Clinical Trials on Mitochondrial Function, Bioenergetics

Total 5227 results

Amazentis SA
University of Washington; Synteract, Inc.

Completed

Bioenergetics and Muscle Function Improvement With AMAZ-02 in Elderly Skeletal Muscle (ENERGIZE Trial)

Aging | Muscle Function | Mitochondrial Function, Bioenergetics

United States
Maastricht University
Wageningen University and Research; Top Institute Food and Nutrition; Netherlands...

Terminated

The Effect of Fish Oils With Dairy or Plant Based Lipids on Mitochondrial and Physical, and Cognitive Function, in Elderly Humans

Cognitive Function | Ageing | Physical Function | Mitochondrial Function

Netherlands
Maastricht University

Terminated

NAD Supplementation Study (NADS)

Aging | Mitochondrial Function

Netherlands
Amazentis SA
Eurofins Optimed

Completed

A Single and Multiple Dose Study of AMAZ-02 to Evaluate Safety and Pharmacokinetics in Elderly Subjects

Aging | Muscle Function | Mitochondrial Dysfunction

France
University of Florida
National Center for Complementary and Integrative Health (NCCIH); Office of...

Completed

Resveratrol to Enhance Vitality and Vigor in Elders (REVIVE)

Physical Function | Mitochondrial Function

United States
Royal Devon and Exeter NHS Foundation Trust
University of Exeter

Completed

Increasing Mitochondrial Function on Skeletal Muscle Performance in Older Men (Rejuvenate)

Impaired Mitochondrial Function, Muscle Performance

United Kingdom
Christopher Bell

Completed

Ergogenic Properties of Magnesium Supplementation

Exercise Performance | Gut -Microbiota | Mitochondrial Function

United States
University of Exeter
Royal Devon and Exeter NHS Foundation Trust

Terminated

Assessing the Effects of Increased Mitochondrial Function Exercise Training on Muscle Performance (Rejuvenate2)

Impaired Mitochondrial Function, Muscle Performance

United Kingdom
Amazentis SA
KGK Science Inc.

Completed

AMAZ-02 Effect on Exercise ToLerance in Healthy, Overweight Middle Aged Subjects (ATLAS Trial) (ATLAS)

Overweight | Healthy Aging | Muscle Function, Mitochondrial Function

Canada
The Hospital for Sick Children

Completed

A Single Case Study of Hypermetabolism

Hypermetabolism Due to Defect in Mitochondria | Luft Disease

Canada
Biofortis, Merieux NutriSciences

Recruiting

Phytochemicals on "Metabolic Aging" in Older Overweight Adults

Mitochondrial Functions

United States
The Swedish School of Sport and Health Sciences
Swedish Research Council for Sport Science

Completed

Dose-response Relationship Between Exercise and Health Outcomes

Glucose Intolerance | Mitochondrial Function

Sweden
Al-Azhar University
University Hospital Fattouma Bourguiba

Completed

Laparoscopic Assisted Dismembered Pyeloplasty Versus Open Pyeloplasty in (UPJO) With Poorly Function Kidney in Pediatrics

Uretro-pelvic Junction Obstruction | Poorly Function Kidney

Egypt
VA Office of Research and Development

Active, not recruiting

Implementing a Skills-Based Caregiver Training Program (Caregivers FIRST): Function QUERI 2.0

Cognitive Function | Functional Status

United States
McGill University
Canadian Institutes of Health Research (CIHR)

Completed

Exogenous Ketosis During Bed Rest in Older Adults (KBR)

Muscle Atrophy | Cognitive Function | Muscle Protein Synthesis | Insulin Sensitivity | Muscle Strength | Functional Capacity | Physical Inactivity | Mitochondrial Function

Canada
Cambridge University Hospitals NHS Foundation Trust
University of Cambridge; Medical Research Council Mitochondrial Biology Unit

Completed

Nicotinamide Riboside and Mitochondrial Biogenesis

Mitochondrial Diseases | Mitochondrial Myopathies | Progressive External Ophthalmoplegia | Progressive Ophthalmoplegia | Progressive; Ophthalmoplegia, External | Mitochondria DNA Deletion | MELAS

United Kingdom
Xuzhou Central Hospital
The Affiliated Hospital of Xuzhou Medical University

Not yet recruiting

rTMS in the Prevention and Treatment of Postoperative Executive Dysfunction

Functional Magnetic Resonance Imaging | Executive Function Disorder
University of Aarhus
Novo Nordisk A/S

Enrolling by invitation

Cardiac Mitochondrial Function After Heart Transplantation (ENERGY-HTX)

Cardiac Allograft Vasculopathy | Acute Cellular Graft Rejection | Mitochondrial Function | Primary Graft Failure

Denmark
Stealth BioTherapeutics Inc.

