placebo in Addition to Eltrombopag in Primary Immune Thrombocytopenia Patients Who Failed Steroids (VAYHIT2)

Primary Immune Thrombocytopenia

United States, China, Germany, Spain, Singapore, Japan, Taiwan, Belgium, Italy, Czechia, Hungary, Malaysia, Korea, Republic of, Turkey, Argentina, Thailand, India, United Kingdom, France, Australia, Romania, Austria, Norway, Netherlands, Philippin...
Sohag University

Not yet recruiting

" Effect of Single-nucleotide Polymorphism of CD40 Gene rs1883832 C/T on the Risk of Immune Thrombocytopenic Purpura "

Immune Thrombocytopenic Purpura

Egypt
The First Affiliated Hospital of Soochow University

Recruiting

Construction of a Database for TTP

TTP - Thrombotic Thrombocytopenic Purpura

China
Wuhan Union Hospital, China
Jiangsu Hengrui Pharmaceutical Co., Ltd.

Not yet recruiting

Efficacy and Safety of TPO Receptor Agonists in the Treatment of Elderly ITP Patients

Primary Immune Thrombocytopenia
Beijing InnoCare Pharma Tech Co., Ltd.

Recruiting

A Study to Evaluate the Efficacy and Safety of Orelabrutinib in Adult Patients With Immune Thrombocytopenia

Primary Immune Thrombocytopenia

China
Sohag University

Not yet recruiting

Study of T Cells and Natural Killer Cells Expression in Patients With Immune Thrombocytopenic Purpura

Immune Thrombocytopenic Purpura
Shandong University

Not yet recruiting

A Clinical Trial of the Orelabrutinib in the Management of Refractory ITP

Immune Thrombocytopenia | Bruton's Tyrosine Kinase
University College, London

Recruiting

The United Kingdom Thrombotic Thrombocytopenic Purpura Registry (UK TTP Registry)

TTP - Thrombotic Thrombocytopenic Purpura

United Kingdom
University Hospital, Toulouse

Recruiting

French Adult Primary Immune Thrombocytopenia (FAITH)

Thrombocytopenia

France
Bioverativ, a Sanofi company

Completed

A Phase 2a Study Evaluating BIVV020 in Adults With Persistent/Chronic Immune Thrombocytopenia (ITP)

Immune Thrombocytopenia (ITP)

Germany, United States, Czechia, Netherlands, Spain, United Kingdom
Octapharma

Active, not recruiting

Study to Evaluate the Efficacy and Safety of PANZYGA in Pediatric Patients With Chronic Immune Thrombocytopenia (ITP)

Chronic Immune Thrombocytopenia

United States
Rigel Pharmaceuticals

Completed

Open Label Study of R788 in the Treatment of Persistent/Chronic Immune Thrombocytopenic Purpura (ITP)

Immune Thrombocytopenic Purpura

Spain, United States, Australia, Poland, United Kingdom, Canada, Czechia, Bulgaria, Romania, Austria, Denmark, Hungary, Italy, Netherlands, Norway
Peking University People's Hospital

Completed

A Study of Zanubrutinib in Patients With ITP

Immune Thrombocytopenia | Bruton Tyrosine Kinase

China
argenx
Quintiles, Inc.

Completed

A Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of ARGX-113 in Patients With ITP

Primary Immune Thrombocytopenia

Austria, Belgium, France, Germany, Spain, Czechia, Hungary, Poland, Ukraine, United Kingdom
University College, London

Completed

The Use of Rituximab in Acute Thrombotic Thrombocytopenic Purpura (TTP)

Thrombotic Thrombocytopenic Purpura (TTP)

United Kingdom
argenx

Active, not recruiting

A Long-term Study to Assess the Safety and Efficacy of Efgartigimod in Adult Patients With Primary Immune Thrombocytopenia (ITP). (ADVANCE+)

Primary Immune Thrombocytopenia

United States, Austria, Belgium, Bulgaria, Czechia, France, Georgia, Germany, Hungary, Italy, Japan, Netherlands, Poland, Russian Federation, Spain, Turkey, United Kingdom, Ukraine

Clinical Trials on Microangiopathies thrombotiques

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