Clinical Trials on Mismatch Repair Gene Mutation
Total 452 results
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Institut für Klinische Krebsforschung IKF GmbH...Medizinische Hochschule Hannover, Germany, Prof. Dr. Arndt Vogel; MSD Sharp...RecruitingBiliary Tract Cancer | HER2 Gene MutationGermany
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University of Colorado, DenverRecruitingNon-Small Cell Lung Cancer | ALK Gene Mutation | EGFR Gene Mutation | BRAF V600E | Non-Small Cell Carcinoma of Lung, TNM Stage 4 | ROSE Cluster 1United States
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Ying LinRecruitingHer-2 Negative Breast Cancer | HRR Gene MutationChina
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)CompletedMetastatic Malignant Neoplasm | Advanced Malignant Neoplasm | Recurrent Malignant Neoplasm | Refractory Malignant Neoplasm | BRAF Gene MutationUnited States
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Fondazione Policlinico Universitario Agostino Gemelli...RecruitingNSCLC Stage IV | ALK Gene Mutation | ALK Sensitizing MutationItaly
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Aarhus University HospitalRoche Pharma AGEnrolling by invitationLung Cancer | ALK Gene Mutation | Resistance, Disease | MutationDenmark
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Day One Biopharmaceuticals, Inc.RecruitingMelanoma | Colorectal Cancer | Solid Tumor | Non Small Cell Lung Cancer | Bladder Cancer | Thyroid Cancer, Papillary | Pilocytic Astrocytoma | Bladder Urothelial Carcinoma | Non-Small Cell Adenocarcinoma | MEK Mutation | RAS Mutation | Pancreatic Acinar Carcinoma | RAF Mutation | CRAF Gene Amplification | RAF1 Gene Amplification and other conditionsUnited States, Canada, Korea, Republic of, Spain, Australia, Belgium, France
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West Cancer CenterAmgen; University of Tennessee Health Science CenterUnknownMelanoma | BRAF Gene MutationUnited States
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RWJ Barnabas Health at Jersey City Medical CenterUnknownLynch Syndrome | Endometrial Cancer | Somatic Mutation | Cancer Gene MutationUnited States
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OnKure, Inc.Active, not recruitingMelanoma | NRAS Gene Mutation | RAS MutationUnited States
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University Medical Center NijmegenActive, not recruitingOvarian Cancer | BRCA1 Gene Mutation | BRCA2 Gene MutationNetherlands
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Rottapharm BiotechAgenus Inc.Active, not recruitingSolid Tumor | Metastatic Microsatellite-stable Colorectal Cancer | Mismatch Repair Protein Proficient | Refractory Metastatic Colorectal CancerItaly
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UNICANCERARCAGY/ GINECO GROUP; SOLTI Breast Cancer Research GroupActive, not recruitingER-positive and HER2-negative Metastatic or Locally Advanced Breast Cancer | a Germline or Somatic BRCA Mutation, or a Deleterious Alteration of Other Genes Involved in Homologous Recombination Repair (HRR) or in MSI StatusFrance
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Fudan UniversityPeking University First Hospital; Xiangya Hospital of Central South University and other collaboratorsUnknownGene Mutation | Epilepsy Idiopathic | Clinical Disease and/or SyndromeChina
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University of California, San FranciscoBeiGene USA, Inc.; Pacific Pediatric Neuro-Oncology ConsortiumRecruitingGlioblastoma | Malignant Glioma | Recurrent Glioblastoma | Recurrent WHO Grade III Glioma | WHO Grade III Glioma | IDH2 Gene Mutation | IDH1 Gene Mutation | Low Grade Glioma | Recurrent WHO Grade II Glioma | WHO Grade II GliomaUnited States
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University of ChicagoNovartisTerminatedHead and Neck Squamous Cell Carcinoma | Recurrent Head and Neck Carcinoma | Human Papillomavirus Infection | Recurrent Oropharyngeal Squamous Cell Carcinoma | FGFR Gene Amplification | FGFR1 Gene Amplification | FGFR2 Gene Amplification | FGFR2 Gene Mutation | FGFR3 Gene Mutation | Recurrent Nasopharynx...United States
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)Active, not recruitingEGFR NP_005219.2:p.S492R | KRAS Gene Mutation | MAP2K1 Gene Mutation | Metastatic Colorectal Adenocarcinoma | Refractory Colorectal Adenocarcinoma | Stage IV Colorectal Cancer AJCC v7 | Stage IVA Colorectal Cancer AJCC v7 | Stage IVB Colorectal Cancer AJCC v7United States
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Universiti Sains MalaysiaCompletedOpioid Dependence | Methadone Toxicity | HERG Gene MutationMalaysia
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National Taiwan University HospitalRecruitingCancer | Drug-Related Side Effects and Adverse Reactions | Cancer, Treatment-Related | EGFR Gene MutationTaiwan
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VA Office of Research and DevelopmentMerck Sharp & Dohme LLCRecruitingMetastatic Castration Resistant Prostate CancerUnited States
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Myat Htut NyuntKangwon National UniversityCompletedDay-3 Positive of Parasitaemia | Prevalence of Drug Resistance Gene MutationMyanmar
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Sebastian BauerHannover Medical School; University Hospital Tuebingen; Universitätsmedizin Mannheim and other collaboratorsUnknownGIST, Malignant | KIT Gene Mutation | KIT Exon 13 MutationGermany
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SUNHO（China）BioPharmaceutical CO., Ltd.RecruitingHER2 Gene MutationChina
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Shimaa KamalActive, not recruitingGene Mutation in Infantile Onset Diabetes MellitusEgypt