Active, not recruiting

Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nuclear DNA Mutations (nPMD) (NuPower)

Mitochondrial Diseases | Mitochondrial Myopathies | Mitochondrial Complex I Deficiency | Mitochondrial Pathology | Mitochondrial DNA Depletion | Mitochondrial DNA Mutation | Mitochondrial DNA Deletion | Mitochondrial Metabolism Defect

Spain, United States, Italy, Netherlands, Australia, Germany, Hungary, New Zealand, Norway, United Kingdom
McGill University Health Centre/Research Institute...

Recruiting

Deoxynucleosides Pyrimidines as Treatment for Mitochondrial Depletion Syndrome (dC-dT-MDS)

Mitochondrial Diseases | Mitochondrial Encephalomyopathy | Mitochondrial Encephalopathy | Mitochondrial DNA Depletion | Mitochondrial Metabolism Disorders

Canada
Stealth BioTherapeutics Inc.

Completed

Safety, Tolerability, Efficacy of MTP-131 for Treatment of Mitochondrial Disease in Subjects From the MMPOWER Study (MMPOWER-2)

Primary Mitochondrial Disease

United States
Stealth BioTherapeutics Inc.

Terminated

Open-Label Extension Trial to Characterize the Long-term Safety and Tolerability of Elamipretide in Subjects With Genetically Confirmed Primary Mitochondrial Myopathy (PMM)

Primary Mitochondrial Disease

United States
Rigshospitalet, Denmark
University of Copenhagen

Recruiting

Human Mitochondrial Stress-driven Obesity Resistance (MITO-OB-RES)

Mitochondrial Diseases | Mitochondrial Myopathies | Mitochondrial Disorder

Denmark
Children's Hospital of Philadelphia
University of Pennsylvania; United Mitochondrial Disease Foundation (UMDF)

Recruiting

Mitochondrial Myopathy Rating Scale

Primary Mitochondrial Disease

United States
Khondrion BV
Radboud University Medical Center

Completed

The KHENERGY Study (KHENERGY)

Mitochondrial Diseases | Mitochondrial Myopathies | MELAS | Mitochondrial Encephalomyopathies | MIDD

Netherlands
Newcastle-upon-Tyne Hospitals NHS Trust
Newcastle University

Completed

A Study of Bezafibrate in Mitochondrial Myopathy

Mitochondrial Diseases

United Kingdom
Massachusetts General Hospital

Completed

Defining 31Phosphorous Magnetic Resonance Spectroscopy Characteristics in Patients With Mitochondrial Myopathy

Mitochondrial Disease

United States
Minovia Therapeutics Ltd.

Not yet recruiting

A First in Human Study to Evaluate the Safety of Infusion of MNV-BM-PLC (Autologous CD34+ Cells Enriched With Placenta Derived Allogeneic Mitochondria) in Patients With Primary Mitochondrial Diseases Associated With Mitochondrial DNA Mutation or Deletion

Primary Mitochondrial Diseases

Israel
Reata, a wholly owned subsidiary of Biogen
AbbVie

Completed

RTA 408 Capsules in Patients With Mitochondrial Myopathy - MOTOR

MItochondrial Myopathies

United States, Denmark
University Hospital, Bordeaux

Recruiting

Mitochondrial Disease-associated ImmunoDeficiencies (MitoID)

Mitochondrial Disorders

France
Cliniques universitaires Saint-Luc- Université...