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Rhythm Pharmaceuticals, Inc.CompletedPro-opiomelanocortin (POMC), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) and Leptin Receptor (LepR) Gene MutationsUnited States, Israel, Canada, Germany, Greece, Italy, Portugal
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Daiichi Sankyo, Inc.No longer availableAcute Myeloid Leukemia With Gene Mutations
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Roswell Park Cancer InstituteAstraZenecaActive, not recruitingBRCA1 Gene Mutation | BRCA2 Gene Mutation | Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Ovarian Serous AdenocarcinomaUnited States
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Guangxi Medical UniversityCompletedFull Gene Sequences of c-KIT、PDGFRA and DOG1 Are Analyzed With the Screening-sequencing Approach | Investigate the Characteristics and Variations Associated With the Different Gene Mutations of c-KIT、PDGFRA and DOG1 in GIST Patients
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Jonsson Comprehensive Cancer CenterAstraZenecaActive, not recruitingGlioblastoma | Recurrent Glioblastoma | EGFR Gene Mutation | Supratentorial Glioblastoma | EGFR Gene Amplification | TP53 wt AlleleUnited States
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RenJi HospitalPeking University First Hospital; Shanghai Zhongshan Hospital; First Affiliated... and other collaboratorsRecruitingKidney Cancer | Renal Cell Carcinoma | ALK Gene Mutation | MET Gene Mutation | HLRCC | Renal Tumor Histology | Cutaneous Leiomyoma | BAP1 Tumor Predisposition Syndrome | VHL Syndrome | Birt-Hogg-Dube Syndrome | Familial Renal Cancer | FLCN Gene Mutation | FH Gene Mutation | Cutaneous Leiomyomata With Uterine LeiomyomataChina
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Centro di Riferimento Oncologico - AvianoRecruitingBreast Neoplasms | Breast Diseases | Antineoplastic Agents | Aromatase Inhibitors | Neoplasms, Breast | Hormone Receptor Positive Breast Carcinoma | ESR1 Gene MutationItaly
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Taiho Oncology, Inc.TerminatedNon-Small Cell Lung Cancer | KRAS Gene Mutation | Advanced or Metastatic Solid Tumors Irrespective of Gene AlterationsUnited States
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Massachusetts General HospitalGlaxoSmithKlineRecruitingRecurrent Glioma | Low-grade Glioma | Glioma, Malignant | IDH2 Gene Mutation | IDH1 MutationUnited States
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Chonnam National University HospitalCompletedLung Neoplasms | EGFR Gene MutationsKorea, Republic of
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Asan Medical CenterUnknownCancer | Lung Cancer Metastatic | MET Gene MutationKorea, Republic of
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Collin BlakelyPuma Biotechnology, Inc.Active, not recruitingLung Cancer Metastatic | EGFR Gene MutationUnited States
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MedSIRStemline Therapeutics, Inc.Not yet recruitingAdvanced Breast Cancer | ER-positive Breast Cancer | HER2-negative Breast Cancer | ESR1 Gene Mutation
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AstraZenecaCompletedAdvanced Solid Malignancies | Breast Cancer - ER+, HER2 - | Breast Cancer - ER+, HER2-, PIK3CA Gene MutationUnited States, United Kingdom
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Third Affiliated Hospital, Sun Yat-Sen UniversityRecruitingColorectal Cancer | Neoadjuvant Therapy | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)China
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Sun Yat-sen UniversityRecruitingColorectal Cancer | Neoadjuvant Therapy | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)China
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Sun Yat-sen UniversityThe Second Affiliated Hospital of Kunming Medical UniversityCompletedColorectal Cancer Metastatic | Microsatellite Instability High | Mismatch Repair DeficiencyChina
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Memorial Sloan Kettering Cancer CenterRecruitingStudy of Cemiplimab Combined With Dabrafenib and Trametinib in People With Anaplastic Thyroid CancerThyroid Cancer | Anaplastic Thyroid Cancer | BRAF Gene Mutation | BRAF Mutation-Related TumorsUnited States
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Instituto Nacional de Cancerologia de MexicoUnknownEGFR Gene Mutation | Tyrosine Kinase Mutation | Non-Small Cell AdenocarcinomaMexico
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Abramson Cancer Center at Penn MedicineRecruitingBreast Cancer | Gastric Cancer | Cancer Gene MutationUnited States
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Consorzio OncotechActive, not recruitingMetastatic Breast Cancer | Triple Negative Breast Cancer | PD-L1 Gene MutationItaly
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Ikena OncologyRecruitingColorectal Cancer | Pancreatic Cancer | Thyroid Carcinoma | Solid Tumor, Adult | Malignant Melanoma | Non-Small Cell Lung Carcinoma | BRAF Gene Mutation | Gliomas, Malignant | Ras (Kras or Nras) Gene Mutation | CRAF Gene MutationUnited States
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LiuYingNot yet recruitingColorectal Cancer | Neoadjuvant Therapy | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)China
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Monaldi HospitalRecruitingHeart Failure | Lamin A/C Gene Mutation | LaminopathyItaly
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Memorial Sloan Kettering Cancer CenterAgios Pharmaceuticals, Inc.RecruitingChondrosarcoma | IDH1 Gene Mutation | Chondrosarcoma, Grade 2 | Chondrosarcoma, Grade 3United States
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University of Illinois at ChicagoWithdrawnVHL Gene Mutation | Polycythemia; Familial | Erythrocytosis; Familial | HIF-2alpha Erythrocytosis | PHD2 Erythrocytosis | Chuvash Erythrocytosis