Recruiting

Intermittent Versus Continuous Surface O2 During HMP of DCD Kidneys (HMPO2)

Ischemia Reperfusion Injury | Kidney Transplant; Complications | Delayed Graft Function | Mitochondrial

Belgium
Children's Hospital of Philadelphia
National Institute of Neurological Disorders and Stroke (NINDS)

Recruiting

Validation of Oxygen Nanosensor in Mitochondrial Myopathy

Mitochondrial Diseases | Mitochondrial Myopathies

United States
Reneo Pharma Ltd

Terminated

An Open Label, Long Term Safety Study of REN001 in Primary Mitochondrial Myopathy Patients (Stride Ahead)

Primary Mitochondrial Myopathy

Spain, Australia, Belgium, Denmark, Canada, United Kingdom, France, Germany, Hungary, Italy, Netherlands, New Zealand
Rigshospitalet, Denmark
University of Copenhagen

Recruiting

Mitochondrial Dysfunctions Driving Insulin Resistance (MITO-DYS-IR)

Mitochondrial Diseases | Mitochondrial Myopathies | Mitochondrial Disorders

Denmark
Rigshospitalet, Denmark
University of Copenhagen

Recruiting

Exercise-mediated Rescue of Mitochondrial Dysfunctions Driving Insulin Resistance (EX-MITO-DYS-IR)

Mitochondrial Diseases | Mitochondrial Myopathies | Mitochondrial Disorders

Denmark
Cristina Domínguez González

Recruiting

Natural History in Primary Mitochondrial Myopathies (NHPMM)

Primary Mitochondrial Myopathies

Spain
Children's Hospital of Philadelphia
United States Department of Defense

Recruiting

Applying pGz in Mitochondrial Disease

Mitochondrial Diseases | Mitochondrial Myopathies

United States
The Emmes Company, LLC
United Mitochondrial Disease Foundation; PolG Foundation Mito Australia

Recruiting

Mitochondrial Video Assessment Source Material Study

PolG, Primary Mitochondrial Myopathy

United States
Federal University of Vicosa

Completed

Eccentrically Reinforced Resistance Training vs. Traditional Resistance Training in Sedentary Older Women

Depression | Executive Function | Physical Functional Performance

Brazil
Stealth BioTherapeutics Inc.

Completed

Safety, Tolerability, and Efficacy of MTP-131 for the Treatment of Mitochondrial Myopathy (MMPOWER)

Mitochondrial Myopathy

United States
Children's Hospital of Philadelphia
National Institute of Neurological Disorders and Stroke (NINDS); North American...

Recruiting

Promoting Resilience in Stress Management (PRISM) and Clinical-focused Narrative (CFN) Pilot in Adults With Primary Mitochondrial Disease (PMD).

Mitochondrial Diseases | Mitochondrial Myopathies | MELAS | Mitochondrial Encephalomyopathies | MERRF

United States
Reneo Pharma Ltd

Completed

An Efficacy and Safety Study of 24 Week Treatment With Mavodelpar (REN001) in Primary Mitochondrial Myopathy Patients (STRIDE)

Primary Mitochondrial Myopathy

United States, Spain, Australia, France, United Kingdom, New Zealand, Denmark, Norway, Czechia, Belgium, Canada, Germany, Hungary, Italy, Netherlands
Stealth BioTherapeutics Inc.

Terminated

A Trial to Evaluate Safety and Efficacy of Elamipretide Primary Mitochondrial Myopathy Followed by Open-Label Extension (MMPOWER-3)

Primary Mitochondrial Myopathy

United States, Germany, Canada, Italy, United Kingdom, Denmark, Hungary
Reneo Pharma Ltd

Terminated

A Study of the Safety of REN001 in Patients With Primary Mitochondrial Myopathy

Primary Mitochondrial Myopathy

United Kingdom
Radboud University Medical Center

Completed

DINAMITE Study Nutritional State and Effect Diet in Mitochondrial Disease (DINAMITE)

Mitochondrial Disorders
Centre Hospitalier Universitaire de Nice

Recruiting

MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases (MITOMICS)

Mitochondrial Diseases

France
Columbia University
National Institute of Mental Health (NIMH); Massachusetts General Hospital; Dartmouth... and other collaborators

Completed

Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE)

Mitochondrial Diseases

United States
Children's Hospital of Philadelphia

Enrolling by invitation

CrCest Study in Primary Mitochondrial Disease

Mitochondrial Diseases

United States
Centre Hospitalier Universitaire de Nice

Completed

Identification of New Candidate Genes in Patients With Mitochondrial Disease by High Resolution Chromosome Analysis on DNA Chip (ACPA HR)

Mitochondrial Diseases

France
Abliva AB

Completed

Drug-drug Interaction Study of KL1333 in Healthy Subjects

Mitochondrial Disease

United Kingdom

Clinical Trials on Mitochondrial Function, Bioenergetics

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